|
US2859239A
(en)
|
1956-08-17 |
1958-11-04 |
Dow Chemical Co |
Acrylic acid compounds
|
|
CH549339A
(de)
|
1971-05-12 |
1974-05-31 |
Ciba Geigy Ag |
Herbizides mittel.
|
|
US5763647A
(en)
*
|
1990-03-30 |
1998-06-09 |
Shionogi & Co., Ltd. |
Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
|
|
CA2072270A1
(en)
|
1991-06-26 |
1992-12-27 |
Joseph V. Koleske |
Production of unsaturated cycloaliphatic esters and derivatives thereof
|
|
ATE401312T1
(de)
|
1997-12-15 |
2008-08-15 |
Astellas Pharma Inc |
Pyrimidin-5-carboxamid-derivate
|
|
AU5438299A
(en)
|
1998-08-29 |
2000-03-21 |
Astrazeneca Ab |
Pyrimidine compounds
|
|
WO2000075113A1
(en)
|
1999-06-09 |
2000-12-14 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel heterocyclic carboxamide derivatives
|
|
WO2000076980A1
(en)
|
1999-06-10 |
2000-12-21 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
|
|
US6498165B1
(en)
|
1999-06-30 |
2002-12-24 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
CA2381882C
(en)
|
1999-08-13 |
2011-01-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
JPWO2003082855A1
(ja)
|
2002-03-28 |
2005-08-04 |
協和醗酵工業株式会社 |
抗炎症剤
|
|
ES2373226T3
(es)
|
2002-06-28 |
2012-02-01 |
Astellas Pharma Inc. |
Derivado de diaminopirimidincarboxamida.
|
|
RS51752B
(sr)
|
2002-07-29 |
2011-12-31 |
Rigel Pharmaceuticals |
Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina
|
|
WO2004054617A1
(ja)
|
2002-12-13 |
2004-07-01 |
Kyowa Hakko Kogyo Co., Ltd. |
中枢疾患の予防および/または治療剤
|
|
WO2004063141A1
(ja)
*
|
2003-01-16 |
2004-07-29 |
Toray Fine Chemicals Co,. Ltd. |
光学活性ジアシル酒石酸の回収方法
|
|
JP2006516561A
(ja)
|
2003-01-17 |
2006-07-06 |
ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー |
細胞増殖の阻害剤としての2−アミノピリジン置換ヘテロ環類
|
|
ATE440087T1
(de)
|
2003-01-30 |
2009-09-15 |
Boehringer Ingelheim Pharma |
2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
|
|
RU2395500C2
(ru)
|
2003-08-15 |
2010-07-27 |
Новартис Аг |
2,4-пиримидиндиамины, применяемые в лечении неопластических болезней, воспалительных и иммунных расстройств
|
|
AU2004275733A1
(en)
|
2003-09-24 |
2005-04-07 |
Wyeth Holdings Corporation |
5-arylpyrimidines as anticancer agents
|
|
WO2005095382A1
(ja)
|
2004-03-30 |
2005-10-13 |
Kyowa Hakko Kogyo Co., Ltd. |
抗腫瘍剤
|
|
US7601714B2
(en)
|
2004-07-08 |
2009-10-13 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Pyrimidine derivatives useful as inhibitors of PKC-theta
|
|
US20080027034A1
(en)
|
2004-09-10 |
2008-01-31 |
Shah Tushar P |
Ciclesonide and Syk Inhibitor Combination and Method of Use Thereof
|
|
WO2006027378A1
(en)
|
2004-09-10 |
2006-03-16 |
Altana Pharma Ag |
Roflumilast and syk inhibitor combination and methods of use thereof
|
|
JP2006124387A
(ja)
|
2004-09-30 |
2006-05-18 |
Taisho Pharmaceut Co Ltd |
新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
|
|
RU2410379C2
(ru)
|
2004-09-30 |
2011-01-27 |
Тиботек Фармасьютикалз Лтд. |
5-замещенные пиримидины, ингибирующие вич
|
|
WO2006091737A1
(en)
|
2005-02-24 |
2006-08-31 |
Kemia, Inc. |
Modulators of gsk-3 activity
|
|
JP2008533042A
(ja)
|
2005-03-10 |
2008-08-21 |
バイエル・フアーマシユーチカルズ・コーポレーシヨン |
過剰増殖性疾患の処置のためのピリミジン誘導体
|
|
WO2007032445A1
(ja)
|
2005-09-16 |
2007-03-22 |
Kyowa Hakko Kogyo Co., Ltd. |
タンパク質キナーゼ阻害剤
|
|
WO2008009458A1
(en)
|
2006-07-21 |
2008-01-24 |
Novartis Ag |
2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US20080139531A1
(en)
|
2006-12-04 |
2008-06-12 |
Alcon Manufacturing Ltd. |
Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
|
|
CL2007003693A1
(es)
|
2006-12-22 |
2008-06-27 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
|
|
ES2593486T3
(es)
|
2007-04-18 |
2016-12-09 |
Pfizer Products Inc. |
Derivados de sulfonil amida para el tratamiento del crecimiento celular anómalo
|
|
US20090036440A1
(en)
|
2007-04-27 |
2009-02-05 |
Astrazeneca Ab |
Novel pyrimidine derivatives - 816
|
|
BRPI0814821A2
(pt)
|
2007-07-16 |
2015-02-03 |
Astrazeneca Ab |
Composto, composição farmacêutica, e, processo para preparar um composto
|
|
EP2183225A1
(en)
|
2007-07-17 |
2010-05-12 |
Rigel Pharmaceuticals, Inc. |
Cyclic amine substituted pyrimidinediamines as pkc inhibitors
|
|
JP5269444B2
(ja)
*
|
2008-03-11 |
2013-08-21 |
東ソー・ファインケム株式会社 |
固体ルイス酸触媒、それを用いたディールスアルダー付加物の製造方法
|
|
CA2723205C
(en)
|
2008-04-16 |
2017-03-14 |
Portola Pharmaceuticals, Inc. |
2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors
|
|
KR20100132550A
(ko)
|
2008-04-16 |
2010-12-17 |
포톨라 파마슈티컬스, 인코포레이티드 |
syk 또는 JAK 키나제 억제제로서의 2,6-디아미노-피리미딘-5-일-카르복스아미드
|
|
WO2009131687A2
(en)
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
EP2280969A1
(en)
|
2008-04-29 |
2011-02-09 |
F. Hoffmann-La Roche AG |
Pyrimidinyl pyridone inhibitors of jnk.
|
|
WO2009143389A1
(en)
|
2008-05-21 |
2009-11-26 |
Ariad Pharmaceuticals, Inc. |
Phosphorous derivatives as kinase inhibitors
|
|
PE20100087A1
(es)
|
2008-06-25 |
2010-02-08 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US8450335B2
(en)
|
2008-06-27 |
2013-05-28 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US20110159019A1
(en)
|
2008-09-01 |
2011-06-30 |
Akira Tanaka |
2,4-diaminopyrimidine compound
|
|
EP2159220A1
(en)
|
2008-09-02 |
2010-03-03 |
Nabriva Therapeutics AG |
Organic compounds
|
|
TWI453207B
(zh)
*
|
2008-09-08 |
2014-09-21 |
Signal Pharm Llc |
胺基三唑并吡啶,其組合物及使用其之治療方法
|
|
JP2012502882A
(ja)
|
2008-09-18 |
2012-02-02 |
アステラス製薬株式会社 |
複素環カルボキサミド化合物
|
|
WO2010038081A2
(en)
|
2008-10-03 |
2010-04-08 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
|
RU2522001C2
(ru)
|
2008-10-31 |
2014-07-10 |
Сентокор Орто Байотек Инк. |
Дифференцирование человеческих эмбриональных стволовых клеток в линию панкреатических эндокринных клеток
|
|
WO2010068863A2
(en)
|
2008-12-12 |
2010-06-17 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
|
WO2010080864A1
(en)
|
2009-01-12 |
2010-07-15 |
Array Biopharma Inc. |
Piperidine-containing compounds and use thereof
|
|
JP2012515148A
(ja)
|
2009-01-13 |
2012-07-05 |
グラクソ グループ リミテッド |
Sykキナーゼ阻害剤としてのピリミジンカルボキサミド誘導体
|
|
JP5781943B2
(ja)
|
2009-01-21 |
2015-09-24 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なn2−(3−ピリジルまたはフェニル)−n4−(4−ピペリジル)−2,4−ピリミジンジアミン誘導体
|
|
WO2010129802A1
(en)
|
2009-05-06 |
2010-11-11 |
Portola Pharmaceuticals, Inc. |
Inhibitors of jak
|
|
KR101614572B1
(ko)
|
2009-05-08 |
2016-04-21 |
아스테라스 세이야쿠 가부시키가이샤 |
디아미노 헤테로환 카르복사미드 화합물
|
|
JP2012148977A
(ja)
|
2009-05-20 |
2012-08-09 |
Astellas Pharma Inc |
アミノシクロヘキシルアルキル基を有する2,4−ジアミノピリミジン化合物
|
|
CN102498110A
(zh)
|
2009-06-10 |
2012-06-13 |
雅培制药有限公司 |
作为激酶抑制剂的2-(lh-吡唑-4-基氨基)-嘧啶
|
|
JP2012197231A
(ja)
|
2009-08-06 |
2012-10-18 |
Oncotherapy Science Ltd |
Ttk阻害作用を有するピリジンおよびピリミジン誘導体
|
|
WO2011065800A2
(ko)
|
2009-11-30 |
2011-06-03 |
주식회사 오스코텍 |
피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
|
|
CA2780759A1
(en)
|
2009-12-01 |
2011-06-09 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
EP2582671A4
(en)
*
|
2010-06-17 |
2014-02-26 |
Reddys Lab Ltd Dr |
PROCESS FOR PREPARING A SINGLE ENANTIOMER FROM 3-AMINOPIPERIDIN DIHYDROCHLORIDE
|
|
US8710223B2
(en)
|
2010-07-21 |
2014-04-29 |
Rigel Pharmaceuticals, Inc. |
Protein kinase C inhibitors and uses thereof
|
|
US8580805B2
(en)
|
2010-08-31 |
2013-11-12 |
Hubert Maehr |
Pyrimidine carboxamide derivatives
|
|
WO2012045020A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combinations of 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide and fludarabine
|
|
US20130244963A1
(en)
|
2010-09-30 |
2013-09-19 |
Portola Pharmaceuticals, Inc. |
Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
|
|
EP4328223A3
(en)
|
2011-04-22 |
2024-11-06 |
Signal Pharmaceuticals, LLC |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
|
|
WO2014019166A1
(zh)
*
|
2012-08-01 |
2014-02-06 |
上海威智医药科技有限公司 |
高活性硼烷类化合物的工业化生产方法
|
|
JP2014031327A
(ja)
*
|
2012-08-02 |
2014-02-20 |
Kaneka Corp |
光学活性シス−2−アミノ−シクロヘキサンカルボン酸誘導体およびその前駆体の製造法
|
|
ES2812605T3
(es)
|
2013-12-20 |
2021-03-17 |
Signal Pharm Llc |
Compuestos de diaminopirimidilo sustituidos, composiciones de los mismos y procedimientos de tratamiento con ellos
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
TWI523838B
(zh)
*
|
2014-03-21 |
2016-03-01 |
Far Eastern New Century Corp |
Terephthalic acid and 4-methyl-3-cyclohexene-1-carboxylic acid Ester preparation method
|
|
HUE054694T2
(hu)
|
2014-10-06 |
2021-09-28 |
Signal Pharm Llc |
Szubsztituált aminpurin vegyületek, ezek összetételei, és az ezekkel végzett kezelések módszerei
|
|
CN107108524A
(zh)
|
2014-12-16 |
2017-08-29 |
西格诺药品有限公司 |
2‑(叔丁基氨基)‑4‑((1r,3r,4r)‑3‑羟基‑4‑甲基环己基氨基)‑嘧啶‑5‑甲酰胺的配制物
|
|
JP6903577B2
(ja)
|
2014-12-16 |
2021-07-14 |
シグナル ファーマシューティカルズ,エルエルシー |
皮膚におけるc−Jun N末端キナーゼの阻害の測定方法
|
|
US20180022710A1
(en)
|
2015-01-29 |
2018-01-25 |
Signal Pharmaceuticals, Llc |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
WO2017019487A1
(en)
*
|
2015-07-24 |
2017-02-02 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|