JP2020537654A5 - - Google Patents
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- Publication number
- JP2020537654A5 JP2020537654A5 JP2020521453A JP2020521453A JP2020537654A5 JP 2020537654 A5 JP2020537654 A5 JP 2020537654A5 JP 2020521453 A JP2020521453 A JP 2020521453A JP 2020521453 A JP2020521453 A JP 2020521453A JP 2020537654 A5 JP2020537654 A5 JP 2020537654A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- peptide
- acceptable salt
- oligonucleotide conjugate
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *CC1OC(*)CN(CN=C)C1 Chemical compound *CC1OC(*)CN(CN=C)C1 0.000 description 7
- WDEMIXBRPVTUPL-UHFFFAOYSA-N CC(C)N(CC1)CCN1C(C(C)(C)OCCC(C)(C)O)=O Chemical compound CC(C)N(CC1)CCN1C(C(C)(C)OCCC(C)(C)O)=O WDEMIXBRPVTUPL-UHFFFAOYSA-N 0.000 description 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023071470A JP7702444B2 (ja) | 2017-10-17 | 2023-04-25 | アンチセンス送達のための細胞透過性ペプチド |
| JP2025032837A JP2025087783A (ja) | 2017-10-17 | 2025-03-03 | アンチセンス送達のための細胞透過性ペプチド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762573379P | 2017-10-17 | 2017-10-17 | |
| US62/573,379 | 2017-10-17 | ||
| PCT/US2018/056205 WO2019079386A1 (en) | 2017-10-17 | 2018-10-17 | CELL PENETRATION PEPTIDES FOR ANTISENSE ADMINISTRATION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023071470A Division JP7702444B2 (ja) | 2017-10-17 | 2023-04-25 | アンチセンス送達のための細胞透過性ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020537654A JP2020537654A (ja) | 2020-12-24 |
| JP2020537654A5 true JP2020537654A5 (https=) | 2021-11-11 |
| JP7320500B2 JP7320500B2 (ja) | 2023-08-03 |
Family
ID=66174189
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020521453A Active JP7320500B2 (ja) | 2017-10-17 | 2018-10-17 | アンチセンス送達のための細胞透過性ペプチド |
| JP2023071470A Active JP7702444B2 (ja) | 2017-10-17 | 2023-04-25 | アンチセンス送達のための細胞透過性ペプチド |
| JP2025032837A Pending JP2025087783A (ja) | 2017-10-17 | 2025-03-03 | アンチセンス送達のための細胞透過性ペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023071470A Active JP7702444B2 (ja) | 2017-10-17 | 2023-04-25 | アンチセンス送達のための細胞透過性ペプチド |
| JP2025032837A Pending JP2025087783A (ja) | 2017-10-17 | 2025-03-03 | アンチセンス送達のための細胞透過性ペプチド |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12138312B2 (https=) |
| EP (1) | EP3697422A4 (https=) |
| JP (3) | JP7320500B2 (https=) |
| MA (1) | MA50834A (https=) |
| TW (2) | TW202423453A (https=) |
| WO (1) | WO2019079386A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA52148A (fr) * | 2018-03-16 | 2021-01-20 | Sarepta Therapeutics Inc | Peptides chimères pour administration d'antisens |
| WO2021150867A1 (en) * | 2020-01-24 | 2021-07-29 | Sarepta Therapeutics, Inc. | Designing antisense oligonucleotide delivery peptides by interpretable machine learning |
| US20240041050A1 (en) * | 2020-12-16 | 2024-02-08 | Pioneer Hi-Bred International, Inc. | Cell penetrating peptide mediated rna transduction within insect cells |
| WO2023034515A2 (en) * | 2021-09-03 | 2023-03-09 | Sarepta Therapeutics, Inc. | Delivery of anitsense oligomers by mirror image peptides |
| CN114380886B (zh) * | 2022-01-26 | 2022-10-21 | 深圳深创生物药业有限公司 | 一种肿瘤靶向多肽、多肽偶联药物及其应用 |
| EP4230196A1 (en) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of dystrophinopathies |
| EP4612292A1 (en) * | 2022-11-02 | 2025-09-10 | Sarepta Therapeutics, Inc. | Formulation of an antisense oligomer conjugate |
| TW202519660A (zh) * | 2023-08-02 | 2025-05-16 | 美商薩羅塔治療公司 | 針對反義寡聚物遞送之非標準細胞穿透肽 |
| WO2026080471A2 (en) | 2024-10-07 | 2026-04-16 | Flagship Pioneering Innovations Vi, Llc | Compositions of trem conjugates and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2735568T3 (da) * | 2006-05-10 | 2017-11-13 | Sarepta Therapeutics Inc | Oligonukleotidanaloger med kationiske bindinger mellem underenheder |
| EP3443976A1 (en) * | 2007-06-29 | 2019-02-20 | Sarepta Therapeutics, Inc. | Tissue specific peptide conjugates and methods |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| US9161948B2 (en) * | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| WO2012150960A1 (en) * | 2011-05-05 | 2012-11-08 | Avi Biopharma, Inc. | Peptide oligonucleotide conjugates |
| KR102451116B1 (ko) * | 2011-10-27 | 2022-10-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| KR102240217B1 (ko) * | 2012-09-25 | 2021-04-14 | 젠자임 코포레이션 | 근긴장성 이영양증의 치료용 펩티드-결합 모르폴리노 안티센스 올리고뉴클레오티드 |
| WO2014124952A1 (en) | 2013-02-12 | 2014-08-21 | Syddansk Universitet | "clickable" alkyne-lna oligonucleotides |
| WO2017066789A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs with modified sugar |
| MA52148A (fr) * | 2018-03-16 | 2021-01-20 | Sarepta Therapeutics Inc | Peptides chimères pour administration d'antisens |
-
2018
- 2018-10-17 WO PCT/US2018/056205 patent/WO2019079386A1/en not_active Ceased
- 2018-10-17 EP EP18868379.1A patent/EP3697422A4/en active Pending
- 2018-10-17 US US16/756,616 patent/US12138312B2/en active Active
- 2018-10-17 JP JP2020521453A patent/JP7320500B2/ja active Active
- 2018-10-17 MA MA050834A patent/MA50834A/fr unknown
- 2018-10-17 TW TW112133920A patent/TW202423453A/zh unknown
- 2018-10-17 TW TW107136614A patent/TWI837102B/zh active
-
2023
- 2023-04-25 JP JP2023071470A patent/JP7702444B2/ja active Active
-
2024
- 2024-08-09 US US18/799,673 patent/US20250135015A1/en active Pending
-
2025
- 2025-03-03 JP JP2025032837A patent/JP2025087783A/ja active Pending
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