JP2021182946A5 - - Google Patents

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JP2021182946A5
JP2021182946A5 JP2021144677A JP2021144677A JP2021182946A5 JP 2021182946 A5 JP2021182946 A5 JP 2021182946A5 JP 2021144677 A JP2021144677 A JP 2021144677A JP 2021144677 A JP2021144677 A JP 2021144677A JP 2021182946 A5 JP2021182946 A5 JP 2021182946A5
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JP2021182946A (ja
JP7736489B2 (ja
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Priority to JP2023060170A priority patent/JP2023073510A/ja
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Priority to JP2025188613A priority patent/JP2026016798A/ja
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JP2021144677A 2014-05-01 2021-09-06 オリゴヌクレオチド組成物及びその作製方法 Active JP7736489B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022005584A JP7308309B2 (ja) 2014-05-01 2022-01-18 オリゴヌクレオチド組成物及びその作製方法
JP2023060170A JP2023073510A (ja) 2014-05-01 2023-04-03 オリゴヌクレオチド組成物及びその作製方法
JP2025188613A JP2026016798A (ja) 2014-05-01 2025-11-07 オリゴヌクレオチド組成物及びその作製方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461987396P 2014-05-01 2014-05-01
US61/987,396 2014-05-01
US201562151909P 2015-04-23 2015-04-23
US62/151,909 2015-04-23
JP2019234301A JP2020050670A (ja) 2014-05-01 2019-12-25 オリゴヌクレオチド組成物及びその作製方法

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JP2019234301A Division JP2020050670A (ja) 2014-05-01 2019-12-25 オリゴヌクレオチド組成物及びその作製方法

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JP2022005584A Division JP7308309B2 (ja) 2014-05-01 2022-01-18 オリゴヌクレオチド組成物及びその作製方法

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JP2021182946A JP2021182946A (ja) 2021-12-02
JP2021182946A5 true JP2021182946A5 (https=) 2022-01-26
JP7736489B2 JP7736489B2 (ja) 2025-09-09

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Family Applications (7)

Application Number Title Priority Date Filing Date
JP2016564990A Active JP7040892B2 (ja) 2014-05-01 2015-04-29 オリゴヌクレオチド組成物及びその作製方法
JP2018088277A Pending JP2018131453A (ja) 2014-05-01 2018-05-01 オリゴヌクレオチド組成物及びその作製方法
JP2019234301A Withdrawn JP2020050670A (ja) 2014-05-01 2019-12-25 オリゴヌクレオチド組成物及びその作製方法
JP2021144677A Active JP7736489B2 (ja) 2014-05-01 2021-09-06 オリゴヌクレオチド組成物及びその作製方法
JP2022005584A Active JP7308309B2 (ja) 2014-05-01 2022-01-18 オリゴヌクレオチド組成物及びその作製方法
JP2023060170A Withdrawn JP2023073510A (ja) 2014-05-01 2023-04-03 オリゴヌクレオチド組成物及びその作製方法
JP2025188613A Pending JP2026016798A (ja) 2014-05-01 2025-11-07 オリゴヌクレオチド組成物及びその作製方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2016564990A Active JP7040892B2 (ja) 2014-05-01 2015-04-29 オリゴヌクレオチド組成物及びその作製方法
JP2018088277A Pending JP2018131453A (ja) 2014-05-01 2018-05-01 オリゴヌクレオチド組成物及びその作製方法
JP2019234301A Withdrawn JP2020050670A (ja) 2014-05-01 2019-12-25 オリゴヌクレオチド組成物及びその作製方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2022005584A Active JP7308309B2 (ja) 2014-05-01 2022-01-18 オリゴヌクレオチド組成物及びその作製方法
JP2023060170A Withdrawn JP2023073510A (ja) 2014-05-01 2023-04-03 オリゴヌクレオチド組成物及びその作製方法
JP2025188613A Pending JP2026016798A (ja) 2014-05-01 2025-11-07 オリゴヌクレオチド組成物及びその作製方法

Country Status (33)

Country Link
US (6) US9796747B2 (https=)
EP (2) EP3137479B1 (https=)
JP (7) JP7040892B2 (https=)
KR (4) KR20230088509A (https=)
CN (3) CN117357548A (https=)
AP (1) AP2016009489A0 (https=)
AU (3) AU2015253158B2 (https=)
BR (1) BR112016025196B1 (https=)
CL (4) CL2016002749A1 (https=)
DK (1) DK3137479T5 (https=)
EA (1) EA034882B9 (https=)
ES (1) ES2963740T3 (https=)
FI (1) FI3137479T3 (https=)
HR (1) HRP20231505T1 (https=)
HU (1) HUE064289T2 (https=)
IL (2) IL248044B (https=)
JO (2) JOP20200257A1 (https=)
LT (1) LT3137479T (https=)
MA (1) MA63525B1 (https=)
MX (2) MX382233B (https=)
MY (2) MY178617A (https=)
PE (1) PE20170147A1 (https=)
PH (1) PH12016502080A1 (https=)
PL (1) PL3137479T3 (https=)
PT (1) PT3137479T (https=)
RS (1) RS64860B1 (https=)
SG (2) SG11201608226YA (https=)
SI (1) SI3137479T1 (https=)
SM (1) SMT202300405T1 (https=)
TW (2) TWI712413B (https=)
UA (1) UA126108C2 (https=)
WO (1) WO2015168310A1 (https=)
ZA (2) ZA201606624B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME02933B (me) * 2004-07-02 2018-04-20 Geron Corp Sinteza zaštićenih 3'-amino nukleozionih monomera
JOP20200257A1 (ar) * 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
AU2016250576C1 (en) 2015-04-23 2021-05-06 Geron Corporation Methods of polynucleotide preparation using multivalent cation salt compositions
MA49555A (fr) * 2017-07-10 2021-04-28 Geron Corp Procédé amélioré de préparation d'imetelstat
CN114901269A (zh) 2019-10-28 2022-08-12 美国杰龙生物医药公司 3-棕榈酰基-酰胺基-1,2-丙二醇和3-棕榈酰基-酰胺基-2-羟基-1-二甲氧基三苯基甲基醚-丙烷的结晶固体及其制备和使用方法
AU2020372865A1 (en) * 2019-10-28 2022-05-26 Geron Corporation Amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane salts and methods of making the same
KR20220123300A (ko) 2020-01-08 2022-09-06 닛토덴코 가부시키가이샤 분절-타입 아미디트(segment-type amidite)를 사용한 핵산 합성 방법
KR20240100491A (ko) 2021-10-15 2024-07-01 코덱시스, 인코포레이티드 조작된 말단 데옥시뉴클레오티딜 트랜스퍼라제 변이체
KR20250008345A (ko) 2023-07-07 2025-01-14 주식회사 엘지에너지솔루션 체결기구 및 체결기구를 포함하는 전지팩

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046720A (en) 1974-01-17 1977-09-06 California Institute Of Technology Crosslinked, porous, polyacrylate beads
US4394448A (en) 1978-02-24 1983-07-19 Szoka Jr Francis C Method of inserting DNA into living cells
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4678814A (en) 1981-03-30 1987-07-07 California Institute Of Technology Polyacrolein microspheres
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US6448392B1 (en) 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
EP0462145B1 (en) 1989-03-07 1994-04-27 Genentech, Inc. Covalent conjugates of lipid and oligonucleotide
US4958013A (en) 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US6395492B1 (en) 1990-01-11 2002-05-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US6114513A (en) 1990-01-11 2000-09-05 Isis Pharmaceuticals, Inc. Thiol-derivatized oligonucleotides
US6153737A (en) 1990-01-11 2000-11-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
CA2079109A1 (en) 1990-03-29 1991-09-30 John A. Latham Oligonucleotide-transport agent disulfide conjugates
US5420330A (en) 1990-09-07 1995-05-30 Pharmacia P-L Biochemicals Inc. Lipo-phosphoramidites
US5419966A (en) 1991-06-10 1995-05-30 Microprobe Corporation Solid support for synthesis of 3'-tailed oligonucleotides
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
US5837453A (en) 1992-05-13 1998-11-17 Geron Corporation Telomerase activity assays
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5629154A (en) 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
US6235886B1 (en) 1993-09-03 2001-05-22 Isis Pharmaceuticals, Inc. Methods of synthesis and use
US7067497B2 (en) 1992-09-29 2006-06-27 Isis Pharmaceuticals, Inc. Modulation of telomere length by oligonucleotides having a G-core sequence
IL107150A0 (en) 1992-09-29 1993-12-28 Isis Pharmaceuticals Inc Oligonucleotides having a conserved g4 core sequence
US6087491A (en) 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
US5476925A (en) 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
DE4331670A1 (de) 1993-09-17 1995-03-23 Hoechst Ag Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung
EP0724589B1 (en) 1993-10-18 2005-12-07 The Walter And Eliza Hall Institute Of Medical Research A method for enhancing neurone survival and agents useful for same
US5863726A (en) 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
US5726297A (en) 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
HUT76094A (en) 1994-03-18 1997-06-30 Lynx Therapeutics Oligonucleotide n3'-p5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties
US5599922A (en) 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
GB9413035D0 (en) 1994-06-29 1994-08-17 Scras Antisense oligonucleeotides
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
AU696702B2 (en) 1994-07-07 1998-09-17 Geron Corporation Mammalian telomerase
JPH10509447A (ja) 1994-11-07 1998-09-14 ハイブライドン インコーポレイテッド 3h−1,2−ベンゾジチオール−3−1,1−ジオキシドを用いた▲上35▼s−標識オリゴヌクレオチドの合成
US5656638A (en) 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5760062A (en) 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5840490A (en) 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
US5770613A (en) 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
US5859233A (en) 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
US5684143A (en) 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
GB9606158D0 (en) 1996-03-23 1996-05-29 Ciba Geigy Ag Chemical compounds
US6015710A (en) 1996-04-09 2000-01-18 The University Of Texas System Modulation of mammalian telomerase by peptide nucleic acids
AU2445997A (en) * 1996-04-10 1997-10-29 Lynx Therapeutics, Inc. Telomerase inhibitors
US6111085A (en) 1996-09-13 2000-08-29 Isis Pharmaceuticals, Inc. Carbamate-derivatized nucleosides and oligonucleosides
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6001991A (en) 1996-10-04 1999-12-14 Isis Pharmaceuticals Inc. Antisense oligonucleotide modulation of MDR P-glycoprotein gene expression
AU733610B2 (en) 1996-12-20 2001-05-17 Geron Corporation Methods for detecting and inhibiting the RNA component of telomerase
US5846723A (en) 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
US5877309A (en) 1997-08-13 1999-03-02 Isis Pharmaceuticals, Inc. Antisense oligonucleotides against JNK
US5998604A (en) 1997-09-15 1999-12-07 The Perkin-Elmer Corporation Polynucleotide purification method
JP3722630B2 (ja) 1998-10-28 2005-11-30 パイオニア株式会社 記録再生装置
US6656730B1 (en) 1999-06-15 2003-12-02 Isis Pharmaceuticals, Inc. Oligonucleotides conjugated to protein-binding drugs
CN1317291C (zh) 1999-09-10 2007-05-23 杰龙公司 寡核苷酸n3′→p5′硫代氨基磷酸酯,其合成及应用
GB9927674D0 (en) * 1999-11-23 2000-01-19 Aegis Eng Ltd Protective material
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
US7563618B2 (en) 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
AU2002245717A1 (en) * 2001-03-23 2002-10-08 Geron Corporation Oligonucleotide conjugates
CN100393209C (zh) 2003-09-09 2008-06-11 杰龙公司 用于端粒酶抑制的改性寡核苷酸
US20120329858A1 (en) * 2010-08-04 2012-12-27 Geron Corporation Modified oligonucleotides for telomerase inhibition
ME02933B (me) 2004-07-02 2018-04-20 Geron Corp Sinteza zaštićenih 3'-amino nukleozionih monomera
WO2006023880A2 (en) * 2004-08-23 2006-03-02 Isis Pharmaceuticals, Inc. Compounds and methods for the characterization of oligonucleotides
EP1812598A1 (en) * 2004-10-18 2007-08-01 Codon Devices, Inc. Methods for assembly of high fidelity synthetic polynucleotides
EP1876893B1 (en) 2005-04-15 2012-04-11 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
WO2007127163A2 (en) * 2006-04-24 2007-11-08 Geron Corporation Cns-tumor treatment method and composition
SI2898887T1 (sl) 2006-10-30 2019-01-31 Geron Corporation Kombinirani telomerazni inhibitor in gemcitabin za zdravljenje raka
WO2008094640A2 (en) * 2007-01-30 2008-08-07 Geron Corporation Compounds having anti-adhesive effects on cancer cells
US9106103B2 (en) 2011-09-23 2015-08-11 Eaton Corporation Unintteruptible power supply systems and methods employing on-demand energy storage
US9006630B2 (en) 2012-01-13 2015-04-14 Altasens, Inc. Quality of optically black reference pixels in CMOS iSoCs
US20150342982A1 (en) 2012-12-07 2015-12-03 Geron Corporation Use of Telomerase Inhibitors for the Treatment of Myeloproliferative Disorders and Myeloproliferative Neoplasms
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
JOP20200257A1 (ar) * 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها

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