JP2020524136A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020524136A5 JP2020524136A5 JP2019567573A JP2019567573A JP2020524136A5 JP 2020524136 A5 JP2020524136 A5 JP 2020524136A5 JP 2019567573 A JP2019567573 A JP 2019567573A JP 2019567573 A JP2019567573 A JP 2019567573A JP 2020524136 A5 JP2020524136 A5 JP 2020524136A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- groups
- alkyl
- different
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004001 thioalkyl group Chemical group 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 CCC(C)*[n]1nnc(*)c1 Chemical compound CCC(C)*[n]1nnc(*)c1 0.000 description 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305664.9 | 2017-06-06 | ||
| EP17305664.9A EP3412652A1 (en) | 2017-06-06 | 2017-06-06 | Inhibitors of rac1 and uses thereof for treating cancers |
| PCT/EP2018/064928 WO2018224563A1 (en) | 2017-06-06 | 2018-06-06 | Inhibitors of rac1 and uses thereof for treating cancers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020524136A JP2020524136A (ja) | 2020-08-13 |
| JP2020524136A5 true JP2020524136A5 (enExample) | 2021-07-26 |
| JP7316227B2 JP7316227B2 (ja) | 2023-07-27 |
Family
ID=59034696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019567573A Active JP7316227B2 (ja) | 2017-06-06 | 2018-06-06 | がん治療のためのｒａｃ１阻害剤及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11795144B2 (enExample) |
| EP (2) | EP3412652A1 (enExample) |
| JP (1) | JP7316227B2 (enExample) |
| CA (1) | CA3066031A1 (enExample) |
| WO (1) | WO2018224563A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3412651A1 (en) * | 2017-06-06 | 2018-12-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibitors of rac1 and uses thereof for inducing bronchodilatation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2192490A (en) * | 1936-03-21 | 1940-03-05 | Hoffmann La Roche | Derivatives of 4-aminobenzenesulphonamides and process for the manufacture of same |
| US2407309A (en) * | 1942-02-04 | 1946-09-10 | Squibb & Sons Inc | Chemotherapeutic agents of the sulphonamide type |
| US5939451A (en) * | 1996-06-28 | 1999-08-17 | Hoffmann-La Roche Inc. | Use of sulfonamides |
| JPH10193554A (ja) | 1997-01-16 | 1998-07-28 | Fuji Photo Film Co Ltd | ネガ型画像記録材料 |
| US6521658B1 (en) * | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| CA2379526A1 (en) | 2002-03-28 | 2003-09-28 | Gilles Sauve | Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors |
| GB0215650D0 (en) * | 2002-07-05 | 2002-08-14 | Cyclacel Ltd | Bisarylsufonamide compounds |
| AU2004263179B8 (en) | 2003-08-08 | 2011-07-14 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| US8673910B2 (en) | 2008-06-30 | 2014-03-18 | H. Lee Moffitt Cancer Center And Research Institute | Proteasome inhibitors for selectively inducing apoptosis in cancer cells |
| CN101429142B (zh) * | 2008-12-17 | 2011-11-16 | 山东大学 | 一种含氮多羟基芳香类化合物及其制备方法和应用 |
| US20110275635A1 (en) * | 2009-01-09 | 2011-11-10 | The Uab Research Foundation | Small molecule inhibitors of nads, namnat, and nmnat |
| WO2010111713A2 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | N-linked glycan biosynthesis modulators |
| WO2012142698A1 (en) * | 2011-04-20 | 2012-10-26 | Universite Laval | Alkylurea derivatives active against cancer cells |
| US9499488B2 (en) | 2011-07-11 | 2016-11-22 | Beth Israel Deaconess Medical Center, Inc. | Vitamin D receptor agonists and uses thereof |
| WO2015138377A1 (en) | 2014-03-10 | 2015-09-17 | The University Of Chicago | Methods of treating cancer using rad51small molecule stimulators |
-
2017
- 2017-06-06 EP EP17305664.9A patent/EP3412652A1/en not_active Withdrawn
-
2018
- 2018-06-06 EP EP18728643.0A patent/EP3634949B1/en active Active
- 2018-06-06 CA CA3066031A patent/CA3066031A1/en active Pending
- 2018-06-06 WO PCT/EP2018/064928 patent/WO2018224563A1/en not_active Ceased
- 2018-06-06 JP JP2019567573A patent/JP7316227B2/ja active Active
- 2018-06-06 US US16/619,311 patent/US11795144B2/en active Active