SG11201911597YA - B4galt1 variants and uses thereof - Google Patents

B4galt1 variants and uses thereof

Info

Publication number
SG11201911597YA
SG11201911597YA SG11201911597YA SG11201911597YA SG11201911597YA SG 11201911597Y A SG11201911597Y A SG 11201911597YA SG 11201911597Y A SG11201911597Y A SG 11201911597YA SG 11201911597Y A SG11201911597Y A SG 11201911597YA SG 11201911597Y A SG11201911597Y A SG 11201911597YA
Authority
SG
Singapore
Prior art keywords
b4galt1
variants
b4galt1 variants
Prior art date
Application number
SG11201911597YA
Other languages
English (en)
Inventor
May Montasser
Hout Cristopher Van
Alan Shuldiner
Giusy Gatta
Matthew Healy
Marja Puurunen
Original Assignee
Regeneron Pharma
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Univ Maryland filed Critical Regeneron Pharma
Publication of SG11201911597YA publication Critical patent/SG11201911597YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01133—Xylosylprotein 4-beta-galactosyltransferase (2.4.1.133)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201911597YA 2017-06-05 2018-06-04 B4galt1 variants and uses thereof SG11201911597YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762515140P 2017-06-05 2017-06-05
US201762550161P 2017-08-25 2017-08-25
US201862659344P 2018-04-18 2018-04-18
PCT/US2018/035806 WO2018226560A1 (en) 2017-06-05 2018-06-04 B4galt1 variants and uses thereof

Publications (1)

Publication Number Publication Date
SG11201911597YA true SG11201911597YA (en) 2020-01-30

Family

ID=62705750

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201911597YA SG11201911597YA (en) 2017-06-05 2018-06-04 B4galt1 variants and uses thereof

Country Status (14)

Country Link
US (2) US10738284B2 (cg-RX-API-DMAC7.html)
EP (1) EP3635102B1 (cg-RX-API-DMAC7.html)
JP (2) JP7661009B2 (cg-RX-API-DMAC7.html)
KR (1) KR102624979B1 (cg-RX-API-DMAC7.html)
CN (1) CN110997906B (cg-RX-API-DMAC7.html)
AU (1) AU2018282072B2 (cg-RX-API-DMAC7.html)
CA (1) CA3065938A1 (cg-RX-API-DMAC7.html)
DK (1) DK3635102T3 (cg-RX-API-DMAC7.html)
ES (1) ES3049196T3 (cg-RX-API-DMAC7.html)
FI (1) FI3635102T3 (cg-RX-API-DMAC7.html)
IL (1) IL271073B2 (cg-RX-API-DMAC7.html)
MX (1) MX2019014661A (cg-RX-API-DMAC7.html)
SG (1) SG11201911597YA (cg-RX-API-DMAC7.html)
WO (1) WO2018226560A1 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
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EP3635102B1 (en) 2017-06-05 2025-08-13 Regeneron Pharmaceuticals, Inc. B4galt1 variants and uses thereof
IL295080A (en) * 2020-03-04 2022-09-01 Regeneron Pharma A rodent model of b4galt1-mediated functions
WO2023232983A1 (en) 2022-06-01 2023-12-07 E-Therapeutics Plc Inhibitors of expression and/or function
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CN115960926A (zh) * 2022-12-30 2023-04-14 南方科技大学 一种mRNA及含有mRNA的药物
WO2025021989A1 (en) * 2023-07-27 2025-01-30 E-Therapeutics Plc Inhibitors of expression and/or function

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Also Published As

Publication number Publication date
US10738284B2 (en) 2020-08-11
IL271073B2 (en) 2025-10-01
FI3635102T3 (fi) 2025-10-28
CA3065938A1 (en) 2018-12-13
EP3635102A1 (en) 2020-04-15
JP2020527329A (ja) 2020-09-10
RU2019144018A3 (cg-RX-API-DMAC7.html) 2022-03-04
JP2023113657A (ja) 2023-08-16
IL271073A (en) 2020-01-30
US20200399617A1 (en) 2020-12-24
KR102624979B1 (ko) 2024-01-16
EP3635102B1 (en) 2025-08-13
DK3635102T3 (da) 2025-10-27
JP7661009B2 (ja) 2025-04-14
US20180346888A1 (en) 2018-12-06
WO2018226560A1 (en) 2018-12-13
AU2018282072B2 (en) 2024-06-27
IL271073B1 (en) 2025-06-01
MX2019014661A (es) 2020-07-29
RU2019144018A (ru) 2021-07-09
ES3049196T3 (en) 2025-12-15
CN110997906B (zh) 2024-05-07
AU2018282072A1 (en) 2020-01-16
CN110997906A (zh) 2020-04-10
US12480103B2 (en) 2025-11-25
KR20200024772A (ko) 2020-03-09

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