CN110944676A - 用作铁(iii)mri造影剂的化合物 - Google Patents

用作铁(iii)mri造影剂的化合物 Download PDF

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Publication number
CN110944676A
CN110944676A CN201880048229.9A CN201880048229A CN110944676A CN 110944676 A CN110944676 A CN 110944676A CN 201880048229 A CN201880048229 A CN 201880048229A CN 110944676 A CN110944676 A CN 110944676A
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CN
China
Prior art keywords
macrocyclic
groups
pendant
group
iii
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Pending
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CN201880048229.9A
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English (en)
Chinese (zh)
Inventor
珍妮特·R.·莫罗
埃里克·M.·斯纳德
迪达·阿西克
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Research Foundation of the State University of New York
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Research Foundation of the State University of New York
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Publication of CN110944676A publication Critical patent/CN110944676A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880048229.9A 2017-05-19 2018-05-21 用作铁(iii)mri造影剂的化合物 Pending CN110944676A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762508548P 2017-05-19 2017-05-19
US62/508,548 2017-05-19
PCT/US2018/033759 WO2018213853A1 (en) 2017-05-19 2018-05-21 Compounds for use as iron(iii) mri contrast agents

Publications (1)

Publication Number Publication Date
CN110944676A true CN110944676A (zh) 2020-03-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880048229.9A Pending CN110944676A (zh) 2017-05-19 2018-05-21 用作铁(iii)mri造影剂的化合物

Country Status (7)

Country Link
US (2) US11261208B2 (https=)
EP (1) EP3624859A4 (https=)
JP (1) JP7390284B2 (https=)
KR (2) KR20250073575A (https=)
CN (1) CN110944676A (https=)
AU (1) AU2018270520B2 (https=)
WO (1) WO2018213853A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646009A (zh) * 2018-11-16 2021-11-12 纽约州立大学研究基金会 用作铁(iii)mri造影剂且含阴离子侧基和辅助基团的化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3624859A4 (en) * 2017-05-19 2021-03-03 The Research Foundation for The State University of New York Compounds for use as iron(iii) mri contrast agents
US20240228524A1 (en) * 2021-03-20 2024-07-11 The Research Foundation For The State University Of New York Iron(iii) macrocyclic complexes with mixed hyroxyl pendants as mri contrast agents
DE102021214708A1 (de) 2021-12-20 2023-06-22 Henkel Ag & Co. Kgaa Metallkomplexe und Geschirrspülmittel, die sie enthalten
AU2023313342A1 (en) 2022-07-28 2024-12-19 Bracco Imaging Spa 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents
WO2025163025A1 (en) * 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140193344A1 (en) * 2011-05-11 2014-07-10 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
US20160228581A1 (en) * 2013-09-12 2016-08-11 The Research Foundation For The State University Of New York Macrocycles, cobalt and iron complexes of same, and methods of making and using same

Family Cites Families (3)

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US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US10556873B2 (en) 2008-02-22 2020-02-11 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
EP3624859A4 (en) * 2017-05-19 2021-03-03 The Research Foundation for The State University of New York Compounds for use as iron(iii) mri contrast agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140193344A1 (en) * 2011-05-11 2014-07-10 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
US20160228581A1 (en) * 2013-09-12 2016-08-11 The Research Foundation For The State University Of New York Macrocycles, cobalt and iron complexes of same, and methods of making and using same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHANG-TONG YANG等: "Synthesis and Characterization of a Novel Macrocyclic Chelator with 3-Hydroxy-4-Pyrone Chelating Arms and Its Complexes with Medicinally Important Metals", 《INORGANIC CHEMISTRY》 *
CLAUDIA STOCKHEIM等: "First-row transition-metal complexes of mixed ‘pendant-arm’ derivatives of 1,4,7-triazacyclononane containing phenolate and carboxylate functional groups", 《J CHEM. SOC., DALTON TRANS.》 *
DANIEL R. GAMELIN等: "Excited-State Contributions to Ground-State Properties of Mixed-Valence Dimers: Spectral and Electronic-Structural Studies of [Fe2(OH)3(tmtacn)2]2+ Related to the [Fe2S2]+ Active Sites of Plant-Type Ferredoxins", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 *
ULF AUERBACH等: "Synthesis and coordination chemistry of the hexadentate ligands 1,4,7-tris(2-hydroxybenzyl)-1,4,7-triazacyclononane(H3L1) and 1,4,7-tris(3-tert-butyl-2-hydroxybenzyl)-1,4,7-triazacyclononane(H3L2).Crystal structures of [HL1CuII] and [L2FeIII]acacH", 《INORGANIC CHEMISTRY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646009A (zh) * 2018-11-16 2021-11-12 纽约州立大学研究基金会 用作铁(iii)mri造影剂且含阴离子侧基和辅助基团的化合物

Also Published As

Publication number Publication date
US20200079806A1 (en) 2020-03-12
KR20200010385A (ko) 2020-01-30
JP2020520998A (ja) 2020-07-16
EP3624859A4 (en) 2021-03-03
US12534487B2 (en) 2026-01-27
EP3624859A1 (en) 2020-03-25
KR20250073575A (ko) 2025-05-27
JP7390284B2 (ja) 2023-12-01
US11261208B2 (en) 2022-03-01
WO2018213853A1 (en) 2018-11-22
KR102811655B1 (ko) 2025-05-21
US20220259244A1 (en) 2022-08-18
AU2018270520A1 (en) 2019-12-12
AU2018270520B2 (en) 2022-01-06

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