JP2020534872A5 - - Google Patents
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- JP2020534872A5 JP2020534872A5 JP2020538759A JP2020538759A JP2020534872A5 JP 2020534872 A5 JP2020534872 A5 JP 2020534872A5 JP 2020538759 A JP2020538759 A JP 2020538759A JP 2020538759 A JP2020538759 A JP 2020538759A JP 2020534872 A5 JP2020534872 A5 JP 2020534872A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- perturbation
- functionalized
- beads
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023171925A JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762562912P | 2017-09-25 | 2017-09-25 | |
| US201762562905P | 2017-09-25 | 2017-09-25 | |
| US62/562,905 | 2017-09-25 | ||
| US62/562,912 | 2017-09-25 | ||
| PCT/US2018/052497 WO2019060857A1 (en) | 2017-09-25 | 2018-09-24 | CHEMICAL LIBRARIES CODED BY OLIGONUCLEOTIDES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171925A Division JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534872A JP2020534872A (ja) | 2020-12-03 |
| JP2020534872A5 true JP2020534872A5 (enExample) | 2021-11-04 |
| JP7361700B2 JP7361700B2 (ja) | 2023-10-16 |
Family
ID=65807199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538759A Active JP7361700B2 (ja) | 2017-09-25 | 2018-09-24 | オリゴヌクレオチドにコードされた化学ライブラリ |
| JP2023171925A Pending JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171925A Pending JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US11084037B2 (enExample) |
| EP (1) | EP3687687A4 (enExample) |
| JP (2) | JP7361700B2 (enExample) |
| KR (2) | KR102671480B1 (enExample) |
| CN (2) | CN111971124B (enExample) |
| CA (1) | CA3076747A1 (enExample) |
| IL (1) | IL273511A (enExample) |
| WO (2) | WO2019060857A1 (enExample) |
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| CN110331447B (zh) * | 2019-07-08 | 2022-05-27 | 上海药明康德新药开发有限公司 | DNA编码化合物库构建中制备On-DNA芳基炔烃化合物的方法 |
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| US12577702B2 (en) | 2020-01-28 | 2026-03-17 | Plexium, Inc. | Oligonucleotide encoded chemical libraries, related systems, devices, and methods for detecting, analyzing, quantifying, and testing biologics/genetics |
| WO2021188500A1 (en) | 2020-03-16 | 2021-09-23 | Fluent Biosciences Inc. | Multi-omic analysis in monodisperse droplets |
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| CA3189597A1 (en) | 2020-07-15 | 2022-01-20 | Fluent Biosciences Inc. | Tiered ligation oligos |
| EP4208565A4 (en) * | 2020-09-01 | 2024-10-09 | Replay Holdings, LLC | Methods and systems for nucleic acid synthesis |
| KR20240013103A (ko) * | 2021-04-16 | 2024-01-30 | 플렉시움 인코포레이티드 | 조합 라이브러리용 분석 디바이스 |
| KR20240012371A (ko) * | 2021-04-16 | 2024-01-29 | 플렉시움 인코포레이티드 | 분석 디바이스용 캡 |
| JP2024521331A (ja) * | 2021-06-07 | 2024-05-31 | プレクシアム・インコーポレイテッド | ビーズのサイズ除外機能を備えたアッセイ装置用の移送ディスペンサ |
| CN113403690B (zh) * | 2021-06-21 | 2022-07-19 | 吉林大学 | 一种dna编码化合物库药物分子垂钓方法 |
| IL309566A (en) | 2021-06-24 | 2024-02-01 | Illumina Inc | Methods and compositions for combinatorial indexing of bead-based nucleic acids |
| JP2024525724A (ja) * | 2021-07-15 | 2024-07-12 | フルーエント バイオサイエンシーズ インコーポレイテッド | Dnaコード化ライブラリーの予め鋳型化された即時パーティション化 |
| CN113549676B (zh) * | 2021-08-24 | 2022-12-27 | 重庆范德瓦尔斯生物科技有限公司 | 一种基于磁珠的RNA pull down新方法 |
| US20240393342A1 (en) * | 2021-09-27 | 2024-11-28 | The University Of Tokyo | Cell labeling molecule and method for analyzing cell |
| WO2023095841A1 (ja) * | 2021-11-24 | 2023-06-01 | 日産化学株式会社 | Dnaコード化ライブラリの評価方法 |
| US20250051762A1 (en) * | 2021-12-09 | 2025-02-13 | University Of Florida Research | Platform using dna-encoded small molecule libraries and rna selection to design small molecules that target rna |
| EP4444910A4 (en) | 2021-12-10 | 2025-11-05 | Bio Rad Laboratories Inc | Compositions, processes and systems for the treatment of samples with functionalized particles of adjustable morphology |
| WO2023174845A1 (en) * | 2022-03-13 | 2023-09-21 | Eleven Therapeutics Ltd | System and method for high throughput evaluation of chemical modifications of nucleic acid molecules |
| US12577556B2 (en) | 2022-05-09 | 2026-03-17 | Zafrens Inc. | Perturbation beads for use in assays |
| WO2025159784A1 (en) * | 2024-01-23 | 2025-07-31 | Zafrens Inc. | Capture beads for use in assays |
| CN115058492B (zh) * | 2022-07-07 | 2025-09-19 | 东南大学 | 一种基于均分组合编码微球的空间转录组测序文库构建方法 |
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| WO2024091949A1 (en) * | 2022-10-24 | 2024-05-02 | 1859, Inc. | Methods and systems for encoded effector screening |
| EP4642963A1 (en) * | 2022-12-29 | 2025-11-05 | Illumina, Inc. | Generation of a large library of barcoded beads using combinatorial split-pool strategy and chemical ligation |
| EP4683618A1 (en) * | 2023-03-20 | 2026-01-28 | Fluid Discovery | Core-shell gel particles for separating and analyzing rna and dna from a cell |
| WO2025014746A1 (en) * | 2023-07-07 | 2025-01-16 | California Institute Of Technology | Molecular detection using barcode probes or barcode fusion probes and hybridization chain reaction |
| WO2025085861A1 (en) * | 2023-10-20 | 2025-04-24 | Spectral Therapeutics, Inc. | Composite particles for use in generating spectrally encoded libraries of chemical compounds, and methods of making and using the same |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| CN1525171A (zh) * | 1993-10-01 | 2004-09-01 | ŦԼ�и��ױ��Ǵ�ѧ���� | 用标示物编码的多元组合化学库 |
| NZ276860A (en) * | 1993-11-02 | 1997-09-22 | Affymax Tech Nv | Apparatus and its use for synthesising diverse molecular products on substrates |
| CZ392697A3 (cs) * | 1995-06-07 | 1998-06-17 | Lynx Therapeutics, Inc. | Oligonukleotidové značky pro stanovení druhu a identifikaci |
| US5958703A (en) * | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
| WO1999060007A2 (en) * | 1998-05-15 | 1999-11-25 | Isis Innovation Limited | Libraries of oligomers labelled with different tags |
| DE10050085C1 (de) * | 2000-10-10 | 2001-10-31 | Jochem Koetting | Verschlußelement und Verschlußsystem für Behältnisse und Gefäße |
| US20040009583A1 (en) * | 2002-02-05 | 2004-01-15 | Genome Therapeutics Corporation | Seal for microtiter plate and methods of use thereof |
| SE526038C2 (sv) * | 2002-07-08 | 2005-06-21 | Gambro Lundia Ab | Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav |
| US8597597B2 (en) * | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
| BRPI0414004A (pt) * | 2003-08-27 | 2006-10-24 | Harvard College | controle eletrÈnico de espécies fluìdicas |
| CN101189345A (zh) * | 2005-02-01 | 2008-05-28 | Ab先进基因分析公司 | 珠基测序的试剂、方法和文库 |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| DE102006028101B4 (de) * | 2006-06-19 | 2014-02-13 | Siemens Aktiengesellschaft | Verfahren zur Analyse von amplifizierten Nukleinsäuren |
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| EP2222832A4 (en) * | 2007-11-15 | 2012-08-29 | Seng Entpr Ltd | PICOLITER WELL SUPPORT AND METHOD FOR THE PRODUCTION THEREOF |
| CA2720587A1 (en) * | 2008-04-09 | 2009-10-15 | Francis Barany | Coferons and methods of making and using them |
| WO2010091144A1 (en) | 2009-02-04 | 2010-08-12 | Wake Forest University Health Sciences | Compositions, methods, and kits for identifying candidate molecules from encoded chemical libraries |
| US9347092B2 (en) * | 2009-02-25 | 2016-05-24 | Roche Molecular System, Inc. | Solid support for high-throughput nucleic acid analysis |
| EP2789694A1 (en) * | 2009-04-02 | 2014-10-15 | Fluidigm Corporation | Microfluidic device with reaction product recovery system |
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| WO2012048341A1 (en) * | 2010-10-08 | 2012-04-12 | President And Fellows Of Harvard College | High-throughput single cell barcoding |
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| CN110249050B (zh) * | 2016-11-08 | 2023-08-18 | 南纳治疗有限公司 | 无标签编码化合物文库 |
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| US11584956B2 (en) * | 2018-12-21 | 2023-02-21 | Microsoft Technology Licensing, Llc | Selectively controllable cleavable linkers |
-
2018
- 2018-09-24 US US16/140,494 patent/US11084037B2/en active Active
- 2018-09-24 JP JP2020538759A patent/JP7361700B2/ja active Active
- 2018-09-24 CA CA3076747A patent/CA3076747A1/en active Pending
- 2018-09-24 WO PCT/US2018/052497 patent/WO2019060857A1/en not_active Ceased
- 2018-09-24 EP EP18859564.9A patent/EP3687687A4/en active Pending
- 2018-09-24 US US16/139,831 patent/US20190210018A1/en not_active Abandoned
- 2018-09-24 CN CN201880072082.7A patent/CN111971124B/zh active Active
- 2018-09-24 KR KR1020207012104A patent/KR102671480B1/ko active Active
- 2018-09-24 WO PCT/US2018/052438 patent/WO2019060830A1/en not_active Ceased
- 2018-09-24 KR KR1020247017956A patent/KR20240091184A/ko active Pending
- 2018-09-24 CN CN202210926208.0A patent/CN115506034B/zh active Active
-
2019
- 2019-08-07 US US16/534,922 patent/US10946383B2/en active Active
- 2019-08-07 US US16/534,886 patent/US10828643B2/en active Active
-
2020
- 2020-03-23 IL IL273511A patent/IL273511A/en unknown
- 2020-05-08 US US16/870,809 patent/US10981170B2/en active Active
-
2021
- 2021-03-12 US US17/200,538 patent/US20220025358A1/en active Pending
- 2021-04-21 US US17/236,283 patent/US11577249B2/en active Active
-
2023
- 2023-01-06 US US18/151,343 patent/US12030057B2/en active Active
- 2023-10-03 JP JP2023171925A patent/JP2024001119A/ja active Pending
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