JP2020523037A5 - - Google Patents
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- JP2020523037A5 JP2020523037A5 JP2020518110A JP2020518110A JP2020523037A5 JP 2020523037 A5 JP2020523037 A5 JP 2020523037A5 JP 2020518110 A JP2020518110 A JP 2020518110A JP 2020518110 A JP2020518110 A JP 2020518110A JP 2020523037 A5 JP2020523037 A5 JP 2020523037A5
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Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| HK1254190A1 (zh) | 2015-05-08 | 2019-07-12 | President And Fellows Of Harvard College | 通用供体干细胞和相关方法 |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| MX2020007071A (es) | 2018-01-05 | 2020-11-11 | Platelet Biogenesis Inc | Composiciones y metodos para producir megacariocitos. |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| US10724052B2 (en) | 2018-09-07 | 2020-07-28 | Crispr Therapeutics Ag | Universal donor cells |
| WO2020118447A1 (en) * | 2018-12-13 | 2020-06-18 | Sinai Health System | Immunomodulatory cells and uses thereof |
| CN113544261B (zh) * | 2019-02-27 | 2024-10-01 | 武田药品工业株式会社 | 用于同种异体疗法的改良的干细胞群 |
| CN110179824A (zh) * | 2019-04-01 | 2019-08-30 | 普米斯生物技术(珠海)有限公司 | 一种通过免疫调控治疗ii型糖尿病的新方法 |
| SG11202112506SA (en) | 2019-05-10 | 2021-12-30 | Univ California | Modified pluripotent cells |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| EP4021934A4 (en) * | 2019-08-30 | 2024-02-14 | The Regents of the University of California | Gene fragment overexpression screening methodologies, and uses thereof |
| AU2020340622A1 (en) | 2019-09-05 | 2022-03-03 | Crispr Therapeutics Ag | Universal donor cells |
| CA3164591A1 (en) | 2020-01-13 | 2021-07-22 | William Dowdle | Modification of blood type antigens |
| WO2021163451A1 (en) * | 2020-02-14 | 2021-08-19 | Asklepios Biopharmaceutical, Inc. | Method of treating gene therapy associated toxicity with antibiotics |
| WO2021197430A1 (en) * | 2020-04-01 | 2021-10-07 | Nanjing Legend Biotech Co., Ltd. | Compositions and methods for reducing graft rejection in allogeneic cell therapy |
| CN115697355A (zh) * | 2020-04-30 | 2023-02-03 | 全国儿童医院研究所 | 用抗TGF-β的NK细胞克服免疫抑制 |
| CN112089847B (zh) * | 2020-08-31 | 2021-05-28 | 高连如 | 一种融合pnv靶向缺血心肌血管的干细胞药物及制备方法 |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
| AU2021414405A1 (en) | 2020-12-31 | 2023-08-10 | Crispr Therapeutics Ag | Universal donor cells |
| CN112972681B (zh) * | 2021-01-27 | 2022-06-07 | 西安交通大学 | Mt-nd6作为新靶点在代谢综合征诊断和治疗药物中的应用 |
| CN115124625B (zh) * | 2021-03-24 | 2024-11-26 | 圣安生医股份有限公司 | 免疫调节及抗肿瘤相关纳米抗体、其核酸编码序列及应用 |
| US20230016422A1 (en) * | 2021-06-23 | 2023-01-19 | Crispr Therapeutics Ag | Engineered cells with improved protection from natural killer cell killing |
| WO2023023278A2 (en) * | 2021-08-18 | 2023-02-23 | University Of Utah Research Foundation | Multigene constructs for treatment of age-related macular degeneration and other complement dysregulation-related conditions |
| WO2023098729A1 (en) * | 2021-11-30 | 2023-06-08 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric genes |
| KR102803344B1 (ko) * | 2022-01-19 | 2025-05-07 | 고려대학교 산학협력단 | Mfg-e8의 활성 제어를 통한 전능성 줄기세포의 선택적 세포사멸 유도 |
| WO2024012420A1 (zh) * | 2022-07-11 | 2024-01-18 | 士泽生物医药(苏州)有限公司 | 一种表达faslg的通用型细胞及其制备方法 |
| WO2024091959A1 (en) * | 2022-10-24 | 2024-05-02 | The Regents Of The University Of California | Drug resistant immune cells |
| CN116785312B (zh) * | 2023-06-21 | 2023-11-14 | 天津医科大学眼科医院 | miR-15a-5p在治疗眼底疾病中的应用 |
| CN119055769B (zh) * | 2023-08-17 | 2025-09-05 | 南方医科大学南方医院 | 抗血管生成药物在提高软组织移植物保留率中的应用 |
| WO2025064604A2 (en) * | 2023-09-19 | 2025-03-27 | Musc Foundation For Research Development | Combination engineered cell therapy |
| WO2025106557A1 (en) * | 2023-11-13 | 2025-05-22 | Bluerock Therapeutics Lp | Genetically modified cells for enhanced immune evasion in allogeneic cellular therapies |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002072798A1 (en) * | 2001-03-13 | 2002-09-19 | Johns Hopkins University School Of Medicine | Fas ligand-expressing hematopoietic cells for transplantation |
| EP1879448A2 (en) * | 2005-02-25 | 2008-01-23 | University of Chicago | Compositions and methods related to serpin spi6 |
| NZ597304A (en) * | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
| EP2300023A2 (en) | 2008-05-16 | 2011-03-30 | Genelux Corporation | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
| EP2547328B1 (en) * | 2010-02-11 | 2017-06-07 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Ccr7 ligand delivery and co-delivery in immunotherapy |
| TWI677507B (zh) * | 2012-06-22 | 2019-11-21 | 達特茅斯學院基金會 | 新穎之vista-ig構築體及vista-ig用於治療自體免疫、過敏及發炎病症之用途 |
| JP6297559B2 (ja) * | 2012-07-31 | 2018-03-20 | バジル・エム・ハンタッシュBasil M. HANTASH | Hlag改変された細胞および方法 |
| EP3021942A4 (en) * | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| SG10202006338UA (en) | 2014-06-18 | 2020-08-28 | Albert Einstein College Medicine Inc | Syntac polypeptides and uses thereof |
| WO2016081924A1 (en) * | 2014-11-20 | 2016-05-26 | Duke University | Compositions, systems and methods for cell therapy |
| ES2969389T3 (es) * | 2014-12-05 | 2024-05-17 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 47 humanizado |
| HUE055500T2 (hu) * | 2015-03-09 | 2021-11-29 | Sinai Health Sys | Eszközök és módszerek a sejtdivíciós loci használatára a sejtek szaporodásának szabályozására |
| EP3274715A4 (en) * | 2015-03-27 | 2018-10-10 | University of Southern California | Hla-g as a novel target for car t-cell immunotherapy |
| HK1254190A1 (zh) | 2015-05-08 | 2019-07-12 | President And Fellows Of Harvard College | 通用供体干细胞和相关方法 |
| US11207393B2 (en) * | 2015-10-16 | 2021-12-28 | President And Fellows Of Harvard College | Regulatory T cell PD-1 modulation for regulating T cell effector immune responses |
| MX2019008413A (es) | 2017-01-13 | 2019-09-13 | Univ California | Celulas pluripotentes inmunodiseñadas. |
| EP4017508A1 (en) | 2019-08-23 | 2022-06-29 | Sana Biotechnology, Inc. | Cd24 expressing cells and uses thereof |
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2018
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- 2018-06-12 EP EP18818206.7A patent/EP3638258A4/en active Pending
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- 2018-06-12 KR KR1020247039926A patent/KR20250005439A/ko active Pending
- 2018-06-12 KR KR1020207000550A patent/KR102738427B1/ko active Active
- 2018-06-12 AU AU2018285972A patent/AU2018285972B2/en active Active
- 2018-06-12 GB GB1917408.5A patent/GB2588249B/en active Active
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- 2018-06-12 CN CN201880038734.5A patent/CN110869494B/zh active Active
- 2018-06-12 US US16/621,490 patent/US20210161971A1/en not_active Abandoned
- 2018-06-12 JP JP2020518110A patent/JP7391016B2/ja active Active
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2023
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2024
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