JP2020532542A5 - - Google Patents
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- JP2020532542A5 JP2020532542A5 JP2020512549A JP2020512549A JP2020532542A5 JP 2020532542 A5 JP2020532542 A5 JP 2020532542A5 JP 2020512549 A JP2020512549 A JP 2020512549A JP 2020512549 A JP2020512549 A JP 2020512549A JP 2020532542 A5 JP2020532542 A5 JP 2020532542A5
- Authority
- JP
- Japan
- Prior art keywords
- coor
- alkyl
- halogen
- amino
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 48
- 229910052736 halogen Inorganic materials 0.000 claims 45
- 150000002367 halogens Chemical class 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- 229910052799 carbon Inorganic materials 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- -1 6-amino-9H-purine-9-yl Chemical group 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 8
- 125000000107 disulfanyl group Chemical group [*]SS[H] 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 4
- WYCJWOAQAMWVLL-UHFFFAOYSA-N octadecane-3,12-dione Chemical compound CCC(CCCCCCCCC(CCCCCC)=O)=O WYCJWOAQAMWVLL-UHFFFAOYSA-N 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 0 CC*(C)C(C1)C1(CC1)O[C@]1*(C)CC Chemical compound CC*(C)C(C1)C1(CC1)O[C@]1*(C)CC 0.000 description 1
- KKOXZFIROVCRBT-PTIXEKJTSA-N Nc1ncnc2c1nc[n]2C[C@@H]([C@@H]1F)O[C@H](COP(O)(O[C@H]2C([n]3nnc4c3cccc4C(F)(F)F)O[C@H](CO3)[C@H]2O)S)[C@H]1O[P@]3(S)=O Chemical compound Nc1ncnc2c1nc[n]2C[C@@H]([C@@H]1F)O[C@H](COP(O)(O[C@H]2C([n]3nnc4c3cccc4C(F)(F)F)O[C@H](CO3)[C@H]2O)S)[C@H]1O[P@]3(S)=O KKOXZFIROVCRBT-PTIXEKJTSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552689P | 2017-08-31 | 2017-08-31 | |
| US62/552,689 | 2017-08-31 | ||
| PCT/US2018/048662 WO2019046498A1 (en) | 2017-08-31 | 2018-08-30 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532542A JP2020532542A (ja) | 2020-11-12 |
| JP2020532542A5 true JP2020532542A5 (cg-RX-API-DMAC7.html) | 2021-09-24 |
| JP7209697B2 JP7209697B2 (ja) | 2023-01-20 |
Family
ID=63529006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512549A Active JP7209697B2 (ja) | 2017-08-31 | 2018-08-30 | 抗癌剤としての環状ジヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10947263B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3676278B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7209697B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102651946B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN111051327B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2945140T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019046498A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102885797B1 (ko) | 2017-10-10 | 2025-11-12 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 시클릭 디뉴클레오티드 |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3728282B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| KR20200130362A (ko) * | 2018-03-08 | 2020-11-18 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 시클릭 디뉴클레오티드 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| BR112020018905A2 (pt) | 2018-04-13 | 2021-02-09 | Bristol-Myers Squibb Company | reagentes com base em fósforo (v), processos para a preparação dos mesmos e seu uso na fabricação de compostos organofosforados (v) estéreo definidos |
| KR20210015937A (ko) | 2018-06-01 | 2021-02-10 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 방광암을 치료하기 위한 방법 |
| US11161864B2 (en) | 2018-10-29 | 2021-11-02 | Venenum Biodesign, LLC | Sting agonists |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
| WO2020212600A1 (en) | 2019-04-18 | 2020-10-22 | Nuseed Global Innovation Ltd. | Meal fraction of brassica carinata oilseed |
| EP3966222A4 (en) | 2019-05-09 | 2023-10-04 | Aligos Therapeutics, Inc. | MODIFIED CYCLIC DI-NUCLEOSIDE COMPOUNDS AS STING MODULATORS |
| CN114206898B (zh) * | 2019-07-25 | 2024-06-25 | 百济神州有限公司 | 作为sting激动剂的环状二核苷酸 |
| MX2022008123A (es) * | 2020-01-16 | 2022-07-21 | Bristol Myers Squibb Co | Reactivos y su uso para modular la sintesis enantiodivergente de enlaces c-p. |
| US20230141284A1 (en) | 2020-04-10 | 2023-05-11 | Ono Pharmaceutical Co., Ltd. | Cancer therapeutic method |
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| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ｏｘ４０ｌ抗體 |
| AU2006230099B2 (en) | 2005-03-25 | 2012-04-19 | Gitr, Inc. | GITR binding molecules and uses therefor |
| SG195607A1 (en) | 2005-05-10 | 2013-12-30 | Incyte Corp | Modulators of indoleamine 2,3-dioxygenase and methods of using the same |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| EP2064207B1 (en) | 2006-09-19 | 2013-11-06 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
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| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
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| HUE026201T2 (en) | 2009-12-10 | 2016-05-30 | Hoffmann La Roche | Antibodies binding to human CSF1R extracellular domain 4 and their use |
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-
2018
- 2018-08-30 KR KR1020207008757A patent/KR102651946B1/ko active Active
- 2018-08-30 EP EP18766542.7A patent/EP3676278B1/en active Active
- 2018-08-30 JP JP2020512549A patent/JP7209697B2/ja active Active
- 2018-08-30 US US16/641,679 patent/US10947263B2/en active Active
- 2018-08-30 WO PCT/US2018/048662 patent/WO2019046498A1/en not_active Ceased
- 2018-08-30 ES ES18766542T patent/ES2945140T3/es active Active
- 2018-08-30 CN CN201880055306.3A patent/CN111051327B/zh active Active