JP2020521958A5 - - Google Patents
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- JP2020521958A5 JP2020521958A5 JP2019564473A JP2019564473A JP2020521958A5 JP 2020521958 A5 JP2020521958 A5 JP 2020521958A5 JP 2019564473 A JP2019564473 A JP 2019564473A JP 2019564473 A JP2019564473 A JP 2019564473A JP 2020521958 A5 JP2020521958 A5 JP 2020521958A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- aliquot
- analyzer
- processed
- mass spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 238000000034 method Methods 0.000 claims description 98
- 238000004458 analytical method Methods 0.000 claims description 74
- 239000012491 analyte Substances 0.000 claims description 53
- 239000003153 chemical reaction reagent Substances 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims description 27
- 238000001514 detection method Methods 0.000 claims description 13
- 238000004949 mass spectrometry Methods 0.000 claims description 10
- 238000010828 elution Methods 0.000 claims description 9
- 230000003287 optical effect Effects 0.000 claims description 9
- 238000005070 sampling Methods 0.000 claims description 8
- 238000003018 immunoassay Methods 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000000523 sample Substances 0.000 claims 122
- 150000002500 ions Chemical class 0.000 claims 12
- 238000002360 preparation method Methods 0.000 claims 10
- 239000002904 solvent Substances 0.000 claims 4
- 239000007850 fluorescent dye Substances 0.000 claims 3
- 238000005086 pumping Methods 0.000 claims 3
- 239000007853 buffer solution Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- 239000012488 sample solution Substances 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 239000012925 reference material Substances 0.000 claims 1
- 239000002699 waste material Substances 0.000 claims 1
- 238000007885 magnetic separation Methods 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 239000000090 biomarker Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000006920 protein precipitation Effects 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023037413A JP7594618B2 (ja) | 2017-05-22 | 2023-03-10 | 複数の検出能力を有する統合試料処理システム |
| JP2024113092A JP2024133264A (ja) | 2017-05-22 | 2024-07-16 | 複数の検出能力を有する統合試料処理システム |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762509601P | 2017-05-22 | 2017-05-22 | |
| US62/509,601 | 2017-05-22 | ||
| US201762607773P | 2017-12-19 | 2017-12-19 | |
| US62/607,773 | 2017-12-19 | ||
| PCT/US2018/033927 WO2018217778A1 (en) | 2017-05-22 | 2018-05-22 | Integrated sample processing system with multiple detection capability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023037413A Division JP7594618B2 (ja) | 2017-05-22 | 2023-03-10 | 複数の検出能力を有する統合試料処理システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020521958A JP2020521958A (ja) | 2020-07-27 |
| JP2020521958A5 true JP2020521958A5 (https=) | 2021-07-26 |
Family
ID=62621016
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564473A Withdrawn JP2020521958A (ja) | 2017-05-22 | 2018-05-22 | 複数の検出能力を有する統合試料処理システム |
| JP2023037413A Active JP7594618B2 (ja) | 2017-05-22 | 2023-03-10 | 複数の検出能力を有する統合試料処理システム |
| JP2024113092A Pending JP2024133264A (ja) | 2017-05-22 | 2024-07-16 | 複数の検出能力を有する統合試料処理システム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023037413A Active JP7594618B2 (ja) | 2017-05-22 | 2023-03-10 | 複数の検出能力を有する統合試料処理システム |
| JP2024113092A Pending JP2024133264A (ja) | 2017-05-22 | 2024-07-16 | 複数の検出能力を有する統合試料処理システム |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11402386B2 (https=) |
| EP (2) | EP4411387A3 (https=) |
| JP (3) | JP2020521958A (https=) |
| CN (2) | CN110959185B (https=) |
| WO (1) | WO2018217778A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018217778A1 (en) * | 2017-05-22 | 2018-11-29 | Beckman Coulter, Inc. | Integrated sample processing system with multiple detection capability |
| US11125738B2 (en) | 2018-11-06 | 2021-09-21 | Thermo Finnigan Llc | Blood sample analysis systems and methods |
| WO2020129032A1 (en) * | 2018-12-21 | 2020-06-25 | Dh Technologies Development Pte. Ltd. | Method for measuring testosterone using lc-msms |
| WO2020225971A1 (ja) | 2019-05-08 | 2020-11-12 | 株式会社日立ハイテク | 自動分析装置の前処理方法 |
| CA3156003A1 (en) * | 2019-09-25 | 2021-04-01 | The Trustees Of Indiana University | Apparatus and method for pulsed mode charge detection mass spectrometry |
| WO2021064559A1 (en) | 2019-09-30 | 2021-04-08 | Dh Technologies Development Pte. Ltd. | Sampling probe with internal sampling for use in mass spectrometry systems and methods |
| KR102849777B1 (ko) | 2019-10-10 | 2025-08-22 | 더 트러스티즈 오브 인디애나 유니버시티 | 입자들을 식별, 선택 및 정제하기 위한 시스템 및 방법 |
| CN113777332B (zh) * | 2020-06-09 | 2024-06-18 | 深圳迈瑞生物医疗电子股份有限公司 | 免疫分析仪和自身免疫分析方法 |
| WO2022146775A1 (en) * | 2020-12-30 | 2022-07-07 | Beckman Coulter, Inc. | Integrated automated analyzer and methods of analyzing whole blood and plasma from a single sample tube |
| CN116670513A (zh) * | 2020-12-30 | 2023-08-29 | 贝克曼库尔特有限公司 | 利用单个校准品的临床实验室自动化系统 |
| WO2022172199A1 (en) * | 2021-02-10 | 2022-08-18 | Dh Technologies Development Pte. Ltd. | Affinity selection by mass spectrometry workflow using magnetic particles |
| EP4308917B1 (en) | 2021-03-19 | 2025-04-30 | DH Technologies Development Pte. Ltd. | Non-contact sampler with an open-port interface for liquid chromatography systems |
| CN117178343A (zh) | 2021-03-23 | 2023-12-05 | Dh科技发展私人贸易有限公司 | 输送液体中的基于气泡的样品分离 |
| WO2022254404A1 (en) * | 2021-06-03 | 2022-12-08 | Dh Technologies Development Pte. Ltd. | System and methods for sample processing with mass spectrometry incorporating magnetic beads |
| CN114047345B (zh) * | 2021-11-09 | 2022-09-09 | 中元汇吉生物技术股份有限公司 | 一种样本优先调度方法、调度系统及检测系统 |
| EP4430382A1 (en) | 2021-11-12 | 2024-09-18 | Beckman Coulter, Inc. | System and methods for surface enhanced raman spectroscopy |
| CN116413253B (zh) * | 2023-03-15 | 2025-10-10 | 宁波海尔施智造有限公司 | 一种人乳头瘤病毒检测试剂及其应用 |
| US12605394B2 (en) | 2024-07-25 | 2026-04-21 | Visionary Assets, Llc | Compositions containing cannabinoid nanoparticles |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58628B2 (ja) * | 1976-08-17 | 1983-01-07 | 株式会社島津製作所 | 自動分折装置 |
| US20030027216A1 (en) | 2001-07-02 | 2003-02-06 | Kiernan Urban A. | Analysis of proteins from biological fluids using mass spectrometric immunoassay |
| US6746648B1 (en) | 2000-06-15 | 2004-06-08 | Beckman Coulter, Inc. | Method and system for transporting and storing multiple reagent packs and reagent packs used therein |
| US6520755B1 (en) | 2000-10-10 | 2003-02-18 | Beckman Coulter, Inc. | Fluid-moving device with integrated valve |
| US6843481B1 (en) | 2000-10-10 | 2005-01-18 | Beckman Coulter, Inc. | Fluid-moving device with a clearance seal |
| US7128874B2 (en) | 2001-01-26 | 2006-10-31 | Beckman Coulter, Inc. | Method and system for picking and placing vessels |
| US6790412B2 (en) | 2001-02-06 | 2004-09-14 | Beckman Coulter, Inc. | Bulk vessel feeder |
| US7217391B2 (en) | 2001-03-16 | 2007-05-15 | Beckman Coulter, Inc. | Rotary incubation station for immunoassay systems |
| US6790413B2 (en) | 2001-05-03 | 2004-09-14 | Beckman Coulter, Inc. | Sample presentation unit |
| US7632686B2 (en) | 2002-10-03 | 2009-12-15 | Anderson Forschung Group | High sensitivity quantitation of peptides by mass spectrometry |
| US20060159587A1 (en) * | 2005-01-19 | 2006-07-20 | Beckman Coulter, Inc. | Automated clinical analyzer with dual level storage and access |
| JP2007000687A (ja) | 2005-06-21 | 2007-01-11 | Shimadzu Corp | 生体試料中のペプチド分析方法及び装置 |
| ATE495447T1 (de) | 2006-07-03 | 2011-01-15 | Univ Johns Hopkins | Peptidantikörperdepletion und anwendung zur probenvorbereitung für massenspektrometrie |
| JP2010175355A (ja) | 2009-01-29 | 2010-08-12 | Hitachi High-Technologies Corp | 自動分析装置 |
| DE112010000814B4 (de) * | 2009-02-10 | 2021-09-09 | Hitachi High-Tech Corporation | Immunanalytisches Verfahren und immunanalytisches System mit Verwendung der Massenspektrometertechnologie |
| US9415392B2 (en) * | 2009-03-24 | 2016-08-16 | The University Of Chicago | Slip chip device and methods |
| JP5390021B2 (ja) * | 2009-07-29 | 2014-01-15 | エフ．ホフマン−ラ ロシュ アーゲー | 自動分析器 |
| DE202011111050U1 (de) * | 2010-10-29 | 2018-11-20 | Thermo Fisher Scientific Oy | Automatisiertes System zur Probenaufbereitung und -analyse |
| EP2466308B1 (en) | 2010-12-14 | 2018-02-07 | Universitätsmedizin Greifswald Körperschaft des Öffentlichen Rechts Institut für Immunologie und Transfusionsmedizin Abteilung Immunologie | Immunoassay device and use of the device (immunoassay) |
| CN103782166B (zh) | 2011-06-06 | 2018-01-16 | 沃特世科技公司 | 用于定量样品中目标分析物的组合物、方法和试剂盒 |
| US9328386B2 (en) * | 2011-08-16 | 2016-05-03 | Evotec (München) Gmbh | Markers for susceptibility to an inhibitor of an Src-family kinase |
| US9074236B2 (en) * | 2012-05-01 | 2015-07-07 | Oxoid Limited | Apparatus and methods for microbial identification by mass spectrometry |
| SG11201408652SA (en) | 2012-06-26 | 2015-01-29 | Biodesix Inc | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| US20160026754A1 (en) | 2013-03-14 | 2016-01-28 | President And Fellows Of Harvard College | Methods and systems for identifying a physiological state of a target cell |
| WO2015105883A1 (en) | 2014-01-07 | 2015-07-16 | Arizona Board Of Regents On Behalf Of Arizona State University | Apolipoprotein c biomarkers and methods for cholesterol efflux and cardiovascular health |
| DE112015002589T5 (de) * | 2014-07-07 | 2017-06-01 | Hitachi High-Technologies Corporation | Analysenvorrichtung und Analysenverfahren |
| JP2016156675A (ja) | 2015-02-24 | 2016-09-01 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び分析方法 |
| MX388995B (es) * | 2015-06-25 | 2025-03-20 | Native Microbials Inc | Métodos, aparatos y sistemas para analizar cepas de microorganismos de comunidades heterogéneas complejas, predecir e indentificar sus relaciones funcionales e interacciones y seleccionar y sintetizar conjuntos microbianos basados en estos. |
| WO2018217778A1 (en) | 2017-05-22 | 2018-11-29 | Beckman Coulter, Inc. | Integrated sample processing system with multiple detection capability |
-
2018
- 2018-05-22 WO PCT/US2018/033927 patent/WO2018217778A1/en not_active Ceased
- 2018-05-22 EP EP24166653.6A patent/EP4411387A3/en active Pending
- 2018-05-22 CN CN201880049114.1A patent/CN110959185B/zh active Active
- 2018-05-22 US US16/616,052 patent/US11402386B2/en active Active
- 2018-05-22 JP JP2019564473A patent/JP2020521958A/ja not_active Withdrawn
- 2018-05-22 CN CN202310699080.3A patent/CN116825604A/zh active Pending
- 2018-05-22 EP EP18731643.5A patent/EP3631839B1/en active Active
-
2022
- 2022-07-25 US US17/814,530 patent/US11988670B2/en active Active
-
2023
- 2023-03-10 JP JP2023037413A patent/JP7594618B2/ja active Active
-
2024
- 2024-04-09 US US18/630,611 patent/US20250027950A1/en active Pending
- 2024-07-16 JP JP2024113092A patent/JP2024133264A/ja active Pending
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