JP2020529997A5 - - Google Patents
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- JP2020529997A5 JP2020529997A5 JP2020505792A JP2020505792A JP2020529997A5 JP 2020529997 A5 JP2020529997 A5 JP 2020529997A5 JP 2020505792 A JP2020505792 A JP 2020505792A JP 2020505792 A JP2020505792 A JP 2020505792A JP 2020529997 A5 JP2020529997 A5 JP 2020529997A5
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- 239000003446 ligand Substances 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 11
- 239000013289 nano-metal-organic framework Substances 0.000 claims 10
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims 9
- 239000002955 immunomodulating agent Substances 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 8
- 229910021645 metal ion Inorganic materials 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 6
- 238000004132 cross linking Methods 0.000 claims 6
- 229910052741 iridium Inorganic materials 0.000 claims 6
- 150000004032 porphyrins Chemical group 0.000 claims 6
- 229910052707 ruthenium Inorganic materials 0.000 claims 6
- 150000002500 ions Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 4
- 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- VQGHOUODWALEFC-UHFFFAOYSA-N 2-phenylpyridine Chemical compound C1=CC=CC=C1C1=CC=CC=N1 VQGHOUODWALEFC-UHFFFAOYSA-N 0.000 claims 3
- 150000004696 coordination complex Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 239000003504 photosensitizing agent Substances 0.000 claims 3
- 229910052697 platinum Inorganic materials 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- -1 (5,5'-di (4-carboxy-phenyl) -2,2'-bipyridine) Iridium (III) chloride Chemical compound 0.000 claims 2
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 2
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 229940044665 STING agonist Drugs 0.000 claims 2
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 2
- 230000000536 complexating effect Effects 0.000 claims 2
- 125000002228 disulfide group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 2
- 229960001756 oxaliplatin Drugs 0.000 claims 2
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 2
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 2
- JFJNVIPVOCESGZ-UHFFFAOYSA-N 2,3-dipyridin-2-ylpyridine Chemical compound N1=CC=CC=C1C1=CC=CN=C1C1=CC=CC=N1 JFJNVIPVOCESGZ-UHFFFAOYSA-N 0.000 claims 1
- 150000005360 2-phenylpyridines Chemical class 0.000 claims 1
- ZQJIBJGQZQYQED-UHFFFAOYSA-L 4-[6-[5-(4-carboxyphenyl)pyridin-2-yl]pyridin-3-yl]benzoic acid 2-pyridin-2-ylpyridine ruthenium(2+) dichloride Chemical compound [Ru](Cl)Cl.C(=O)(O)C1=CC=C(C=C1)C=1C=CC(=NC1)C1=NC=C(C=C1)C1=CC=C(C=C1)C(=O)O.N1=C(C=CC=C1)C1=NC=CC=C1.N1=C(C=CC=C1)C1=NC=CC=C1 ZQJIBJGQZQYQED-UHFFFAOYSA-L 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000009849 Female Genital Neoplasms Diseases 0.000 claims 1
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000016624 Retinal neoplasm Diseases 0.000 claims 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical group [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
- QYKMXTVPHUMWJW-UHFFFAOYSA-N [Ir].C(=O)(O)C1=CC=C(C=C1)C=1C=CC(=NC1)C1=NC=C(C=C1)C1=CC=C(C=C1)C(=O)O Chemical compound [Ir].C(=O)(O)C1=CC=C(C=C1)C=1C=CC(=NC1)C1=NC=C(C=C1)C1=CC=C(C=C1)C(=O)O QYKMXTVPHUMWJW-UHFFFAOYSA-N 0.000 claims 1
- 229910052797 bismuth Inorganic materials 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical group C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 1
- 229930002875 chlorophyll Chemical group 0.000 claims 1
- 235000019804 chlorophyll Nutrition 0.000 claims 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical group C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010918 connective tissue cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- JVZRCNQLWOELDU-UHFFFAOYSA-N gamma-Phenylpyridine Natural products C1=CC=CC=C1C1=CC=NC=C1 JVZRCNQLWOELDU-UHFFFAOYSA-N 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 229910052735 hafnium Inorganic materials 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims 1
- MILUBEOXRNEUHS-UHFFFAOYSA-N iridium(3+) Chemical compound [Ir+3] MILUBEOXRNEUHS-UHFFFAOYSA-N 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229910052747 lanthanoid Inorganic materials 0.000 claims 1
- 150000002602 lanthanoids Chemical class 0.000 claims 1
- 229910052745 lead Inorganic materials 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 239000002055 nanoplate Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000012044 organic layer Substances 0.000 claims 1
- 229910052762 osmium Inorganic materials 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical group N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000008933 retinal cancer Diseases 0.000 claims 1
- 229910052702 rhenium Inorganic materials 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims 1
- 0 *C([C@@](*1)C(*)=C(*)C=I)c2c1c(*)c(*)cn2 Chemical compound *C([C@@](*1)C(*)=C(*)C=I)c2c1c(*)c(*)cn2 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762540275P | 2017-08-02 | 2017-08-02 | |
| US62/540,275 | 2017-08-02 | ||
| US201862623826P | 2018-01-30 | 2018-01-30 | |
| US62/623,826 | 2018-01-30 | ||
| PCT/US2018/045005 WO2019028250A1 (en) | 2017-08-02 | 2018-08-02 | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529997A JP2020529997A (ja) | 2020-10-15 |
| JP2020529997A5 true JP2020529997A5 (https=) | 2021-09-09 |
| JP7364552B2 JP7364552B2 (ja) | 2023-10-18 |
Family
ID=65233051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505792A Active JP7364552B2 (ja) | 2017-08-02 | 2018-08-02 | Ｘ線誘起光線力学療法、放射線療法、放射線力学療法、化学療法、免疫療法、及びそれらの任意の組み合わせのための、ナノスケール金属有機層及び金属有機ナノプレート |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11826426B2 (https=) |
| EP (1) | EP3638367A4 (https=) |
| JP (1) | JP7364552B2 (https=) |
| CN (1) | CN111194232B (https=) |
| WO (1) | WO2019028250A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| EP3638367A4 (en) | 2017-08-02 | 2021-07-21 | The University of Chicago | NANOMETRIC ORGANOMETALLIC AND NANOPLAQUE ORGANOMETALLIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RADIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION OF THESE |
| US20190314324A1 (en) | 2018-04-13 | 2019-10-17 | The University Of Chicago | Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy |
| CN110256482B (zh) * | 2019-06-19 | 2021-04-06 | 吉林大学 | 一种杂多钒酸盐化合物及其制备方法 |
| CN110227157A (zh) * | 2019-06-21 | 2019-09-13 | 南开大学 | 掺钆硅纳米粒子/光敏剂自组装金属有机框架纳米材料的制备方法 |
| WO2021237209A1 (en) * | 2020-05-22 | 2021-11-25 | The University Of Chicago | Metal-organic frameworks deliver small molecules and biomacromolecules for cancer immunotherapy |
| CN116744909A (zh) * | 2020-05-22 | 2023-09-12 | 芝加哥大学 | 金属有机框架递送小分子和生物大分子用于癌症免疫治疗 |
| CN111939124B (zh) * | 2020-07-13 | 2022-06-28 | 东南大学 | 一种金属聚合物、金属聚合物纳米胶束及其制备方法和应用 |
| CN111804346B (zh) * | 2020-07-17 | 2023-09-12 | 中国人民解放军国防科技大学 | 一种快速制备金属有机层材料的方法及应用 |
| CN112007170B (zh) * | 2020-08-14 | 2023-06-13 | 南方医科大学皮肤病医院（广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心） | 免疫佐剂功能化金属有机框架材料及其制备方法与应用 |
| CN112294956B (zh) * | 2020-11-13 | 2023-05-05 | 中山大学 | 一种金属铱光敏剂及其制备方法和应用 |
| US20240000940A1 (en) | 2020-12-01 | 2024-01-04 | Nanobiotix S.A. | Porous, high-z and carbon-free particles as radioenhancers |
| CN114106060B (zh) * | 2021-09-08 | 2024-02-27 | 上海市质子重离子临床技术研发中心 | 一种基于铱配合物的双金属中心化合物在制备放射动力学药物中的应用及其制备方法 |
| CN113754699B (zh) * | 2021-09-08 | 2024-06-14 | 上海市质子重离子临床技术研发中心 | 一种铱配合物聚集体在制备放射动力学药物中的应用及制备方法 |
| CN114805826B (zh) * | 2022-03-11 | 2023-03-21 | 湖北工业大学 | 一种Eu3+功能化MOF荧光探针及其制备方法和检测四环素类药物的应用 |
| CN115575372A (zh) * | 2022-10-27 | 2023-01-06 | 浙江清华柔性电子技术研究院 | 氧传感器荧光膜的制作方法、氧传感器荧光膜及氧传感器 |
| EP4633676A1 (en) | 2022-12-12 | 2025-10-22 | Nanobiotix | Novel metal oxide nanoparticles and compositions thereof for use as radioenhancers or for visualizing biological tissue |
| CN118812426B (zh) * | 2023-04-18 | 2025-12-12 | 中国科学技术大学 | 二价金属阳离子化合物及其制备方法和应用 |
| CN116270544B (zh) * | 2023-05-23 | 2023-08-01 | 深圳市第二人民医院(深圳市转化医学研究院) | 铂卟啉纳米材料及其制备方法 |
| CN117338930B (zh) * | 2023-11-03 | 2026-03-17 | 海南大学 | Bp/PCN-224/Fe3O4纳米异质结的制备及应用 |
| CN118671344B (zh) * | 2024-07-01 | 2025-04-22 | 威特曼医学检验(南京)有限公司 | 一种测定甲胎蛋白含量的均相化学发光试剂盒 |
| CN119119328A (zh) * | 2024-09-04 | 2024-12-13 | 江南大学 | 一种用于近红外光固化的负载光引发剂上转换MOFs复合材料及其制备方法 |
| CN120381439B (zh) * | 2025-02-24 | 2026-04-24 | 苏州大学 | 一种基于吡啶基卟啉的聚乙二醇化的纳米颗粒及其制备方法与应用 |
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-
2018
- 2018-08-02 EP EP18840272.1A patent/EP3638367A4/en active Pending
- 2018-08-02 US US16/634,486 patent/US11826426B2/en active Active
- 2018-08-02 WO PCT/US2018/045005 patent/WO2019028250A1/en not_active Ceased
- 2018-08-02 JP JP2020505792A patent/JP7364552B2/ja active Active
- 2018-08-02 CN CN201880064003.8A patent/CN111194232B/zh not_active Expired - Fee Related
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