CA3066031A1 - Inhibitors of rac1 and uses thereof for treating cancers - Google Patents
Inhibitors of rac1 and uses thereof for treating cancers Download PDFInfo
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- CA3066031A1 CA3066031A1 CA3066031A CA3066031A CA3066031A1 CA 3066031 A1 CA3066031 A1 CA 3066031A1 CA 3066031 A CA3066031 A CA 3066031A CA 3066031 A CA3066031 A CA 3066031A CA 3066031 A1 CA3066031 A1 CA 3066031A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305664.9A EP3412652A1 (en) | 2017-06-06 | 2017-06-06 | Inhibitors of rac1 and uses thereof for treating cancers |
| EP17305664.9 | 2017-06-06 | ||
| PCT/EP2018/064928 WO2018224563A1 (en) | 2017-06-06 | 2018-06-06 | Inhibitors of rac1 and uses thereof for treating cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3066031A1 true CA3066031A1 (en) | 2018-12-13 |
Family
ID=59034696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3066031A Pending CA3066031A1 (en) | 2017-06-06 | 2018-06-06 | Inhibitors of rac1 and uses thereof for treating cancers |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11795144B2 (enExample) |
| EP (2) | EP3412652A1 (enExample) |
| JP (1) | JP7316227B2 (enExample) |
| CA (1) | CA3066031A1 (enExample) |
| WO (1) | WO2018224563A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3412651A1 (en) | 2017-06-06 | 2018-12-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibitors of rac1 and uses thereof for inducing bronchodilatation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2192490A (en) * | 1936-03-21 | 1940-03-05 | Hoffmann La Roche | Derivatives of 4-aminobenzenesulphonamides and process for the manufacture of same |
| US2407309A (en) * | 1942-02-04 | 1946-09-10 | Squibb & Sons Inc | Chemotherapeutic agents of the sulphonamide type |
| US5939451A (en) * | 1996-06-28 | 1999-08-17 | Hoffmann-La Roche Inc. | Use of sulfonamides |
| JPH10193554A (ja) * | 1997-01-16 | 1998-07-28 | Fuji Photo Film Co Ltd | ネガ型画像記録材料 |
| US6521658B1 (en) * | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| CA2379526A1 (en) * | 2002-03-28 | 2003-09-28 | Gilles Sauve | Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors |
| GB0215650D0 (en) | 2002-07-05 | 2002-08-14 | Cyclacel Ltd | Bisarylsufonamide compounds |
| CA2539227A1 (en) | 2003-08-08 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| US8673910B2 (en) | 2008-06-30 | 2014-03-18 | H. Lee Moffitt Cancer Center And Research Institute | Proteasome inhibitors for selectively inducing apoptosis in cancer cells |
| CN101429142B (zh) * | 2008-12-17 | 2011-11-16 | 山东大学 | 一种含氮多羟基芳香类化合物及其制备方法和应用 |
| US20110275635A1 (en) * | 2009-01-09 | 2011-11-10 | The Uab Research Foundation | Small molecule inhibitors of nads, namnat, and nmnat |
| WO2010111713A2 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | N-linked glycan biosynthesis modulators |
| WO2012142698A1 (en) * | 2011-04-20 | 2012-10-26 | Universite Laval | Alkylurea derivatives active against cancer cells |
| US9499488B2 (en) | 2011-07-11 | 2016-11-22 | Beth Israel Deaconess Medical Center, Inc. | Vitamin D receptor agonists and uses thereof |
| WO2015138377A1 (en) | 2014-03-10 | 2015-09-17 | The University Of Chicago | Methods of treating cancer using rad51small molecule stimulators |
-
2017
- 2017-06-06 EP EP17305664.9A patent/EP3412652A1/en not_active Withdrawn
-
2018
- 2018-06-06 CA CA3066031A patent/CA3066031A1/en active Pending
- 2018-06-06 EP EP18728643.0A patent/EP3634949B1/en active Active
- 2018-06-06 JP JP2019567573A patent/JP7316227B2/ja active Active
- 2018-06-06 US US16/619,311 patent/US11795144B2/en active Active
- 2018-06-06 WO PCT/EP2018/064928 patent/WO2018224563A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP3412652A1 (en) | 2018-12-12 |
| US11795144B2 (en) | 2023-10-24 |
| EP3634949A1 (en) | 2020-04-15 |
| EP3634949B1 (en) | 2025-03-19 |
| JP2020524136A (ja) | 2020-08-13 |
| WO2018224563A9 (en) | 2021-04-22 |
| WO2018224563A1 (en) | 2018-12-13 |
| JP7316227B2 (ja) | 2023-07-27 |
| US20200095199A1 (en) | 2020-03-26 |
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| EEER | Examination request |
Effective date: 20220922 |