JP2020520644A5 - - Google Patents
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- JP2020520644A5 JP2020520644A5 JP2019563585A JP2019563585A JP2020520644A5 JP 2020520644 A5 JP2020520644 A5 JP 2020520644A5 JP 2019563585 A JP2019563585 A JP 2019563585A JP 2019563585 A JP2019563585 A JP 2019563585A JP 2020520644 A5 JP2020520644 A5 JP 2020520644A5
- Authority
- JP
- Japan
- Prior art keywords
- fatty
- coa
- yarrowia lipolytica
- polyunsaturated
- recombinant yarrowia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 244000005700 microbiome Species 0.000 claims 21
- 241000235015 Yarrowia lipolytica Species 0.000 claims 20
- 150000002185 fatty acyl-CoAs Chemical class 0.000 claims 12
- 238000006243 chemical reaction Methods 0.000 claims 11
- 150000002191 fatty alcohols Chemical class 0.000 claims 10
- 102000004190 Enzymes Human genes 0.000 claims 9
- 108090000790 Enzymes Proteins 0.000 claims 9
- 230000037430 deletion Effects 0.000 claims 9
- 238000012217 deletion Methods 0.000 claims 9
- 230000035772 mutation Effects 0.000 claims 9
- 150000002190 fatty acyls Chemical group 0.000 claims 8
- 102000004316 Oxidoreductases Human genes 0.000 claims 7
- 108090000854 Oxidoreductases Proteins 0.000 claims 7
- 241000195620 Euglena Species 0.000 claims 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- 229930195729 fatty acid Natural products 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 102100039702 Alcohol dehydrogenase class-3 Human genes 0.000 claims 5
- 101000959452 Homo sapiens Alcohol dehydrogenase class-3 Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 claims 4
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 101150035823 FAO1 gene Proteins 0.000 claims 3
- 108010011927 Long-chain-alcohol dehydrogenase Proteins 0.000 claims 3
- 241000235013 Yarrowia Species 0.000 claims 3
- 102100034111 Activin receptor type-1 Human genes 0.000 claims 2
- 102100034134 Activin receptor type-1B Human genes 0.000 claims 2
- 102100027840 Acyl-CoA wax alcohol acyltransferase 1 Human genes 0.000 claims 2
- 108010025188 Alcohol oxidase Proteins 0.000 claims 2
- BBRMJCAPNGJKEM-UHFFFAOYSA-N Alk12 Natural products CCCCCCCC=CC=CC(=O)NCC(C)C BBRMJCAPNGJKEM-UHFFFAOYSA-N 0.000 claims 2
- 102100031795 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Human genes 0.000 claims 2
- 102100025423 Bone morphogenetic protein receptor type-1A Human genes 0.000 claims 2
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 2
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 2
- 101150023395 DGA1 gene Proteins 0.000 claims 2
- 101100004038 Homo sapiens AWAT1 gene Proteins 0.000 claims 2
- 101000799140 Homo sapiens Activin receptor type-1 Proteins 0.000 claims 2
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 claims 2
- 101000775437 Homo sapiens All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 claims 2
- 101000934638 Homo sapiens Bone morphogenetic protein receptor type-1A Proteins 0.000 claims 2
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 claims 2
- 101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 claims 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 2
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 claims 2
- FQVLRGLGWNWPSS-BXBUPLCLSA-N (4r,7s,10s,13s,16r)-16-acetamido-13-(1h-imidazol-5-ylmethyl)-10-methyl-6,9,12,15-tetraoxo-7-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide Chemical compound N1C(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CC1=CN=CN1 FQVLRGLGWNWPSS-BXBUPLCLSA-N 0.000 claims 1
- 102100034135 Activin receptor type-1C Human genes 0.000 claims 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 1
- 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 claims 1
- 102100034042 Alcohol dehydrogenase 1C Human genes 0.000 claims 1
- 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 claims 1
- 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 claims 1
- 102100027052 Bone morphogenetic protein receptor type-1B Human genes 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 101000796894 Coturnix japonica Alcohol dehydrogenase 1 Proteins 0.000 claims 1
- 101100009781 Danio rerio dmbx1a gene Proteins 0.000 claims 1
- 241000195619 Euglena gracilis Species 0.000 claims 1
- YPZRHBJKEMOYQH-UYBVJOGSSA-N FADH2 Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C(NC(=O)NC2=O)=C2NC2=C1C=C(C)C(C)=C2 YPZRHBJKEMOYQH-UYBVJOGSSA-N 0.000 claims 1
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 claims 1
- 101000799193 Homo sapiens Activin receptor type-1C Proteins 0.000 claims 1
- 101000780443 Homo sapiens Alcohol dehydrogenase 1A Proteins 0.000 claims 1
- 101000780463 Homo sapiens Alcohol dehydrogenase 1C Proteins 0.000 claims 1
- 101000984546 Homo sapiens Bone morphogenetic protein receptor type-1B Proteins 0.000 claims 1
- 101100084403 Homo sapiens PRODH gene Proteins 0.000 claims 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 claims 1
- 101150105372 POX1 gene Proteins 0.000 claims 1
- 101150059359 POX2 gene Proteins 0.000 claims 1
- 101150053659 POX4 gene Proteins 0.000 claims 1
- 101150004239 POX5 gene Proteins 0.000 claims 1
- 102100028772 Proline dehydrogenase 1, mitochondrial Human genes 0.000 claims 1
- 101100313649 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) POT1 gene Proteins 0.000 claims 1
- 101100269259 Yarrowia lipolytica (strain CLIB 122 / E 150) ADH2 gene Proteins 0.000 claims 1
- 101100268910 Yarrowia lipolytica (strain CLIB 122 / E 150) POX1 gene Proteins 0.000 claims 1
- 101100268919 Yarrowia lipolytica (strain CLIB 122 / E 150) POX2 gene Proteins 0.000 claims 1
- 101100194320 Zea mays PER1 gene Proteins 0.000 claims 1
- 101100029251 Zea mays PER2 gene Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507654P | 2017-05-17 | 2017-05-17 | |
| US62/507,654 | 2017-05-17 | ||
| PCT/US2018/033151 WO2018213554A1 (en) | 2017-05-17 | 2018-05-17 | Microorganisms for the production of insect pheromones and related compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020520644A JP2020520644A (ja) | 2020-07-16 |
| JP2020520644A5 true JP2020520644A5 (enExample) | 2020-08-27 |
| JP7216018B2 JP7216018B2 (ja) | 2023-01-31 |
Family
ID=64274732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563585A Active JP7216018B2 (ja) | 2017-05-17 | 2018-05-17 | 昆虫フェロモンの生成のための微生物及び関連する化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11104921B2 (enExample) |
| EP (1) | EP3635124A4 (enExample) |
| JP (1) | JP7216018B2 (enExample) |
| CN (1) | CN110914442B (enExample) |
| AR (1) | AR112543A1 (enExample) |
| MX (1) | MX382401B (enExample) |
| WO (1) | WO2018213554A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE053613T2 (hu) | 2015-11-18 | 2021-07-28 | Provivi Inc | Mikroorganizmusok rovarferomonok és kapcsolódó vegyületek elõállítására |
| JP2019517797A (ja) | 2016-06-06 | 2019-06-27 | プロヴィヴィ インコーポレイテッド | 脂肪アルコールおよび脂肪アルデヒドの半生合成的生産 |
| US11104921B2 (en) | 2017-05-17 | 2021-08-31 | Provivi, Inc. | Microorganisms for the production of insect pheromones and related compounds |
| WO2020169389A1 (en) * | 2019-02-19 | 2020-08-27 | Biophero Aps | Methods and cell factories for producing insect pheromones |
| WO2020185627A1 (en) * | 2019-03-08 | 2020-09-17 | Massachusetts Institute Of Technology | Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides |
| AU2020363960A1 (en) * | 2019-10-10 | 2022-04-21 | River Stone Biotech Aps | Genetically modified host cells producing benzylisoquinoline alkaloids |
| US20230031596A1 (en) * | 2019-12-11 | 2023-02-02 | Provivi, Inc. | Biosynthesis of insect pheromones and precursors thereof |
| CN110938579A (zh) * | 2019-12-13 | 2020-03-31 | 杭州唯铂莱生物科技有限公司 | 酪氨酸解氨酶重组菌、酪氨酸解氨酶及其制备方法和应用 |
| CN115103900A (zh) * | 2019-12-20 | 2022-09-23 | 费罗生物公司 | 产生e8,e10-十二碳二烯基辅酶a、可得蒙及其衍生物的酵母细胞和方法 |
| EP4087402A4 (en) * | 2020-02-07 | 2024-03-13 | Board of Regents of the University of Nebraska | METHOD FOR PRODUCING INSECT PHEROMONES |
| WO2021262906A1 (en) * | 2020-06-23 | 2021-12-30 | Provivi, Inc. | Synthesis of complex insect pheromone blends and reaction apparatuses for the same |
| CN111909915A (zh) * | 2020-07-28 | 2020-11-10 | 深圳润康生态环境股份有限公司 | 脂肪酶基因、脂肪酶及其应用 |
| CN112299991B (zh) * | 2020-09-08 | 2022-10-11 | 宁波纽康生物技术有限公司 | (e,e,z)-10,12,14-十六碳三烯乙酸酯的制备方法及组合物和诱芯 |
| CN112680365B (zh) * | 2021-02-02 | 2023-01-31 | 吉林农业大学 | 一种白僵菌用液体培养基及白僵菌菌剂制备方法 |
| US20230159978A1 (en) * | 2021-11-22 | 2023-05-25 | ExxonMobil Technology and Engineering Company | Screening of Engineered Biocatalysts for Oxyfunctionalization of Olefins |
| CN115452991B (zh) * | 2022-09-15 | 2024-07-12 | 江苏科技大学 | 十四碳烯酸和十六碳烯醛在检测检疫性害虫中的应用 |
| IL322458A (en) * | 2023-02-02 | 2025-09-01 | Atgc Biotech Pvt Ltd | Process for producing pheromones and their applications |
| CN118955670B (zh) * | 2024-10-17 | 2025-04-18 | 湘湖实验室(农业浙江省实验室) | 用于合成十八碳烯类化合物的蛋白及合成十八碳烯类化合物的方法 |
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- 2018-05-17 US US16/614,144 patent/US11104921B2/en active Active
- 2018-05-17 AR ARP180101321 patent/AR112543A1/es unknown
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- 2018-05-17 WO PCT/US2018/033151 patent/WO2018213554A1/en not_active Ceased
- 2018-05-17 CN CN201880046757.0A patent/CN110914442B/zh active Active
- 2018-05-17 EP EP18803040.7A patent/EP3635124A4/en active Pending
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