JP2020529987A5 - - Google Patents
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- JP2020529987A5 JP2020529987A5 JP2020505224A JP2020505224A JP2020529987A5 JP 2020529987 A5 JP2020529987 A5 JP 2020529987A5 JP 2020505224 A JP2020505224 A JP 2020505224A JP 2020505224 A JP2020505224 A JP 2020505224A JP 2020529987 A5 JP2020529987 A5 JP 2020529987A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *CC(CCCCCCN*I)IC(c1c(*)[n]nc1)=*C(c(cc1*)ccc1O)=I Chemical compound *CC(CCCCCCN*I)IC(c1c(*)[n]nc1)=*C(c(cc1*)ccc1O)=I 0.000 description 2
- OJTMTIGSEODYKN-ONEGZZNKSA-N CN(C)C/C=C/C(N1CC(COc2c(cn[nH]3)c3cc(-c(cc3)ccc3O)c2)C1)=O Chemical compound CN(C)C/C=C/C(N1CC(COc2c(cn[nH]3)c3cc(-c(cc3)ccc3O)c2)C1)=O OJTMTIGSEODYKN-ONEGZZNKSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021043173A JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Ｊａｋキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539642P | 2017-08-01 | 2017-08-01 | |
| US62/539,642 | 2017-08-01 | ||
| PCT/US2018/044508 WO2019027960A1 (en) | 2017-08-01 | 2018-07-31 | BICYCLIC PYRAZOLO AND TRIAZOLO COMPOUNDS AS JAK KINASE INHIBITORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021043173A Division JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Ｊａｋキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529987A JP2020529987A (ja) | 2020-10-15 |
| JP2020529987A5 true JP2020529987A5 (enExample) | 2021-04-30 |
| JP7098716B2 JP7098716B2 (ja) | 2022-07-11 |
Family
ID=63209687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505224A Expired - Fee Related JP7098716B2 (ja) | 2017-08-01 | 2018-07-31 | Ｊａｋキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
| JP2021043173A Withdrawn JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Ｊａｋキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021043173A Withdrawn JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Ｊａｋキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US10392368B2 (enExample) |
| EP (1) | EP3652169A1 (enExample) |
| JP (2) | JP7098716B2 (enExample) |
| KR (1) | KR20200036004A (enExample) |
| CN (1) | CN111032646B (enExample) |
| AR (1) | AR112348A1 (enExample) |
| AU (1) | AU2018312349A1 (enExample) |
| BR (1) | BR112020002265A2 (enExample) |
| CA (1) | CA3069990A1 (enExample) |
| CL (1) | CL2020000283A1 (enExample) |
| CO (1) | CO2020001469A2 (enExample) |
| EA (1) | EA038912B1 (enExample) |
| IL (1) | IL272031A (enExample) |
| MA (1) | MA49570A (enExample) |
| MX (1) | MX2020001170A (enExample) |
| MY (1) | MY200629A (enExample) |
| PE (1) | PE20201028A1 (enExample) |
| PH (1) | PH12020500201A1 (enExample) |
| SG (1) | SG11202000602YA (enExample) |
| TW (1) | TW201920150A (enExample) |
| UA (1) | UA125318C2 (enExample) |
| WO (1) | WO2019027960A1 (enExample) |
| ZA (1) | ZA202000561B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3652169A1 (en) | 2017-08-01 | 2020-05-20 | Theravance Biopharma R&D IP, LLC | Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors |
| JP2022518741A (ja) * | 2019-01-23 | 2022-03-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ＪＡＫキナーゼ阻害剤としてのイミダゾ［１，５－ａ］ピリジン、１，２，４－トリアゾロ［４，３－ａ］ピリジンおよびイミダゾ［１，５－ａ］ピラジン |
| CN114126618A (zh) * | 2019-07-15 | 2022-03-01 | 诺华股份有限公司 | 用肝脏x受体激动剂治疗睑板腺功能障碍的方法 |
| WO2021205322A1 (en) * | 2020-04-08 | 2021-10-14 | Pfizer Inc. | Crystalline forms of 3-cyano-1-[4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl]cyclobutaneacetonitrile, and use thereof |
| JP2023528239A (ja) * | 2020-05-14 | 2023-07-04 | テラバンス バイオファーマ アールアンドディー アイピー リミテッド ライアビリティ カンパニー | 腸管選択的ｊａｋ３阻害剤の投与 |
| CN114075220A (zh) * | 2020-08-13 | 2022-02-22 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| CN114075221B (zh) * | 2020-08-13 | 2024-08-23 | 广东东阳光药业股份有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| WO2022053000A1 (zh) * | 2020-09-10 | 2022-03-17 | 四川海思科制药有限公司 | 一种碳环酰胺衍生物及其在医药上的应用 |
| US20240316040A1 (en) * | 2020-12-29 | 2024-09-26 | Abbvie Inc. | Extended release upadacitinib formulations |
| WO2022199599A1 (zh) * | 2021-03-23 | 2022-09-29 | 凯复(苏州)生物医药有限公司 | 丙烯酰基取代的化合物、包含其的药物组合物及其用途 |
| WO2022212181A1 (en) * | 2021-03-29 | 2022-10-06 | Bristol-Myers Squibb Company | Crystal forms of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide |
| CN113061137B (zh) * | 2021-04-02 | 2022-08-02 | 广西医科大学 | 含氮杂环衍生物或其药学上可接受的盐和用途 |
| EP4696710A3 (en) * | 2021-05-03 | 2026-05-06 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of prurigo nodularis |
| WO2023116748A1 (zh) * | 2021-12-23 | 2023-06-29 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| WO2023165562A1 (zh) * | 2022-03-02 | 2023-09-07 | 南京明德新药研发有限公司 | 含氮杂环类化合物及其应用 |
| GB202213163D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| GB202213164D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| WO2025201397A1 (en) * | 2024-03-27 | 2025-10-02 | Insilico Medicine Ip Limited | Tead inhibitors and methods of uses thereof |
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| IL158448A0 (en) | 2001-04-20 | 2004-05-12 | Wyeth Corp | Heterocyclylalkoxy- alkylthio-and-alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| JP4810427B2 (ja) | 2003-05-22 | 2011-11-09 | アボット・ラボラトリーズ | インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤 |
| EP1647549A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
| US20070104780A1 (en) | 2005-10-25 | 2007-05-10 | Lipari John M | Formulation comprising a drug of low water solubility and method of use thereof |
| US20090247554A1 (en) | 2006-03-30 | 2009-10-01 | Takeda San Diego, Inc. | Kinase inhibitors |
| KR100834758B1 (ko) | 2006-07-05 | 2008-06-05 | 삼성전자주식회사 | 컴퓨터 시스템 보안 장치 및 방법 |
| JP2009007342A (ja) | 2007-06-01 | 2009-01-15 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| EP2300437B1 (en) | 2008-06-05 | 2013-11-20 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| JP5502077B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | 新規な化合物 |
| EP2280705B1 (en) | 2008-06-05 | 2014-10-08 | Glaxo Group Limited | Novel compounds |
| WO2010012121A1 (zh) | 2008-07-28 | 2010-02-04 | 江苏国华投资有限公司 | 芳烷基哌啶（嗪）衍生物及其在治疗精神分裂症中的应用 |
| TW201111385A (en) | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
| FR2951172B1 (fr) | 2009-10-13 | 2014-09-26 | Pf Medicament | Derives pyrazolopyridines en tant qu'agent anticancereux |
| JP2013512878A (ja) | 2009-12-03 | 2013-04-18 | グラクソ グループ リミテッド | 新規化合物 |
| WO2011067365A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Benzpyrazole derivatives as inhibitors of p13 kinases |
| TW201200518A (en) | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| SI2635299T1 (sl) | 2010-11-02 | 2020-02-28 | The Trustees Of Columbia University In The City Of New York | Postopki za zdravljenje motenj izgube las |
| US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN102993201A (zh) * | 2011-09-14 | 2013-03-27 | 赛诺菲 | 作为激酶抑制剂的6-(4-羟基-苯基)-3-苯乙烯基-1H-吡唑并[3，4-b]吡啶-4-羧酸酰胺衍生物 |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US20130102601A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2013060636A1 (en) | 2011-10-25 | 2013-05-02 | Sanofi | 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013085802A1 (en) * | 2011-12-06 | 2013-06-13 | Merck Sharp & Dohme Corp. | Pyrrolopyrimidines as janus kinase inhibitors |
| US8377946B1 (en) * | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| ES2694681T3 (es) | 2012-03-29 | 2018-12-26 | The Trustees Of Columbia University In The City Of New York | Métodos para tratar trastornos de pérdida capilar |
| WO2013167403A1 (en) * | 2012-05-09 | 2013-11-14 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
| TWI629275B (zh) | 2013-03-13 | 2018-07-11 | 賽諾菲公司 | Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途 |
| JP2016113366A (ja) * | 2013-03-29 | 2016-06-23 | 大鵬薬品工業株式会社 | アセトアミド基を有する１，２，４−トリアジン−６−カルボキサミド誘導体 |
| ES2654051T3 (es) | 2013-12-05 | 2018-02-12 | Pfizer Inc. | Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinil acrilamidas |
| EP3097091A1 (en) | 2014-01-24 | 2016-11-30 | AbbVie Inc. | 6-phenyl- or 6-(pyridin-3-yl)indazole derivatives and methods of use |
| EP4019518A1 (en) * | 2014-02-28 | 2022-06-29 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| CN106459048A (zh) | 2014-05-14 | 2017-02-22 | 辉瑞公司 | 吡唑并吡啶类和吡唑并嘧啶类 |
| US10519160B2 (en) | 2014-07-18 | 2019-12-31 | The General Hospital Corporation | Imaging agents for neural flux |
| CA2965741C (en) | 2014-11-03 | 2022-05-17 | Iomet Pharma Ltd | Pharmaceutical compound |
| CN105837574B (zh) | 2015-02-02 | 2018-03-02 | 四川大学 | N‑(3‑哌啶基)‑芳香胺衍生物及其制备方法和用途 |
| ES2928757T3 (es) * | 2015-05-01 | 2022-11-22 | Pfizer | Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa |
| JP2018515501A (ja) | 2015-05-07 | 2018-06-14 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨークＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｃｏｌｕｍｂｉａ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎ Ｔｈｅ Ｃｉｔｙ Ｏｆ Ｎｅｗ Ｙｏｒｋ | 発毛を促進する方法及び組成物 |
| EP3371184A1 (en) | 2015-11-03 | 2018-09-12 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| WO2017143014A1 (en) | 2016-02-16 | 2017-08-24 | Brian Kim | Jak inhibitors and uses thereof |
| KR102329162B1 (ko) | 2016-06-30 | 2021-11-22 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 피라졸로피리미딘 유도체 |
| US9956158B2 (en) | 2016-09-08 | 2018-05-01 | Synergistic Therapeutics, Llc | Topical hair growth formulation |
| JP7082120B2 (ja) | 2016-10-21 | 2022-06-07 | ニンバス ラクシュミ， インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| US20180117148A1 (en) | 2016-10-28 | 2018-05-03 | Andrew J. Holman | Compounds, pharmaceutical compositions and methods of treatments of immune related diseases and disorders |
| KR102032418B1 (ko) * | 2017-06-15 | 2019-10-16 | 한국화학연구원 | 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| EP3652169A1 (en) | 2017-08-01 | 2020-05-20 | Theravance Biopharma R&D IP, LLC | Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors |
| KR102821964B1 (ko) | 2017-11-03 | 2025-06-19 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 치환된 피롤로피리미딘 jak 억제제 및 이의 제조 및 사용 방법 |
| KR102577241B1 (ko) | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체 |
| KR102577242B1 (ko) | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체 |
| PL3733673T3 (pl) | 2017-12-28 | 2022-09-26 | Daewoong Pharmaceutical Co., Ltd. | Pochodna oksyfluoropiperydyny jako inhibitor kinazy |
| JP2022518741A (ja) * | 2019-01-23 | 2022-03-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ＪＡＫキナーゼ阻害剤としてのイミダゾ［１，５－ａ］ピリジン、１，２，４－トリアゾロ［４，３－ａ］ピリジンおよびイミダゾ［１，５－ａ］ピラジン |
| JP2023528239A (ja) * | 2020-05-14 | 2023-07-04 | テラバンス バイオファーマ アールアンドディー アイピー リミテッド ライアビリティ カンパニー | 腸管選択的ｊａｋ３阻害剤の投与 |
-
2018
- 2018-07-31 EP EP18755621.2A patent/EP3652169A1/en not_active Withdrawn
- 2018-07-31 JP JP2020505224A patent/JP7098716B2/ja not_active Expired - Fee Related
- 2018-07-31 WO PCT/US2018/044508 patent/WO2019027960A1/en not_active Ceased
- 2018-07-31 AR ARP180102151 patent/AR112348A1/es unknown
- 2018-07-31 MX MX2020001170A patent/MX2020001170A/es unknown
- 2018-07-31 CN CN201880050675.3A patent/CN111032646B/zh not_active Expired - Fee Related
- 2018-07-31 SG SG11202000602YA patent/SG11202000602YA/en unknown
- 2018-07-31 US US16/050,227 patent/US10392368B2/en active Active
- 2018-07-31 BR BR112020002265-9A patent/BR112020002265A2/pt not_active Application Discontinuation
- 2018-07-31 EA EA202090413A patent/EA038912B1/ru unknown
- 2018-07-31 AU AU2018312349A patent/AU2018312349A1/en not_active Abandoned
- 2018-07-31 KR KR1020207005956A patent/KR20200036004A/ko not_active Withdrawn
- 2018-07-31 MA MA049570A patent/MA49570A/fr unknown
- 2018-07-31 UA UAA202001352A patent/UA125318C2/uk unknown
- 2018-07-31 CA CA3069990A patent/CA3069990A1/en not_active Abandoned
- 2018-07-31 MY MYPI2020000251A patent/MY200629A/en unknown
- 2018-07-31 PE PE2020000171A patent/PE20201028A1/es unknown
- 2018-07-31 TW TW107126579A patent/TW201920150A/zh unknown
-
2019
- 2019-06-28 US US16/456,179 patent/US10538513B2/en active Active
- 2019-11-19 US US16/688,109 patent/US10968205B2/en not_active Expired - Fee Related
-
2020
- 2020-01-14 IL IL272031A patent/IL272031A/en unknown
- 2020-01-27 PH PH12020500201A patent/PH12020500201A1/en unknown
- 2020-01-28 ZA ZA2020/00561A patent/ZA202000561B/en unknown
- 2020-01-31 CL CL2020000283A patent/CL2020000283A1/es unknown
- 2020-02-11 CO CONC2020/0001469A patent/CO2020001469A2/es unknown
-
2021
- 2021-02-22 US US17/249,128 patent/US20220119369A1/en not_active Abandoned
- 2021-03-17 JP JP2021043173A patent/JP2021098751A/ja not_active Withdrawn
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