CN110865132A - 样品注射器 - Google Patents

样品注射器 Download PDF

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Publication number
CN110865132A
CN110865132A CN201910787638.7A CN201910787638A CN110865132A CN 110865132 A CN110865132 A CN 110865132A CN 201910787638 A CN201910787638 A CN 201910787638A CN 110865132 A CN110865132 A CN 110865132A
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CN
China
Prior art keywords
sample
port
pump
analytical
sample loop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910787638.7A
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English (en)
Chinese (zh)
Inventor
A·西弗斯·恩格尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN110865132A publication Critical patent/CN110865132A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/18—Injection using a septum or microsyringe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

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  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201910787638.7A 2018-08-27 2019-08-26 样品注射器 Pending CN110865132A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18190878.1A EP3617701B1 (en) 2018-08-27 2018-08-27 Sample injector with sample loop and buffer loop
EP18190878.1 2018-08-27

Publications (1)

Publication Number Publication Date
CN110865132A true CN110865132A (zh) 2020-03-06

Family

ID=63407076

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910787638.7A Pending CN110865132A (zh) 2018-08-27 2019-08-26 样品注射器

Country Status (5)

Country Link
US (1) US11408865B2 (https=)
EP (1) EP3617701B1 (https=)
JP (1) JP6843932B2 (https=)
CN (1) CN110865132A (https=)
ES (1) ES2999149T3 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3617701B1 (en) * 2018-08-27 2024-10-23 F. Hoffmann-La Roche AG Sample injector with sample loop and buffer loop
EP3847454A1 (en) 2018-09-05 2021-07-14 Waters Technologies Corporation Interface module for two-dimensional liquid chromatography
EP3748354B1 (en) * 2019-06-04 2022-04-06 F. Hoffmann-La Roche AG Quick liquid exchange in liquid chromatography
US11774415B2 (en) 2020-03-26 2023-10-03 Waters Technologies Corporation Metering pump for liquid chromatography
ES3043035T3 (en) * 2020-08-28 2025-11-24 Hoffmann La Roche Sample injector
EP3991820A1 (en) * 2020-11-03 2022-05-04 Sartorius Stedim Biotech GmbH System for membrane chromatography
CN121511405A (zh) * 2023-08-09 2026-02-10 株式会社岛津制作所 在线进样器
CN117686607A (zh) * 2023-12-05 2024-03-12 杭州谱育科技发展有限公司 应用于液相色谱的进样器和方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH055728A (ja) * 1991-06-27 1993-01-14 Yokogawa Electric Corp 試料注入器
WO2004025272A1 (en) * 2002-09-11 2004-03-25 Waters Investments Limited Pressurized fluid sample injector apparatus and method
EP1536228A1 (en) * 2003-11-27 2005-06-01 Agilent Technologies, Inc. Dual loop autosampling
CA2645453A1 (en) * 2007-12-10 2009-06-10 Dionex Softron Gmbh Autosampler for high-performance liquid chromatography
WO2011052445A1 (ja) * 2009-10-26 2011-05-05 株式会社日立ハイテクノロジーズ 液体試料分析装置及び液体試料導入装置
CN104813164A (zh) * 2012-11-30 2015-07-29 安捷伦科技有限公司 用于液相色谱的混合器旁路样品注射
JP2016070695A (ja) * 2014-09-26 2016-05-09 株式会社島津製作所 オートサンプラ及びそのオートサンプラを備えた液体クロマトグラフ
WO2017103180A1 (en) * 2015-12-18 2017-06-22 F. Hoffmann-La Roche Ag Automated clinical diagnostic system and method
CN107709985A (zh) * 2015-07-06 2018-02-16 株式会社岛津制作所 自动进样器以及液相色谱仪
CN108072724A (zh) * 2016-11-10 2018-05-25 道尼克斯索芙特隆公司 液相色谱系统、方法和用途
EP3617701A1 (en) * 2018-08-27 2020-03-04 F. Hoffmann-La Roche AG Sample injector with sample loop and buffer loop

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6250659A (ja) 1985-08-29 1987-03-05 Shimadzu Corp 液体クロマトグラフへの試料導入方法
US6382035B1 (en) * 2001-04-02 2002-05-07 Rheodyne, Lp Multi-valving sample injection apparatus
WO2009059286A1 (en) * 2007-11-02 2009-05-07 Biotrove, Inc. Devices and methods for coupling mass spectrometry devices with chromatography systems
EP2035788A2 (en) * 2006-06-30 2009-03-18 Waters Investments Limited Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography
WO2009111228A2 (en) * 2008-02-29 2009-09-11 Waters Technologies Corporation Chromatography-based monitoring and control of multiple process streams
EP2343549B1 (en) 2008-10-03 2020-08-19 ARKRAY, Inc. Analyzing device and method for controlling same
EP2572188B1 (en) * 2010-05-21 2014-03-05 Antec Leyden B.V. Analytical apparatus comprising an electrochemical flow cell and a structure elucidation spectrometer
JP5505249B2 (ja) 2010-10-19 2014-05-28 株式会社島津製作所 オンライン試料導入装置
DE202011111050U1 (de) * 2010-10-29 2018-11-20 Thermo Fisher Scientific Oy Automatisiertes System zur Probenaufbereitung und -analyse
DE202016100451U1 (de) * 2015-06-25 2016-02-16 Dionex Softron Gmbh Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH055728A (ja) * 1991-06-27 1993-01-14 Yokogawa Electric Corp 試料注入器
WO2004025272A1 (en) * 2002-09-11 2004-03-25 Waters Investments Limited Pressurized fluid sample injector apparatus and method
EP1536228A1 (en) * 2003-11-27 2005-06-01 Agilent Technologies, Inc. Dual loop autosampling
CA2645453A1 (en) * 2007-12-10 2009-06-10 Dionex Softron Gmbh Autosampler for high-performance liquid chromatography
WO2011052445A1 (ja) * 2009-10-26 2011-05-05 株式会社日立ハイテクノロジーズ 液体試料分析装置及び液体試料導入装置
CN104813164A (zh) * 2012-11-30 2015-07-29 安捷伦科技有限公司 用于液相色谱的混合器旁路样品注射
JP2016070695A (ja) * 2014-09-26 2016-05-09 株式会社島津製作所 オートサンプラ及びそのオートサンプラを備えた液体クロマトグラフ
CN107709985A (zh) * 2015-07-06 2018-02-16 株式会社岛津制作所 自动进样器以及液相色谱仪
WO2017103180A1 (en) * 2015-12-18 2017-06-22 F. Hoffmann-La Roche Ag Automated clinical diagnostic system and method
CN108072724A (zh) * 2016-11-10 2018-05-25 道尼克斯索芙特隆公司 液相色谱系统、方法和用途
EP3617701A1 (en) * 2018-08-27 2020-03-04 F. Hoffmann-La Roche AG Sample injector with sample loop and buffer loop

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王福荣: "《生物工程分析与检验（第二版）》", 中国轻工业出版社 *

Also Published As

Publication number Publication date
US11408865B2 (en) 2022-08-09
ES2999149T3 (en) 2025-02-24
EP3617701B1 (en) 2024-10-23
JP6843932B2 (ja) 2021-03-17
EP3617701A1 (en) 2020-03-04
JP2020038205A (ja) 2020-03-12
US20200064314A1 (en) 2020-02-27

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