JP2020527547A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020527547A5 JP2020527547A5 JP2019572783A JP2019572783A JP2020527547A5 JP 2020527547 A5 JP2020527547 A5 JP 2020527547A5 JP 2019572783 A JP2019572783 A JP 2019572783A JP 2019572783 A JP2019572783 A JP 2019572783A JP 2020527547 A5 JP2020527547 A5 JP 2020527547A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- liver
- formula
- subject
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023107837A JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1710229.4 | 2017-06-27 | ||
| GBGB1710229.4A GB201710229D0 (en) | 2017-06-27 | 2017-06-27 | Compounds for new use |
| PCT/GB2018/051752 WO2019002828A1 (en) | 2017-06-27 | 2018-06-22 | 3-HYDROXYBUTYRATE COMPOUNDS FOR USE IN THE REDUCTION OF HEPATIC FAT |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107837A Division JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527547A JP2020527547A (ja) | 2020-09-10 |
| JP2020527547A5 true JP2020527547A5 (https=) | 2021-07-29 |
| JP7374000B2 JP7374000B2 (ja) | 2023-11-06 |
Family
ID=59523693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572783A Active JP7374000B2 (ja) | 2017-06-27 | 2018-06-22 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
| JP2023107837A Active JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107837A Active JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12439944B2 (https=) |
| EP (2) | EP4215189A1 (https=) |
| JP (2) | JP7374000B2 (https=) |
| KR (1) | KR102680437B1 (https=) |
| CN (1) | CN110869012B (https=) |
| AU (1) | AU2018293398B2 (https=) |
| CA (1) | CA3066948A1 (https=) |
| DK (1) | DK3644982T3 (https=) |
| ES (1) | ES2945964T3 (https=) |
| GB (2) | GB201710229D0 (https=) |
| PL (1) | PL3644982T3 (https=) |
| TW (1) | TWI811222B (https=) |
| WO (1) | WO2019002828A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201710229D0 (en) * | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
| GB201715654D0 (en) | 2017-09-27 | 2017-11-08 | Tdeltas Ltd | Method of treatment |
| GB2577723A (en) | 2018-10-04 | 2020-04-08 | Tdeltas Ltd | Compounds for new use |
| ES2941943T3 (es) | 2019-01-17 | 2023-05-26 | Ketolipix Therapeutics Gmbh | Método para la producción de glicéridos de ácidos hidroxicarboxílicos |
| CN109700021A (zh) * | 2019-03-04 | 2019-05-03 | 清华大学 | 3-羟基丁酸及其衍生物在制备预防和治疗肥胖及肥胖相关疾病的产品中的应用 |
| CN110776425B (zh) * | 2019-10-23 | 2021-02-26 | 清华大学 | 一种(r)-3-羟基丁酸及其低聚物的制备方法 |
| JP7638693B2 (ja) * | 2020-12-15 | 2025-03-04 | 大阪瓦斯株式会社 | ヒドロキシアルカン酸結晶の製造方法及びヒドロキシアルカン酸の結晶多形体 |
| US20240196917A1 (en) * | 2021-06-01 | 2024-06-20 | Osaka Gas Co., Ltd. | Oil and fat composition containing 3-hydroxybutyric acid |
| WO2023283654A1 (en) * | 2021-07-09 | 2023-01-12 | Georgia State University Research Foundation, Inc. | The use of beta-hydroxybutyrates for the treatment or prevention of aneurysms and dissections |
| IT202100020441A1 (it) * | 2021-07-30 | 2023-01-30 | Unichem Estense S R L | Miscela di un mono-estere e un di-estere, in cui detti mono-estere e di-estere sono esteri dell’acido (R)-3-idrossibutanoico con un polialcol, processo per la preparazione della miscela e relativi usi medici |
| CN113712140A (zh) * | 2021-09-13 | 2021-11-30 | 珠海麦得发生物科技股份有限公司 | 一种含(r)-3羟基丁酸的固体饮料及其制备方法 |
| AU2022381752B2 (en) * | 2021-11-04 | 2026-01-08 | Vdf Futureceuticals, Inc | Ketone precursors and methods therefor |
| CN118591523A (zh) * | 2021-11-12 | 2024-09-03 | 阿萨达股份公司 | 多元醇衍生的化合物 |
| AU2022411334A1 (en) * | 2021-12-14 | 2024-06-13 | Suntory Holdings Limited | Carbonated beverage, and method for enhancing sense of carbonation of beverage |
| CN118382365A (zh) * | 2021-12-14 | 2024-07-23 | 三得利控股株式会社 | 含有3羟基丁酸及低级脂肪族醇的饮料及呈味改善方法 |
| JP7223193B1 (ja) | 2022-05-26 | 2023-02-15 | 大阪瓦斯株式会社 | 内臓脂肪低減剤およびその用途 |
| CN116966173A (zh) * | 2023-06-15 | 2023-10-31 | 浙江大学 | 3-羟基苯乙酸在制备改善非酒精性脂肪肝药物中的应用 |
| CN118903420A (zh) * | 2024-07-02 | 2024-11-08 | 南方医科大学 | Irf4抑制剂在治疗非酒精性脂肪性肝炎的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| CN1315473C (zh) | 1997-03-17 | 2007-05-16 | 英国技术集团国际有限公司 | 治疗组合物 |
| EP2258742A1 (en) * | 1997-12-22 | 2010-12-08 | Metabolix, Inc. | Polyhydroxyalkanoate compositons having controlled degradation rates |
| EP2275468A1 (en) * | 2000-07-14 | 2011-01-19 | Metabolix, Inc. | Polyurethanes obtained from hydroxyalkanoates and isocyanates |
| EP1648952B1 (en) * | 2003-06-03 | 2018-03-07 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives |
| SE0400355D0 (sv) * | 2004-02-17 | 2004-02-17 | Synbiotics Ab | New synbiotec use |
| WO2006020137A2 (en) * | 2004-07-16 | 2006-02-23 | Ketocytonyx Inc. | Oligomeric compounds |
| EP1778615A4 (en) | 2004-07-20 | 2010-01-06 | Btg Int Ltd | OLIGOMERE KETONE COMPOUNDS |
| WO2008110034A1 (en) | 2007-03-14 | 2008-09-18 | Shantou University | 3-hydroxy fatty acid and its derivatives for improving of learning and/or memory of subjects |
| EP2240017B1 (en) | 2008-01-04 | 2019-03-13 | Oxford University Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| JP5773870B2 (ja) * | 2008-08-21 | 2015-09-02 | アイシス イノヴェイション リミテッド | ヒドロキシ酪酸エステル及びその医学的使用 |
| WO2011078204A1 (ja) | 2009-12-24 | 2011-06-30 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
| US8865641B2 (en) * | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
| GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| GB2515603B (en) | 2013-03-14 | 2015-10-14 | Isis Innovation | Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate |
| CA2902603C (en) | 2013-03-19 | 2021-03-02 | University Of South Florida | Compositions and methods for producing elevated and sustained ketosis |
| IN2013MU01468A (https=) * | 2013-04-22 | 2015-04-17 | Cadila Healthcare Ltd | |
| US11814664B2 (en) * | 2013-05-24 | 2023-11-14 | Genomatica, Inc. | Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate |
| GB201314127D0 (en) | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
| US20150283163A1 (en) | 2014-04-04 | 2015-10-08 | Organic Medical Ventures, L.L.C. | Muscle treatment composition and method making same |
| US20180008629A1 (en) | 2015-01-29 | 2018-01-11 | Yale University | Compositions and Methods for Treating NLRP3 Inflammasome-Related Diseases and Disorders |
| EA201791982A1 (ru) * | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
| CA3021784A1 (en) | 2016-04-19 | 2017-10-26 | Keto Patent Group, Inc. | Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans |
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| GB201710229D0 (en) | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
-
2017
- 2017-06-27 GB GBGB1710229.4A patent/GB201710229D0/en not_active Ceased
-
2018
- 2018-06-22 PL PL18737388.1T patent/PL3644982T3/pl unknown
- 2018-06-22 EP EP23161905.7A patent/EP4215189A1/en active Pending
- 2018-06-22 US US16/626,293 patent/US12439944B2/en active Active
- 2018-06-22 CA CA3066948A patent/CA3066948A1/en active Pending
- 2018-06-22 GB GB1810300.2A patent/GB2567273B/en active Active
- 2018-06-22 AU AU2018293398A patent/AU2018293398B2/en active Active
- 2018-06-22 KR KR1020207002473A patent/KR102680437B1/ko active Active
- 2018-06-22 ES ES18737388T patent/ES2945964T3/es active Active
- 2018-06-22 DK DK18737388.1T patent/DK3644982T3/da active
- 2018-06-22 CN CN201880042880.5A patent/CN110869012B/zh active Active
- 2018-06-22 JP JP2019572783A patent/JP7374000B2/ja active Active
- 2018-06-22 EP EP18737388.1A patent/EP3644982B1/en active Active
- 2018-06-22 WO PCT/GB2018/051752 patent/WO2019002828A1/en not_active Ceased
- 2018-06-22 TW TW107121496A patent/TWI811222B/zh active
-
2023
- 2023-06-30 JP JP2023107837A patent/JP7632979B2/ja active Active
-
2025
- 2025-09-18 US US19/332,258 patent/US20260007157A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020527547A5 (https=) | ||
| US20230293458A1 (en) | Multibiotic agents and methods of using the same | |
| JP7261850B2 (ja) | 肝毒性および脂肪性肝疾患の処置に有効な化合物およびその使用 | |
| Cheng et al. | Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity | |
| US20220409650A1 (en) | Compositions and methods for ascaroside modification of mammalian microbiota | |
| JP2011502174A5 (https=) | ||
| CN110183431B (zh) | 一类用于肝病治疗或预防的化合物 | |
| US20200254105A1 (en) | Drug composition for parenteral administration | |
| JP2019534273A (ja) | モノアセチルジアシルグリセロール化合物を含有する肝炎の予防または治療用組成物 | |
| JP6377713B2 (ja) | 薬剤 | |
| US20090326259A1 (en) | NF-Kappabeta Activation Inhibitor | |
| JP2021525775A5 (https=) | ||
| JP7759109B2 (ja) | Ｅｏｍｅｓ陽性ＣＤ４陽性Ｔ細胞の増加に起因する進行型疾患治療剤 | |
| JP2020026434A (ja) | 癌治療剤 | |
| TW202237073A (zh) | 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途 | |
| WO2016006548A1 (ja) | ＰＰＡＲγ活性化剤 | |
| WO2019121734A1 (en) | Method for improving the oral bioavailability of a drug | |
| JP2022504207A5 (https=) | ||
| JP6043997B2 (ja) | 炎症性サイトカインの機能を抑制する炎症性疾患治療剤 | |
| KR102625224B1 (ko) | 피라졸-온 유도체를 유효성분으로 포함하는 자가면역질환의 예방, 개선 또는 치료용 조성물 | |
| US8614250B2 (en) | Uses of adipic acid | |
| JPWO2019234402A5 (https=) | ||
| TWI797455B (zh) | 安卓錠化合物用於預防或治療非酒精性脂肪肝病的用途 | |
| JP2001226263A (ja) | 肥満予防剤 | |
| JPWO2020070506A5 (https=) |