JP2020520393A5 - - Google Patents
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- JP2020520393A5 JP2020520393A5 JP2019558350A JP2019558350A JP2020520393A5 JP 2020520393 A5 JP2020520393 A5 JP 2020520393A5 JP 2019558350 A JP2019558350 A JP 2019558350A JP 2019558350 A JP2019558350 A JP 2019558350A JP 2020520393 A5 JP2020520393 A5 JP 2020520393A5
- Authority
- JP
- Japan
- Prior art keywords
- dendrimer
- integer
- composition
- pamam
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000412 dendrimer Substances 0.000 claims description 44
- 229920000736 dendritic polymer Polymers 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 30
- 229920000962 poly(amidoamine) Polymers 0.000 claims description 16
- SENLDUJVTGGYIH-UHFFFAOYSA-N n-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-[2-[bis[3-(2-aminoethylamino)-3-oxopropyl]amino]ethyl]amino]propanamide Chemical compound NCCNC(=O)CCN(CCC(=O)NCCN)CCN(CCC(=O)NCCN)CCC(=O)NCCN SENLDUJVTGGYIH-UHFFFAOYSA-N 0.000 claims description 12
- 238000002583 angiography Methods 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 230000002792 vascular Effects 0.000 claims description 6
- -1 poly (amide amine Chemical class 0.000 claims description 5
- JVJFIQYAHPMBBX-UHFFFAOYSA-N 4-hydroxynonenal Chemical compound CCCCCC(O)C=CC=O JVJFIQYAHPMBBX-UHFFFAOYSA-N 0.000 claims description 4
- 201000007737 Retinal degeneration Diseases 0.000 claims description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 208000030533 eye disease Diseases 0.000 claims description 4
- 238000012014 optical coherence tomography Methods 0.000 claims description 4
- 230000001575 pathological effect Effects 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- GIANIJCPTPUNBA-QMMMGPOBSA-N (2s)-3-(4-hydroxyphenyl)-2-nitramidopropanoic acid Chemical compound [O-][N+](=O)N[C@H](C(=O)O)CC1=CC=C(O)C=C1 GIANIJCPTPUNBA-QMMMGPOBSA-N 0.000 claims description 2
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims description 2
- HCAJQHYUCKICQH-VPENINKCSA-N 8-Oxo-7,8-dihydro-2'-deoxyguanosine Chemical compound C1=2NC(N)=NC(=O)C=2NC(=O)N1[C@H]1C[C@H](O)[C@@H](CO)O1 HCAJQHYUCKICQH-VPENINKCSA-N 0.000 claims description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 208000001953 Hypotension Diseases 0.000 claims description 2
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 2
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 claims description 2
- 206010030113 Oedema Diseases 0.000 claims description 2
- 208000003435 Optic Neuritis Diseases 0.000 claims description 2
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims description 2
- 201000007527 Retinal artery occlusion Diseases 0.000 claims description 2
- 206010038848 Retinal detachment Diseases 0.000 claims description 2
- 206010038926 Retinopathy hypertensive Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 206010046914 Vaginal infection Diseases 0.000 claims description 2
- 201000008100 Vaginitis Diseases 0.000 claims description 2
- 229960004308 acetylcysteine Drugs 0.000 claims description 2
- 229960002833 aflibercept Drugs 0.000 claims description 2
- 108010081667 aflibercept Proteins 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 230000033115 angiogenesis Effects 0.000 claims description 2
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims description 2
- 206010063452 arteriosclerotic retinopathy Diseases 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229940111134 coxibs Drugs 0.000 claims description 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims description 2
- 229960003957 dexamethasone Drugs 0.000 claims description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims description 2
- 150000002344 gold compounds Chemical class 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 201000001948 hypertensive retinopathy Diseases 0.000 claims description 2
- 230000036543 hypotension Effects 0.000 claims description 2
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 claims description 2
- 229960004657 indocyanine green Drugs 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 230000000938 luteal effect Effects 0.000 claims description 2
- 229960001810 meprednisone Drugs 0.000 claims description 2
- PIDANAQULIKBQS-RNUIGHNZSA-N meprednisone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)CC2=O PIDANAQULIKBQS-RNUIGHNZSA-N 0.000 claims description 2
- 229960004023 minocycline Drugs 0.000 claims description 2
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 claims description 2
- 230000036542 oxidative stress Effects 0.000 claims description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 2
- 230000004264 retinal detachment Effects 0.000 claims description 2
- 208000032253 retinal ischemia Diseases 0.000 claims description 2
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims description 2
- 229960001860 salicylate Drugs 0.000 claims description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 2
- 229960002930 sirolimus Drugs 0.000 claims description 2
- 206010043207 temporal arteritis Diseases 0.000 claims description 2
- 229960002117 triamcinolone acetonide Drugs 0.000 claims description 2
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims description 2
- 210000005166 vasculature Anatomy 0.000 claims 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 125000005466 alkylenyl group Chemical group 0.000 description 2
- IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930187593 rose bengal Natural products 0.000 description 1
- 229940081623 rose bengal Drugs 0.000 description 1
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762490936P | 2017-04-27 | 2017-04-27 | |
| US62/490,936 | 2017-04-27 | ||
| PCT/US2018/029882 WO2018201007A2 (en) | 2017-04-27 | 2018-04-27 | Dendrimer compositions for use in angiography |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020520393A JP2020520393A (ja) | 2020-07-09 |
| JP2020520393A5 true JP2020520393A5 (https=) | 2021-05-27 |
| JP7178108B2 JP7178108B2 (ja) | 2022-11-25 |
Family
ID=63919237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558350A Active JP7178108B2 (ja) | 2017-04-27 | 2018-04-27 | 血管造影において使用するためのデンドリマー組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11160881B2 (https=) |
| EP (1) | EP3615086A4 (https=) |
| JP (1) | JP7178108B2 (https=) |
| CN (1) | CN110913916A (https=) |
| AU (1) | AU2018258654B2 (https=) |
| CA (1) | CA3061630C (https=) |
| IL (1) | IL270169B2 (https=) |
| WO (1) | WO2018201007A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK4364724T3 (da) | 2018-05-10 | 2025-12-22 | Regeneron Pharma | Formuleringer med høj koncentration af VEGF-receptorfusionsprotein |
| JP7759322B2 (ja) | 2019-12-04 | 2025-10-23 | アシュバッタ セラピューティクス， インコーポレイテッド | 眼に薬物送達するためのデンドリマー組成物および方法 |
| CN112023061B (zh) * | 2020-07-30 | 2022-07-12 | 东华大学 | 一种功能化树状大分子包裹金纳米颗粒/PD-L1 siRNA复合物及其制备和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2093165C1 (ru) | 1993-07-06 | 1997-10-20 | Линд Роберт Мейнгардтович | Средство для лечения конъюнктивитов |
| AU6269799A (en) | 1998-09-28 | 2000-04-17 | Johns Hopkins University, The | Adrenoleukodystrophy treatments and drug screening |
| US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
| US20030180250A1 (en) | 2002-03-22 | 2003-09-25 | Council Of Scientific And Industrial Research | Compositions and complexes containing a macromolecular compound as potential anti-inflammatory agents |
| AU2003301129A1 (en) | 2002-12-20 | 2004-07-22 | Control Delivery Systems, Inc. | Steroid compositions for intraocular use |
| EP1689354A4 (en) | 2003-11-20 | 2010-07-14 | Othera Holding Inc | REDUCTION OF CATARACTS, MACULAR GENERATION AND OTHER EYES DISEASES |
| US20050276917A1 (en) | 2004-06-15 | 2005-12-15 | Helene Bolm | Process for the preparation of powder coatings |
| EP1676569A1 (en) | 2004-12-30 | 2006-07-05 | Pevion Biotech Ltd. | Lyophilization of virosomes |
| MX2007010402A (es) | 2005-04-20 | 2008-01-22 | Dendritic Nanotechnologies Inc | Polimeros dendriticos con amplificacion mejorada y funcionalidad interior. |
| US7674781B2 (en) | 2006-04-28 | 2010-03-09 | Heather Sheardown | Hyaluronic acid-retaining polymers |
| MX2008014520A (es) | 2006-05-22 | 2008-11-27 | Elan Pharm Inc | Preparacion de conjugados polimericos de compuestos terapeuticos, agricolas, y de aditivos para alimentos. |
| PL2214646T3 (pl) | 2007-10-05 | 2021-12-20 | Wayne State University | Dendrymery do przedłużonego uwalniania związków |
| JP5659789B2 (ja) | 2008-04-04 | 2015-01-28 | コニカミノルタ株式会社 | 非水系インクジェットインク、非水系インクジェットインクの製造方法及びインクジェット記録方法 |
| WO2009142754A1 (en) | 2008-05-22 | 2009-11-26 | Goverment Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dendritic conjugates and methods of use |
| US20100015231A1 (en) | 2008-07-17 | 2010-01-21 | E.I. Du Pont De Nemours And Company | Low swell, long-lived hydrogel sealant |
| US8821870B2 (en) | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| WO2010039861A2 (en) | 2008-09-30 | 2010-04-08 | The Regents Of The University Of Michigan | Dendrimer conjugates |
| CA2767163A1 (en) | 2009-06-15 | 2010-12-23 | Wayne State University | Dendrimer based nanodevices for therapeutic and imaging purposes |
| US20120177593A1 (en) | 2009-07-20 | 2012-07-12 | The Regents Of The University Of Michigan | Synthesis of dendrimer conjugates |
| WO2011072290A2 (en) | 2009-12-11 | 2011-06-16 | The Regents Of The University Of Michigan | Targeted dendrimer-drug conjugates |
| EP2552458A4 (en) | 2010-03-31 | 2014-08-27 | Univ Wayne State | INJECTABLE DENDRIMER HYDROGEL NANOPARTICLES |
| JP2013540748A (ja) | 2010-09-16 | 2013-11-07 | コーネル ユニバーシティー | 血液脳関門の透過性を調節するためのアデノシン受容体シグナル伝達の使用法 |
| WO2012142470A1 (en) | 2011-04-13 | 2012-10-18 | Massachusetts Institute Of Technology | Biocompatible adhesive materials and methods |
| US20130123330A1 (en) | 2011-07-15 | 2013-05-16 | Patrick Y. Lu | Dual Targeted siRNA Therapeutics for Treatment of Diabetic Retinopathy and Other Ocular Neovascularization Diseases |
| US20130165771A1 (en) * | 2011-12-17 | 2013-06-27 | Ming Ni | Use of fitc-dextran as dye for fundus angiography and methods thereof |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| US20150352230A1 (en) | 2013-01-11 | 2015-12-10 | The Regents Of The University Of Michigan | Synthesis and isolation of dendrimer based imaging systems |
| WO2014178892A1 (en) | 2013-05-03 | 2014-11-06 | Scanlan Thomas S | Use of sobetirome in the treatment of x-linked adrenolenoleukodystrophy |
| US20160122406A1 (en) | 2013-06-07 | 2016-05-05 | The Administrators Of The Tulane Educational Fund | Analogs of pituitary adenylate cyclase-activating polypeptide (pacap) and methods for their use |
| CN105813690A (zh) | 2013-08-21 | 2016-07-27 | 协和大学 | 树状聚合物-白藜芦醇复合物 |
| WO2015038493A1 (en) | 2013-09-10 | 2015-03-19 | The Research Foundation For The State University Of New York | Synthesis of novel asymmetric bow-tie pamam dendrimer-based conjugates for tumor-targeting drug delivery |
| CN103804693B (zh) * | 2014-01-24 | 2016-03-09 | 中国科学院化学研究所 | 树枝状聚缩酮及其制备方法和应用 |
| HUE042226T2 (hu) * | 2014-03-21 | 2019-06-28 | Sun Patent Trust | Ütemezéskérési eljárás D2D kommunikációhoz |
| CA2946422C (en) * | 2014-04-30 | 2019-03-05 | The Johns Hopkins University | Dendrimer compositions and their use in treatment of diseases of the eye |
| US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
| CN103999853B (zh) | 2014-06-11 | 2015-07-22 | 中国农业大学 | 荧光树枝状纳米大分子在制备药物载体中的应用 |
| JP6342575B2 (ja) | 2014-08-13 | 2018-06-13 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 脳腫瘍への選択的デンドリマー送達 |
| CN106659798A (zh) * | 2014-08-13 | 2017-05-10 | 约翰霍普金斯大学 | 树枝状聚合物组合物和在治疗神经与cns病症中的用途 |
| CA3003589C (en) | 2015-10-29 | 2021-12-07 | The Johns Hopkins University | Dendrimer compositions and methods for treatment of peroxisomal disorders and leukodystrophies |
| CN108289872B (zh) | 2015-10-29 | 2021-04-02 | 约翰霍普金斯大学 | 树枝状聚合物组合物和其在坏死性小肠结肠炎和其它胃肠道病症治疗中的用途 |
| JP6986758B2 (ja) | 2016-02-08 | 2021-12-22 | ザ・ジョンズ・ホプキンス・ユニバーシティー | デンドリマー−生体接着性ポリマーヒドロゲルナノ接着剤およびその使用 |
| US11918657B2 (en) * | 2017-11-10 | 2024-03-05 | The Johns Hopkins University | Dendrimer delivery system and methods of use thereof |
-
2018
- 2018-04-27 IL IL270169A patent/IL270169B2/en unknown
- 2018-04-27 US US16/608,691 patent/US11160881B2/en active Active
- 2018-04-27 WO PCT/US2018/029882 patent/WO2018201007A2/en not_active Ceased
- 2018-04-27 JP JP2019558350A patent/JP7178108B2/ja active Active
- 2018-04-27 AU AU2018258654A patent/AU2018258654B2/en active Active
- 2018-04-27 CN CN201880037028.9A patent/CN110913916A/zh active Pending
- 2018-04-27 CA CA3061630A patent/CA3061630C/en active Active
- 2018-04-27 EP EP18791444.5A patent/EP3615086A4/en active Pending
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