JP2021014467A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021014467A5 JP2021014467A5 JP2020188063A JP2020188063A JP2021014467A5 JP 2021014467 A5 JP2021014467 A5 JP 2021014467A5 JP 2020188063 A JP2020188063 A JP 2020188063A JP 2020188063 A JP2020188063 A JP 2020188063A JP 2021014467 A5 JP2021014467 A5 JP 2021014467A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- ketone
- ketone body
- composition
- precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- 150000002576 ketones Chemical class 0.000 claims 24
- 239000002243 precursor Substances 0.000 claims 12
- 235000015872 dietary supplement Nutrition 0.000 claims 5
- 239000000017 hydrogel Substances 0.000 claims 4
- WHBMMWSBFZVSSR-GSVOUGTGSA-M (R)-3-hydroxybutyrate Chemical compound C[C@@H](O)CC([O-])=O WHBMMWSBFZVSSR-GSVOUGTGSA-M 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 2
- 208000021642 Muscular disease Diseases 0.000 claims 2
- 201000009623 Myopathy Diseases 0.000 claims 2
- 235000013361 beverage Nutrition 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002503 metabolic effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 239000013589 supplement Substances 0.000 claims 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 2
- AOWPVIWVMWUSBD-COBSHVIPSA-N 3-hydroxybutyl (3r)-3-hydroxybutanoate Chemical compound CC(O)CCOC(=O)C[C@@H](C)O AOWPVIWVMWUSBD-COBSHVIPSA-N 0.000 claims 1
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 239000004358 Butane-1, 3-diol Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- AOWPVIWVMWUSBD-RNFRBKRXSA-N [(3r)-3-hydroxybutyl] (3r)-3-hydroxybutanoate Chemical compound C[C@@H](O)CCOC(=O)C[C@@H](C)O AOWPVIWVMWUSBD-RNFRBKRXSA-N 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000012041 food component Nutrition 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 229920005646 polycarboxylate Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1002983.3 | 2010-02-22 | ||
| GBGB1002983.3A GB201002983D0 (en) | 2010-02-22 | 2010-02-22 | Nutritinal composition |
| JP2017002060A JP6830359B2 (ja) | 2010-02-22 | 2017-01-10 | 栄養組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017002060A Division JP6830359B2 (ja) | 2010-02-22 | 2017-01-10 | 栄養組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021014467A JP2021014467A (ja) | 2021-02-12 |
| JP2021014467A5 true JP2021014467A5 (https=) | 2021-10-14 |
| JP7427572B2 JP7427572B2 (ja) | 2024-02-05 |
Family
ID=42114192
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554245A Active JP6116913B2 (ja) | 2010-02-22 | 2011-02-22 | 栄養組成物 |
| JP2017002060A Active JP6830359B2 (ja) | 2010-02-22 | 2017-01-10 | 栄養組成物 |
| JP2020188063A Active JP7427572B2 (ja) | 2010-02-22 | 2020-11-11 | 栄養組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554245A Active JP6116913B2 (ja) | 2010-02-22 | 2011-02-22 | 栄養組成物 |
| JP2017002060A Active JP6830359B2 (ja) | 2010-02-22 | 2017-01-10 | 栄養組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10660958B2 (https=) |
| EP (1) | EP2539312B1 (https=) |
| JP (3) | JP6116913B2 (https=) |
| AU (1) | AU2011217499B2 (https=) |
| CA (1) | CA2790790C (https=) |
| GB (2) | GB201002983D0 (https=) |
| WO (1) | WO2011101171A1 (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323237B1 (en) * | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| EP1648952B1 (en) | 2003-06-03 | 2018-03-07 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives |
| ES2574557T3 (es) * | 2004-09-21 | 2016-06-20 | Btg International Limited | Miméticos dopaminérgicos |
| EP2240017B1 (en) | 2008-01-04 | 2019-03-13 | Oxford University Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| GB201002983D0 (en) | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
| GB201206192D0 (en) * | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| DK2914251T3 (da) | 2012-11-05 | 2019-11-04 | Us Health | Ketonlegemer til beskyttelse af væv mod beskadigelse som følge af ioniseringsstråling |
| GB201304467D0 (en) * | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| GB2515603B (en) | 2013-03-14 | 2015-10-14 | Isis Innovation | Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate |
| CA2902603C (en) * | 2013-03-19 | 2021-03-02 | University Of South Florida | Compositions and methods for producing elevated and sustained ketosis |
| DE102013012494A1 (de) * | 2013-07-26 | 2015-01-29 | Irma Baumeister | Verwendung von ß-Hydroxybuttersäure und Acetessigsäure sowie ihrer Salze (ß-Hydroxybutyrat und Acetacetat) als Mittel zur Behandlung bei erworbener Hypoglycorrhachie in Folge von Meningitis, Encephalitis oder Blutung in die Liquorräume |
| US9249378B2 (en) | 2013-08-02 | 2016-02-02 | Eastman Chemical Company | Aqueous cleaning compositions having enhanced properties |
| US9255059B2 (en) | 2013-08-02 | 2016-02-09 | Eastman Chemical Company | Method for producing an alkyl 3-hydroxybutyrate |
| US9388114B2 (en) | 2013-08-02 | 2016-07-12 | Eastman Chemical Company | Compositions including an alkyl 3-hydroxybutyrate |
| US9163202B2 (en) | 2013-08-02 | 2015-10-20 | Eastman Chemical Company | Aqueous cleaning compositions including an alkyl 3-hydroxybutyrate |
| GB201314127D0 (en) * | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
| US10596129B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| US10245243B1 (en) | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US10596130B2 (en) | 2017-12-19 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| US10596131B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US20190091189A1 (en) * | 2016-03-21 | 2019-03-28 | Csilla Ari D'Agostino | Administration of exogenous ketone to lower blood glucose |
| WO2017165443A1 (en) * | 2016-03-21 | 2017-09-28 | Csilla Ari D'agostino | Methods of improving motor function using ketone supplementation |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12599579B2 (en) | 2016-04-19 | 2026-04-14 | Axcess Global Sciences, Llc | Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| WO2017213999A1 (en) | 2016-06-07 | 2017-12-14 | The J. David Gladstone Institutes | Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same |
| US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
| US9925164B1 (en) * | 2017-01-12 | 2018-03-27 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for traumatic brain injury |
| US20190231742A1 (en) * | 2017-04-20 | 2019-08-01 | Theodore B. VANITALLIE | Nutritional agents used to prevent and treat hypersensitivity and other allergic-type disorders |
| WO2019018683A1 (en) | 2017-07-21 | 2019-01-24 | Buck Institute For Research On Aging | BETA-HYDROXYBUTYRATE AND BUTANEDIOL ENANTIOMERS AND METHODS OF USE THEREOF |
| US11760963B2 (en) | 2017-08-23 | 2023-09-19 | KetoneAid Inc. | Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| WO2019147503A1 (en) | 2018-01-25 | 2019-08-01 | Buck Institute For Research On Aging | Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds |
| US10512615B1 (en) | 2018-08-27 | 2019-12-24 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11129802B2 (en) | 2018-08-27 | 2021-09-28 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11241401B2 (en) | 2020-02-06 | 2022-02-08 | Axcess Global Sciences, Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
| US10980772B2 (en) | 2018-08-27 | 2021-04-20 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| GB2575623B (en) | 2018-06-04 | 2022-10-26 | Tdeltas Ltd | 3-hydroxybutyrate esters for treating cancer cachexia |
| CA3022995C (en) | 2018-06-12 | 2019-10-15 | Ketofibe (9211-3133 Quebec Inc.) | Novel ketogenic compounds, compositions, methods and use thereof |
| US20200222353A1 (en) * | 2019-01-14 | 2020-07-16 | Christopher David Thompson | Ketone ester and ketone salt compositions and methods for using the same |
| CA3097783C (en) * | 2019-03-14 | 2023-01-03 | Neuroenergy Ventures, Inc. | Taste-masking formulation for ketone body compounds |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12396974B2 (en) | 2020-03-27 | 2025-08-26 | KetoneAid | Ketone ester as a therapeutic treatment of Covid-19 and related viral infections |
| EP4146337B1 (de) * | 2020-07-13 | 2024-04-17 | KetoLipix Therapeutics GmbH | Verfahren zur herstellung von polyglycerinestern von mit oxobutanol veresterten polycarbonsäuren |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| US20220249497A1 (en) * | 2021-02-05 | 2022-08-11 | Health Via Modern Nutrition, Inc. | Compositions and methods for improving relaxation, sleep, cognition, and/or physical performance |
| US20230143566A1 (en) * | 2021-11-09 | 2023-05-11 | Operade LLC | Keto ester compositions and methods for using same |
| US11807600B2 (en) | 2021-11-12 | 2023-11-07 | Samuel J. Rozzoni | Synthesis of novel ketone body analogs for use as a nutritional supplement |
| WO2026003892A1 (en) | 2024-06-28 | 2026-01-02 | Dr. Schär S.P.A. | Ketogenic food formulation |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU507322A1 (ru) | 1973-07-26 | 1976-03-25 | Московский Научно-Исследовательский Институт Косметологии | Регул тор гормонального обмена кожи |
| US3984566A (en) | 1974-02-25 | 1976-10-05 | Scott Eugene J Van | Method of alleviating the symptoms of dandruff |
| IT1051853B (it) | 1975-01-07 | 1981-05-20 | Basf Ag | Butandiol 1.3 3 mono 3 idros sibutirrati butandiol 1.3 1mono 3 idrossibutirrati e processi per la loro preparazione |
| US4380549A (en) | 1975-07-23 | 1983-04-19 | Scott Eugene J Van | Topical treatment of dry skin |
| JPS54138126A (en) | 1978-04-17 | 1979-10-26 | Ajinomoto Co Inc | Remedy for diabetes |
| JPS5747446A (en) * | 1980-09-05 | 1982-03-18 | Nippon Oil & Fats Co Ltd | Nutrious food composition |
| EP0250559A1 (en) | 1985-12-18 | 1988-01-07 | VEECH, Richard L. | Parenteral nutrition therapy with amino acids |
| JPH0755158B2 (ja) | 1986-10-30 | 1995-06-14 | チッソ株式会社 | 光学活性エステルの製造法 |
| JP2579779B2 (ja) | 1987-10-08 | 1997-02-12 | 日本車輌製造株式会社 | 飼料の製造法 |
| US5126373A (en) | 1987-11-19 | 1992-06-30 | Henri Brunengraber | Composition for parenteral and oral nutrition |
| BE1001209A3 (fr) | 1987-11-19 | 1989-08-22 | Solvay | Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol. |
| JPH0383950A (ja) | 1989-08-28 | 1991-04-09 | Kanegafuchi Chem Ind Co Ltd | グリセリド誘導体およびその製造法 |
| JP2873497B2 (ja) | 1990-09-03 | 1999-03-24 | 理化学研究所 | 脂質代謝調節剤 |
| JP2884123B2 (ja) | 1992-01-17 | 1999-04-19 | 高砂香料工業株式会社 | 生分解性光学活性ポリマー、その中間体オリゴマー、およびそれらの製造方法 |
| US5654266A (en) | 1992-02-10 | 1997-08-05 | Chen; Chung-Ho | Composition for tissues to sustain viability and biological functions in surgery and storage |
| US5281691A (en) | 1992-06-19 | 1994-01-25 | Eastman Kodak Company | Poly(3-hydroxyalkanoates) |
| JP3193542B2 (ja) | 1993-09-08 | 2001-07-30 | カネボウ株式会社 | 皮膚老化防止化粧料 |
| WO1995009144A1 (en) | 1993-09-30 | 1995-04-06 | Eastman Chemical Company | Nutritive water soluble glycerol esters of hydroxy butyric acid |
| ATE196486T1 (de) | 1994-08-10 | 2000-10-15 | Peter Neuenschwander | Biokompatibles blockcopolymer |
| JPH08191664A (ja) * | 1995-01-12 | 1996-07-30 | Yoshihide Hagiwara | 新規コーヒー抽出物の製造法 |
| US6306828B1 (en) | 1995-04-06 | 2001-10-23 | Baxter International, Inc. | Enantiomerically-enhanced nutritional energy substrates |
| JP4598203B2 (ja) | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
| US6126953A (en) | 1996-08-19 | 2000-10-03 | The Procter & Gamble Company | Fragrance delivery systems for personal care articles |
| JPH10175855A (ja) | 1996-10-16 | 1998-06-30 | Taisho Pharmaceut Co Ltd | 肉体疲労改善剤 |
| US6316038B1 (en) | 1997-03-17 | 2001-11-13 | Btg International Limited | Therapeutic compositions |
| US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| CN1315473C (zh) | 1997-03-17 | 2007-05-16 | 英国技术集团国际有限公司 | 治疗组合物 |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| JPH10265378A (ja) | 1997-03-25 | 1998-10-06 | Ofutekusu:Kk | 角膜上皮損傷治療剤 |
| JP3869071B2 (ja) * | 1997-05-14 | 2007-01-17 | 三栄源エフ・エフ・アイ株式会社 | 甘味食品 |
| AU7580098A (en) | 1997-05-15 | 1998-12-08 | University Of Washington | Composition and methods for treating alzheimer's disease and other amyloidoses |
| US6727258B2 (en) | 1997-10-29 | 2004-04-27 | King Pharmaceutical Research & Development, Inc. | Allosteric adenosine receptor modulators |
| GB9723590D0 (en) | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
| DE69922206T2 (de) | 1998-07-22 | 2005-11-24 | Metabolix, Inc., Cambridge | Nahrungs- und therapeutische verwendung von hydroxyalkanoat oligomere |
| DK1123094T3 (da) * | 1998-09-15 | 2007-08-20 | Btg Int Ltd | Terapeutiske præparater (II) |
| AU6988100A (en) | 1999-08-20 | 2001-03-19 | Unilever Plc | A method for reducing skin irritation and sting from weak carboxylic acid |
| BR0107626A (pt) | 2000-01-14 | 2002-10-15 | Genset Sa | Cabeças globulares de obg3 e usos destes para diminuir a massa corporal |
| US20070179197A1 (en) * | 2000-05-01 | 2007-08-02 | Accera, Inc. | Compositions and methods for improving or preserving brain function |
| WO2007115282A2 (en) | 2006-04-03 | 2007-10-11 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
| AU2001257451A1 (en) | 2000-05-01 | 2001-11-12 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism |
| EP2275468A1 (en) | 2000-07-14 | 2011-01-19 | Metabolix, Inc. | Polyurethanes obtained from hydroxyalkanoates and isocyanates |
| AUPR177300A0 (en) | 2000-11-29 | 2000-12-21 | Centre For Molecular Biology And Medicine | Therapeutic methods |
| US20050129783A1 (en) | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| DE20205184U1 (de) | 2002-03-27 | 2002-12-19 | Bartz, Volker, 35440 Linden | Blutfettsenker zur oralen Einnahme |
| CN1483355A (zh) | 2002-09-16 | 2004-03-24 | 岚 高 | 抗疲劳饮料配方 |
| US20060189545A1 (en) | 2003-03-06 | 2006-08-24 | Henderson Samuel T | Novel chemical entities and methods for their use in treatment of metabolic disorders |
| WO2004105742A1 (en) | 2003-06-02 | 2004-12-09 | Isis Innovation Limited | Treatment of muscle fatigue |
| EP1648952B1 (en) * | 2003-06-03 | 2018-03-07 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives |
| JP2005247821A (ja) | 2004-02-06 | 2005-09-15 | Ophtecs Corp | 炎症性サイトカインの産生を抑制するための眼科用組成物 |
| DE102004007029A1 (de) | 2004-02-12 | 2005-09-08 | Consortium für elektrochemische Industrie GmbH | Verfahren zur enantioselektiven Reduktion von Ketoverbindungen durch Enzyme |
| WO2006020137A2 (en) | 2004-07-16 | 2006-02-23 | Ketocytonyx Inc. | Oligomeric compounds |
| US8124063B2 (en) | 2004-10-25 | 2012-02-28 | Conopco, Inc. | Method for moisturizing human skin using dihydroxypropyltri(C1-C3 alkyl) ammonium salts |
| GB0427145D0 (en) * | 2004-12-10 | 2005-01-12 | Ketocytonyx Inc | Compositions for use in surgery |
| ITTO20040918A1 (it) * | 2004-12-29 | 2005-03-29 | Luigi Ambrosio | Idrogel polimerici superassorbenti biodegradabili e procedimento per la loro preparazione |
| WO2007001883A2 (en) | 2005-06-20 | 2007-01-04 | Accera, Inc. | Method to reduce oxidative damage and improve mitochondrial efficiency |
| CA2631264A1 (en) | 2005-11-29 | 2007-06-07 | Basf Se | Process for esterifying or transesterifying side chains in polymers |
| PL2004160T3 (pl) | 2006-04-12 | 2013-02-28 | Unilever Nv | Doustna kompozycja o przeciwstarzeniowym działaniu na skórę |
| US7807718B2 (en) | 2006-06-30 | 2010-10-05 | Sami A. Hashim | Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose |
| JP5030553B2 (ja) | 2006-11-24 | 2012-09-19 | 有限会社ノーベル医学研究所 | ドライマウスおよび／または唾液分泌障害を処置するための医薬 |
| EP2094830B1 (en) * | 2006-12-19 | 2013-04-10 | Basf Se | Uses and methods for preventing and/or treating caries caused by mutans streptococci |
| EP2141995B1 (en) | 2007-03-27 | 2014-11-05 | Perscitus Biosciences, LLC | Compositions and their uses in protecting cells from toxic exposures |
| JP5065742B2 (ja) * | 2007-04-18 | 2012-11-07 | 三栄源エフ・エフ・アイ株式会社 | 香味の発現性及び持続性が改善された調味食品 |
| CA2685380A1 (en) * | 2007-05-14 | 2008-11-20 | Neuera Pharmaceuticals, Inc. | Inhibitors of acetyl-coa carboxylase for treatment of neuronal hypometabolism |
| WO2009023357A2 (en) | 2007-05-25 | 2009-02-19 | University Of Rochester | Curcumin derivatives and their use as radioprotectors |
| ES2664777T5 (es) * | 2007-10-04 | 2021-10-25 | Nestle Sa | Composiciones y procedimientos para mejorar la función cognitiva |
| EP2240017B1 (en) | 2008-01-04 | 2019-03-13 | Oxford University Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
| JP5773870B2 (ja) * | 2008-08-21 | 2015-09-02 | アイシス イノヴェイション リミテッド | ヒドロキシ酪酸エステル及びその医学的使用 |
| US8642654B2 (en) * | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| US9034613B2 (en) | 2009-04-16 | 2015-05-19 | Isis Innovation Limited | Process for the preparation of (3R)-hydroxybutyl (3R)-hydroxybutyrate by enzymatic enantioselective reduction employing Lactobacillus brevis alcohol dehydrogenase |
| GB201002983D0 (en) | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
| FR2958154B1 (fr) | 2010-04-01 | 2012-06-08 | Oreal | Procede de soin et/ou de maquillage des rides |
| JP6291256B2 (ja) | 2011-02-17 | 2018-03-14 | シーエイチディー・バイオサイエンス，インコーポレーテッド | ペルオキシα−ケトカルボン酸を含む組成物、および該組成物を産生し、そして用いるための方法 |
| WO2012113415A1 (en) | 2011-02-24 | 2012-08-30 | N.V. Nutricia | Ketogenic diet composition for the treatment of chemo therapy and/or radiation therapy patients |
| GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| DK2914251T3 (da) | 2012-11-05 | 2019-11-04 | Us Health | Ketonlegemer til beskyttelse af væv mod beskadigelse som følge af ioniseringsstråling |
| GB201304467D0 (en) | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| GB2515603B (en) | 2013-03-14 | 2015-10-14 | Isis Innovation | Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate |
| GB201314127D0 (en) | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
-
2010
- 2010-02-22 GB GBGB1002983.3A patent/GB201002983D0/en not_active Ceased
-
2011
- 2011-02-22 CA CA2790790A patent/CA2790790C/en active Active
- 2011-02-22 JP JP2012554245A patent/JP6116913B2/ja active Active
- 2011-02-22 US US13/580,602 patent/US10660958B2/en active Active
- 2011-02-22 GB GB1215209.6A patent/GB2490462B/en active Active
- 2011-02-22 AU AU2011217499A patent/AU2011217499B2/en active Active
- 2011-02-22 WO PCT/EP2011/000833 patent/WO2011101171A1/en not_active Ceased
- 2011-02-22 EP EP11708186.9A patent/EP2539312B1/en active Active
-
2017
- 2017-01-10 JP JP2017002060A patent/JP6830359B2/ja active Active
-
2020
- 2020-05-22 US US16/881,597 patent/US11571479B2/en active Active
- 2020-11-11 JP JP2020188063A patent/JP7427572B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021014467A5 (https=) | ||
| JP7628826B2 (ja) | ベータ－ヒドロキシブチレートおよびアセトアセテートを用いたケト積重のための組成物および方法 | |
| US11786499B2 (en) | Ketone body esters of S-beta-hydroxybutyrate and/or S-1,3-butanediol for modifying metabolic function | |
| JP7300449B2 (ja) | 非ラセミ体のベータ－ヒドロキシブチレート化合物及びｓ－エナンチオマー富化組成物並びに使用方法 | |
| JP7585037B2 (ja) | 非ラセミ体のベータ－ヒドロキシブチレート化合物及びｒ－エナンチオマー富化組成物並びに使用方法 | |
| JP6830359B2 (ja) | 栄養組成物 | |
| KR100545630B1 (ko) | 필수 지방산과 생물활성 이황화물을 함유하는 치료 및식이요법 조성물 | |
| JP6092836B2 (ja) | ヒドロキシ酪酸エステル及びその医学的使用 | |
| WO2019200132A1 (en) | Compositions and methods for supplementing the diet | |
| RU2001110097A (ru) | Терапевтические композиции (ii) | |
| JP2021527108A (ja) | 新規のケトン体生成化合物、組成物、方法およびその使用 | |
| JPWO2008149802A1 (ja) | アンドログラホリドを有効成分とする抗疲労剤及び経口組成物 | |
| US20190119705A1 (en) | Substantially non-racemic ketone ester of beta hydroxybutyrate and production process thereof | |
| JP5119509B2 (ja) | 活動意欲向上剤 | |
| EP3801490B1 (en) | Compounds for use in cancer cachexia | |
| AU5253501A (en) | Dietary supplement energy-providing to skeletal muscles and protecting the cardiovascular tract | |
| WO2022140130A1 (en) | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function | |
| JP2001098294A (ja) | 体内蓄積脂肪の利用促進剤 | |
| CN120501225A (zh) | 一种复合抗氧化固体饮料及其制备方法 | |
| JP2007236383A (ja) | 発毛及び又は育毛用栄養補助食品 | |
| CN103989185A (zh) | 一种含有辅酶q10的深海鱼油软胶囊 | |
| CN112120211A (zh) | 一种具有辅助降血脂的复合植物软胶囊及其制备方法 |