JP2020531423A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020531423A5 JP2020531423A5 JP2020508394A JP2020508394A JP2020531423A5 JP 2020531423 A5 JP2020531423 A5 JP 2020531423A5 JP 2020508394 A JP2020508394 A JP 2020508394A JP 2020508394 A JP2020508394 A JP 2020508394A JP 2020531423 A5 JP2020531423 A5 JP 2020531423A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- substituted
- pharmaceutical composition
- alkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 41
- 125000000217 alkyl group Chemical group 0.000 claims 34
- 206010028980 Neoplasm Diseases 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 30
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 29
- 238000000034 method Methods 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 21
- 150000002367 halogens Chemical class 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000004093 cyano group Chemical group *C#N 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 13
- 201000010536 head and neck cancer Diseases 0.000 claims 13
- 208000014829 head and neck neoplasm Diseases 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 206010039491 Sarcoma Diseases 0.000 claims 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims 5
- 108010044495 Fetal Hemoglobin Proteins 0.000 claims 5
- 206010025323 Lymphomas Diseases 0.000 claims 5
- 108010016797 Sickle Hemoglobin Proteins 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 4
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 4
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 210000001161 mammalian embryo Anatomy 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 102100021519 Hemoglobin subunit beta Human genes 0.000 claims 3
- 108091005904 Hemoglobin subunit beta Proteins 0.000 claims 3
- 208000010505 Nose Neoplasms Diseases 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 3
- 210000002308 embryonic cell Anatomy 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 230000001771 impaired effect Effects 0.000 claims 3
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 3
- 208000037830 nasal cancer Diseases 0.000 claims 3
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 2
- 206010005949 Bone cancer Diseases 0.000 claims 2
- 208000018084 Bone neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 2
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims 2
- 206010061252 Intraocular melanoma Diseases 0.000 claims 2
- 206010062038 Lip neoplasm Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 2
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 201000005969 Uveal melanoma Diseases 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 125000005392 carboxamide group Chemical class NC(=O)* 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 201000011523 endocrine gland cancer Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 201000006866 hypopharynx cancer Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 210000001821 langerhans cell Anatomy 0.000 claims 2
- 201000006721 lip cancer Diseases 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002575 ocular melanoma Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000007056 sickle cell anemia Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 210000000115 thoracic cavity Anatomy 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010055031 vascular neoplasm Diseases 0.000 claims 2
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000003200 Adenoma Diseases 0.000 claims 1
- 208000006468 Adrenal Cortex Neoplasms Diseases 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010056979 Colitis microscopic Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 208000006926 Discoid Lupus Erythematosus Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000037396 Intraductal Noninfiltrating Carcinoma Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 1
- 208000004059 Male Breast Neoplasms Diseases 0.000 claims 1
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 201000004458 Myoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010061332 Paraganglion neoplasm Diseases 0.000 claims 1
- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims 1
- 208000002471 Penile Neoplasms Diseases 0.000 claims 1
- 206010034299 Penile cancer Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000008183 Pulmonary blastoma Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010043391 Thalassaemia beta Diseases 0.000 claims 1
- 206010043515 Throat cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 201000002454 adrenal cortex cancer Diseases 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 206010003549 asthenia Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 208000005980 beta thalassemia Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
- 210000003969 blast cell Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000008609 collagenous colitis Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000028715 ductal breast carcinoma in situ Diseases 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 208000024348 heart neoplasm Diseases 0.000 claims 1
- 208000034737 hemoglobinopathy Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 201000008298 histiocytosis Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000018337 inherited hemoglobinopathy Diseases 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 210000004153 islets of langerhan Anatomy 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000004341 lymphocytic colitis Diseases 0.000 claims 1
- 201000003175 male breast cancer Diseases 0.000 claims 1
- 208000010907 male breast carcinoma Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000025854 malignant tumor of adrenal cortex Diseases 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 208000025189 neoplasm of testis Diseases 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000003154 papilloma Diseases 0.000 claims 1
- 208000029211 papillomatosis Diseases 0.000 claims 1
- 208000007312 paraganglioma Diseases 0.000 claims 1
- 208000010916 pituitary tumor Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 208000026691 scrotum cancer Diseases 0.000 claims 1
- 201000001814 scrotum neoplasm Diseases 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000037968 sinus cancer Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 208000037959 spinal tumor Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 210000004500 stellate cell Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000025444 tumor of salivary gland Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 208000037965 uterine sarcoma Diseases 0.000 claims 1
- 206010046885 vaginal cancer Diseases 0.000 claims 1
- 208000013139 vaginal neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762545936P | 2017-08-15 | 2017-08-15 | |
| US62/545,936 | 2017-08-15 | ||
| US201862712864P | 2018-07-31 | 2018-07-31 | |
| US62/712,864 | 2018-07-31 | ||
| PCT/US2018/046541 WO2019036377A1 (en) | 2017-08-15 | 2018-08-13 | TRICYCLIC COMPOUNDS AS HISTONE INHIBITORS METHYLTRANSFERASES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531423A JP2020531423A (ja) | 2020-11-05 |
| JP2020531423A5 true JP2020531423A5 (https=) | 2021-09-30 |
| JP7267993B2 JP7267993B2 (ja) | 2023-05-02 |
Family
ID=63452724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508394A Active JP7267993B2 (ja) | 2017-08-15 | 2018-08-13 | ヒストンメチルトランスフェラーゼ阻害剤としての三環式化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11661410B2 (https=) |
| EP (1) | EP3668863B1 (https=) |
| JP (1) | JP7267993B2 (https=) |
| CN (1) | CN111372927A (https=) |
| BR (1) | BR112020003073A2 (https=) |
| ES (1) | ES3016407T3 (https=) |
| IL (1) | IL272507A (https=) |
| MX (1) | MX2020001825A (https=) |
| SA (1) | SA520411303B1 (https=) |
| SG (1) | SG11202001090WA (https=) |
| TW (1) | TW201920136A (https=) |
| WO (1) | WO2019036377A1 (https=) |
| ZA (1) | ZA202001503B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110621316B (zh) | 2017-04-21 | 2024-01-26 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| US11584734B2 (en) | 2017-08-15 | 2023-02-21 | Global Blood Therapeutics, Inc. | Tricyclic compounds as histone methyltransferase inhibitors |
| CN116940571A (zh) * | 2021-03-15 | 2023-10-24 | 诺华股份有限公司 | 苯并异噁唑衍生物及其用途 |
| CN116802182A (zh) * | 2021-03-15 | 2023-09-22 | 诺华股份有限公司 | 吡唑并吡啶衍生物及其用途 |
| IL313087B2 (en) * | 2021-11-25 | 2026-02-01 | Shanghai Jemincare Pharmaceuticals Co Ltd | ATX inhibitors, their preparation method, their application and their medicinal salt |
| CN118373805B (zh) * | 2024-03-06 | 2026-03-06 | 中山大学 | 一种nsd2小分子抑制剂及其制备方法及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| WO2015085229A1 (en) | 2013-12-08 | 2015-06-11 | Van Andel Research Institute | Autophagy inhibitors |
| US9284272B2 (en) | 2014-03-28 | 2016-03-15 | Abbvie Inc. | Inhibitors of histone methyltransferase G9a |
| CN106536509B (zh) | 2014-06-16 | 2020-06-09 | 基础应用医学研究基金会 | 作为组蛋白甲基转移酶和dna甲基转移酶的双重抑制剂的新型化合物 |
| US20190127354A1 (en) | 2015-12-14 | 2019-05-02 | Fundación Para La Investigación Médica Aplicada | 2,4,6,7-tetrasubstituted quinoline compounds as inhibitors of dna methyltransferases |
| EP3416963B1 (en) | 2016-02-17 | 2021-07-28 | Global Blood Therapeutics, Inc. | Histone methyltransferase inhibitors |
| US11584734B2 (en) | 2017-08-15 | 2023-02-21 | Global Blood Therapeutics, Inc. | Tricyclic compounds as histone methyltransferase inhibitors |
-
2018
- 2018-08-13 EP EP18762967.0A patent/EP3668863B1/en active Active
- 2018-08-13 CN CN201880064130.8A patent/CN111372927A/zh active Pending
- 2018-08-13 ES ES18762967T patent/ES3016407T3/es active Active
- 2018-08-13 MX MX2020001825A patent/MX2020001825A/es unknown
- 2018-08-13 WO PCT/US2018/046541 patent/WO2019036377A1/en not_active Ceased
- 2018-08-13 JP JP2020508394A patent/JP7267993B2/ja active Active
- 2018-08-13 US US16/639,051 patent/US11661410B2/en active Active
- 2018-08-13 BR BR112020003073-2A patent/BR112020003073A2/pt not_active Application Discontinuation
- 2018-08-13 SG SG11202001090WA patent/SG11202001090WA/en unknown
- 2018-08-14 TW TW107128321A patent/TW201920136A/zh unknown
-
2020
- 2020-02-06 IL IL272507A patent/IL272507A/en unknown
- 2020-02-11 SA SA520411303A patent/SA520411303B1/ar unknown
- 2020-03-10 ZA ZA2020/01503A patent/ZA202001503B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020531423A5 (https=) | ||
| RU2015143717A (ru) | 2-Аминопиримидин-6-оны и аналоги, проявляющие противораковые и антипролиферативные действия | |
| IL277783B2 (en) | Shp2 inhibitor compositions, methods for treating cancer and methods for identifying a subject with shp2 mutations | |
| JP2025504486A5 (https=) | ||
| JP2020504716A5 (https=) | ||
| JP2024113019A5 (https=) | ||
| JP2016516702A5 (https=) | ||
| US12358906B2 (en) | Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors | |
| JP2015502979A5 (https=) | ||
| JP2021515775A5 (https=) | ||
| JP2020514409A5 (https=) | ||
| JP2016519147A5 (https=) | ||
| JP2020515571A5 (https=) | ||
| JP2020172535A5 (https=) | ||
| JP2019535720A5 (https=) | ||
| JP2022137047A5 (https=) | ||
| JP2020508302A5 (https=) | ||
| RU2014125230A (ru) | Пиридонамиды и их аналоги, демонстрирующие противораковую и антипролиферативную активность | |
| JP2017537114A5 (https=) | ||
| RU2012151012A (ru) | Циклопропиловые дикарбоксамиды и аналоги, обладающие противораковым и антипролиферативным действием | |
| US11919858B2 (en) | Aminonapthoquinone compounds and pharmaceutical composition for blocking ubiquitination-proteasome system in diseases | |
| KR20220024191A (ko) | 항암제 조합 요법 | |
| RU2010128107A (ru) | Лечение рака ингибиторами топоизомеразы в комбинации с ингибиторами parp | |
| JP2017509682A5 (https=) | ||
| JP2008528467A5 (https=) |