JP2021191763A5 - - Google Patents
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- JP2021191763A5 JP2021191763A5 JP2021136539A JP2021136539A JP2021191763A5 JP 2021191763 A5 JP2021191763 A5 JP 2021191763A5 JP 2021136539 A JP2021136539 A JP 2021136539A JP 2021136539 A JP2021136539 A JP 2021136539A JP 2021191763 A5 JP2021191763 A5 JP 2021191763A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 30
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 5
- 208000009829 Lewy Body Disease Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 2
- 208000015872 Gaucher disease Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 208000009144 Pure autonomic failure Diseases 0.000 claims 1
- 208000032859 Synucleinopathies Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022136108A JP7608404B2 (ja) | 2015-07-13 | 2022-08-29 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2024221962A JP2025041734A (ja) | 2015-07-13 | 2024-12-18 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1512203.9 | 2015-07-13 | ||
| GBGB1512203.9A GB201512203D0 (en) | 2015-07-13 | 2015-07-13 | Agents,uses and methods |
| JP2018501163A JP7012004B2 (ja) | 2015-07-13 | 2016-07-12 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501163A Division JP7012004B2 (ja) | 2015-07-13 | 2016-07-12 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022136108A Division JP7608404B2 (ja) | 2015-07-13 | 2022-08-29 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021191763A JP2021191763A (ja) | 2021-12-16 |
| JP2021191763A5 true JP2021191763A5 (https=) | 2022-03-02 |
| JP7138322B2 JP7138322B2 (ja) | 2022-09-16 |
Family
ID=54013851
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501163A Active JP7012004B2 (ja) | 2015-07-13 | 2016-07-12 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2021136539A Active JP7138322B2 (ja) | 2015-07-13 | 2021-08-24 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2022136108A Active JP7608404B2 (ja) | 2015-07-13 | 2022-08-29 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2024221962A Pending JP2025041734A (ja) | 2015-07-13 | 2024-12-18 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501163A Active JP7012004B2 (ja) | 2015-07-13 | 2016-07-12 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022136108A Active JP7608404B2 (ja) | 2015-07-13 | 2022-08-29 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2024221962A Pending JP2025041734A (ja) | 2015-07-13 | 2024-12-18 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Country Status (40)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB201512203D0 (en) * | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| BR112018014281A2 (pt) | 2016-11-15 | 2018-12-18 | H Lundbeck As | agentes, usos e métodos para o tratamento da sinucleinopatia |
| EP3555127B1 (en) | 2016-12-16 | 2024-12-18 | H. Lundbeck A/S | Agents, uses and methods |
| US10364286B2 (en) * | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| BR112019013953A2 (pt) | 2017-01-06 | 2020-02-11 | Abl Bio Inc. | Anticorpo anti-a-syn e uso do mesmo |
| CA3051839A1 (en) | 2017-02-17 | 2018-08-23 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| IL269550B2 (en) | 2017-03-27 | 2025-01-01 | Chase Therapeutics Corp | Combining a 5HT3 antagonist and pramipexole for the treatment of synucleinopathies |
| EP3618870A4 (en) * | 2017-05-01 | 2021-04-21 | The Trustees of The University of Pennsylvania | MONOCLONAL ANTIBODIES AGAINST ALPHA-SYNUCLEIN FIBRILLES |
| US11155608B2 (en) | 2017-08-23 | 2021-10-26 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against pathological alpha-synuclein, and methods using same |
| KR102508933B1 (ko) * | 2017-11-17 | 2023-03-13 | 에이비엘바이오 주식회사 | 알파-시누클레인에 대한 항체 및 그 용도 |
| EP3725806A4 (en) | 2017-12-14 | 2022-03-30 | ABL Bio Inc. | BISPECIFIC ANTIBODIES AGAINST A-SYN/IGF1R AND ASSOCIATED USE |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| WO2019147904A1 (en) * | 2018-01-26 | 2019-08-01 | Quantum-Si Incorporated | Machine learning enabled pulse and base calling for sequencing devices |
| US20210032369A1 (en) * | 2018-02-12 | 2021-02-04 | The Scripps Research Institute | Methods related to parkinson?s disease and synucleinopathies |
| CA3108986A1 (en) * | 2018-08-09 | 2020-02-13 | Ventana Medical Systems, Inc. | Determination of parkinson's disease |
| TWI734279B (zh) * | 2018-12-14 | 2021-07-21 | 美商美國禮來大藥廠 | 抗α-突觸核蛋白抗體及其用途 |
| JP7689373B2 (ja) * | 2019-04-18 | 2025-06-06 | エイシー イミューン ソシエテ アノニム | 治療及び診断のための新規分子 |
| JP2022531177A (ja) * | 2019-04-29 | 2022-07-06 | トーマス・ジェファーソン・ユニバーシティ | 神経変性障害を治療するための方法 |
| CA3159964A1 (en) * | 2019-12-04 | 2021-06-10 | Ac Immune Sa | Novel molecules for therapy and diagnosis |
| KR102466943B1 (ko) * | 2020-04-02 | 2022-11-14 | 한국과학기술연구원 | 갭을 갖는 바이오 센서를 이용한 파킨슨병 모니터링 방법 및 시스템 |
| CN111537738A (zh) * | 2020-05-18 | 2020-08-14 | 南通大学附属医院 | 用于超早期帕金森病检测的试剂盒 |
| JP2024534901A (ja) * | 2021-09-01 | 2024-09-26 | ヴァクシニティ， インコーポレイテッド | シヌクレイノパチーの予防及び治療のための方法 |
| EP4401770A2 (en) | 2021-09-16 | 2024-07-24 | H. Lundbeck A/S | Compositions and methods for treating synucleinopathies |
| CN117430686B (zh) * | 2022-07-22 | 2025-07-01 | 深圳市安群生物工程有限公司 | α-突触核蛋白抗原表位肽及测定唾液中SNCA试剂盒和在帕金森病诊断中的应用 |
| WO2024177999A2 (en) * | 2023-02-21 | 2024-08-29 | The Regents Of The University Of Michigan | Human aggregated alpha-synuclein binding molecules |
| CN116077524A (zh) * | 2023-02-27 | 2023-05-09 | 广西馨海药业科技有限公司 | 氯化铷在制备治疗帕金森综合征的药物中的用途 |
| WO2025076635A1 (en) * | 2023-10-12 | 2025-04-17 | Universite Laval | Anti-alpha-synuclein antibodies and uses thereof |
| WO2025186235A1 (en) | 2024-03-05 | 2025-09-12 | H. Lundbeck A/S | Compositions and methods for treating multiple system atrophy (msa) |
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| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
-
2015
- 2015-07-13 GB GBGB1512203.9A patent/GB201512203D0/en not_active Ceased
-
2016
- 2016-07-11 JO JOP/2016/0140A patent/JO3692B1/ar active
- 2016-07-12 WO PCT/EP2016/066476 patent/WO2017009312A1/en not_active Ceased
- 2016-07-12 PL PL16738736.4T patent/PL3322722T3/pl unknown
- 2016-07-12 AR ARP160102110A patent/AR105336A1/es unknown
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