JP2021503490A5 - - Google Patents

Info

Publication number

JP2021503490A5

JP2021503490A5 JP2020543658A JP2020543658A JP2021503490A5 JP 2021503490 A5 JP2021503490 A5 JP 2021503490A5 JP 2020543658 A JP2020543658 A JP 2020543658A JP 2020543658 A JP2020543658 A JP 2020543658A JP 2021503490 A5 JP2021503490 A5 JP 2021503490A5

Authority

JP

Japan

Prior art keywords

compound according

compound

formula

derivative

acid

Prior art date

2018-10-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 40
• 239000002184 metal Substances 0.000 claims 7
• 229910052751 metal Inorganic materials 0.000 claims 7
• 230000002285 radioactive effect Effects 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 6
• 239000012453 solvate Substances 0.000 claims 6
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 4
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 3
• KSFQNMZAJKFRIO-UHFFFAOYSA-N 1-ethyl-3-hydroxypyridin-4-one Chemical compound CCN1C=CC(=O)C(O)=C1 KSFQNMZAJKFRIO-UHFFFAOYSA-N 0.000 claims 2
• JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 claims 2
• OOLRAQKFMNOZBV-UHFFFAOYSA-N 8-n-[(4-aminophenyl)methyl]-3,6,10,13,16,19-hexazabicyclo[6.6.6]icosane-1,8-diamine Chemical compound C1=CC(N)=CC=C1CNC1(CNCCNC2)CNCCNCC2(N)CNCCNC1 OOLRAQKFMNOZBV-UHFFFAOYSA-N 0.000 claims 2
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• JVHROZDXPAUZFK-UHFFFAOYSA-N TETA Chemical compound OC(=O)CN1CCCN(CC(O)=O)CCN(CC(O)=O)CCCN(CC(O)=O)CC1 JVHROZDXPAUZFK-UHFFFAOYSA-N 0.000 claims 2
• 239000000654 additive Substances 0.000 claims 2
• 230000000996 additive effect Effects 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 238000003384 imaging method Methods 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 229960003330 pentetic acid Drugs 0.000 claims 2
• GRUVVLWKPGIYEG-UHFFFAOYSA-N 2-[2-[carboxymethyl-[(2-hydroxyphenyl)methyl]amino]ethyl-[(2-hydroxyphenyl)methyl]amino]acetic acid Chemical compound C=1C=CC=C(O)C=1CN(CC(=O)O)CCN(CC(O)=O)CC1=CC=CC=C1O GRUVVLWKPGIYEG-UHFFFAOYSA-N 0.000 claims 1
• FDSYTWVNUJTPMA-UHFFFAOYSA-N 2-[3,9-bis(carboxymethyl)-3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl]acetic acid Chemical compound C1N(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC2=CC=CC1=N2 FDSYTWVNUJTPMA-UHFFFAOYSA-N 0.000 claims 1
• 125000006290 2-hydroxybenzyl group Chemical group [H]OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 1
• QXFUBAAEKCHBQY-UHFFFAOYSA-N 3-[hydroxy(methyl)phosphoryl]propanoic acid Chemical compound CP(O)(=O)CCC(O)=O QXFUBAAEKCHBQY-UHFFFAOYSA-N 0.000 claims 1
• -1 6-carboxy-2-pyridylmethyl Chemical group 0.000 claims 1
• 239000007983 Tris buffer Substances 0.000 claims 1
• 239000002738 chelating agent Substances 0.000 claims 1
• 150000002739 metals Chemical class 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• JITIEKDDGKWPGT-HDIXRZANSA-N OC(CC[C@@H](C(O)=O)NC(N[C@@H](CCCCNC([C@H](Cc1cc(cccc2)c2cc1)NC(C1CCC(CNC([C@H](CCCCNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)NC(CNC(CCc2ccccc2)=O)=O)=O)CC1)=O)=O)C(O)=O)=O)=O Chemical compound OC(CC[C@@H](C(O)=O)NC(N[C@@H](CCCCNC([C@H](Cc1cc(cccc2)c2cc1)NC(C1CCC(CNC([C@H](CCCCNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)NC(CNC(CCc2ccccc2)=O)=O)=O)CC1)=O)=O)C(O)=O)=O)=O JITIEKDDGKWPGT-HDIXRZANSA-N 0.000 description 1