JP2021505141A5 - - Google Patents
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- Publication number
- JP2021505141A5 JP2021505141A5 JP2020530565A JP2020530565A JP2021505141A5 JP 2021505141 A5 JP2021505141 A5 JP 2021505141A5 JP 2020530565 A JP2020530565 A JP 2020530565A JP 2020530565 A JP2020530565 A JP 2020530565A JP 2021505141 A5 JP2021505141 A5 JP 2021505141A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- item
- rodent
- gene
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 545
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 claims description 178
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 claims description 175
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 107
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 107
- 108060003951 Immunoglobulin Proteins 0.000 claims description 71
- 102000018358 immunoglobulin Human genes 0.000 claims description 71
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 54
- 108091026890 Coding region Proteins 0.000 claims description 45
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 45
- 210000004602 germ cell Anatomy 0.000 claims description 31
- 108010008286 DNA nucleotidylexotransferase Proteins 0.000 claims description 29
- 102100033215 DNA nucleotidylexotransferase Human genes 0.000 claims description 29
- 150000007523 nucleic acids Chemical group 0.000 claims description 12
- 230000000392 somatic effect Effects 0.000 claims description 11
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 10
- 241000699670 Mus sp. Species 0.000 claims description 8
- 238000012239 gene modification Methods 0.000 claims description 5
- 230000005017 genetic modification Effects 0.000 claims description 4
- 235000013617 genetically modified food Nutrition 0.000 claims description 4
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 241000283984 Rodentia Species 0.000 description 477
- 210000004027 cell Anatomy 0.000 description 137
- 238000000034 method Methods 0.000 description 128
- 239000012634 fragment Substances 0.000 description 41
- 229920001184 polypeptide Polymers 0.000 description 37
- 108090000765 processed proteins & peptides Proteins 0.000 description 37
- 102000004196 processed proteins & peptides Human genes 0.000 description 37
- 108700029229 Transcriptional Regulatory Elements Proteins 0.000 description 36
- 241000282412 Homo Species 0.000 description 25
- 239000000427 antigen Substances 0.000 description 23
- 108091007433 antigens Proteins 0.000 description 23
- 102000036639 antigens Human genes 0.000 description 23
- 239000002773 nucleotide Substances 0.000 description 22
- 125000003729 nucleotide group Chemical group 0.000 description 22
- 108091008109 Pseudogenes Proteins 0.000 description 10
- 102000057361 Pseudogenes Human genes 0.000 description 10
- 102000001183 RAG-1 Human genes 0.000 description 10
- 108060006897 RAG1 Proteins 0.000 description 10
- 101001061851 Homo sapiens V(D)J recombination-activating protein 2 Proteins 0.000 description 9
- 102100029591 V(D)J recombination-activating protein 2 Human genes 0.000 description 9
- 230000003053 immunization Effects 0.000 description 9
- 108010029485 Protein Isoforms Proteins 0.000 description 5
- 102000001708 Protein Isoforms Human genes 0.000 description 5
- 210000000349 chromosome Anatomy 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000028993 immune response Effects 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 101150075516 RAG2 gene Proteins 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024012752A JP7765514B2 (ja) | 2017-12-05 | 2024-01-31 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
| JP2025179615A JP2026016575A (ja) | 2017-12-05 | 2025-10-24 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762594946P | 2017-12-05 | 2017-12-05 | |
| US201762594944P | 2017-12-05 | 2017-12-05 | |
| US62/594,944 | 2017-12-05 | ||
| US62/594,946 | 2017-12-05 | ||
| US201762609251P | 2017-12-21 | 2017-12-21 | |
| US201762609241P | 2017-12-21 | 2017-12-21 | |
| US62/609,251 | 2017-12-21 | ||
| US62/609,241 | 2017-12-21 | ||
| PCT/US2018/063841 WO2019113065A1 (en) | 2017-12-05 | 2018-12-04 | Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024012752A Division JP7765514B2 (ja) | 2017-12-05 | 2024-01-31 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505141A JP2021505141A (ja) | 2021-02-18 |
| JP2021505141A5 true JP2021505141A5 (https=) | 2022-01-11 |
| JP7430636B2 JP7430636B2 (ja) | 2024-02-13 |
Family
ID=64734263
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530565A Active JP7430636B2 (ja) | 2017-12-05 | 2018-12-04 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
| JP2024012752A Active JP7765514B2 (ja) | 2017-12-05 | 2024-01-31 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
| JP2025179615A Pending JP2026016575A (ja) | 2017-12-05 | 2025-10-24 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024012752A Active JP7765514B2 (ja) | 2017-12-05 | 2024-01-31 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
| JP2025179615A Pending JP2026016575A (ja) | 2017-12-05 | 2025-10-24 | 操作された免疫グロブリンラムダ軽鎖を有する非ヒト動物及びその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US11051498B2 (https=) |
| EP (3) | EP4140297B1 (https=) |
| JP (3) | JP7430636B2 (https=) |
| KR (2) | KR102760506B1 (https=) |
| CN (2) | CN111432635B (https=) |
| AU (2) | AU2018381316B2 (https=) |
| BR (1) | BR112020011184A2 (https=) |
| CA (1) | CA3084049A1 (https=) |
| DK (2) | DK4140297T3 (https=) |
| ES (2) | ES3035461T3 (https=) |
| FI (1) | FI4140297T3 (https=) |
| HR (2) | HRP20250920T1 (https=) |
| HU (2) | HUE060608T2 (https=) |
| IL (2) | IL318197A (https=) |
| LT (2) | LT4140297T (https=) |
| MX (2) | MX2020005830A (https=) |
| PL (2) | PL4140297T3 (https=) |
| PT (2) | PT4140297T (https=) |
| RS (2) | RS63772B1 (https=) |
| SG (1) | SG11202003044SA (https=) |
| SI (2) | SI3720279T1 (https=) |
| SM (2) | SMT202500277T1 (https=) |
| TW (2) | TWI827567B (https=) |
| WO (1) | WO2019113065A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6482757B2 (ja) | 2010-07-26 | 2019-03-13 | トリアンニ インコーポレイテッドＴｒｉａｎｎｉ，Ｉｎｃ． | トランスジェニック動物および使用方法 |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| PL2958937T3 (pl) | 2013-02-22 | 2019-01-31 | Regeneron Pharmaceuticals, Inc. | Myszy ekspresjonujące humanizowany główny układ zgodności tkankowej |
| EP3384030A4 (en) | 2015-12-03 | 2019-07-03 | Trianni, Inc. | IMPROVED IMMUNOGLULINIVITY |
| DK4140297T3 (da) | 2017-12-05 | 2025-06-23 | Regeneron Pharma | Mus med en konstrueret immunglobulin-lambda-letkæde og anvendelser deraf |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| JP2022520819A (ja) | 2019-02-22 | 2022-04-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変ナトリウムチャネルを有する齧歯類およびその使用方法 |
| WO2021003152A1 (en) * | 2019-07-01 | 2021-01-07 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| CA3144956A1 (en) * | 2019-07-01 | 2021-01-07 | Trianni, Inc. | Transgenic mammals and methods of use |
| CA3187680A1 (en) | 2020-09-11 | 2022-03-17 | Yashu Liu | Identification and production of antigen-specific antibodies |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| TW202242114A (zh) | 2020-12-23 | 2022-11-01 | 美商再生元醫藥公司 | 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法 |
| CA3165366A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN114763558B (zh) * | 2021-01-14 | 2024-02-20 | 上海泰槿生物技术有限公司 | 重组基因组、非人哺乳动物细胞及其产生方法和用途 |
| AU2022249328A1 (en) * | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
| CN121065267A (zh) * | 2024-06-04 | 2025-12-05 | 赛业（苏州）生物科技有限公司 | 用于制备四元固定轻链的基因修饰的啮齿动物及其制备方法 |
| EP4671705A1 (de) | 2024-06-25 | 2025-12-31 | Harro Höfliger Verpackungsmaschinen GmbH | Vorrichtung und verfahren zum prüfen des sprühstrahls einer baugruppe für sprühapplikatoren |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| AU669124B2 (en) * | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| EP1500329B1 (en) * | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| EA013564B1 (ru) * | 2000-08-03 | 2010-06-30 | Терапеутик Хьюман Поликлоналз Инк. | Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7435871B2 (en) | 2001-11-30 | 2008-10-14 | Amgen Fremont Inc. | Transgenic animals bearing human Igλ light chain genes |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| CA2696934A1 (en) * | 2007-09-12 | 2010-02-16 | Probiodrug Ag | Transgenic mice |
| PL3456190T3 (pl) * | 2008-06-27 | 2022-06-06 | Merus N.V. | Wytwarzające przeciwciała transgeniczne zwierzę z gatunku myszy |
| EP2346994B1 (en) | 2008-09-30 | 2022-02-16 | Ablexis, LLC | Knock-in mice for the production of chimeric antibodies |
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| US9445581B2 (en) * | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| RU2425880C2 (ru) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US9012717B2 (en) | 2010-06-22 | 2015-04-21 | Regeneron Pharmaceuticals, Inc. | Human lambda light chain mice |
| RU2722373C2 (ru) | 2011-02-25 | 2020-05-29 | Редженерон Фармасьютикалс, Инк. | Мыши adam6 |
| KR20160098514A (ko) | 2011-10-17 | 2016-08-18 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| RU2664181C2 (ru) * | 2011-12-20 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной легкой цепью |
| RS62023B1 (sr) | 2012-02-01 | 2021-07-30 | Regeneron Pharma | Humanizovani glodari koji eksprimiraju teške lance koji sadrže vl domene |
| PT3597037T (pt) * | 2012-06-12 | 2021-06-01 | Regeneron Pharma | Animais não humanos humanizados com lócus de cadeia pesada de imunoglobulina restrito |
| MX2015010841A (es) | 2013-02-20 | 2016-05-09 | Regeneron Pharma | Modificacion genetica de ratas. |
| SI2986729T1 (sl) | 2013-04-16 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Ciljana sprememba genoma podgane |
| DE112014004537T5 (de) * | 2013-10-01 | 2016-07-21 | Kymab Limited | Tiermodelle und therapeutische Moleküle |
| HUE049405T2 (hu) | 2014-06-23 | 2020-09-28 | Regeneron Pharma | Nukleáz-közvetített DNS-összeállítás |
| ES2731437T3 (es) | 2014-11-21 | 2019-11-15 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías |
| KR102530821B1 (ko) | 2014-12-19 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 단계 다중 표적화를 통한 표적화된 유전자 변형을 위한 방법 및 조성물 |
| HUE061619T2 (hu) | 2016-06-03 | 2023-07-28 | Regeneron Pharma | Exogén terminális dezoxinukleotid-transzferázt expresszáló rágcsálók |
| GB201710984D0 (en) * | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
| DK4140297T3 (da) | 2017-12-05 | 2025-06-23 | Regeneron Pharma | Mus med en konstrueret immunglobulin-lambda-letkæde og anvendelser deraf |
-
2018
- 2018-12-04 DK DK22188627.8T patent/DK4140297T3/da active
- 2018-12-04 FI FIEP22188627.8T patent/FI4140297T3/fi active
- 2018-12-04 HU HUE18821945A patent/HUE060608T2/hu unknown
- 2018-12-04 IL IL318197A patent/IL318197A/en unknown
- 2018-12-04 US US16/209,820 patent/US11051498B2/en active Active
- 2018-12-04 US US16/769,821 patent/US20210345591A1/en not_active Abandoned
- 2018-12-04 EP EP22188627.8A patent/EP4140297B1/en active Active
- 2018-12-04 LT LTEP22188627.8T patent/LT4140297T/lt unknown
- 2018-12-04 HR HRP20250920TT patent/HRP20250920T1/hr unknown
- 2018-12-04 EP EP18821945.5A patent/EP3720279B1/en active Active
- 2018-12-04 DK DK18821945.5T patent/DK3720279T3/da active
- 2018-12-04 SI SI201830769T patent/SI3720279T1/sl unknown
- 2018-12-04 PL PL22188627.8T patent/PL4140297T3/pl unknown
- 2018-12-04 EP EP25169830.4A patent/EP4596688A3/en active Pending
- 2018-12-04 AU AU2018381316A patent/AU2018381316B2/en active Active
- 2018-12-04 JP JP2020530565A patent/JP7430636B2/ja active Active
- 2018-12-04 PT PT221886278T patent/PT4140297T/pt unknown
- 2018-12-04 ES ES22188627T patent/ES3035461T3/es active Active
- 2018-12-04 BR BR112020011184-8A patent/BR112020011184A2/pt unknown
- 2018-12-04 TW TW107143491A patent/TWI827567B/zh active
- 2018-12-04 CN CN201880078631.1A patent/CN111432635B/zh active Active
- 2018-12-04 SM SM20250277T patent/SMT202500277T1/it unknown
- 2018-12-04 CN CN202211211765.0A patent/CN116058333A/zh active Pending
- 2018-12-04 WO PCT/US2018/063841 patent/WO2019113065A1/en not_active Ceased
- 2018-12-04 CA CA3084049A patent/CA3084049A1/en active Pending
- 2018-12-04 KR KR1020207016646A patent/KR102760506B1/ko active Active
- 2018-12-04 SM SM20220448T patent/SMT202200448T1/it unknown
- 2018-12-04 SI SI201831243T patent/SI4140297T1/sl unknown
- 2018-12-04 MX MX2020005830A patent/MX2020005830A/es unknown
- 2018-12-04 HR HRP20221459TT patent/HRP20221459T1/hr unknown
- 2018-12-04 SG SG11202003044SA patent/SG11202003044SA/en unknown
- 2018-12-04 PL PL18821945.5T patent/PL3720279T3/pl unknown
- 2018-12-04 PT PT188219455T patent/PT3720279T/pt unknown
- 2018-12-04 ES ES18821945T patent/ES2928995T3/es active Active
- 2018-12-04 TW TW112148224A patent/TW202438676A/zh unknown
- 2018-12-04 HU HUE22188627A patent/HUE071852T2/hu unknown
- 2018-12-04 LT LTEPPCT/US2018/063841T patent/LT3720279T/lt unknown
- 2018-12-04 IL IL274797A patent/IL274797B2/en unknown
- 2018-12-04 RS RS20221094A patent/RS63772B1/sr unknown
- 2018-12-04 RS RS20250752A patent/RS67058B1/sr unknown
- 2018-12-04 KR KR1020257002291A patent/KR20250022220A/ko active Pending
-
2020
- 2020-07-13 MX MX2024004496A patent/MX2024004496A/es unknown
-
2021
- 2021-06-01 US US17/335,727 patent/US12356967B2/en active Active
-
2024
- 2024-01-31 JP JP2024012752A patent/JP7765514B2/ja active Active
-
2025
- 2025-06-11 US US19/234,795 patent/US20260020545A1/en active Pending
- 2025-06-18 AU AU2025204547A patent/AU2025204547A1/en active Pending
- 2025-10-24 JP JP2025179615A patent/JP2026016575A/ja active Pending
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