CN110959185B - 具有多种检测能力的集成样品处理系统 - Google Patents

具有多种检测能力的集成样品处理系统 Download PDF

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Publication number
CN110959185B
CN110959185B CN201880049114.1A CN201880049114A CN110959185B CN 110959185 B CN110959185 B CN 110959185B CN 201880049114 A CN201880049114 A CN 201880049114A CN 110959185 B CN110959185 B CN 110959185B
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sample
mass spectrometer
aliquot
processed
analysis
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Chinese (zh)
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CN110959185A (zh
Inventor
阿伦·胡德松
水谷高雪
苏巴西什·普尔卡亚斯塔
托马斯·W·罗斯科
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DH Technologies Development Pte Ltd
Beckman Coulter Inc
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DH Technologies Development Pte Ltd
Beckman Coulter Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/025—Detectors specially adapted to particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN201880049114.1A 2017-05-22 2018-05-22 具有多种检测能力的集成样品处理系统 Active CN110959185B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310699080.3A CN116825604A (zh) 2017-05-22 2018-05-22 样品处理系统和由其执行的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762509601P 2017-05-22 2017-05-22
US62/509,601 2017-05-22
US201762607773P 2017-12-19 2017-12-19
US62/607,773 2017-12-19
PCT/US2018/033927 WO2018217778A1 (en) 2017-05-22 2018-05-22 Integrated sample processing system with multiple detection capability

Related Child Applications (1)

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CN202310699080.3A Division CN116825604A (zh) 2017-05-22 2018-05-22 样品处理系统和由其执行的方法

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CN110959185A CN110959185A (zh) 2020-04-03
CN110959185B true CN110959185B (zh) 2023-06-30

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CN202310699080.3A Pending CN116825604A (zh) 2017-05-22 2018-05-22 样品处理系统和由其执行的方法

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US (3) US11402386B2 (https=)
EP (2) EP4411387A3 (https=)
JP (3) JP2020521958A (https=)
CN (2) CN110959185B (https=)
WO (1) WO2018217778A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018217778A1 (en) * 2017-05-22 2018-11-29 Beckman Coulter, Inc. Integrated sample processing system with multiple detection capability
US11125738B2 (en) 2018-11-06 2021-09-21 Thermo Finnigan Llc Blood sample analysis systems and methods
WO2020129032A1 (en) * 2018-12-21 2020-06-25 Dh Technologies Development Pte. Ltd. Method for measuring testosterone using lc-msms
WO2020225971A1 (ja) 2019-05-08 2020-11-12 株式会社日立ハイテク 自動分析装置の前処理方法
CA3156003A1 (en) * 2019-09-25 2021-04-01 The Trustees Of Indiana University Apparatus and method for pulsed mode charge detection mass spectrometry
WO2021064559A1 (en) 2019-09-30 2021-04-08 Dh Technologies Development Pte. Ltd. Sampling probe with internal sampling for use in mass spectrometry systems and methods
KR102849777B1 (ko) 2019-10-10 2025-08-22 더 트러스티즈 오브 인디애나 유니버시티 입자들을 식별, 선택 및 정제하기 위한 시스템 및 방법
CN113777332B (zh) * 2020-06-09 2024-06-18 深圳迈瑞生物医疗电子股份有限公司 免疫分析仪和自身免疫分析方法
WO2022146775A1 (en) * 2020-12-30 2022-07-07 Beckman Coulter, Inc. Integrated automated analyzer and methods of analyzing whole blood and plasma from a single sample tube
CN116670513A (zh) * 2020-12-30 2023-08-29 贝克曼库尔特有限公司 利用单个校准品的临床实验室自动化系统
WO2022172199A1 (en) * 2021-02-10 2022-08-18 Dh Technologies Development Pte. Ltd. Affinity selection by mass spectrometry workflow using magnetic particles
EP4308917B1 (en) 2021-03-19 2025-04-30 DH Technologies Development Pte. Ltd. Non-contact sampler with an open-port interface for liquid chromatography systems
CN117178343A (zh) 2021-03-23 2023-12-05 Dh科技发展私人贸易有限公司 输送液体中的基于气泡的样品分离
WO2022254404A1 (en) * 2021-06-03 2022-12-08 Dh Technologies Development Pte. Ltd. System and methods for sample processing with mass spectrometry incorporating magnetic beads
CN114047345B (zh) * 2021-11-09 2022-09-09 中元汇吉生物技术股份有限公司 一种样本优先调度方法、调度系统及检测系统
EP4430382A1 (en) 2021-11-12 2024-09-18 Beckman Coulter, Inc. System and methods for surface enhanced raman spectroscopy
CN116413253B (zh) * 2023-03-15 2025-10-10 宁波海尔施智造有限公司 一种人乳头瘤病毒检测试剂及其应用
US12605394B2 (en) 2024-07-25 2026-04-21 Visionary Assets, Llc Compositions containing cannabinoid nanoparticles

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5323691A (en) * 1976-08-17 1978-03-04 Shimadzu Corp Automatic analyzer
CN102308215A (zh) * 2009-02-10 2012-01-04 株式会社日立高新技术 使用了质谱分析技术的免疫分析方法和免疫分析系统
CN103370627A (zh) * 2010-10-29 2013-10-23 恩姆菲舍尔科技公司 用于样品制备和分析的自动化系统的系统布局
WO2016006398A1 (ja) * 2014-07-07 2016-01-14 株式会社 日立ハイテクノロジーズ 分析装置および分析方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030027216A1 (en) 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
US6746648B1 (en) 2000-06-15 2004-06-08 Beckman Coulter, Inc. Method and system for transporting and storing multiple reagent packs and reagent packs used therein
US6520755B1 (en) 2000-10-10 2003-02-18 Beckman Coulter, Inc. Fluid-moving device with integrated valve
US6843481B1 (en) 2000-10-10 2005-01-18 Beckman Coulter, Inc. Fluid-moving device with a clearance seal
US7128874B2 (en) 2001-01-26 2006-10-31 Beckman Coulter, Inc. Method and system for picking and placing vessels
US6790412B2 (en) 2001-02-06 2004-09-14 Beckman Coulter, Inc. Bulk vessel feeder
US7217391B2 (en) 2001-03-16 2007-05-15 Beckman Coulter, Inc. Rotary incubation station for immunoassay systems
US6790413B2 (en) 2001-05-03 2004-09-14 Beckman Coulter, Inc. Sample presentation unit
US7632686B2 (en) 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry
US20060159587A1 (en) * 2005-01-19 2006-07-20 Beckman Coulter, Inc. Automated clinical analyzer with dual level storage and access
JP2007000687A (ja) 2005-06-21 2007-01-11 Shimadzu Corp 生体試料中のペプチド分析方法及び装置
ATE495447T1 (de) 2006-07-03 2011-01-15 Univ Johns Hopkins Peptidantikörperdepletion und anwendung zur probenvorbereitung für massenspektrometrie
JP2010175355A (ja) 2009-01-29 2010-08-12 Hitachi High-Technologies Corp 自動分析装置
US9415392B2 (en) * 2009-03-24 2016-08-16 The University Of Chicago Slip chip device and methods
JP5390021B2 (ja) * 2009-07-29 2014-01-15 エフ．ホフマン−ラ ロシュ アーゲー 自動分析器
EP2466308B1 (en) 2010-12-14 2018-02-07 Universitätsmedizin Greifswald Körperschaft des Öffentlichen Rechts Institut für Immunologie und Transfusionsmedizin Abteilung Immunologie Immunoassay device and use of the device (immunoassay)
CN103782166B (zh) 2011-06-06 2018-01-16 沃特世科技公司 用于定量样品中目标分析物的组合物、方法和试剂盒
US9328386B2 (en) * 2011-08-16 2016-05-03 Evotec (München) Gmbh Markers for susceptibility to an inhibitor of an Src-family kinase
US9074236B2 (en) * 2012-05-01 2015-07-07 Oxoid Limited Apparatus and methods for microbial identification by mass spectrometry
SG11201408652SA (en) 2012-06-26 2015-01-29 Biodesix Inc Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
US20160026754A1 (en) 2013-03-14 2016-01-28 President And Fellows Of Harvard College Methods and systems for identifying a physiological state of a target cell
WO2015105883A1 (en) 2014-01-07 2015-07-16 Arizona Board Of Regents On Behalf Of Arizona State University Apolipoprotein c biomarkers and methods for cholesterol efflux and cardiovascular health
JP2016156675A (ja) 2015-02-24 2016-09-01 株式会社日立ハイテクノロジーズ 自動分析装置及び分析方法
MX388995B (es) * 2015-06-25 2025-03-20 Native Microbials Inc Métodos, aparatos y sistemas para analizar cepas de microorganismos de comunidades heterogéneas complejas, predecir e indentificar sus relaciones funcionales e interacciones y seleccionar y sintetizar conjuntos microbianos basados en estos.
WO2018217778A1 (en) 2017-05-22 2018-11-29 Beckman Coulter, Inc. Integrated sample processing system with multiple detection capability

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5323691A (en) * 1976-08-17 1978-03-04 Shimadzu Corp Automatic analyzer
CN102308215A (zh) * 2009-02-10 2012-01-04 株式会社日立高新技术 使用了质谱分析技术的免疫分析方法和免疫分析系统
CN103370627A (zh) * 2010-10-29 2013-10-23 恩姆菲舍尔科技公司 用于样品制备和分析的自动化系统的系统布局
WO2016006398A1 (ja) * 2014-07-07 2016-01-14 株式会社 日立ハイテクノロジーズ 分析装置および分析方法

Also Published As

Publication number Publication date
CN110959185A (zh) 2020-04-03
JP2023060337A (ja) 2023-04-27
EP3631839A1 (en) 2020-04-08
US20250027950A1 (en) 2025-01-23
US11988670B2 (en) 2024-05-21
EP4411387A3 (en) 2024-11-13
US20230011115A1 (en) 2023-01-12
JP2020521958A (ja) 2020-07-27
CN116825604A (zh) 2023-09-29
JP2024133264A (ja) 2024-10-01
EP4411387A2 (en) 2024-08-07
WO2018217778A1 (en) 2018-11-29
EP3631839B1 (en) 2024-04-03
JP7594618B2 (ja) 2024-12-04
US11402386B2 (en) 2022-08-02
US20210003586A1 (en) 2021-01-07

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