JP2021046446A5 - - Google Patents
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- Publication number
- JP2021046446A5 JP2021046446A5 JP2020215171A JP2020215171A JP2021046446A5 JP 2021046446 A5 JP2021046446 A5 JP 2021046446A5 JP 2020215171 A JP2020215171 A JP 2020215171A JP 2020215171 A JP2020215171 A JP 2020215171A JP 2021046446 A5 JP2021046446 A5 JP 2021046446A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- kit
- glucocorticoid
- pharmaceutically acceptable
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003862 glucocorticoid Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 230000037396 body weight Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 208000034578 Multiple myelomas Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 229960003957 dexamethasone Drugs 0.000 claims 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 3
- 229960001347 fluocinolone acetonide Drugs 0.000 claims 3
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 229960004618 prednisone Drugs 0.000 claims 3
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- 229910002651 NO3 Inorganic materials 0.000 claims 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- -1 glucronate Chemical compound 0.000 claims 2
- 229930195712 glutamate Natural products 0.000 claims 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 2
- 229940079826 hydrogen sulfite Drugs 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims 2
- 229940049920 malate Drugs 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical group CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 230000000306 recurrent effect Effects 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims 2
- 229960001860 salicylate Drugs 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 2
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 claims 2
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 1
- ZSIOKTKBCUFLNW-UHFFFAOYSA-N CCCCCN(CCCCC)c1ccc2[n](C)c(CCCCCCC(NO)=O)nc2c1 Chemical compound CCCCCN(CCCCC)c1ccc2[n](C)c(CCCCCCC(NO)=O)nc2c1 ZSIOKTKBCUFLNW-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1409485.8A GB201409485D0 (en) | 2014-05-28 | 2014-05-28 | Pharmaceutical composition |
| GB1409485.8 | 2014-05-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569598A Division JP2017518292A (ja) | 2014-05-28 | 2015-05-26 | グルココルチコイド及びｅｄｏ−ｓ１０１を含む組合せ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021046446A JP2021046446A (ja) | 2021-03-25 |
| JP2021046446A5 true JP2021046446A5 (enExample) | 2021-06-17 |
Family
ID=51177587
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569598A Pending JP2017518292A (ja) | 2014-05-28 | 2015-05-26 | グルココルチコイド及びｅｄｏ−ｓ１０１を含む組合せ |
| JP2020215171A Pending JP2021046446A (ja) | 2014-05-28 | 2020-12-24 | グルココルチコイド及びｅｄｏ−ｓ１０１を含む組合せ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569598A Pending JP2017518292A (ja) | 2014-05-28 | 2015-05-26 | グルココルチコイド及びｅｄｏ−ｓ１０１を含む組合せ |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US10744120B2 (enExample) |
| EP (1) | EP3148584B1 (enExample) |
| JP (2) | JP2017518292A (enExample) |
| KR (1) | KR20170008846A (enExample) |
| CN (1) | CN106488776B (enExample) |
| AU (1) | AU2015266053B2 (enExample) |
| BR (1) | BR112016027043B1 (enExample) |
| CA (1) | CA2950340C (enExample) |
| DK (1) | DK3148584T3 (enExample) |
| EA (1) | EA038323B1 (enExample) |
| ES (1) | ES2885429T3 (enExample) |
| GB (1) | GB201409485D0 (enExample) |
| IL (1) | IL249230A0 (enExample) |
| MX (1) | MX383254B (enExample) |
| PH (1) | PH12016502352A1 (enExample) |
| SG (2) | SG10201810404XA (enExample) |
| TW (1) | TWI731837B (enExample) |
| UA (1) | UA121392C2 (enExample) |
| WO (1) | WO2015181157A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US11266631B2 (en) | 2016-10-11 | 2022-03-08 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709402D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| AU2019400983B2 (en) | 2018-12-18 | 2025-07-03 | Mundipharma International Corporation Limited | Compounds for treating multiple myeloma |
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| DE34727C (de) | Ch. H. TH. HAVEMANN in Paris, 16 rue Bleue | Verfahren zur direkten Gewinnung metallischen Bleis | ||
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| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
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| GB9126209D0 (en) | 1991-12-10 | 1992-02-12 | Orion Yhtymae Oy | Drug formulations for parenteral use |
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| JP6525474B2 (ja) | 2013-12-06 | 2019-06-05 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オーロラキナーゼ阻害剤と抗ｃｄ３０抗体の併用 |
| NZ630314A (en) | 2014-02-18 | 2016-03-31 | Celgene Corp | Combination therapy for hematological malignancies |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| JP2017537164A (ja) | 2014-12-05 | 2017-12-14 | ユニヴァーシティ・オブ・モデナ・アンド・レッジョ・エミリア | リンパ腫の治療に使用されるヒストン脱アセチル化酵素阻害剤とベンダムスチンとの組み合わせ |
| CN106580971B (zh) | 2015-10-20 | 2019-11-12 | 杭州梯诺医药科技有限公司 | 一种药物组合物及其制备方法 |
| US20180098969A1 (en) | 2016-10-11 | 2018-04-12 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| US11266631B2 (en) | 2016-10-11 | 2022-03-08 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| AU2019400983B2 (en) | 2018-12-18 | 2025-07-03 | Mundipharma International Corporation Limited | Compounds for treating multiple myeloma |
-
2014
- 2014-05-28 GB GBGB1409485.8A patent/GB201409485D0/en not_active Ceased
-
2015
- 2015-05-26 UA UAA201613346A patent/UA121392C2/uk unknown
- 2015-05-26 AU AU2015266053A patent/AU2015266053B2/en active Active
- 2015-05-26 ES ES15724308T patent/ES2885429T3/es active Active
- 2015-05-26 SG SG10201810404XA patent/SG10201810404XA/en unknown
- 2015-05-26 KR KR1020167035845A patent/KR20170008846A/ko not_active Ceased
- 2015-05-26 JP JP2016569598A patent/JP2017518292A/ja active Pending
- 2015-05-26 WO PCT/EP2015/061572 patent/WO2015181157A1/en not_active Ceased
- 2015-05-26 US US15/314,180 patent/US10744120B2/en active Active
- 2015-05-26 MX MX2016015437A patent/MX383254B/es unknown
- 2015-05-26 EP EP15724308.0A patent/EP3148584B1/en active Active
- 2015-05-26 BR BR112016027043-6A patent/BR112016027043B1/pt active IP Right Grant
- 2015-05-26 DK DK15724308.0T patent/DK3148584T3/da active
- 2015-05-26 EA EA201692481A patent/EA038323B1/ru unknown
- 2015-05-26 SG SG11201609362YA patent/SG11201609362YA/en unknown
- 2015-05-26 CN CN201580027933.2A patent/CN106488776B/zh active Active
- 2015-05-26 TW TW104116781A patent/TWI731837B/zh active
- 2015-05-26 CA CA2950340A patent/CA2950340C/en active Active
-
2016
- 2016-11-25 PH PH12016502352A patent/PH12016502352A1/en unknown
- 2016-11-27 IL IL249230A patent/IL249230A0/en unknown
-
2020
- 2020-08-14 US US16/994,154 patent/US11541038B2/en active Active
- 2020-12-24 JP JP2020215171A patent/JP2021046446A/ja active Pending
-
2022
- 2022-12-19 US US18/083,651 patent/US12064417B2/en active Active
-
2024
- 2024-07-17 US US18/775,245 patent/US20250049762A1/en active Pending
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