JP2020537652A5 - - Google Patents
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- Publication number
- JP2020537652A5 JP2020537652A5 JP2020521444A JP2020521444A JP2020537652A5 JP 2020537652 A5 JP2020537652 A5 JP 2020537652A5 JP 2020521444 A JP2020521444 A JP 2020521444A JP 2020521444 A JP2020521444 A JP 2020521444A JP 2020537652 A5 JP2020537652 A5 JP 2020537652A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- pharmaceutically acceptable
- acceptable salt
- oligonucleotide conjugate
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)N1CC(*)OC(C)C1 Chemical compound CC(C)N1CC(*)OC(C)C1 0.000 description 2
- PVMNSAIKFPWDQG-UHFFFAOYSA-N CC(C)(C)N1CCNCC1 Chemical compound CC(C)(C)N1CCNCC1 PVMNSAIKFPWDQG-UHFFFAOYSA-N 0.000 description 1
- QJQUFJQKQQYYHZ-UHFFFAOYSA-N CC(C)c(c(F)c(c(-c(c([I]=C)c(c(C(C)C)c1F)F)c1[I]=C)c1F)F)c1F Chemical compound CC(C)c(c(F)c(c(-c(c([I]=C)c(c(C(C)C)c1F)F)c1[I]=C)c1F)F)c1F QJQUFJQKQQYYHZ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023129042A JP2023138661A (ja) | 2017-10-17 | 2023-08-08 | 二環式ペプチドオリゴヌクレオチドコンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762573473P | 2017-10-17 | 2017-10-17 | |
| US62/573,473 | 2017-10-17 | ||
| PCT/US2018/056178 WO2019079367A1 (en) | 2017-10-17 | 2018-10-17 | OLIGONUCLEOTIDE CONJUGATES-BICYCLIC PEPTIDES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023129042A Division JP2023138661A (ja) | 2017-10-17 | 2023-08-08 | 二環式ペプチドオリゴヌクレオチドコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020537652A JP2020537652A (ja) | 2020-12-24 |
| JP2020537652A5 true JP2020537652A5 (https=) | 2021-11-11 |
| JP7356416B2 JP7356416B2 (ja) | 2023-10-04 |
Family
ID=66173478
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020521444A Active JP7356416B2 (ja) | 2017-10-17 | 2018-10-17 | 二環式ペプチドオリゴヌクレオチドコンジュゲート |
| JP2023129042A Pending JP2023138661A (ja) | 2017-10-17 | 2023-08-08 | 二環式ペプチドオリゴヌクレオチドコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023129042A Pending JP2023138661A (ja) | 2017-10-17 | 2023-08-08 | 二環式ペプチドオリゴヌクレオチドコンジュゲート |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12502432B2 (https=) |
| EP (1) | EP3700537A4 (https=) |
| JP (2) | JP7356416B2 (https=) |
| TW (1) | TWI816703B (https=) |
| WO (1) | WO2019079367A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3142017C (en) * | 2019-06-14 | 2023-09-19 | Laboratory Corporation Of America Holdings | Ion-pairing free lc-ms bioanalysis of oligonucleotides |
| EP4658280A2 (en) * | 2023-02-01 | 2025-12-10 | Alnylam Pharmaceuticals, Inc. | Six membered ring containing oligomers |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2735568T3 (da) * | 2006-05-10 | 2017-11-13 | Sarepta Therapeutics Inc | Oligonukleotidanaloger med kationiske bindinger mellem underenheder |
| US20100016215A1 (en) * | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| KR102451116B1 (ko) * | 2011-10-27 | 2022-10-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| KR102240217B1 (ko) | 2012-09-25 | 2021-04-14 | 젠자임 코포레이션 | 근긴장성 이영양증의 치료용 펩티드-결합 모르폴리노 안티센스 올리고뉴클레오티드 |
| WO2014124952A1 (en) * | 2013-02-12 | 2014-08-21 | Syddansk Universitet | "clickable" alkyne-lna oligonucleotides |
| EP3297649B1 (en) | 2015-05-19 | 2023-10-11 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| WO2017066789A1 (en) * | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs with modified sugar |
-
2018
- 2018-10-17 JP JP2020521444A patent/JP7356416B2/ja active Active
- 2018-10-17 TW TW107136579A patent/TWI816703B/zh active
- 2018-10-17 EP EP18868378.3A patent/EP3700537A4/en active Pending
- 2018-10-17 WO PCT/US2018/056178 patent/WO2019079367A1/en not_active Ceased
- 2018-10-17 US US16/756,435 patent/US12502432B2/en active Active
-
2023
- 2023-08-08 JP JP2023129042A patent/JP2023138661A/ja active Pending
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