JP2021501576A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021501576A5 JP2021501576A5 JP2020524113A JP2020524113A JP2021501576A5 JP 2021501576 A5 JP2021501576 A5 JP 2021501576A5 JP 2020524113 A JP2020524113 A JP 2020524113A JP 2020524113 A JP2020524113 A JP 2020524113A JP 2021501576 A5 JP2021501576 A5 JP 2021501576A5
- Authority
- JP
- Japan
- Prior art keywords
- tag
- binding
- biological
- binding substance
- library
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 92
- 239000003795 chemical substances by application Substances 0.000 claims description 45
- 239000000126 substance Substances 0.000 claims description 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 21
- 238000012546 transfer Methods 0.000 claims description 20
- 239000007787 solid Substances 0.000 claims description 15
- 108020004707 nucleic acids Proteins 0.000 claims description 13
- 102000039446 nucleic acids Human genes 0.000 claims description 13
- 150000007523 nucleic acids Chemical class 0.000 claims description 13
- 229920001184 polypeptide Polymers 0.000 claims description 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 230000003993 interaction Effects 0.000 claims description 9
- 239000011159 matrix material Substances 0.000 claims description 8
- 238000012163 sequencing technique Methods 0.000 claims description 6
- 108091023037 Aptamer Proteins 0.000 claims description 5
- 150000004676 glycans Chemical class 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims 7
- 239000002299 complementary DNA Substances 0.000 claims 7
- 108020004999 messenger RNA Proteins 0.000 claims 7
- 108091026890 Coding region Proteins 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000012165 high-throughput sequencing Methods 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 description 29
- 108010026552 Proteome Proteins 0.000 description 14
- 108020004414 DNA Proteins 0.000 description 11
- 230000037452 priming Effects 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108091034117 Oligonucleotide Proteins 0.000 description 8
- 102000053602 DNA Human genes 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 238000013519 translation Methods 0.000 description 6
- 125000006850 spacer group Chemical group 0.000 description 5
- 239000000020 Nitrocellulose Substances 0.000 description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 230000003321 amplification Effects 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 230000005291 magnetic effect Effects 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 4
- 239000002105 nanoparticle Substances 0.000 description 4
- 229920001220 nitrocellulos Polymers 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 230000005298 paramagnetic effect Effects 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 230000002255 enzymatic effect Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 241000238421 Arthropoda Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108091008102 DNA aptamers Proteins 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 108010079855 Peptide Aptamers Proteins 0.000 description 2
- 108010043958 Peptoids Proteins 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000021736 acetylation Effects 0.000 description 2
- 238000006640 acetylation reaction Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 230000022131 cell cycle Effects 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000012292 cell migration Effects 0.000 description 2
- 230000010307 cell transformation Effects 0.000 description 2
- 230000033077 cellular process Effects 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000032459 dedifferentiation Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000002122 magnetic nanoparticle Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 230000011987 methylation Effects 0.000 description 2
- 238000007069 methylation reaction Methods 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 239000002091 nanocage Substances 0.000 description 2
- 239000002078 nanoshell Substances 0.000 description 2
- 230000009635 nitrosylation Effects 0.000 description 2
- 108091008104 nucleic acid aptamers Proteins 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000026731 phosphorylation Effects 0.000 description 2
- 238000006366 phosphorylation reaction Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000004481 post-translational protein modification Effects 0.000 description 2
- 239000002096 quantum dot Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 230000034512 ubiquitination Effects 0.000 description 2
- 238000010798 ubiquitination Methods 0.000 description 2
- 239000007806 chemical reaction intermediate Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579840P | 2017-10-31 | 2017-10-31 | |
| US62/579,840 | 2017-10-31 | ||
| US201762582916P | 2017-11-07 | 2017-11-07 | |
| US62/582,916 | 2017-11-07 | ||
| PCT/US2018/058583 WO2019089851A1 (en) | 2017-10-31 | 2018-10-31 | Methods and kits using nucleic acid encoding and/or label |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501576A JP2021501576A (ja) | 2021-01-21 |
| JP2021501576A5 true JP2021501576A5 (enExample) | 2021-12-09 |
| JP7253833B2 JP7253833B2 (ja) | 2023-04-07 |
Family
ID=66332291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524113A Active JP7253833B2 (ja) | 2017-10-31 | 2018-10-31 | 核酸エンコーディングおよび／または標識を使用する方法およびキット |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20210355483A1 (enExample) |
| EP (1) | EP3704246A4 (enExample) |
| JP (1) | JP7253833B2 (enExample) |
| AU (1) | AU2018358247A1 (enExample) |
| CA (1) | CA3081451A1 (enExample) |
| SG (1) | SG11202003923PA (enExample) |
| WO (1) | WO2019089851A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE112012002570B4 (de) | 2011-06-23 | 2023-11-23 | Board Of Regents, The University Of Texas System | Identifizieren von Peptiden auf der Einzelmolekülebene |
| US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
| EP3543703A1 (en) | 2014-09-15 | 2019-09-25 | Board of Regents, The University of Texas System | Improved single molecule peptide sequencing |
| KR102741603B1 (ko) | 2016-05-02 | 2024-12-16 | 엔코디아, 인코포레이티드 | 암호화 핵산을 사용한 거대분자 분석 |
| EP3548652B1 (en) | 2016-12-01 | 2024-04-03 | Nautilus Subsidiary, Inc. | Methods of assaying proteins |
| SG11202003923PA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Methods and kits using nucleic acid encoding and/or label |
| KR102556494B1 (ko) | 2017-10-31 | 2023-07-18 | 엔코디아, 인코포레이티드 | 핵산 암호화 및/또는 표지를 이용한 분석용 키트 |
| CA3086915A1 (en) | 2017-12-29 | 2019-07-04 | Sujal M. Patel | Decoding approaches for protein identification |
| WO2019195633A1 (en) | 2018-04-04 | 2019-10-10 | Ignite Biosciences, Inc. | Methods of generating nanoarrays and microarrays |
| US20210239705A1 (en) * | 2018-06-06 | 2021-08-05 | Nautilus Biotechnology, Inc. | Methods and applications of protein identification |
| WO2020014586A1 (en) | 2018-07-12 | 2020-01-16 | Board Of Regents, The University Of Texas System | Molecular neighborhood detection by oligonucleotides |
| WO2020051162A1 (en) * | 2018-09-04 | 2020-03-12 | Encodia, Inc. | Proximity interaction analysis |
| EP3884048A4 (en) | 2018-11-20 | 2022-08-17 | Nautilus Biotechnology, Inc. | DESIGN AND SELECTION OF AFFINITY REAGENTS |
| EP3963091A4 (en) | 2019-04-29 | 2023-07-19 | Nautilus Biotechnology, Inc. | METHODS AND SYSTEMS FOR ON-CHIP INTEGRATED SINGLE MOLECULE DETECTION |
| EP3963070A4 (en) | 2019-04-30 | 2023-02-22 | Encodia, Inc. | METHODS OF PREPARATION OF ANALYTES AND RELATED KITS |
| US20220235405A1 (en) * | 2019-05-20 | 2022-07-28 | Encodia, Inc. | Methods and related kits for spatial analysis |
| US12377635B2 (en) | 2019-10-30 | 2025-08-05 | Nautilus Subsidiary, Inc. | Flow cell systems and methods |
| IL289295B2 (en) * | 2019-12-23 | 2025-07-01 | Illumina Cambridge Ltd | A nanoparticle with a single site for attaching a polynucleotide template |
| EP4073263A4 (en) | 2020-01-07 | 2023-11-08 | Encodia, Inc. | METHOD FOR STABLE COMPLEX FORMATION AND CORRESPONDING KITS |
| WO2021141924A1 (en) | 2020-01-07 | 2021-07-15 | Encodia, Inc. | Methods for stable complex formation and related kits |
| WO2021141922A1 (en) * | 2020-01-07 | 2021-07-15 | Encodia, Inc. | Methods for information transfer and related kits |
| WO2021163625A1 (en) * | 2020-02-12 | 2021-08-19 | Universal Sequencing Technology Corporation | Methods for intracellular barcoding and spatial barcoding |
| US20230146476A1 (en) * | 2020-02-29 | 2023-05-11 | President And Fellows Of Harvard College | Nanoswitch caliper trains for high-throughput, high-resolution structural analysis of biomolecules |
| JP2023538074A (ja) | 2020-08-19 | 2023-09-06 | エンコディア， インコーポレイテッド | 連続エンコーディング方法及び関連キット |
| WO2022067019A1 (en) * | 2020-09-26 | 2022-03-31 | The Regents Of The University Of California | Hybrid protocols and barcoding schemes for multiple sequencing technologies |
| US20230220589A1 (en) * | 2020-09-30 | 2023-07-13 | Encodia, Inc. | Polypeptide terminal binders and uses thereof |
| KR20230118570A (ko) | 2020-11-11 | 2023-08-11 | 노틸러스 서브시디어리, 인크. | 강화된 결합 및 검출 특성을 갖는 친화성 시약 |
| US12467081B2 (en) | 2020-11-23 | 2025-11-11 | Pleno, Inc. | Encoded endonuclease assays |
| WO2022115608A1 (en) * | 2020-11-25 | 2022-06-02 | Alida Biosciences, Inc. | Multiplexed profiling of rna and dna modifications |
| WO2022251457A2 (en) * | 2021-05-26 | 2022-12-01 | Board Of Regents, The University Of Texas System | Compositions, methods, and utility of conjugated biomolecule barcodes |
| CN113908589B (zh) * | 2021-10-08 | 2022-09-27 | 天津工业大学 | 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法 |
| US12474346B2 (en) | 2021-11-05 | 2025-11-18 | Encodia, Inc. | Methods and kits for multicycle encoding assay |
| EP4437135A4 (en) * | 2021-11-23 | 2025-12-03 | Pleno Inc | CODED ENDONUCLEASE ASSAYS |
| EP4437125A1 (en) * | 2021-11-24 | 2024-10-02 | Alida Biosciences, Inc. | Rna and dna analysis using engineered surfaces |
| US20250101496A1 (en) * | 2021-12-21 | 2025-03-27 | Encodia, Inc. | Methods for balancing encoding signals of analytes |
| EP4206674B1 (en) | 2021-12-28 | 2025-10-22 | Encodia, Inc. | High-throughput serotyping and antibody profiling assays |
| CN120092180A (zh) | 2022-08-02 | 2025-06-03 | 格里菲克生物技术公司 | 通过可聚合分子偶联进行蛋白质测序 |
| WO2024040236A2 (en) | 2022-08-19 | 2024-02-22 | Abrus Bio, Inc. | Determination of protein information by recoding amino acid polymers into dna polymers |
| WO2024050553A1 (en) * | 2022-09-01 | 2024-03-07 | The Johns Hopkins University | Methods for measuring telomere length |
| US20240200058A1 (en) * | 2022-12-06 | 2024-06-20 | Shifeng Li | Methods and appratus for protein and peptide sequencing |
| CN115881218B (zh) * | 2022-12-15 | 2023-06-09 | 哈尔滨星云医学检验所有限公司 | 用于全基因组关联分析的基因自动选择方法 |
| EP4638786A1 (en) * | 2022-12-23 | 2025-10-29 | Illumina, Inc. | Spatial mrna/protein co-assays using aptamers |
| US20240327902A1 (en) * | 2023-03-31 | 2024-10-03 | Shifeng Li | Methods for detecting and analysis of proteins |
| WO2025085861A1 (en) * | 2023-10-20 | 2025-04-24 | Spectral Therapeutics, Inc. | Composite particles for use in generating spectrally encoded libraries of chemical compounds, and methods of making and using the same |
| US20250154584A1 (en) * | 2023-11-09 | 2025-05-15 | Encodia, Inc. | Methods for identifying polypeptides |
| WO2025144972A1 (en) * | 2023-12-29 | 2025-07-03 | Illumina, Inc. | Materials and methods for preparation of a spatial transcriptomics library |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US6875851B1 (en) | 1999-03-05 | 2005-04-05 | University Of Georgia Research Foundation, Inc. | Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis |
| JP2003536048A (ja) | 1999-03-23 | 2003-12-02 | バイオヴェイション リミテッド | タンパク質の単離および分析 |
| US7306904B2 (en) | 2000-02-18 | 2007-12-11 | Olink Ab | Methods and kits for proximity probing |
| US6511809B2 (en) | 2000-06-13 | 2003-01-28 | E. I. Du Pont De Nemours And Company | Method for the detection of an analyte by means of a nucleic acid reporter |
| US6800453B2 (en) | 2001-01-23 | 2004-10-05 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| EP1451356A1 (en) | 2001-11-23 | 2004-09-01 | Simon Fredriksson | Method and kit for proximity probing with multivalent proximity probes |
| EP1578935A2 (en) | 2002-10-10 | 2005-09-28 | Diversa Corporation | Proteases, nucleic acids encoding them and methods for making and using them |
| WO2005015239A2 (en) | 2003-08-07 | 2005-02-17 | Cornell Research Foundation, Inc. | Method for n-terminal labeling of proteins |
| US7198900B2 (en) | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
| ATE447626T1 (de) * | 2003-09-18 | 2009-11-15 | Nuevolution As | Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen |
| EP1561755A2 (en) | 2003-10-16 | 2005-08-10 | Shimadzu Corporation | Method for derivatizing protein or peptide to sulfonic acid derivative |
| JP5646127B2 (ja) | 2003-12-17 | 2014-12-24 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | コードされたライブラリーの合成のための方法 |
| DE602005017370D1 (de) | 2004-03-22 | 2009-12-10 | Nuevolution As | Ligationscodierung unter verwendung von oligonukleotidbausteinen |
| AU2005241003B2 (en) | 2004-04-14 | 2011-05-19 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
| US20060199279A1 (en) | 2005-03-07 | 2006-09-07 | Viorica Lopez-Avila | Methods for identifying post-translationally modified polypeptides |
| US7883848B2 (en) | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
| LT3018206T (lt) | 2005-12-01 | 2021-12-10 | Nuevolution A/S | Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei |
| WO2009050261A1 (en) | 2007-10-19 | 2009-04-23 | Pronota N.V. | Preparation of samples for proteome analysis |
| WO2010065322A1 (en) | 2008-12-01 | 2010-06-10 | Research Triangle Institute | Concurrent identification of multitudes of polypeptides |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| WO2011056185A2 (en) | 2009-11-04 | 2011-05-12 | President And Fellows Of Harvard College | Reactivity-dependent and interaction-dependent pcr |
| AU2010328226A1 (en) | 2009-12-07 | 2012-06-28 | Prognosys Biosciences, Inc. | Peptide display arrays |
| US20110245101A1 (en) | 2010-04-05 | 2011-10-06 | Prognosys Biosciences, Inc. | Co-localization affinity assays |
| GB201101621D0 (en) | 2011-01-31 | 2011-03-16 | Olink Ab | Method and product |
| EP3150750B1 (en) | 2011-04-08 | 2018-12-26 | Prognosys Biosciences, Inc. | Peptide constructs and assay systems |
| US20130052665A1 (en) | 2011-08-25 | 2013-02-28 | Bruce Xuefeng Ling | Methods for diagnosis of systemic juvenile idiopathic arthritis |
| US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
| US9435810B2 (en) | 2013-03-15 | 2016-09-06 | Washington University | Molecules and methods for iterative polypeptide analysis and processing |
| WO2014176355A1 (en) | 2013-04-23 | 2014-10-30 | President And Fellows Of Harvard College | In situ interaction determination |
| WO2015070037A2 (en) * | 2013-11-08 | 2015-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
| US9834814B2 (en) * | 2013-11-22 | 2017-12-05 | Agilent Technologies, Inc. | Spatial molecular barcoding of in situ nucleic acids |
| WO2015148606A2 (en) | 2014-03-25 | 2015-10-01 | President And Fellows Of Harvard College | Barcoded protein array for multiplex single-molecule interaction profiling |
| EP3143165A4 (en) | 2014-05-15 | 2018-05-16 | Two Pore Guys, Inc. | Scaffold data storage and target detection in a sample using a nanopore |
| CN113249435B (zh) | 2014-06-26 | 2024-09-03 | 10X基因组学有限公司 | 分析来自单个细胞或细胞群体的核酸的方法 |
| WO2016011364A1 (en) | 2014-07-18 | 2016-01-21 | Cdi Laboratories, Inc. | Methods and compositions to identify, quantify, and characterize target analytes and binding moieties |
| WO2016019360A1 (en) | 2014-08-01 | 2016-02-04 | Dovetail Genomics Llc | Tagging nucleic acids for sequence assembly |
| EP3543703A1 (en) | 2014-09-15 | 2019-09-25 | Board of Regents, The University of Texas System | Improved single molecule peptide sequencing |
| PL3650458T3 (pl) * | 2015-02-24 | 2023-11-06 | City Of Hope | Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie |
| EP3262192B1 (en) | 2015-02-27 | 2020-09-16 | Becton, Dickinson and Company | Spatially addressable molecular barcoding |
| US20180284125A1 (en) | 2015-03-11 | 2018-10-04 | The Broad Institute, Inc. | Proteomic analysis with nucleic acid identifiers |
| KR102741603B1 (ko) * | 2016-05-02 | 2024-12-16 | 엔코디아, 인코포레이티드 | 암호화 핵산을 사용한 거대분자 분석 |
| WO2018005720A1 (en) | 2016-06-30 | 2018-01-04 | President And Fellows Of Harvard College | Method of determining the molecular binding between libraries of molecules |
| CN109923216B (zh) | 2016-08-31 | 2024-08-02 | 哈佛学院董事及会员团体 | 将生物分子的检测组合到使用荧光原位测序的单个试验的方法 |
| EP4029939B1 (en) | 2017-01-30 | 2023-06-28 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| US20180251825A1 (en) | 2017-02-02 | 2018-09-06 | New York Genome Center Inc. | Methods and compositions for identifying or quantifying targets in a biological sample |
| US20200348307A1 (en) | 2017-10-31 | 2020-11-05 | Encodia, Inc. | Methods and compositions for polypeptide analysis |
| SG11202003923PA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Methods and kits using nucleic acid encoding and/or label |
| KR102556494B1 (ko) | 2017-10-31 | 2023-07-18 | 엔코디아, 인코포레이티드 | 핵산 암호화 및/또는 표지를 이용한 분석용 키트 |
| CA3086915A1 (en) | 2017-12-29 | 2019-07-04 | Sujal M. Patel | Decoding approaches for protein identification |
-
2018
- 2018-10-31 SG SG11202003923PA patent/SG11202003923PA/en unknown
- 2018-10-31 CA CA3081451A patent/CA3081451A1/en active Pending
- 2018-10-31 US US16/760,032 patent/US20210355483A1/en not_active Abandoned
- 2018-10-31 AU AU2018358247A patent/AU2018358247A1/en not_active Abandoned
- 2018-10-31 EP EP18872456.1A patent/EP3704246A4/en active Pending
- 2018-10-31 WO PCT/US2018/058583 patent/WO2019089851A1/en not_active Ceased
- 2018-10-31 JP JP2020524113A patent/JP7253833B2/ja active Active
-
2023
- 2023-03-22 US US18/125,075 patent/US12129463B2/en active Active
-
2024
- 2024-08-09 US US18/799,749 patent/US12467049B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021501576A5 (enExample) | ||
| US11667956B2 (en) | Methods of identifying multiple epitopes in cells | |
| US20230081326A1 (en) | Increasing dynamic range for identifying multiple epitopes in cells | |
| US20220333096A1 (en) | Methods for the production of long length clonal sequence verified nucleic acid constructs | |
| US7901886B2 (en) | Microfluidic extraction method | |
| JP2021501577A5 (enExample) | ||
| Kodadek | Development of protein-detecting microarrays and related devices | |
| JP2019523635A5 (enExample) | ||
| US20220056515A1 (en) | Methods of identifying multiple epitopes in cells | |
| CN116024307A (zh) | 一种含组织位置信息的单细胞文库构建方法及测序方法 | |
| US20200157603A1 (en) | Methods of identifying multiple epitopes in cells | |
| JP2011087573A (ja) | ｃＤＮＡ／ｍＲＮＡ−タンパク質連結体の効率的合成法 | |
| US20100256012A1 (en) | Flexible extraction method for the production of sequence-specific molecule libraries | |
| Weiner et al. | Protein, antibody and small molecule microarrays |