JP2020534872A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020534872A5 JP2020534872A5 JP2020538759A JP2020538759A JP2020534872A5 JP 2020534872 A5 JP2020534872 A5 JP 2020534872A5 JP 2020538759 A JP2020538759 A JP 2020538759A JP 2020538759 A JP2020538759 A JP 2020538759A JP 2020534872 A5 JP2020534872 A5 JP 2020534872A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- perturbation
- functionalized
- beads
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023171925A JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762562905P | 2017-09-25 | 2017-09-25 | |
| US201762562912P | 2017-09-25 | 2017-09-25 | |
| US62/562,912 | 2017-09-25 | ||
| US62/562,905 | 2017-09-25 | ||
| PCT/US2018/052497 WO2019060857A1 (en) | 2017-09-25 | 2018-09-24 | CHEMICAL LIBRARIES CODED BY OLIGONUCLEOTIDES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171925A Division JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534872A JP2020534872A (ja) | 2020-12-03 |
| JP2020534872A5 true JP2020534872A5 (cg-RX-API-DMAC7.html) | 2021-11-04 |
| JP7361700B2 JP7361700B2 (ja) | 2023-10-16 |
Family
ID=65807199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538759A Active JP7361700B2 (ja) | 2017-09-25 | 2018-09-24 | オリゴヌクレオチドにコードされた化学ライブラリ |
| JP2023171925A Pending JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171925A Pending JP2024001119A (ja) | 2017-09-25 | 2023-10-03 | オリゴヌクレオチドにコードされた化学ライブラリ |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US11084037B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3687687A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7361700B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102671480B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN111971124B (cg-RX-API-DMAC7.html) |
| CA (1) | CA3076747A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL273511A (cg-RX-API-DMAC7.html) |
| WO (2) | WO2019060830A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10258590B2 (en) | 2015-10-14 | 2019-04-16 | Alcresta Therapeutics, Inc. | Enteral feeding device and related methods of use |
| EP3472351B1 (de) | 2016-06-15 | 2020-10-28 | Ludwig-Maximilians-Universität München | Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie |
| CA3076747A1 (en) | 2017-09-25 | 2019-03-28 | Plexium, Inc. | Oligonucleotide encoded chemical libraries |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| GB201817321D0 (en) * | 2018-10-24 | 2018-12-05 | Nanna Therapeutics Ltd | Microbeads for tagless encoded chemical library screening |
| CN110359097B (zh) * | 2019-07-08 | 2022-09-20 | 上海药明康德新药开发有限公司 | DNA编码化合物库构建中通过Suzuki偶联反应得到On-DNA芳烃化合物的方法 |
| CN110331447B (zh) * | 2019-07-08 | 2022-05-27 | 上海药明康德新药开发有限公司 | DNA编码化合物库构建中制备On-DNA芳基炔烃化合物的方法 |
| US20220403374A1 (en) * | 2019-09-03 | 2022-12-22 | Flexomics, Llc | Optically readable barcodes and systems and methods for characterizing molecular interactions |
| AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
| WO2021113330A1 (en) * | 2019-12-06 | 2021-06-10 | Bio-Rad Laboratories, Inc. | Sample processing barcoded bead composition, method, manufacturing, and system |
| GB201918340D0 (en) * | 2019-12-12 | 2020-01-29 | Cambridge Entpr Ltd | Spatial barcoding |
| CN115698282A (zh) | 2020-01-13 | 2023-02-03 | 福路伦特生物科学公司 | 单细胞测序 |
| US20230065224A1 (en) * | 2020-01-28 | 2023-03-02 | Plexium, Inc. | Oligonucleotide encoded chemical libraries, related systems, devices, and methods for detecting, analyzing, quantifying, and testing biologics/genetics |
| US11305288B2 (en) | 2020-01-28 | 2022-04-19 | Plexium, Inc. | Assay devices for combinatorial libraries |
| US11027272B1 (en) | 2020-01-28 | 2021-06-08 | Plexium, Inc. | Transfer dispensers for assay devices |
| US11040343B1 (en) | 2020-01-28 | 2021-06-22 | Plexium, Inc. | Caps for assay devices |
| WO2021188500A1 (en) | 2020-03-16 | 2021-09-23 | Fluent Biosciences Inc. | Multi-omic analysis in monodisperse droplets |
| EP4127058A4 (en) | 2020-03-24 | 2024-04-24 | Fluent Biosciences Inc. | VIRAL DETECTION USING MATRIX EMULSIFICATION |
| JP7548305B2 (ja) * | 2020-05-25 | 2024-09-10 | 日産化学株式会社 | 切断可能なdnaコード化ライブラリ |
| US20230249178A1 (en) * | 2020-07-08 | 2023-08-10 | Roche Sequencing Solutions, Inc. | Split-pool synthesis apparatus and methods of performing split-pool synthesis |
| JP2023534028A (ja) | 2020-07-15 | 2023-08-07 | フルーエント バイオサイエンシーズ インコーポレイテッド | 段階的ライゲーション用オリゴ |
| WO2022051369A1 (en) * | 2020-09-01 | 2022-03-10 | Replay Holdings, Llc | Methods and systems for nucleic acid synthesis |
| WO2022220843A1 (en) * | 2021-04-16 | 2022-10-20 | Plexium, Inc. | Caps for assay devices |
| JP2024516375A (ja) * | 2021-04-16 | 2024-04-15 | プレクシアム・インコーポレイテッド | 組合せライブラリ用分析装置 |
| CA3220008A1 (en) | 2021-06-07 | 2022-12-15 | Plexium, Inc. | Transfer dispensers for assay devices with bead size exclusion |
| CN113403690B (zh) * | 2021-06-21 | 2022-07-19 | 吉林大学 | 一种dna编码化合物库药物分子垂钓方法 |
| WO2022271954A1 (en) | 2021-06-24 | 2022-12-29 | Illumina, Inc. | Methods and compositions for combinatorial indexing of bead-based nucleic acids |
| WO2023287957A1 (en) * | 2021-07-15 | 2023-01-19 | Fluent Biosciences, Inc. | Pre-templated instant partitioning of dna-encoded libraries |
| CN113549676B (zh) * | 2021-08-24 | 2022-12-27 | 重庆范德瓦尔斯生物科技有限公司 | 一种基于磁珠的RNA pull down新方法 |
| US20240393342A1 (en) * | 2021-09-27 | 2024-11-28 | The University Of Tokyo | Cell labeling molecule and method for analyzing cell |
| US20250215615A1 (en) * | 2021-11-24 | 2025-07-03 | Nissan Chemical Corporation | Method for evaluating dna-encoded library |
| WO2023108090A2 (en) * | 2021-12-09 | 2023-06-15 | University Of Florida Research Foundation, Incorporated | Platform using dna-encoded small molecule libraries and rna selection to design small molecules that target rna |
| EP4444910A4 (en) | 2021-12-10 | 2025-11-05 | Bio Rad Laboratories Inc | Compositions, processes and systems for the treatment of samples with functionalized particles of adjustable morphology |
| US20250197937A1 (en) * | 2022-03-13 | 2025-06-19 | Eleven Therapeutics Ltd | System and method for high throughput evaluation of chemical modifications of nucleic acid molecules |
| WO2025159785A1 (en) * | 2024-01-23 | 2025-07-31 | Zafrens Inc. | Perturbation beads for use in assays |
| CN115058492B (zh) * | 2022-07-07 | 2025-09-19 | 东南大学 | 一种基于均分组合编码微球的空间转录组测序文库构建方法 |
| WO2024091949A1 (en) * | 2022-10-24 | 2024-05-02 | 1859, Inc. | Methods and systems for encoded effector screening |
| US20250207122A1 (en) * | 2022-12-29 | 2025-06-26 | Illumina, Inc. | Generation of a large library of barcoded beads using combinatorial split-pool strategy and chemical ligation |
| WO2024196941A1 (en) * | 2023-03-20 | 2024-09-26 | Fluid Discovery | Core-shell gel particles for separating and analyzing rna and dna from a cell |
| US20250011843A1 (en) * | 2023-07-07 | 2025-01-09 | California Institute Of Technology | Molecular detection using barcode probes or barcode fusion probes and hybridization chain reaction |
| WO2025085861A1 (en) * | 2023-10-20 | 2025-04-24 | Spectral Therapeutics, Inc. | Composite particles for use in generating spectrally encoded libraries of chemical compounds, and methods of making and using the same |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| CN1525171A (zh) | 1993-10-01 | 2004-09-01 | ŦԼ�и��ױ��Ǵ�ѧ���� | 用标示物编码的多元组合化学库 |
| EP0726906A4 (en) | 1993-11-02 | 1998-10-07 | Affymax Tech Nv | THE SYNTHESIS AND EXAMINATION OF MOLECULAR DIVERSITY |
| ATE466109T1 (de) * | 1995-06-07 | 2010-05-15 | Solexa Inc | Verfahren zur verbesserung der effizienz der polynukleotidsequenzierung |
| US5958703A (en) * | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
| DE69913509T2 (de) * | 1998-05-15 | 2004-09-23 | Oxford Gene Technology Ip Ltd., Kidlington | Bibliotheken von Oligomeren, die mit unterschiedlichen Markierungen (TAGS) markiert sind |
| DE10050085C1 (de) | 2000-10-10 | 2001-10-31 | Jochem Koetting | Verschlußelement und Verschlußsystem für Behältnisse und Gefäße |
| AU2003225552A1 (en) * | 2002-02-05 | 2003-09-02 | Genome Therapeutics Corporation | Seal for microtiter plate and methods of use thereof |
| SE526038C2 (sv) * | 2002-07-08 | 2005-06-21 | Gambro Lundia Ab | Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav |
| US8597597B2 (en) * | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
| EP2662136A3 (en) * | 2003-08-27 | 2013-12-25 | President and Fellows of Harvard College | Method for handling and mixing droplets |
| CN101189345A (zh) * | 2005-02-01 | 2008-05-28 | Ab先进基因分析公司 | 珠基测序的试剂、方法和文库 |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| DE102006028101B4 (de) | 2006-06-19 | 2014-02-13 | Siemens Aktiengesellschaft | Verfahren zur Analyse von amplifizierten Nukleinsäuren |
| CN100417730C (zh) * | 2006-10-10 | 2008-09-10 | 东南大学 | 基于引物延伸的dna测序方法 |
| EP2222832A4 (en) * | 2007-11-15 | 2012-08-29 | Seng Entpr Ltd | PICOLITER WELL SUPPORT AND METHOD FOR THE PRODUCTION THEREOF |
| WO2009126290A2 (en) * | 2008-04-09 | 2009-10-15 | Cornell University | Coferons and methods of making and using them |
| US8741558B2 (en) | 2009-02-04 | 2014-06-03 | Wake Forest University | Compositions, methods, and kits for identifying candidate molecules from encoded chemical libraries |
| US9347092B2 (en) * | 2009-02-25 | 2016-05-24 | Roche Molecular System, Inc. | Solid support for high-throughput nucleic acid analysis |
| JP5985390B2 (ja) * | 2009-04-02 | 2016-09-06 | フリューダイム・コーポレイション | 標的核酸にバーコードを付加するためのマルチプライマー増幅方法 |
| WO2010141390A2 (en) | 2009-06-05 | 2010-12-09 | Life Technologies Corporation | Nucleotide transient binding for sequencing methods |
| AU2010266010B2 (en) * | 2009-06-26 | 2015-08-20 | President And Fellows Of Harvard College | Fluid injection |
| EP3561159B1 (en) * | 2010-10-08 | 2023-09-20 | President and Fellows of Harvard College | High-throughput single cell barcoding |
| CN102485979B (zh) * | 2010-12-02 | 2014-02-19 | 深圳华大基因科技服务有限公司 | Ffpe样品核酸文库,其构建方法和ffpe样品分析方法 |
| US20130344473A1 (en) * | 2011-03-09 | 2013-12-26 | Seng Enterprises Ltd. | Arresting objects |
| WO2012162267A2 (en) * | 2011-05-20 | 2012-11-29 | Fluidigm Corporation | Nucleic acid encoding reactions |
| US20140378345A1 (en) * | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US10436778B2 (en) * | 2013-03-15 | 2019-10-08 | Plexbio Co., Ltd. | Methods and systems for multiplex assays |
| DE202013003390U1 (de) | 2013-04-11 | 2014-07-14 | Brand Gmbh + Co Kg | Pipettiervorrichtung mit einer Mikrodosiereinheit |
| EP3008201B1 (en) | 2013-06-12 | 2019-08-07 | The General Hospital Corporation | Methods for multiplexed detection of target molecules and uses thereof |
| KR102436171B1 (ko) | 2013-06-27 | 2022-08-24 | 10엑스 제노믹스, 인크. | 샘플 처리를 위한 조성물 및 방법 |
| KR102207770B1 (ko) * | 2013-08-05 | 2021-01-26 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| EP2921556A1 (en) * | 2014-03-21 | 2015-09-23 | Lexogen GmbH | Copy number preserving RNA analysis method |
| CN107075543B (zh) * | 2014-04-21 | 2021-11-16 | 哈佛学院院长及董事 | 用于条形码化核酸的系统和方法 |
| EP3169812A4 (en) * | 2014-07-18 | 2017-12-20 | CDI Laboratories Inc. | Methods and compositions to identify, quantify, and characterize target analytes and binding moieties |
| EP4105337A1 (en) * | 2014-09-09 | 2022-12-21 | The Broad Institute, Inc. | A droplet-based method and apparatus for composite single-cell nucleic acid analysis |
| DK3262059T3 (da) | 2015-02-24 | 2022-01-31 | Hope City | Platforme til screening af kemisk kodede, rumligt adresserede biblioteker |
| EP3277843A2 (en) * | 2015-03-30 | 2018-02-07 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| CA2983932C (en) * | 2015-05-11 | 2023-07-25 | Illumina, Inc. | Platform for discovery and analysis of therapeutic agents |
| US20190046985A1 (en) | 2015-09-17 | 2019-02-14 | The Regents Of The University Of California | Droplet-trapping devices for bioassays and diagnostics |
| WO2017075294A1 (en) | 2015-10-28 | 2017-05-04 | The Board Institute Inc. | Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction |
| JP7280181B2 (ja) | 2016-10-01 | 2023-05-23 | バークレー ライツ,インコーポレイテッド | Dnaバーコード組成物及びマイクロ流体デバイスによるインサイチュ同定法 |
| JP2020503846A (ja) * | 2016-11-08 | 2020-02-06 | ナンナ セラピューティクス リミテッドNanna Therapeutics Limited | タグなしコード化化学ライブラリ |
| WO2018089641A2 (en) | 2016-11-10 | 2018-05-17 | The Scripps Research Institute | Encode solid phase compound library with polynucleotide based barcoding |
| CA3076747A1 (en) | 2017-09-25 | 2019-03-28 | Plexium, Inc. | Oligonucleotide encoded chemical libraries |
| US11584956B2 (en) * | 2018-12-21 | 2023-02-21 | Microsoft Technology Licensing, Llc | Selectively controllable cleavable linkers |
-
2018
- 2018-09-24 CA CA3076747A patent/CA3076747A1/en active Pending
- 2018-09-24 KR KR1020207012104A patent/KR102671480B1/ko active Active
- 2018-09-24 WO PCT/US2018/052438 patent/WO2019060830A1/en not_active Ceased
- 2018-09-24 CN CN201880072082.7A patent/CN111971124B/zh active Active
- 2018-09-24 JP JP2020538759A patent/JP7361700B2/ja active Active
- 2018-09-24 KR KR1020247017956A patent/KR20240091184A/ko active Pending
- 2018-09-24 WO PCT/US2018/052497 patent/WO2019060857A1/en not_active Ceased
- 2018-09-24 US US16/140,494 patent/US11084037B2/en active Active
- 2018-09-24 CN CN202210926208.0A patent/CN115506034B/zh active Active
- 2018-09-24 EP EP18859564.9A patent/EP3687687A4/en active Pending
- 2018-09-24 US US16/139,831 patent/US20190210018A1/en not_active Abandoned
-
2019
- 2019-08-07 US US16/534,922 patent/US10946383B2/en active Active
- 2019-08-07 US US16/534,886 patent/US10828643B2/en active Active
-
2020
- 2020-03-23 IL IL273511A patent/IL273511A/en unknown
- 2020-05-08 US US16/870,809 patent/US10981170B2/en active Active
-
2021
- 2021-03-12 US US17/200,538 patent/US20220025358A1/en active Pending
- 2021-04-21 US US17/236,283 patent/US11577249B2/en active Active
-
2023
- 2023-01-06 US US18/151,343 patent/US12030057B2/en active Active
- 2023-10-03 JP JP2023171925A patent/JP2024001119A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020534872A5 (cg-RX-API-DMAC7.html) | ||
| US9850482B2 (en) | Heterologous DNA barcoding method | |
| US20240263353A1 (en) | High-throughput single-cell polyomics | |
| CN105705659B (zh) | 大规模平行单细胞分析 | |
| CN103703143B (zh) | 鉴定细胞中的多个表位的方法 | |
| US20180340939A1 (en) | Multiplex analysis of single cell constituents | |
| FI3896171T3 (fi) | Menetelmä polynukleotidien prosessoimiseksi yksittäisten solujen analysointia varten | |
| CN105264088A (zh) | 提高鉴定细胞中的多个表位的动态范围 | |
| US11814619B2 (en) | Compositions, methods, and systems for single cell barcoding and sequencing | |
| CN115315524A (zh) | 单细胞组合索引的细胞计量术测序 | |
| KR20210084441A (ko) | 어레이 상에서 인덱스 및 바코드를 사용하여 리간드를 확인하기 위한 방법 및 조성물 | |
| WO2022256612A1 (en) | Compositions, methods, and systems for single cell barcoding and sequencing | |
| WO2003068712A3 (fr) | Procede de preparation de biopuces a adn et leurs applications | |
| Kimura et al. | Attachment of oligonucleotide probes to poly carbodiimide‐coated glass for microarray applications | |
| DK2771485T3 (en) | PROCEDURE FOR IDENTIFICATION OF APTAMER | |
| US11970785B2 (en) | Methods and materials for multiplexed collections of functional ligands | |
| Velegraki | Panmicrobial microarrays | |
| FI4077713T3 (fi) | Menetelmä ja kitti kokogenomiamplifikaatioon ja biologisessa näytteessä olevien kohdemolekyylien analysointiin | |
| Khan et al. | Microfluidics for single-cell genomics | |
| Mainland et al. | Next-generation sequencing of the human olfactory receptors | |
| Zhao et al. | Matrix-seq: an adjustable-resolution spatial transcriptomics via microfluidic matrix-based barcoding | |
| RU2021133017A (ru) | Способ и композиция для анализа клеточных компонентов | |
| JP2024512122A (ja) | アダプター二量体検出を用いる核酸ライブラリシーケンシング技術 | |
| KR20250132854A (ko) | 타겟과 결합된 아이디-마이크로파티클를 이용한 병렬 약물스크리닝 방법 | |
| WO2023107598A1 (en) | Single-cell culture and sequencing with lipid-modified oligos |