|
DE3922444A1
(de)
|
1988-03-01 |
1991-01-10 |
Deutsches Krebsforsch |
Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen
|
|
DE3806565A1
(de)
|
1988-03-01 |
1989-09-14 |
Deutsches Krebsforsch |
Virusmodifizierte tumorvakzinen fuer die immuntherapie von tumormetastasen
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5854037A
(en)
|
1989-08-28 |
1998-12-29 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand RNA virus expression systems and vaccines
|
|
US5166057A
(en)
|
1989-08-28 |
1992-11-24 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand rna virus expression-systems
|
|
US5786199A
(en)
|
1989-08-28 |
1998-07-28 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand RNA virus expression systems and vaccines
|
|
CA2161671A1
(en)
|
1993-04-30 |
1994-11-10 |
Robert M. Lorence |
Methods of treating and detecting cancer using viruses
|
|
ATE257175T1
(de)
|
1994-07-18 |
2004-01-15 |
Conzelmann Karl Klaus Prof Dr |
Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus
|
|
US5891680A
(en)
|
1995-02-08 |
1999-04-06 |
Whitehead Institute For Biomedical Research |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
|
|
US7153510B1
(en)
|
1995-05-04 |
2006-12-26 |
Yale University |
Recombinant vesiculoviruses and their uses
|
|
ATE181112T1
(de)
|
1995-08-09 |
1999-06-15 |
Schweiz Serum & Impfinst |
Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren
|
|
US6264957B1
(en)
|
1995-09-27 |
2001-07-24 |
The United States Of America As Represented By The Department Of Health And Human Services |
Product of infectious respiratory syncytial virus from cloned nucleotide sequences
|
|
CN1200037A
(zh)
|
1995-10-17 |
1998-11-25 |
韦恩州立大学 |
鸡白细胞介素－15及其用途
|
|
WO1998002530A1
(en)
|
1996-07-15 |
1998-01-22 |
The Government Of The United States Of America, As Represented By The Department Of Health And Human Services |
Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
|
|
CA2265554A1
(en)
|
1996-09-27 |
1998-04-02 |
American Cyanamid Company |
3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales
|
|
BR9809456B1
(pt)
|
1997-05-23 |
2011-06-28 |
|
molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica.
|
|
DE69837764T2
(de)
|
1997-07-11 |
2008-01-31 |
Yale University, New Haven |
Rhabdovirus mit gentechnisch veränderter hülle
|
|
KR20010030630A
(ko)
|
1997-09-19 |
2001-04-16 |
윌리암 에이취 캘넌, 에곤 이 버그 |
약독화 호흡 신시티아 바이러스
|
|
US7780962B2
(en)
|
1997-10-09 |
2010-08-24 |
Wellstat Biologics Corporation |
Treatment of neoplasms with RNA viruses
|
|
US7470426B1
(en)
|
1997-10-09 |
2008-12-30 |
Wellstat Biologics Corporation |
Treatment of neoplasms with viruses
|
|
CN101618049A
(zh)
|
1997-10-09 |
2010-01-06 |
威尔斯塔特生物公司 |
使用病毒来治疗赘生物
|
|
US20030044384A1
(en)
|
1997-10-09 |
2003-03-06 |
Pro-Virus, Inc. |
Treatment of neoplasms with viruses
|
|
JP4837827B2
(ja)
|
1998-06-12 |
2011-12-14 |
マウント シナイ スクール オブ メディシン |
新規なウイルス増殖方法およびそのためのインターフェロン欠損培養基
|
|
EP0974660A1
(en)
|
1998-06-19 |
2000-01-26 |
Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) |
Newcastle disease virus infectious clones, vaccines and diagnostic assays
|
|
US6544785B1
(en)
|
1998-09-14 |
2003-04-08 |
Mount Sinai School Of Medicine Of New York University |
Helper-free rescue of recombinant negative strand RNA viruses
|
|
US6146642A
(en)
|
1998-09-14 |
2000-11-14 |
Mount Sinai School Of Medicine, Of The City University Of New York |
Recombinant new castle disease virus RNA expression systems and vaccines
|
|
US7052685B1
(en)
|
1998-10-15 |
2006-05-30 |
Trustees Of The University Of Pennsylvania |
Methods for treatment of cutaneous T-cell lymphoma
|
|
IL145899A0
(en)
|
1999-04-15 |
2002-07-25 |
Pro Virus Inc |
Treatment of neoplasms with viruses
|
|
US20030224017A1
(en)
|
2002-03-06 |
2003-12-04 |
Samal Siba K. |
Recombinant Newcastle disease viruses useful as vaccines or vaccine vectors
|
|
US7244558B1
(en)
|
1999-05-05 |
2007-07-17 |
University Of Maryland |
Production of novel Newcastle disease virus strains from cDNAs and improved live attenuated Newcastle disease vaccines
|
|
ES2278621T5
(es)
|
1999-07-14 |
2011-02-02 |
Mount Sinai School Of Medicine Of New York University |
Reconstrucción in vitro de virus arn segmentados de polaridad negativa.
|
|
US6896881B1
(en)
|
1999-09-24 |
2005-05-24 |
Mayo Foundation For Medical Education And Research |
Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
|
|
ATE451835T1
(de)
|
1999-09-24 |
2010-01-15 |
Mayo Foundation |
Therapeutische verfahren und zusammensetzungen unter verwendung von viren der rekombinanten familie der paramyxoviridae
|
|
AUPQ425699A0
(en)
|
1999-11-25 |
1999-12-23 |
University Of Newcastle Research Associates Limited, The |
A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
|
|
ATE305801T1
(de)
|
2000-01-20 |
2005-10-15 |
Univ Zuerich Inst Fuer Medizin |
Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle
|
|
WO2001077394A1
(en)
|
2000-04-10 |
2001-10-18 |
Mount Sinai School Of Medicine Of New York University |
Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
|
|
US6818444B2
(en)
|
2000-08-04 |
2004-11-16 |
Heska Corporation |
Canine and feline proteins, nucleic acid molecules and uses thereof
|
|
US7740863B2
(en)
|
2001-04-06 |
2010-06-22 |
Merial |
Recombinant vaccine against West Nile Virus
|
|
FR2823222B1
(fr)
|
2001-04-06 |
2004-02-06 |
Merial Sas |
Vaccin contre le virus de la fievre du nil
|
|
WO2002102404A1
(en)
|
2001-06-18 |
2002-12-27 |
Institut National De La Recherche Agronomique |
Uses of cytokines
|
|
AU2003223089A1
(en)
|
2002-04-29 |
2003-11-17 |
Hadasit Medical Research Services And Development Company Ltd. |
Compositions and methods for treating cancer with an oncolytic viral agent
|
|
US20050191617A1
(en)
|
2002-06-03 |
2005-09-01 |
Makoto Inoue |
Pramyxovirusl vectors encoding antibody and utilization thereof
|
|
US7971030B2
(en)
|
2002-08-07 |
2011-06-28 |
Mmagix Technology Limited |
Method for using multiple processing resources which share multiple co-processor resources
|
|
SE0203159D0
(sv)
|
2002-10-25 |
2002-10-25 |
Electrolux Ab |
Handtag till ett motordrivet handhållet verktyg
|
|
AU2002953436A0
(en)
|
2002-12-18 |
2003-01-09 |
The University Of Newcastle Research Associates Limited |
A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
|
|
US20040197312A1
(en)
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
|
ES2367027T3
(es)
|
2004-02-27 |
2011-10-27 |
Inserm (Institut National De La Santé Et De La Recherche Medicale) |
Sitio de unión de la il-15 para il-15ralfa y mutantes específicos de il-15 que tienen actividad agonista/antagonista.
|
|
US8114416B2
(en)
|
2004-03-11 |
2012-02-14 |
Viralytics Limited |
Modified oncolytic viruses
|
|
CN101065144B
(zh)
*
|
2004-08-20 |
2012-06-13 |
溶瘤病毒有限公司 |
治疗血液癌症的方法和组合物
|
|
KR101295733B1
(ko)
*
|
2004-08-20 |
2013-08-13 |
비랄리틱스 리미티드 |
혈액암의 치료방법 및 조성물
|
|
JP2008519590A
(ja)
|
2004-11-12 |
2008-06-12 |
バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト |
組換えニューカッスル病ウィルス
|
|
EP1843773A4
(en)
|
2005-01-17 |
2008-07-30 |
Viralytics Ltd |
METHOD AND COMPOSITION FOR TREATING NEOPLASIA
|
|
EP3263581B2
(en)
|
2005-05-17 |
2025-07-09 |
University of Connecticut |
Compositions and methods for immunomodulation in an organism
|
|
US20090214590A1
(en)
|
2005-07-08 |
2009-08-27 |
Wayne State University |
Virus Vaccines Comprising Envelope-Bound Immunomodulatory Proteins and Methods of Use Thereof
|
|
CA2825762A1
(en)
*
|
2005-08-31 |
2007-03-08 |
Oncolytics Biotech Inc. |
Method for enhancing anti-neoplastic activity of an oncolytic virus using modified dendritic cells
|
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
|
PL2251034T3
(pl)
|
2005-12-02 |
2018-07-31 |
Icahn School Of Medicine At Mount Sinai |
Chimeryczne wirusy prezentujące nienatywne białka powierzchniowe i zastosowania tych wirusów
|
|
NZ569541A
(en)
|
2006-01-13 |
2012-05-25 |
Us Gov Health & Human Serv |
Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells
|
|
WO2007113648A2
(en)
|
2006-04-05 |
2007-10-11 |
Pfizer Products Inc. |
Ctla4 antibody combination therapy
|
|
US20090175826A1
(en)
|
2006-06-05 |
2009-07-09 |
Elankumaran Subbiah |
Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
|
|
WO2008011726A1
(en)
|
2006-07-27 |
2008-01-31 |
Ottawa Health Research Institute |
Staged immune-response modulation in oncolytic therapy
|
|
WO2008134879A1
(en)
|
2007-05-04 |
2008-11-13 |
University Health Network |
Il-12 immunotherapy for cancer
|
|
CN101743249B
(zh)
|
2007-05-11 |
2017-08-08 |
阿尔托生物科学有限公司 |
融合分子与il‑15变异体
|
|
BR122017025062B8
(pt)
|
2007-06-18 |
2021-07-27 |
Merck Sharp & Dohme |
anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
|
|
NZ599338A
(en)
|
2007-06-27 |
2013-11-29 |
Marinepolymer Tech Inc |
Complexes of il-15 and il-15ralpha and uses thereof
|
|
EP2085092A1
(en)
|
2008-01-29 |
2009-08-05 |
Bayer Schering Pharma Aktiengesellschaft |
Attenuated oncolytic paramyxoviruses encoding avian cytokines
|
|
AU2009288730B2
(en)
|
2008-08-25 |
2013-06-20 |
Amplimmune, Inc. |
Compositions of PD-1 antagonists and methods of use
|
|
WO2010042433A1
(en)
|
2008-10-06 |
2010-04-15 |
Bristol-Myers Squibb Company |
Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
|
|
CN101787373B
(zh)
|
2009-01-23 |
2013-06-19 |
中国人民解放军第二军医大学东方肝胆外科医院 |
一种携带外源基因在包装细胞中高效生产的重组病毒载体、其构建方法及其用途
|
|
EP2987856B1
(en)
|
2009-02-05 |
2018-07-25 |
Icahn School of Medicine at Mount Sinai |
Chimeric newcastle disease viruses and uses thereof
|
|
WO2010126766A1
(en)
|
2009-04-30 |
2010-11-04 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Inducible interleukin-12
|
|
US20100297072A1
(en)
|
2009-05-19 |
2010-11-25 |
Depinho Ronald A |
Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
|
|
ES2598005T3
(es)
|
2009-08-14 |
2017-01-24 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Uso de IL-15 para aumentar la salida del timo y para tratar la linfopenia
|
|
PL2467158T3
(pl)
|
2009-08-21 |
2017-07-31 |
Merial, Inc. |
Rekombinowana szczepionka z paramyksowirusem ptaków oraz sposób jej wytwarzania i zastosowania
|
|
EP2482849B1
(en)
|
2009-09-30 |
2018-06-06 |
Memorial Sloan-Kettering Cancer Center |
Combination immunotherapy for the treatment of cancer
|
|
WO2011119628A2
(en)
|
2010-03-23 |
2011-09-29 |
The Regents Of The University Of California |
Compositions and methods for self-adjuvanting vaccines against microbes and tumors
|
|
WO2012000188A1
(en)
|
2010-06-30 |
2012-01-05 |
Tot Shanghai Rd Center Co., Ltd. |
Recombinant tumor vaccine and method of producing such
|
|
US8507222B2
(en)
|
2010-09-21 |
2013-08-13 |
Altor Bioscience Corporation |
Multimeric IL-15 soluble fusion molecules and methods of making and using same
|
|
ES2733211T3
(es)
|
2011-04-15 |
2019-11-28 |
Genelux Corp |
Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas
|
|
EP2537933A1
(en)
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
EP2766035B1
(en)
|
2011-10-11 |
2018-03-28 |
Universität Zürich Prorektorat MNW |
Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
|
|
WO2013112942A1
(en)
*
|
2012-01-25 |
2013-08-01 |
Dna Trix, Inc. |
Biomarkers and combination therapies using oncolytic virus and immunomodulation
|
|
EP2669381A1
(en)
|
2012-05-30 |
2013-12-04 |
AmVac AG |
Method for expression of heterologous proteins using a recombinant negative-strand RNA virus vector comprising a mutated P protein
|
|
US20150250837A1
(en)
|
2012-09-20 |
2015-09-10 |
Morningside Technology Ventures Ltd. |
Oncolytic virus encoding pd-1 binding agents and uses of the same
|
|
US20150359853A1
(en)
|
2012-10-24 |
2015-12-17 |
Admune Therapeutics Llc |
Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
|
|
EP2968525A4
(en)
|
2013-03-14 |
2016-10-26 |
Icahn School Med Mount Sinai |
MORBUS NEWCASTLE VIRUSES AND USES THEREOF
|
|
US11401312B2
(en)
|
2013-04-19 |
2022-08-02 |
Cytune Pharma |
Cytokine derived treatment with reduced vascular leak syndrome
|
|
WO2014201492A1
(en)
|
2013-06-17 |
2014-12-24 |
Darren Raymond Shafren |
Methods for the treatment of bladder cancer
|
|
PT3444271T
(pt)
|
2013-08-08 |
2022-01-05 |
Inst Nat Sante Rech Med |
Modulocinas baseadas em il-15 e no domínio sushi de il-15ralfa
|
|
RS59756B1
(sr)
|
2013-08-08 |
2020-02-28 |
Cytune Pharma |
Kombinovana farmaceutska kompozicija
|
|
HUE042382T2
(hu)
|
2013-09-03 |
2019-06-28 |
Medimmune Ltd |
Legyengített Newcastle betegség vírust tartalmazó készítmények és azok alkalmazása neoplázia kezelési eljárásában történõ alkalmazásra
|
|
EP3110443A4
(en)
*
|
2014-02-27 |
2017-11-15 |
Viralytics Limited |
Combination method for treatment of cancer
|
|
EP2915569A1
(en)
|
2014-03-03 |
2015-09-09 |
Cytune Pharma |
IL-15/IL-15Ralpha based conjugates purification method
|
|
ES2811974T3
(es)
|
2014-07-29 |
2021-03-15 |
Novartis Ag |
Regímenes de aumento escalonado de la dosis del heterodímero de il-15 e il-15ralfa para tratar afecciones
|
|
EP3197911A4
(en)
|
2014-09-22 |
2018-06-20 |
Intrexon Corporation |
Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
|
|
US11377693B2
(en)
|
2014-12-09 |
2022-07-05 |
Merck Sharp & Dohme Llc |
System and methods for deriving gene signature biomarkers of response to PD-1 antagonists
|
|
CN106166294A
(zh)
|
2015-05-18 |
2016-11-30 |
国科丹蓝生物科技（北京）有限公司 |
一种用于术前介入放疗治疗肿瘤的化合物
|
|
US10344067B2
(en)
|
2016-02-25 |
2019-07-09 |
Deutsches Krebsforschungszentrum |
RNA viruses expressing IL-12 for immunovirotherapy
|
|
CN105734023B
(zh)
|
2016-03-28 |
2019-04-26 |
江苏康缘瑞翱生物医药科技有限公司 |
一种重组新城疫病毒在制备抗肝癌药物中的应用
|