KR20250073575A - 철 (iii) mri 조영제로서 사용을 위한 화합물 - Google Patents

철 (iii) mri 조영제로서 사용을 위한 화합물 Download PDF

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Publication number
KR20250073575A
KR20250073575A KR1020257016425A KR20257016425A KR20250073575A KR 20250073575 A KR20250073575 A KR 20250073575A KR 1020257016425 A KR1020257016425 A KR 1020257016425A KR 20257016425 A KR20257016425 A KR 20257016425A KR 20250073575 A KR20250073575 A KR 20250073575A
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South Korea
Prior art keywords
macrocyclic
pendant
group
complex
iii
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Pending
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KR1020257016425A
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English (en)
Korean (ko)
Inventor
자넷 알. 모로우
에릭 엠. 스나이더
디다르 아식
Original Assignee
더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕
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Publication of KR20250073575A publication Critical patent/KR20250073575A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020257016425A 2017-05-19 2018-05-21 철 (iii) mri 조영제로서 사용을 위한 화합물 Pending KR20250073575A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762508548P 2017-05-19 2017-05-19
US62/508,548 2017-05-19
KR1020197037503A KR102811655B1 (ko) 2017-05-19 2018-05-21 철 (iii) mri 조영제로서 사용을 위한 화합물
PCT/US2018/033759 WO2018213853A1 (en) 2017-05-19 2018-05-21 Compounds for use as iron(iii) mri contrast agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197037503A Division KR102811655B1 (ko) 2017-05-19 2018-05-21 철 (iii) mri 조영제로서 사용을 위한 화합물

Publications (1)

Publication Number Publication Date
KR20250073575A true KR20250073575A (ko) 2025-05-27

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020257016425A Pending KR20250073575A (ko) 2017-05-19 2018-05-21 철 (iii) mri 조영제로서 사용을 위한 화합물
KR1020197037503A Active KR102811655B1 (ko) 2017-05-19 2018-05-21 철 (iii) mri 조영제로서 사용을 위한 화합물

Family Applications After (1)

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Country Status (7)

Country Link
US (2) US11261208B2 (https=)
EP (1) EP3624859A4 (https=)
JP (1) JP7390284B2 (https=)
KR (2) KR20250073575A (https=)
CN (1) CN110944676A (https=)
AU (1) AU2018270520B2 (https=)
WO (1) WO2018213853A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3624859A4 (en) * 2017-05-19 2021-03-03 The Research Foundation for The State University of New York Compounds for use as iron(iii) mri contrast agents
AU2019381793B2 (en) * 2018-11-16 2025-02-27 The Research Foundation For The State University Of New York Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups
US20240228524A1 (en) * 2021-03-20 2024-07-11 The Research Foundation For The State University Of New York Iron(iii) macrocyclic complexes with mixed hyroxyl pendants as mri contrast agents
DE102021214708A1 (de) 2021-12-20 2023-06-22 Henkel Ag & Co. Kgaa Metallkomplexe und Geschirrspülmittel, die sie enthalten
AU2023313342A1 (en) 2022-07-28 2024-12-19 Bracco Imaging Spa 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents
WO2025163025A1 (en) * 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US10556873B2 (en) 2008-02-22 2020-02-11 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
WO2012155076A2 (en) * 2011-05-11 2012-11-15 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
US10960088B2 (en) * 2013-09-12 2021-03-30 The Research Foundation For The State University Of New York Macrocycles, cobalt and iron complexes of same, and methods of making and using same
EP3624859A4 (en) * 2017-05-19 2021-03-03 The Research Foundation for The State University of New York Compounds for use as iron(iii) mri contrast agents

Also Published As

Publication number Publication date
CN110944676A (zh) 2020-03-31
US20200079806A1 (en) 2020-03-12
KR20200010385A (ko) 2020-01-30
JP2020520998A (ja) 2020-07-16
EP3624859A4 (en) 2021-03-03
US12534487B2 (en) 2026-01-27
EP3624859A1 (en) 2020-03-25
JP7390284B2 (ja) 2023-12-01
US11261208B2 (en) 2022-03-01
WO2018213853A1 (en) 2018-11-22
KR102811655B1 (ko) 2025-05-21
US20220259244A1 (en) 2022-08-18
AU2018270520A1 (en) 2019-12-12
AU2018270520B2 (en) 2022-01-06

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