KR20210029298A - Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질 - Google Patents

Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질 Download PDF

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KR20210029298A
KR20210029298A KR1020217006762A KR20217006762A KR20210029298A KR 20210029298 A KR20210029298 A KR 20210029298A KR 1020217006762 A KR1020217006762 A KR 1020217006762A KR 20217006762 A KR20217006762 A KR 20217006762A KR 20210029298 A KR20210029298 A KR 20210029298A
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gly
thr
leu
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그레고리 피. 창
안 에프. 청
진얀 두
아샤 그린버그
윌리암 해니
드루브 캄 세티
니콜라이 바그트만
브래들리 엠. 룬드
비안카 프린츠
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드래곤플라이 쎄라퓨틱스, 인크.
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020217006762A 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질 Abandoned KR20210029298A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762546300P 2017-08-16 2017-08-16
US201762546297P 2017-08-16 2017-08-16
US62/546,300 2017-08-16
US62/546,297 2017-08-16
US201762552152P 2017-08-30 2017-08-30
US62/552,152 2017-08-30
US201762555114P 2017-09-07 2017-09-07
US62/555,114 2017-09-07
PCT/US2018/000212 WO2019035939A1 (en) 2017-08-16 2018-08-16 PROTEINS BINDING TO NKG2D, CD16 AND EGFR, HLA-E, CCR4, OR PD-L1

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207007137A Division KR20200037388A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, hla-e, ccr4 또는 pd-l1에 결합하는 단백질

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KR20210029298A true KR20210029298A (ko) 2021-03-15

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KR1020217006762A Abandoned KR20210029298A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질
KR1020207007137A Ceased KR20200037388A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, hla-e, ccr4 또는 pd-l1에 결합하는 단백질

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KR1020207007137A Ceased KR20200037388A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, hla-e, ccr4 또는 pd-l1에 결합하는 단백질

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US (2) US20200216544A1 (https=)
EP (2) EP3668893A4 (https=)
JP (2) JP2020531438A (https=)
KR (2) KR20210029298A (https=)
CN (2) CN113004391A (https=)
AU (2) AU2018318698A1 (https=)
BR (1) BR112020003050A2 (https=)
CA (3) CA3176049A1 (https=)
IL (2) IL272553A (https=)
MX (2) MX2020001805A (https=)
SG (2) SG10202102251YA (https=)
WO (1) WO2019035939A1 (https=)

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CA3237846A1 (en) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the nkg2d receptor
BR112020015994A2 (pt) 2018-02-08 2020-12-15 Dragonfly Therapeutics, Inc. Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
AU2019271263A1 (en) * 2018-05-16 2020-12-03 Dragonfly Therapeutics, Inc. Protein binding NKG2D, CD16 and a fibroblast activation protein
EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
US20230067182A1 (en) * 2019-11-29 2023-03-02 Boe Technology Group Co., Ltd. Data Processing Device and Method, and Computer Readable Storage Medium
US20230287081A1 (en) * 2020-04-16 2023-09-14 Nantong Yichen Biopharma. Co. Ltd. PD-1 mutant polypeptide and preparation and application thereof
JP7512394B2 (ja) * 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質
US20230257467A1 (en) * 2020-08-05 2023-08-17 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and egfr
CN112029001B (zh) * 2020-09-02 2022-09-06 南京北恒生物科技有限公司 靶向nk激活性受体的嵌合抗原受体
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
CN115246886A (zh) * 2021-04-27 2022-10-28 丹生医药技术(上海)有限公司 一种抗egfr/vegf双功能融合蛋白及其用途
EP4372001A4 (en) * 2021-07-14 2025-02-12 Jiangsu Hengrui Pharmaceuticals Co., Ltd. ANTIGEN-BINDING MOLECULE SPECIFICALLY BINDING TO HGFR AND EGFR, AND PHARMACEUTICAL USE THEREOF
CN116284430A (zh) * 2021-07-30 2023-06-23 广东菲鹏制药股份有限公司 靶向肿瘤的il15融合蛋白及其应用
WO2023043861A2 (en) * 2021-09-16 2023-03-23 Biohaven Therapeutics Ltd. Conjugated antibodies for treating diseases
WO2023083381A1 (zh) 2021-11-15 2023-05-19 成都百利多特生物药业有限责任公司 双特异性抗体-喜树碱类药物偶联物及其医药用途
EP4476263A4 (en) * 2022-02-09 2026-01-28 Dragonfly Therapeutics Inc PHARMACEUTICAL FORMULATIONS AND THERAPEUTIC USES OF MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO EGFR, NKG2D AND CD16
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