JP2020521755A5 - - Google Patents
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- JP2020521755A5 JP2020521755A5 JP2019565179A JP2019565179A JP2020521755A5 JP 2020521755 A5 JP2020521755 A5 JP 2020521755A5 JP 2019565179 A JP2019565179 A JP 2019565179A JP 2019565179 A JP2019565179 A JP 2019565179A JP 2020521755 A5 JP2020521755 A5 JP 2020521755A5
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- 239000000203 mixture Substances 0.000 claims description 88
- 239000007972 injectable composition Substances 0.000 claims description 83
- 210000004204 blood vessel Anatomy 0.000 claims description 57
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims description 44
- 229960000235 temsirolimus Drugs 0.000 claims description 44
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims description 44
- 239000007924 injection Substances 0.000 claims description 43
- 238000002347 injection Methods 0.000 claims description 43
- 229960003957 dexamethasone Drugs 0.000 claims description 28
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 28
- 210000001367 artery Anatomy 0.000 claims description 22
- 210000003127 knee Anatomy 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 210000004351 coronary vessel Anatomy 0.000 claims description 6
- 239000011627 DL-alpha-tocopherol Substances 0.000 claims description 3
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 229960004543 anhydrous citric acid Drugs 0.000 claims description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 3
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 229940068968 polysorbate 80 Drugs 0.000 claims description 3
- 229960004063 propylene glycol Drugs 0.000 claims description 3
- 239000008354 sodium chloride injection Substances 0.000 claims description 3
- 229960000984 tocofersolan Drugs 0.000 claims description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 description 89
- 239000008194 pharmaceutical composition Substances 0.000 description 36
- 230000032823 cell division Effects 0.000 description 32
- 239000003112 inhibitor Substances 0.000 description 32
- 239000003862 glucocorticoid Substances 0.000 description 14
- 208000019553 vascular disease Diseases 0.000 description 14
- 208000037803 restenosis Diseases 0.000 description 12
- 230000002093 peripheral effect Effects 0.000 description 10
- 239000002872 contrast media Substances 0.000 description 5
- 210000005166 vasculature Anatomy 0.000 description 5
- 208000005764 Peripheral Arterial Disease Diseases 0.000 description 4
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 206010059245 Angiopathy Diseases 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 206010028851 Necrosis Diseases 0.000 description 2
- 229930012538 Paclitaxel Natural products 0.000 description 2
- 206010060872 Transplant failure Diseases 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 210000001627 cerebral artery Anatomy 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 208000030175 lameness Diseases 0.000 description 2
- 210000002414 leg Anatomy 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 229960001592 paclitaxel Drugs 0.000 description 2
- 210000001147 pulmonary artery Anatomy 0.000 description 2
- 210000002254 renal artery Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 241001125046 Sardina pilchardus Species 0.000 description 1
- 229940123237 Taxane Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762511797P | 2017-05-26 | 2017-05-26 | |
| US62/511,797 | 2017-05-26 | ||
| US201862624528P | 2018-01-31 | 2018-01-31 | |
| US62/624,528 | 2018-01-31 | ||
| PCT/US2018/034713 WO2018218182A1 (en) | 2017-05-26 | 2018-05-25 | Combination therapy for treatment of restenosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521755A JP2020521755A (ja) | 2020-07-27 |
| JP2020521755A5 true JP2020521755A5 (https=) | 2021-07-26 |
| JP7137584B2 JP7137584B2 (ja) | 2022-09-14 |
Family
ID=64397143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565179A Active JP7137584B2 (ja) | 2017-05-26 | 2018-05-25 | 再狭窄の処置のための併用療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10576063B2 (https=) |
| EP (1) | EP3629774A4 (https=) |
| JP (1) | JP7137584B2 (https=) |
| KR (1) | KR20200008166A (https=) |
| CN (1) | CN110996687A (https=) |
| AU (1) | AU2018272061A1 (https=) |
| CA (1) | CA3064780A1 (https=) |
| WO (1) | WO2018218182A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018213579A1 (en) * | 2017-05-17 | 2018-11-22 | Massachusetts Institute Of Technology | Self-actuating articles |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| AU2018272061A1 (en) | 2017-05-26 | 2020-01-02 | Mercator Medsystems, Inc. | Combination therapy for treatment of restenosis |
| CN212631328U (zh) | 2018-03-14 | 2021-03-02 | 墨卡托医疗系统公司 | 用于局部药物递送的医疗器械 |
| AU2019269636A1 (en) | 2018-05-17 | 2020-11-19 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| US11497552B2 (en) | 2019-07-09 | 2022-11-15 | Juad, Inc. | Apparatus, systems and methods for transvascular access to the brain |
| AU2020410545A1 (en) * | 2019-12-19 | 2022-08-11 | Triviumvet Dac | Veterinary formulations comprising rapamycin and methods of using the same for treating animal diseases |
| MX2023009197A (es) | 2021-03-11 | 2023-08-21 | Alpha Tau Medical Ltd | Aplicador de radioterapia. |
| CN117529350A (zh) | 2021-06-30 | 2024-02-06 | 阿尔法陶医疗有限公司 | 具有垂直或成角度径向分配的放射治疗施药器 |
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| WO2018057788A1 (en) | 2016-09-22 | 2018-03-29 | Mercator Medsystems, Inc. | Treatment of restenosis using temsirolimus |
| AU2018272061A1 (en) * | 2017-05-26 | 2020-01-02 | Mercator Medsystems, Inc. | Combination therapy for treatment of restenosis |
| US20220105108A1 (en) | 2020-10-01 | 2022-04-07 | Mercator Medsystems, Inc. | Perivascular anti-inflammatory therapy for venous thrombosis |
-
2018
- 2018-05-25 AU AU2018272061A patent/AU2018272061A1/en not_active Abandoned
- 2018-05-25 WO PCT/US2018/034713 patent/WO2018218182A1/en not_active Ceased
- 2018-05-25 CN CN201880049930.2A patent/CN110996687A/zh active Pending
- 2018-05-25 EP EP18806949.6A patent/EP3629774A4/en not_active Withdrawn
- 2018-05-25 CA CA3064780A patent/CA3064780A1/en active Pending
- 2018-05-25 KR KR1020197038156A patent/KR20200008166A/ko not_active Ceased
- 2018-05-25 US US15/990,167 patent/US10576063B2/en active Active
- 2018-05-25 JP JP2019565179A patent/JP7137584B2/ja active Active
-
2019
- 2019-10-02 US US16/591,467 patent/US10925863B2/en active Active
-
2021
- 2021-01-14 US US17/149,631 patent/US11813249B2/en active Active
-
2023
- 2023-10-04 US US18/481,110 patent/US20240024296A1/en not_active Abandoned
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