JP2020520998A5 - - Google Patents
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- Publication number
- JP2020520998A5 JP2020520998A5 JP2020514159A JP2020514159A JP2020520998A5 JP 2020520998 A5 JP2020520998 A5 JP 2020520998A5 JP 2020514159 A JP2020514159 A JP 2020514159A JP 2020514159 A JP2020514159 A JP 2020514159A JP 2020520998 A5 JP2020520998 A5 JP 2020520998A5
- Authority
- JP
- Japan
- Prior art keywords
- pendant
- macrocyclic
- complex
- groups
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 210000000056 organ Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 230000002792 vascular Effects 0.000 claims 5
- -1 Fe (III) cations Chemical class 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- ITWBWJFEJCHKSN-UHFFFAOYSA-N 1,4,7-triazonane Chemical group C1CNCCNCCN1 ITWBWJFEJCHKSN-UHFFFAOYSA-N 0.000 claims 2
- 125000000129 anionic group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000000412 dendrimer Substances 0.000 claims 2
- 229920000736 dendritic polymer Polymers 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical group C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 claims 1
- MDAXKAUIABOHTD-UHFFFAOYSA-N 1,4,8,11-tetraazacyclotetradecane Chemical group C1CNCCNCCCNCCNC1 MDAXKAUIABOHTD-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- 150000004703 alkoxides Chemical class 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000000536 complexating effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- LGAILEFNHXWAJP-BMEPFDOTSA-N macrocycle Chemical group N([C@H]1[C@@H](C)CC)C(=O)C(N=2)=CSC=2CNC(=O)C(=C(O2)C)N=C2[C@H]([C@@H](C)CC)NC(=O)C2=CSC1=N2 LGAILEFNHXWAJP-BMEPFDOTSA-N 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 229960003194 meglumine Drugs 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-M phenolate Chemical compound [O-]C1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-M 0.000 claims 1
- ASRAWSBMDXVNLX-UHFFFAOYSA-N pyrazolynate Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)C=1C(C)=NN(C)C=1OS(=O)(=O)C1=CC=C(C)C=C1 ASRAWSBMDXVNLX-UHFFFAOYSA-N 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000005166 vasculature Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762508548P | 2017-05-19 | 2017-05-19 | |
| US62/508,548 | 2017-05-19 | ||
| PCT/US2018/033759 WO2018213853A1 (en) | 2017-05-19 | 2018-05-21 | Compounds for use as iron(iii) mri contrast agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020520998A JP2020520998A (ja) | 2020-07-16 |
| JP2020520998A5 true JP2020520998A5 (https=) | 2021-04-22 |
| JP7390284B2 JP7390284B2 (ja) | 2023-12-01 |
Family
ID=64274805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020514159A Active JP7390284B2 (ja) | 2017-05-19 | 2018-05-21 | 鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11261208B2 (https=) |
| EP (1) | EP3624859A4 (https=) |
| JP (1) | JP7390284B2 (https=) |
| KR (2) | KR20250073575A (https=) |
| CN (1) | CN110944676A (https=) |
| AU (1) | AU2018270520B2 (https=) |
| WO (1) | WO2018213853A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3624859A4 (en) * | 2017-05-19 | 2021-03-03 | The Research Foundation for The State University of New York | Compounds for use as iron(iii) mri contrast agents |
| AU2019381793B2 (en) * | 2018-11-16 | 2025-02-27 | The Research Foundation For The State University Of New York | Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups |
| US20240228524A1 (en) * | 2021-03-20 | 2024-07-11 | The Research Foundation For The State University Of New York | Iron(iii) macrocyclic complexes with mixed hyroxyl pendants as mri contrast agents |
| DE102021214708A1 (de) | 2021-12-20 | 2023-06-22 | Henkel Ag & Co. Kgaa | Metallkomplexe und Geschirrspülmittel, die sie enthalten |
| AU2023313342A1 (en) | 2022-07-28 | 2024-12-19 | Bracco Imaging Spa | 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents |
| WO2025163025A1 (en) * | 2024-01-31 | 2025-08-07 | Bracco Imaging Spa | Pyridophane macrocyclic ligands and fe(iii) complexes thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US10556873B2 (en) | 2008-02-22 | 2020-02-11 | Illinois Institute Of Technology | Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using |
| WO2012155076A2 (en) * | 2011-05-11 | 2012-11-15 | The Research Foundation Of State University Of New York | Imaging contrast agents and uses thereof |
| US10960088B2 (en) * | 2013-09-12 | 2021-03-30 | The Research Foundation For The State University Of New York | Macrocycles, cobalt and iron complexes of same, and methods of making and using same |
| EP3624859A4 (en) * | 2017-05-19 | 2021-03-03 | The Research Foundation for The State University of New York | Compounds for use as iron(iii) mri contrast agents |
-
2018
- 2018-05-21 EP EP18803302.1A patent/EP3624859A4/en active Pending
- 2018-05-21 CN CN201880048229.9A patent/CN110944676A/zh active Pending
- 2018-05-21 KR KR1020257016425A patent/KR20250073575A/ko active Pending
- 2018-05-21 JP JP2020514159A patent/JP7390284B2/ja active Active
- 2018-05-21 KR KR1020197037503A patent/KR102811655B1/ko active Active
- 2018-05-21 WO PCT/US2018/033759 patent/WO2018213853A1/en not_active Ceased
- 2018-05-21 AU AU2018270520A patent/AU2018270520B2/en active Active
- 2018-05-21 US US16/615,024 patent/US11261208B2/en active Active
-
2022
- 2022-02-28 US US17/682,695 patent/US12534487B2/en active Active
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