JP2020038205A5 - - Google Patents
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- JP2020038205A5 JP2020038205A5 JP2019153383A JP2019153383A JP2020038205A5 JP 2020038205 A5 JP2020038205 A5 JP 2020038205A5 JP 2019153383 A JP2019153383 A JP 2019153383A JP 2019153383 A JP2019153383 A JP 2019153383A JP 2020038205 A5 JP2020038205 A5 JP 2020038205A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- port
- pump
- sample loop
- suction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims description 358
- 238000004811 liquid chromatography Methods 0.000 claims description 171
- 238000004458 analytical method Methods 0.000 claims description 95
- 238000000034 method Methods 0.000 claims description 55
- 239000000538 analytical sample Substances 0.000 claims description 44
- 239000012530 fluid Substances 0.000 claims description 34
- 238000004140 cleaning Methods 0.000 claims description 21
- 230000008569 process Effects 0.000 claims description 8
- 238000007599 discharging Methods 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 description 18
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 238000001514 detection method Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000012491 analyte Substances 0.000 description 4
- 238000000132 electrospray ionisation Methods 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 230000005526 G1 to G0 transition Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000001195 ultra high performance liquid chromatography Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 241001494479 Pecora Species 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000013523 data management Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000005040 ion trap Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005464 sample preparation method Methods 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012384 transportation and delivery Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18190878.1A EP3617701B1 (en) | 2018-08-27 | 2018-08-27 | Sample injector with sample loop and buffer loop |
| EP18190878.1 | 2018-08-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020038205A JP2020038205A (ja) | 2020-03-12 |
| JP2020038205A5 true JP2020038205A5 (https=) | 2021-02-12 |
| JP6843932B2 JP6843932B2 (ja) | 2021-03-17 |
Family
ID=63407076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019153383A Active JP6843932B2 (ja) | 2018-08-27 | 2019-08-26 | サンプルインジェクタ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11408865B2 (https=) |
| EP (1) | EP3617701B1 (https=) |
| JP (1) | JP6843932B2 (https=) |
| CN (1) | CN110865132A (https=) |
| ES (1) | ES2999149T3 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3617701B1 (en) * | 2018-08-27 | 2024-10-23 | F. Hoffmann-La Roche AG | Sample injector with sample loop and buffer loop |
| EP3847454A1 (en) | 2018-09-05 | 2021-07-14 | Waters Technologies Corporation | Interface module for two-dimensional liquid chromatography |
| EP3748354B1 (en) * | 2019-06-04 | 2022-04-06 | F. Hoffmann-La Roche AG | Quick liquid exchange in liquid chromatography |
| US11774415B2 (en) | 2020-03-26 | 2023-10-03 | Waters Technologies Corporation | Metering pump for liquid chromatography |
| ES3043035T3 (en) * | 2020-08-28 | 2025-11-24 | Hoffmann La Roche | Sample injector |
| EP3991820A1 (en) * | 2020-11-03 | 2022-05-04 | Sartorius Stedim Biotech GmbH | System for membrane chromatography |
| CN121511405A (zh) * | 2023-08-09 | 2026-02-10 | 株式会社岛津制作所 | 在线进样器 |
| CN117686607A (zh) * | 2023-12-05 | 2024-03-12 | 杭州谱育科技发展有限公司 | 应用于液相色谱的进样器和方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6250659A (ja) | 1985-08-29 | 1987-03-05 | Shimadzu Corp | 液体クロマトグラフへの試料導入方法 |
| JPH055728A (ja) * | 1991-06-27 | 1993-01-14 | Yokogawa Electric Corp | 試料注入器 |
| US6382035B1 (en) * | 2001-04-02 | 2002-05-07 | Rheodyne, Lp | Multi-valving sample injection apparatus |
| WO2009059286A1 (en) * | 2007-11-02 | 2009-05-07 | Biotrove, Inc. | Devices and methods for coupling mass spectrometry devices with chromatography systems |
| DE10393201T5 (de) * | 2002-09-11 | 2005-09-01 | Waters Investments Ltd., Milford | Hochdruckfluidprobeninjektionsvorrichtung und Verfahren |
| EP1536228A1 (en) * | 2003-11-27 | 2005-06-01 | Agilent Technologies, Inc. | Dual loop autosampling |
| EP2035788A2 (en) * | 2006-06-30 | 2009-03-18 | Waters Investments Limited | Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography |
| DE102007059651B4 (de) * | 2007-12-10 | 2017-05-24 | Dionex Softron Gmbh | Probengeber für die Hochleistungsflüssigkeitschromatographie |
| WO2009111228A2 (en) * | 2008-02-29 | 2009-09-11 | Waters Technologies Corporation | Chromatography-based monitoring and control of multiple process streams |
| EP2343549B1 (en) | 2008-10-03 | 2020-08-19 | ARKRAY, Inc. | Analyzing device and method for controlling same |
| JP5111476B2 (ja) * | 2009-10-26 | 2013-01-09 | 株式会社日立ハイテクノロジーズ | 液体試料分析装置及び液体試料導入装置 |
| EP2572188B1 (en) * | 2010-05-21 | 2014-03-05 | Antec Leyden B.V. | Analytical apparatus comprising an electrochemical flow cell and a structure elucidation spectrometer |
| JP5505249B2 (ja) | 2010-10-19 | 2014-05-28 | 株式会社島津製作所 | オンライン試料導入装置 |
| DE202011111050U1 (de) * | 2010-10-29 | 2018-11-20 | Thermo Fisher Scientific Oy | Automatisiertes System zur Probenaufbereitung und -analyse |
| US9945820B2 (en) * | 2012-11-30 | 2018-04-17 | Agilent Technologies, Inc. | Mixer bypass sample injection for liquid chromatography |
| JP2016070695A (ja) * | 2014-09-26 | 2016-05-09 | 株式会社島津製作所 | オートサンプラ及びそのオートサンプラを備えた液体クロマトグラフ |
| DE202016100451U1 (de) * | 2015-06-25 | 2016-02-16 | Dionex Softron Gmbh | Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie |
| JP6409971B2 (ja) * | 2015-07-06 | 2018-10-24 | 株式会社島津製作所 | オートサンプラ及び液体クロマトグラフ |
| JP6694509B2 (ja) | 2015-12-18 | 2020-05-13 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 自動化された臨床診断システムおよび方法 |
| DE102016121512A1 (de) * | 2016-11-10 | 2018-05-17 | Dionex Softron Gmbh | System, Verfahren und Verwendung der Flüssigkeitschromatografie |
| EP3617701B1 (en) * | 2018-08-27 | 2024-10-23 | F. Hoffmann-La Roche AG | Sample injector with sample loop and buffer loop |
-
2018
- 2018-08-27 EP EP18190878.1A patent/EP3617701B1/en active Active
- 2018-08-27 ES ES18190878T patent/ES2999149T3/es active Active
-
2019
- 2019-08-16 US US16/543,000 patent/US11408865B2/en active Active
- 2019-08-26 CN CN201910787638.7A patent/CN110865132A/zh active Pending
- 2019-08-26 JP JP2019153383A patent/JP6843932B2/ja active Active
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