JP2021046377A - 筋硬度低減剤 - Google Patents
筋硬度低減剤 Download PDFInfo
- Publication number
- JP2021046377A JP2021046377A JP2019170553A JP2019170553A JP2021046377A JP 2021046377 A JP2021046377 A JP 2021046377A JP 2019170553 A JP2019170553 A JP 2019170553A JP 2019170553 A JP2019170553 A JP 2019170553A JP 2021046377 A JP2021046377 A JP 2021046377A
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- JP
- Japan
- Prior art keywords
- muscle hardness
- muscle
- reducing agent
- distillation
- fir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
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- 239000003002 pH adjusting agent Substances 0.000 description 1
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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- 230000021148 sequestering of metal ion Effects 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
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Images
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
原料として、トドマツの葉を用い、以下のようにしてトドマツ精油を得た。すなわち、トドマツ葉を圧砕式粉砕機(KYB製作所製)で粉砕したもの約50kgを、図1に示すマイクロ波蒸留装置の蒸留槽に投入し、攪拌しながら蒸留槽内の圧力を、約20KPaの減圧条件下に保持し、(蒸気温度は約67℃)1時間マイクロ波照射し蒸留した。得られた蒸留物から180g(約180mL)の油性画分を採取した。
下記調製法により調製し、ゲル状の筋硬度低減外用剤(本発明品)を得た。
カルボキシビニルポリマー(商品名:カーボポール941 BF Goodrich社製)0.4gを精製水16.6gに加え攪拌して膨潤させた。これに製造例1で得られたトドマツ蒸留物油性画分3.0gを加えて更に均一になるまで撹拌し、ゲル状外用剤を得た。
運動による筋硬度の上昇を抑制する効果を確認する試験を行った。まず、被験者5名(男性3名、女性2名)の大腿四頭筋ひざ上20cmの場所をデジタル筋硬度計(NEUTON TDMーZ1(RB):(有)トライオール社製)にて測定した。その後、大腿四頭筋全体に実施例1で調製したゲル状外用剤(本発明品)を満遍なく塗り込み、塗布後5分経過後にスクワットを100回実施した。その後2分休息し、さらにスクワット100回を3セット実施した。3セット実施直後(0日経過後)、1日経過後、2日経過後、3日経過後の筋硬度を同様に測定した。スクワット前の筋硬度に対する経過日数ごとの筋硬度の変化率を下記式により算出した。結果を表1(筋硬度)及び3(筋硬度の変化率)、図2に示す。比較として、同じ被験者に対し、上記試験終了から1週間後、本発明品を塗布しなかったこと以外は上記試験と同様にして、スクワット3セットを実施し、筋硬度を測定してその変化率を求めた。結果を表2(筋硬度)及び4(筋硬度の変化率)、図2に示す。
実施例1で作成したゲル状外用剤を用いて筋弛緩作用による筋硬度低減効果を確認する試験を行った。被験者2名(男性)の右大腿四頭筋ひざ上20cmの場所を筋硬度計(TDM−NA1:(株)佐藤商事社製)にて測定した。その後、大腿四頭筋に実施例1で調製した本発明品を満遍なく塗り込んだ後、通常の生活をしてもらい、塗布1時間経過後、同じ場所の筋硬度を測定した。試験は間隔を開けて5回行い、平均値を求めた。結果を表5に示す。
下記処方に基づき、下記調製法により、スチック状の筋硬度低減外用剤を調製した。
(成分) (質量%)
1.ステアリン酸ナトリウム※1 7.0
2.乳酸ナトリウム50%水溶液※2 5.0
3.ポリエチレングリコール※3 30.0
4.イソプロパノール※4 15.0
5.精製水 39.3
6.製造例1のトドマツ蒸留物油性画分 3.0
※1・・・エフコメムAB:(株)ADEKA製
※2・・・和光純薬工業(株)製
※3・・・マクロゴール400:三洋化成工業(株)製
※4・・・和光純薬工業(株)製
製造例1のトドマツ蒸留物油性画分を除く5成分を混合し、70〜90℃にて攪拌しながら30分間加熱還流した。さらに、製造例1のトドマツ蒸留物油性画分0.3gを加え撹拌し、得られた均一な溶液をスチック容器に入れ室温で固め、形状がスチック状である筋硬度低減剤を得た。この製剤を肩こり症の男性に肩に満遍なく塗布し、事務作業を行ってもらったところ、肩こり症状を緩和することができた。
(処方)
(成分) (質量%)
1.製造例1のトドマツ蒸留物油性画分 0.075
2.サリチル酸メチル 1.500
3.l−メントール 4.500
4.ハッカ油 1.120
5.酢酸トコフェロール 0.500
6.dl−カンフル 1.800
7.紫雲膏 30.000
8.水酸化アルミニウム 0.100
9.ポリアクリル酸ナトリウム 7.000
10.カルボキシメチルセルロースナトリウム 2.500
11.カルボキシビニルポリマー 1.000
12.グリセリン 12.000
13.酸化チタン 1.000
14.ソルビトール 15.000
15.精製水 残 量
カルボキシビニルポリマーを精製水に膨潤し、ソルビトールを加えて攪拌する。これにポリアクリル酸ナトリウム、カルボキシメチルセルロースナトリウム、酸化チタン、水酸化アルミニウムをグリセリンに分散させた混合物を投入して混練し、パップ剤基剤組成物を得た。次に紫雲膏を加熱溶解し、それに製造例1のトドマツ蒸留物油性画分以下dl−カンフルまで(成分1〜6)を加え攪拌溶解し、パップ剤基剤組成物に投入して混練し、パップ剤基剤を得た。得られたパップ剤基剤を展延機により支持体上に均一に展延塗布し、剥離ライナーを重ねて所定の形状に裁断することによりパップ剤を得た。
2 … … 蒸留槽
3 … … マイクロ波加熱装置
4 … … 撹拌はね
5 … … 気流流入管
6 … … 蒸留物流出管
7 … … 冷却装置
8 … … 加熱制御装置
9 … … 減圧ポンプ
10 … … 圧力調整弁
11 … … 圧力制御装置
12 … … 蒸留対象物
13 … … 蒸留物
13a… … 油性画分
13b… … 水性画分
Claims (6)
- マツ科モミ属の植物の圧搾液、抽出物または蒸留物を有効成分として含有することを特徴とする筋硬度低減剤。
- 前記マツ科モミ属の植物がトドマツである請求項1に記載の筋硬度低減剤。
- 前記マツ科モミ属の植物の圧搾液、抽出物または蒸留物の含有量が、0.1〜20質量%である請求項1または2記載の筋硬度低減剤。
- 前記マツ科モミ属の植物として、マツ科モミ属の植物の枝及び/または葉の部分を用いるものである請求項1〜3のいずれかの項に記載の筋硬度低減剤。
- ゲル状である請求項1〜4のいずれかの項に記載の筋硬度低減剤。
- 外用剤である請求項1〜5のいずれかの項に記載の筋硬度低減剤。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010098440A1 (ja) * | 2009-02-26 | 2010-09-02 | 日本かおり研究所株式会社 | 高モノテルペン成分含有精油、その製造方法および当該精油を用いた環境汚染物質浄化方法 |
JP2016094354A (ja) * | 2014-11-12 | 2016-05-26 | 三笠製薬株式会社 | 抗炎症外用剤 |
JP2017178874A (ja) * | 2016-03-31 | 2017-10-05 | エステー株式会社 | 鎮痛剤 |
JP2017535539A (ja) * | 2014-10-21 | 2017-11-30 | ユナイテッド カナビス コーポレイション | 大麻抽出物ならびにその調製方法および使用方法 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010098440A1 (ja) * | 2009-02-26 | 2010-09-02 | 日本かおり研究所株式会社 | 高モノテルペン成分含有精油、その製造方法および当該精油を用いた環境汚染物質浄化方法 |
JP2017535539A (ja) * | 2014-10-21 | 2017-11-30 | ユナイテッド カナビス コーポレイション | 大麻抽出物ならびにその調製方法および使用方法 |
JP2016094354A (ja) * | 2014-11-12 | 2016-05-26 | 三笠製薬株式会社 | 抗炎症外用剤 |
JP2017178874A (ja) * | 2016-03-31 | 2017-10-05 | エステー株式会社 | 鎮痛剤 |
Non-Patent Citations (2)
Title |
---|
ウッディエイジ, vol. 6月号, JPN6023013105, 1996, pages 3 - 9, ISSN: 0005028901 * |
北海道大學農學部 演習林研究報告, vol. 48(1), JPN6023013104, 1991, pages 247 - 257, ISSN: 0005028900 * |
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