ES2999149T3 - Sample injector with sample loop and buffer loop - Google Patents

Sample injector with sample loop and buffer loop Download PDF

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Publication number
ES2999149T3
ES2999149T3 ES18190878T ES18190878T ES2999149T3 ES 2999149 T3 ES2999149 T3 ES 2999149T3 ES 18190878 T ES18190878 T ES 18190878T ES 18190878 T ES18190878 T ES 18190878T ES 2999149 T3 ES2999149 T3 ES 2999149T3
Authority
ES
Spain
Prior art keywords
sample
port
pump
sample loop
analytical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18190878T
Other languages
English (en)
Spanish (es)
Inventor
Adrian Sievers-Engler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2999149T3 publication Critical patent/ES2999149T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/18—Injection using a septum or microsyringe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Landscapes

  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
ES18190878T 2018-08-27 2018-08-27 Sample injector with sample loop and buffer loop Active ES2999149T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18190878.1A EP3617701B1 (en) 2018-08-27 2018-08-27 Sample injector with sample loop and buffer loop

Publications (1)

Publication Number Publication Date
ES2999149T3 true ES2999149T3 (en) 2025-02-24

Family

ID=63407076

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18190878T Active ES2999149T3 (en) 2018-08-27 2018-08-27 Sample injector with sample loop and buffer loop

Country Status (5)

Country Link
US (1) US11408865B2 (https=)
EP (1) EP3617701B1 (https=)
JP (1) JP6843932B2 (https=)
CN (1) CN110865132A (https=)
ES (1) ES2999149T3 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3617701B1 (en) * 2018-08-27 2024-10-23 F. Hoffmann-La Roche AG Sample injector with sample loop and buffer loop
EP3847454A1 (en) 2018-09-05 2021-07-14 Waters Technologies Corporation Interface module for two-dimensional liquid chromatography
EP3748354B1 (en) * 2019-06-04 2022-04-06 F. Hoffmann-La Roche AG Quick liquid exchange in liquid chromatography
US11774415B2 (en) 2020-03-26 2023-10-03 Waters Technologies Corporation Metering pump for liquid chromatography
ES3043035T3 (en) * 2020-08-28 2025-11-24 Hoffmann La Roche Sample injector
EP3991820A1 (en) * 2020-11-03 2022-05-04 Sartorius Stedim Biotech GmbH System for membrane chromatography
CN121511405A (zh) * 2023-08-09 2026-02-10 株式会社岛津制作所 在线进样器
CN117686607A (zh) * 2023-12-05 2024-03-12 杭州谱育科技发展有限公司 应用于液相色谱的进样器和方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6250659A (ja) 1985-08-29 1987-03-05 Shimadzu Corp 液体クロマトグラフへの試料導入方法
JPH055728A (ja) * 1991-06-27 1993-01-14 Yokogawa Electric Corp 試料注入器
US6382035B1 (en) * 2001-04-02 2002-05-07 Rheodyne, Lp Multi-valving sample injection apparatus
WO2009059286A1 (en) * 2007-11-02 2009-05-07 Biotrove, Inc. Devices and methods for coupling mass spectrometry devices with chromatography systems
DE10393201T5 (de) * 2002-09-11 2005-09-01 Waters Investments Ltd., Milford Hochdruckfluidprobeninjektionsvorrichtung und Verfahren
EP1536228A1 (en) * 2003-11-27 2005-06-01 Agilent Technologies, Inc. Dual loop autosampling
EP2035788A2 (en) * 2006-06-30 2009-03-18 Waters Investments Limited Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography
DE102007059651B4 (de) * 2007-12-10 2017-05-24 Dionex Softron Gmbh Probengeber für die Hochleistungsflüssigkeitschromatographie
WO2009111228A2 (en) * 2008-02-29 2009-09-11 Waters Technologies Corporation Chromatography-based monitoring and control of multiple process streams
EP2343549B1 (en) 2008-10-03 2020-08-19 ARKRAY, Inc. Analyzing device and method for controlling same
JP5111476B2 (ja) * 2009-10-26 2013-01-09 株式会社日立ハイテクノロジーズ 液体試料分析装置及び液体試料導入装置
EP2572188B1 (en) * 2010-05-21 2014-03-05 Antec Leyden B.V. Analytical apparatus comprising an electrochemical flow cell and a structure elucidation spectrometer
JP5505249B2 (ja) 2010-10-19 2014-05-28 株式会社島津製作所 オンライン試料導入装置
DE202011111050U1 (de) * 2010-10-29 2018-11-20 Thermo Fisher Scientific Oy Automatisiertes System zur Probenaufbereitung und -analyse
US9945820B2 (en) * 2012-11-30 2018-04-17 Agilent Technologies, Inc. Mixer bypass sample injection for liquid chromatography
JP2016070695A (ja) * 2014-09-26 2016-05-09 株式会社島津製作所 オートサンプラ及びそのオートサンプラを備えた液体クロマトグラフ
DE202016100451U1 (de) * 2015-06-25 2016-02-16 Dionex Softron Gmbh Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie
JP6409971B2 (ja) * 2015-07-06 2018-10-24 株式会社島津製作所 オートサンプラ及び液体クロマトグラフ
JP6694509B2 (ja) 2015-12-18 2020-05-13 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 自動化された臨床診断システムおよび方法
DE102016121512A1 (de) * 2016-11-10 2018-05-17 Dionex Softron Gmbh System, Verfahren und Verwendung der Flüssigkeitschromatografie
EP3617701B1 (en) * 2018-08-27 2024-10-23 F. Hoffmann-La Roche AG Sample injector with sample loop and buffer loop

Also Published As

Publication number Publication date
US11408865B2 (en) 2022-08-09
EP3617701B1 (en) 2024-10-23
JP6843932B2 (ja) 2021-03-17
EP3617701A1 (en) 2020-03-04
JP2020038205A (ja) 2020-03-12
CN110865132A (zh) 2020-03-06
US20200064314A1 (en) 2020-02-27

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