JP2020536922A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020536922A5 JP2020536922A5 JP2020520577A JP2020520577A JP2020536922A5 JP 2020536922 A5 JP2020536922 A5 JP 2020536922A5 JP 2020520577 A JP2020520577 A JP 2020520577A JP 2020520577 A JP2020520577 A JP 2020520577A JP 2020536922 A5 JP2020536922 A5 JP 2020536922A5
- Authority
- JP
- Japan
- Prior art keywords
- linear
- branched
- pharmaceutically acceptable
- acceptable salt
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 24
- 125000005843 halogen group Chemical group 0.000 claims description 24
- 125000001188 haloalkyl group Chemical group 0.000 claims description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 13
- 125000006165 cyclic alkyl group Chemical group 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 12
- 150000002825 nitriles Chemical class 0.000 claims description 12
- 125000005842 heteroatom Chemical group 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 150000003457 sulfones Chemical class 0.000 claims description 8
- 150000003462 sulfoxides Chemical class 0.000 claims description 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 4
- GOPDFXUMARJJEA-UHFFFAOYSA-N amino(nitro)azanide Chemical compound N[N-][N+]([O-])=O GOPDFXUMARJJEA-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Chemical group 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 229940124530 sulfonamide Drugs 0.000 claims description 4
- 150000003456 sulfonamides Chemical class 0.000 claims description 4
- 229910052717 sulfur Chemical group 0.000 claims description 4
- 239000011593 sulfur Chemical group 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229930003347 Atropine Natural products 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 230000003551 muscarinic effect Effects 0.000 description 1
- RMHMFHUVIITRHF-UHFFFAOYSA-N pirenzepine Chemical group C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022071400A JP2022101654A (ja) | 2017-11-03 | 2022-04-25 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
| JP2024006023A JP7777613B2 (ja) | 2017-11-03 | 2024-01-18 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762581073P | 2017-11-03 | 2017-11-03 | |
| US62/581,073 | 2017-11-03 | ||
| US201862749610P | 2018-10-23 | 2018-10-23 | |
| US62/749,610 | 2018-10-23 | ||
| PCT/IB2018/058631 WO2019087146A1 (en) | 2017-11-03 | 2018-11-02 | Azabicyclo and diazepine derivatives for treating ocular disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022071400A Division JP2022101654A (ja) | 2017-11-03 | 2022-04-25 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536922A JP2020536922A (ja) | 2020-12-17 |
| JP2020536922A5 true JP2020536922A5 (https=) | 2021-02-04 |
| JP7065180B2 JP7065180B2 (ja) | 2022-05-11 |
Family
ID=64267873
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520577A Active JP7065180B2 (ja) | 2017-11-03 | 2018-11-02 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
| JP2022071400A Pending JP2022101654A (ja) | 2017-11-03 | 2022-04-25 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
| JP2024006023A Active JP7777613B2 (ja) | 2017-11-03 | 2024-01-18 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022071400A Pending JP2022101654A (ja) | 2017-11-03 | 2022-04-25 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
| JP2024006023A Active JP7777613B2 (ja) | 2017-11-03 | 2024-01-18 | 眼疾患を治療するためのアザビシクロ及びジアゼピン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11306090B2 (https=) |
| EP (1) | EP3704117B1 (https=) |
| JP (3) | JP7065180B2 (https=) |
| KR (1) | KR20200083976A (https=) |
| CN (1) | CN111247147B (https=) |
| AU (3) | AU2018362010B2 (https=) |
| BR (1) | BR112020007744A2 (https=) |
| CA (2) | CA3076457C (https=) |
| ES (1) | ES3064457T3 (https=) |
| MX (2) | MX2020004580A (https=) |
| SG (1) | SG11202002692XA (https=) |
| TW (2) | TWI826399B (https=) |
| WO (2) | WO2019087149A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3128224A1 (en) * | 2019-02-01 | 2020-08-06 | Aerie Pharmaceuticals, Inc. | Compounds, compositions and methods for treatment of myopia |
| US12527739B2 (en) | 2022-09-11 | 2026-01-20 | Alcon Inc. | Aqueous pharmaceutical compositions comprising benzyl atropine and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1165037B (de) * | 1961-11-21 | 1964-03-12 | Dr. Schwarz Arzneimittelfabrik G.m.b.H., Monheim (RhId.) | Verfahren zur Herstellung von Estern quaternärer Atropiniumsalze. |
| GB994493A (en) * | 1963-02-06 | 1965-06-10 | Lepetit Spa | Tropine derivative |
| DE1670177A1 (de) | 1966-12-28 | 1970-11-12 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen N-substituierten Noratropiniumsalzen |
| US5223528A (en) | 1986-03-17 | 1993-06-29 | University Of Florida | Anticholinergic compounds, composititons and methods of treatment |
| EP1397132A4 (en) * | 2001-05-25 | 2006-12-13 | Valley Forge Pharmaceuticals I | OPHTHALMIC PIRENZEPINE GEL |
| FR2834511B1 (fr) | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| CN1546490A (zh) | 2003-12-15 | 2004-11-17 | 常俊标 | 不对称双羟基托品类生物碱及其合成新方法和药物用途 |
| CN1283639C (zh) | 2004-06-08 | 2006-11-08 | 吴建梅 | 治疗近视眼的哌仑西平有机酸盐及其滴眼剂 |
| US20070254914A1 (en) * | 2006-05-01 | 2007-11-01 | Non-Profit Organization Chang Gung Memorial Hospital | Low-concentration atropine solution for preventing myopia progression and preparing method thereof |
| SI2657234T1 (sl) | 2010-12-22 | 2017-06-30 | Meiji Seika Pharma Co., Ltd. | Derivat optično-aktivnega diazabiciklooktana in metoda za njegovo izdelavo |
-
2018
- 2018-11-02 WO PCT/IB2018/058637 patent/WO2019087149A1/en not_active Ceased
- 2018-11-02 CA CA3076457A patent/CA3076457C/en active Active
- 2018-11-02 BR BR112020007744-5A patent/BR112020007744A2/pt unknown
- 2018-11-02 TW TW107138927A patent/TWI826399B/zh active
- 2018-11-02 CA CA3205816A patent/CA3205816A1/en active Pending
- 2018-11-02 KR KR1020207010292A patent/KR20200083976A/ko active Pending
- 2018-11-02 TW TW112150515A patent/TWI852865B/zh active
- 2018-11-02 AU AU2018362010A patent/AU2018362010B2/en active Active
- 2018-11-02 US US16/760,192 patent/US11306090B2/en active Active
- 2018-11-02 MX MX2020004580A patent/MX2020004580A/es unknown
- 2018-11-02 EP EP18800336.2A patent/EP3704117B1/en active Active
- 2018-11-02 SG SG11202002692XA patent/SG11202002692XA/en unknown
- 2018-11-02 WO PCT/IB2018/058631 patent/WO2019087146A1/en not_active Ceased
- 2018-11-02 JP JP2020520577A patent/JP7065180B2/ja active Active
- 2018-11-02 CN CN201880068606.5A patent/CN111247147B/zh active Active
- 2018-11-02 ES ES18800336T patent/ES3064457T3/es active Active
-
2020
- 2020-07-13 MX MX2022011310A patent/MX2022011310A/es unknown
-
2021
- 2021-07-16 AU AU2021205100A patent/AU2021205100B2/en active Active
-
2022
- 2022-03-21 US US17/699,606 patent/US11884666B2/en active Active
- 2022-04-25 JP JP2022071400A patent/JP2022101654A/ja active Pending
-
2023
- 2023-04-03 AU AU2023202036A patent/AU2023202036B2/en active Active
- 2023-11-30 US US18/524,807 patent/US12247028B2/en active Active
-
2024
- 2024-01-18 JP JP2024006023A patent/JP7777613B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2006142738A (ru) | Антагонисты рецептора crth2 | |
| ES2906379T3 (es) | Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos | |
| ES2705240T3 (es) | Composiciones farmacéuticas que comprenden donadores de nitroxilo | |
| JP2013508279A5 (https=) | ||
| JP2010501584A5 (https=) | ||
| ES2437346T3 (es) | Procedimiento para la producción de derivado de diamina | |
| JP2017537940A5 (https=) | ||
| JP2009084270A5 (https=) | ||
| JP2013010793A5 (https=) | ||
| RU2008114360A (ru) | Производные диацилиндазола как ингибиторы липаз и фосфолипаз | |
| RU2005137360A (ru) | Органические соединения | |
| RU2014113679A (ru) | N-(2-амино-6,6-дифтор-4,4а,5,6,7,7а-гексагидро-циклопента[e][1,3]оксазин-4-ил)-фенил)-амиды в качестве ингибиторов бета-секретазы 1 | |
| CN102088965B (zh) | 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用 | |
| RU2007101653A (ru) | Производные 1-азабицикло[3.3.1]нонанов | |
| JP2007522162A5 (https=) | ||
| RU2010107169A (ru) | Фармацевтическая композиция, содержащая оптически активное соединение, обладающее активностью агониста рецептора тромбопоэтина, и промежуточное соединение для этого | |
| RU2013148146A (ru) | Производные адамантила | |
| US9713597B2 (en) | Stable aqueous formulation of (E)-4-carboxystyryl-4-chlorobenzyl sulfone | |
| RU2016104844A (ru) | Производные n-мочевино замещенных аминокислот как модуляторы формил-пептидного рецептора | |
| JP2005532331A5 (https=) | ||
| JP2020536922A5 (https=) | ||
| AR029412A1 (es) | Forma cristalina | |
| ES2860949T3 (es) | Formulaciones farmacéuticas radiomitigadoras | |
| JP2012519703A5 (https=) | ||
| JP2008530242A5 (https=) |