JP2020531438A - Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 - Google Patents

Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 Download PDF

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JP2020531438A
JP2020531438A JP2020508477A JP2020508477A JP2020531438A JP 2020531438 A JP2020531438 A JP 2020531438A JP 2020508477 A JP2020508477 A JP 2020508477A JP 2020508477 A JP2020508477 A JP 2020508477A JP 2020531438 A JP2020531438 A JP 2020531438A
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seq
chain variable
binding site
variable domain
antigen
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JP2020531438A5 (ja
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グレゴリー ピー． チャン，
グレゴリー ピー． チャン，
アン エフ． チュン，
アン エフ． チュン，
ジンヤン ドゥ，
ジンヤン ドゥ，
アシャ グリンバーグ，
アシャ グリンバーグ，
ウィリアム ヘイニー，
ウィリアム ヘイニー，
ドゥルヴ カム セティ，
ドゥルヴ カム セティ，
ニコライ ワグトマン，
ニコライ ワグトマン，
ブラッドリー エム． ランディ，
ブラッドリー エム． ランディ，
ビアンカ プリンツ，
ビアンカ プリンツ，
Original Assignee
ドラゴンフライ セラピューティクス， インコーポレイテッド
ドラゴンフライ セラピューティクス， インコーポレイテッド
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Publication of JP2020531438A publication Critical patent/JP2020531438A/ja
Priority to JP2021037440A priority Critical patent/JP2021098732A/ja
Publication of JP2020531438A5 publication Critical patent/JP2020531438A5/ja
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2020508477A 2017-08-16 2018-08-16 Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 Pending JP2020531438A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021037440A JP2021098732A (ja) 2017-08-16 2021-03-09 Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762546300P 2017-08-16 2017-08-16
US201762546297P 2017-08-16 2017-08-16
US62/546,300 2017-08-16
US62/546,297 2017-08-16
US201762552152P 2017-08-30 2017-08-30
US62/552,152 2017-08-30
US201762555114P 2017-09-07 2017-09-07
US62/555,114 2017-09-07
PCT/US2018/000212 WO2019035939A1 (en) 2017-08-16 2018-08-16 PROTEINS BINDING TO NKG2D, CD16 AND EGFR, HLA-E, CCR4, OR PD-L1

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JP2021037440A Division JP2021098732A (ja) 2017-08-16 2021-03-09 Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質

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JP2020531438A true JP2020531438A (ja) 2020-11-05
JP2020531438A5 JP2020531438A5 (ja) 2021-09-24

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JP2021037440A Pending JP2021098732A (ja) 2017-08-16 2021-03-09 Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質

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US (2) US20200216544A1 (https=)
EP (2) EP3668893A4 (https=)
JP (2) JP2020531438A (https=)
KR (2) KR20210029298A (https=)
CN (2) CN113004391A (https=)
AU (2) AU2018318698A1 (https=)
BR (1) BR112020003050A2 (https=)
CA (3) CA3176049A1 (https=)
IL (2) IL272553A (https=)
MX (2) MX2020001805A (https=)
SG (2) SG10202102251YA (https=)
WO (1) WO2019035939A1 (https=)

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CN110944661A (zh) 2017-02-20 2020-03-31 蜻蜓疗法股份有限公司 结合her2、nkg2d和cd16的蛋白质
CA3237846A1 (en) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the nkg2d receptor
BR112020015994A2 (pt) 2018-02-08 2020-12-15 Dragonfly Therapeutics, Inc. Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
AU2019271263A1 (en) * 2018-05-16 2020-12-03 Dragonfly Therapeutics, Inc. Protein binding NKG2D, CD16 and a fibroblast activation protein
EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
US20230067182A1 (en) * 2019-11-29 2023-03-02 Boe Technology Group Co., Ltd. Data Processing Device and Method, and Computer Readable Storage Medium
US20230287081A1 (en) * 2020-04-16 2023-09-14 Nantong Yichen Biopharma. Co. Ltd. PD-1 mutant polypeptide and preparation and application thereof
JP7512394B2 (ja) * 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質
US20230257467A1 (en) * 2020-08-05 2023-08-17 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and egfr
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