JP2020533394A - 体脂肪減少補助剤およびベータグルカンを有効成分とする肥満の予防または治療用組成物 - Google Patents
体脂肪減少補助剤およびベータグルカンを有効成分とする肥満の予防または治療用組成物 Download PDFInfo
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Abstract
Description
本発明は、体脂肪減少補助剤およびベータグルカン(β−glucan)を有効成分として含む、肥満の予防または治療用薬学組成物を提供する。
また、本発明は、体脂肪減少補助剤およびベータグルカンを有効成分として含有する肥満の予防または改善用健康機能食品を提供する。
体脂肪量の監視対象である6週齢の野生型C57BL/6マウスを購入して3日間飼育して、環境に適応させた後に飼育した。具体的に、マウス6匹ずつ総5群に分けて表1に示されたように、投与薬物として、共役リノール酸(CLA)(製造社:シグマアルドリッチ)、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造)(SPG)(製造社:キュジェンバイオテク)およびPBS(Phosphate buffer solution)を併行または単独で毎日1回ずつ経口投与した。具体的に、実験群1−1は、CLA(濃度=10mg/ml)を0.2mL経口投与し、30分経過後、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造を有するSPG)(濃度=0.4mg/ml)を0.2mL経口投与した。また、実験群1−2は、CLA(濃度=10mg/ml)を0.2mL経口投与し、30分経過後、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造を有するSPG)(濃度= 2mg/ml)を0.2mL経口投与した。一方、比較実験群1−1は、CLA(濃度=10mg/ml)を0.2mL経口投与した。また、比較実験群1−2は、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造を有するSPG)(濃度=2mg/ml)を0.2mL経口投与し、比較実験群1−3は、PBS(Phosphate buffer solution)を0.2mL経口投与した。
体脂肪量の監視対象である6週齢の野生型C57BL/6マウスを購入して3日間飼育して、環境に適応させた後に飼育した。具体的に、マウス10匹ずつ総5群に分けて表2に示されたように、投与薬物として、ガルシニアカンボジア抽出物(HCA)(製造社:シグマアルドリッチ)、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造)(SPG)(製造社:キュジェンバイオテク)およびPBS(Phosphate buffer solution)を併行または単独で毎日1回ずつ経口投与した。具体的に、実験群2−1は、HCA(濃度=10mg/ml)を0.2mL経口投与し、30分経過後、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造を有するSPG)(濃度=0.4mg/ml)を0.2mL経口投与した。また、実験群2−2は、HCA(濃度=10mg/ml)を0.2mL経口投与し、30分経過後、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造を有するSPG)(濃度= 2mg/ml)を0.2mL経口投与した。一方、比較実験群2−1は、HCA (濃度=10mg/ml)を0.2mL経口投与下であった。また、比較実験群2−2は、スエヒロタケ由来のベータグルカン(β−(1,6)−分岐された(1,3)−グルカンの構造を有するSPG)(濃度=2mg/ml)を0.2mL経口投与し、比較実験群2−3は、PBS(Phosphate buffer solution)を0.2mL経口投与した。
体脂肪減少補助剤400mgおよびベータグルカン20mg
乳糖水和物 100mg
タルク 10mg
体脂肪減少補助剤100mgおよびベータグルカン20mg
トウモロコシデンプン 100mg
乳糖水和物 100mg
ステアリン酸マグネシウム 2mg
体脂肪減少補助剤100mgおよびベータグルカン20mg
微結晶セルロース 3mg
乳糖水和物 14.8mg
ステアリン酸マグネシウム 0.2mg
体脂肪減少補助剤50mgおよびベータグルカン10mg
マンニトール 180mg
注射用滅菌蒸留水 2974mg
リン酸一水素ナトリウム 26mg
体脂肪減少補助剤100mgおよびベータグルカン10mg
異性化糖 10g
マンニトール5g
精製水 適量
レモン香 適量
体脂肪減少補助剤800mgおよびベータグルカン40mg
ビタミン混合物 適量
ビタミンAアセテート 70μg
ビタミンE 1.0mg
ビタミンB1 0.13mg
ビタミンB2 0.15mg
ビタミンB6 0.5mg
ビタミンB12 0.2μg
ビタミンC 10mg
ビオチン 10μg
ニコチン酸アミド 1.7mg
葉酸 50μg
パントテン酸カルシウム 0.5mg
無機質混合物 適量
硫酸第1鉄 1.75mg
酸化亜鉛 0.82mg
炭酸マグネシウム 25.3mg
第1リン酸カリウム 15mg
第2リン酸カルシウム 55mg
クエン酸カリウム 90mg
炭酸カルシウム 100mg
塩化マグネシウム 24.8mg
体脂肪減少補助剤400mgおよびベータグルカン10mg
ビタミンC 15g
ビタミンE(粉末) 100g
乳酸鉄 19.75g
酸化亜鉛 3.5g
ニコチン酸アミド 3.5g
ビタミンA 0.2g
ビタミンB1 0.25g
ビタミンB2 0.3g
精製水 適量
Claims (12)
- 体脂肪減少補助剤およびベータグルカン(β−glucan)を有効成分として含む、肥満の予防または治療用薬学組成物。
- 前記組成物は、体脂肪減少補助剤による副作用を抑制するためのものであることを特徴とする請求項1に記載の肥満の予防または治療用薬学組成物。
- 前記副作用は、肝毒性または血中総コレステロール含量の増加による副作用であることを特徴とする請求項2に記載の肥満の予防または治療用薬学組成物。
- 前記体脂肪減少補助剤は、共役リノール酸、ガルシニアカンボジア抽出物および食物繊維よりなる群から選択された一つ以上であることを特徴とする請求項1に記載の肥満の予防または治療用薬学組成物。
- 前記体脂肪減少補助剤は、共役リノール酸またはガルシニアカンボジア抽出物であることを特徴とする請求項4に記載の肥満の予防または治療用薬学組成物。
- 前記ベータグルカンは、スエヒロタケ(Schizophyllum commune)またはその培養物から分離したことを特徴とする請求項1に記載の肥満の予防または治療用薬学組成物。
- 前記ベータグルカンは、β−(1,6)−分岐された(1,3)−グルカンの構造を有することを特徴とする請求項1に記載の肥満の予防または治療用薬学組成物。
- 前記体脂肪減少補助剤および前記ベータグルカンは、2:1(w/v:w/v)〜100:1(w/v:w/v)の割合で混合されたことを特徴とする請求項1に記載の肥満の予防または治療用薬学組成物。
- 体脂肪減少補助剤およびベータグルカン(β−glucan)を有効成分として含む、肥満の予防または改善用健康機能食品。
- 体脂肪減少補助剤およびベータグルカン(β−glucan)を、肥満の予防または治療用薬学組成物に使用するための用途。
- 体脂肪減少補助剤およびベータグルカン(β−glucan)を、肥満の予防または改善用健康機能食品に使用するための用途。
- 体脂肪減少補助剤およびベータグルカン(β−glucan)を個体に投与する段階を含む肥満の治療方法。
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KR10-2017-0120338 | 2017-09-19 | ||
KR20170120338 | 2017-09-19 | ||
KR1020180101389A KR102133218B1 (ko) | 2017-09-19 | 2018-08-28 | 체지방 감소 보조제 및 베타글루칸을 유효성분으로 하는 비만 예방 또는 치료용 조성물 |
KR10-2018-0101389 | 2018-08-28 | ||
PCT/KR2018/009976 WO2019059550A2 (ko) | 2017-09-19 | 2018-08-29 | 체지방 감소 보조제 및 베타글루칸을 유효성분으로 하는 비만 예방 또는 치료용 조성물 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007077929A1 (ja) * | 2006-01-06 | 2007-07-12 | Sapporo Breweries Limited | メタボリックシンドローム治療剤及びこれを含む食品 |
JP2007332336A (ja) * | 2006-06-13 | 2007-12-27 | Rikomu:Kk | メタボリックシンドローム治療剤 |
KR20080064703A (ko) * | 2007-01-04 | 2008-07-09 | 주식회사 글루칸 | β-글루칸 및 길경 추출물을 유효성분으로 포함하는 항비만조성물 |
KR100856241B1 (ko) * | 2007-04-25 | 2008-09-03 | 웅진식품주식회사 | 한천을 이용한 다이어트 식품 조성물 |
KR20090108230A (ko) * | 2008-04-11 | 2009-10-15 | 주식회사 케이티앤지 | 비만 억제 또는 치료용 조성물 |
JP2015081239A (ja) * | 2013-10-22 | 2015-04-27 | 株式会社アウレオ | 脂肪蓄積抑制剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006191830A (ja) * | 2005-01-12 | 2006-07-27 | Unitika Ltd | 脂肪の蓄積を抑制する食品 |
GB0809808D0 (en) * | 2008-05-29 | 2008-07-09 | Med Eq As | Composition |
PT104241B (pt) * | 2008-10-29 | 2012-03-06 | Stargate Produtos Farmaceuticos Dieteticos E Nutricionais Lda | Composições incorporando agentes redutores da celulite e inestetismos associados e formulações que as contêm |
-
2018
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007077929A1 (ja) * | 2006-01-06 | 2007-07-12 | Sapporo Breweries Limited | メタボリックシンドローム治療剤及びこれを含む食品 |
JP2007332336A (ja) * | 2006-06-13 | 2007-12-27 | Rikomu:Kk | メタボリックシンドローム治療剤 |
KR20080064703A (ko) * | 2007-01-04 | 2008-07-09 | 주식회사 글루칸 | β-글루칸 및 길경 추출물을 유효성분으로 포함하는 항비만조성물 |
KR100856241B1 (ko) * | 2007-04-25 | 2008-09-03 | 웅진식품주식회사 | 한천을 이용한 다이어트 식품 조성물 |
KR20090108230A (ko) * | 2008-04-11 | 2009-10-15 | 주식회사 케이티앤지 | 비만 억제 또는 치료용 조성물 |
JP2015081239A (ja) * | 2013-10-22 | 2015-04-27 | 株式会社アウレオ | 脂肪蓄積抑制剤 |
Non-Patent Citations (4)
Title |
---|
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 1986, Vol.50, No.1, JPN6021005883, pages 231 - 232, ISSN: 0004455727 * |
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, vol. 2017, Vol.119, No.8, 1600258, JPN6021007219, pages 1 - 10, ISSN: 0004455724 * |
GASTROENTEROLOGY, vol. 2010, Vol.138, No.1, JPN6021007222, pages 65 - 72, ISSN: 0004455726 * |
OPEN ACCESS MACEDONIAN JOURNAL OF MEDICAL SCIENCES, vol. 2017, Vol.5, No.7, JPN6021007221, pages 893 - 898, ISSN: 0004455725 * |
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US20200206291A1 (en) | 2020-07-02 |
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