|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US5294533A
(en)
|
1988-07-05 |
1994-03-15 |
Baylor College Of Medicine |
Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria
|
|
US5135917A
(en)
|
1990-07-12 |
1992-08-04 |
Nova Pharmaceutical Corporation |
Interleukin receptor expression inhibiting antisense oligonucleotides
|
|
US5271941A
(en)
|
1990-11-02 |
1993-12-21 |
Cho Chung Yoon S |
Antisense oligonucleotides of human regulatory subunit RI.sub.α of cAMP-dependent protein kinases
|
|
US5786138A
(en)
|
1993-01-29 |
1998-07-28 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Hyperstabilizing antisense nucleic acid binding agents
|
|
EP0703979B1
(en)
|
1993-06-04 |
2000-09-13 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Method for treating kaposi's sarcoma with antisense oligonucleotides
|
|
US5578716A
(en)
|
1993-12-01 |
1996-11-26 |
Mcgill University |
DNA methyltransferase antisense oligonucleotides
|
|
US5641754A
(en)
|
1994-01-10 |
1997-06-24 |
The Board Of Regents Of The University Of Nebraska |
Antisense oligonucleotide compositions for selectively killing cancer cells
|
|
WO1996005298A1
(en)
|
1994-08-09 |
1996-02-22 |
Ciba-Geigy Ag |
Antitumor antisense oligonucleotides
|
|
US5856103A
(en)
|
1994-10-07 |
1999-01-05 |
Board Of Regents The University Of Texas |
Method for selectively ranking sequences for antisense targeting
|
|
US5994320A
(en)
|
1995-02-06 |
1999-11-30 |
Regents Of The University Of Minnesota |
Antisense oligonucleotides and methods for treating central nervous system tumors
|
|
IT1275862B1
(it)
|
1995-03-03 |
1997-10-24 |
Consiglio Nazionale Ricerche |
Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento
|
|
US6040296A
(en)
|
1995-06-07 |
2000-03-21 |
East Carolina University |
Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
|
|
AU7286696A
(en)
|
1995-10-13 |
1997-05-07 |
F. Hoffmann-La Roche Ag |
Antisense oligomers
|
|
KR19990071523A
(ko)
|
1995-11-21 |
1999-09-27 |
해리 에이. 루스제 |
Il-8 및 il-8 수용체에 대한 안티센스올리고누클레오티드에 의한 종양 성장의 억제방법
|
|
EP1007655A1
(en)
|
1996-02-15 |
2000-06-14 |
National Institutes Of Health |
Rnase l activators and antisense oligonucleotides effective to treat rsv infections
|
|
US5955590A
(en)
|
1996-07-15 |
1999-09-21 |
Worcester Foundation For Biomedical Research |
Conjugates of minor groove DNA binders with antisense oligonucleotides
|
|
US6046004A
(en)
|
1997-02-27 |
2000-04-04 |
Lorne Park Research, Inc. |
Solution hybridization of nucleic acids with antisense probes having modified backbones
|
|
JPH1142091A
(ja)
|
1997-07-25 |
1999-02-16 |
Toagosei Co Ltd |
アンチセンス核酸化合物
|
|
US6046319A
(en)
|
1997-10-22 |
2000-04-04 |
University Technologies International, Inc. |
Antisense oligodeoxynucleotides regulating expression of TNF-α
|
|
US6007995A
(en)
|
1998-06-26 |
1999-12-28 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of TNFR1 expression
|
|
US6013522A
(en)
|
1999-02-23 |
2000-01-11 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of human Smad1 expression
|
|
US6025198A
(en)
|
1999-06-25 |
2000-02-15 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Ship-2 expression
|
|
US6033910A
(en)
|
1999-07-19 |
2000-03-07 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of MAP kinase kinase 6 expression
|
|
JP4968498B2
(ja)
|
2002-01-23 |
2012-07-04 |
ユニバーシティ オブ ユタ リサーチ ファウンデーション |
ジンクフィンガーヌクレアーゼを用いる、標的化された染色体変異誘発
|
|
EP2368982A3
(en)
|
2002-03-21 |
2011-10-12 |
Sangamo BioSciences, Inc. |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
|
US9447434B2
(en)
|
2002-09-05 |
2016-09-20 |
California Institute Of Technology |
Use of chimeric nucleases to stimulate gene targeting
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
WO2005108415A2
(en)
|
2004-04-30 |
2005-11-17 |
Biogen Idec Ma Inc. |
Membrane associated molecules
|
|
US7374927B2
(en)
|
2004-05-03 |
2008-05-20 |
Affymetrix, Inc. |
Methods of analysis of degraded nucleic acid samples
|
|
CA2579677A1
(en)
|
2004-09-16 |
2006-03-30 |
Sangamo Biosciences, Inc. |
Compositions and methods for protein production
|
|
WO2009025645A1
(en)
*
|
2007-08-22 |
2009-02-26 |
Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
|
|
WO2009102820A2
(en)
|
2008-02-11 |
2009-08-20 |
Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services |
Modified sugar substrates and methods of use
|
|
US20110239315A1
(en)
|
2009-01-12 |
2011-09-29 |
Ulla Bonas |
Modular dna-binding domains and methods of use
|
|
US8772008B2
(en)
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
|
WO2011072246A2
(en)
|
2009-12-10 |
2011-06-16 |
Regents Of The University Of Minnesota |
Tal effector-mediated dna modification
|
|
GB201000688D0
(en)
*
|
2010-01-15 |
2010-03-03 |
Diagenic Asa |
Product and method
|
|
WO2011145121A1
(en)
|
2010-05-18 |
2011-11-24 |
Scatolificio Mogliani S.N.C. Di Mogliani Mauro E Andrea |
Cardboard box for stable stacking with other identical specimens
|
|
RU2444378C1
(ru)
|
2010-09-06 |
2012-03-10 |
Олег Германович Макеев |
Способ лечения коронарной недостаточности при моделируемой ишемии миокарда
|
|
GB2537000C
(en)
|
2012-05-25 |
2019-10-09 |
Univ California |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
EP4556564A3
(en)
|
2012-10-23 |
2025-09-03 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
CA2891347C
(en)
|
2012-12-06 |
2018-02-27 |
Sigma-Aldrich Co. Llc |
Crispr-based genome modification and regulation
|
|
EP2896697B1
(en)
|
2012-12-12 |
2015-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
JP2016507244A
(ja)
|
2013-02-27 |
2016-03-10 |
ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum MuenchenDeutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) |
Cas9ヌクレアーゼによる卵母細胞における遺伝子編集
|
|
KR102874079B1
(ko)
|
2013-03-15 |
2025-10-22 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
|
|
CN115261411A
(zh)
|
2013-04-04 |
2022-11-01 |
哈佛学院校长同事会 |
利用CRISPR/Cas系统的基因组编辑的治疗性用途
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
CA3065938A1
(en)
|
2017-06-05 |
2018-12-13 |
Regeneron Pharmaceuticals, Inc. |
B4galt1 variants and uses thereof
|