JP2020519621A5 - - Google Patents
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- JP2020519621A5 JP2020519621A5 JP2019561977A JP2019561977A JP2020519621A5 JP 2020519621 A5 JP2020519621 A5 JP 2020519621A5 JP 2019561977 A JP2019561977 A JP 2019561977A JP 2019561977 A JP2019561977 A JP 2019561977A JP 2020519621 A5 JP2020519621 A5 JP 2020519621A5
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- Prior art keywords
- cancer
- subject
- medicament according
- drug
- inhibits
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 40
- 201000011510 cancer Diseases 0.000 claims 33
- 239000003814 drug Substances 0.000 claims 29
- 229940079593 drug Drugs 0.000 claims 12
- 201000009030 Carcinoma Diseases 0.000 claims 9
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 9
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 9
- 208000032818 Microsatellite Instability Diseases 0.000 claims 8
- 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 claims 8
- 238000002560 therapeutic procedure Methods 0.000 claims 8
- 230000034431 double-strand break repair via homologous recombination Effects 0.000 claims 7
- 230000007547 defect Effects 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 206010008342 Cervix carcinoma Diseases 0.000 claims 5
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 5
- 201000010881 cervical cancer Diseases 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 4
- 206010014733 Endometrial cancer Diseases 0.000 claims 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 4
- 208000009956 adenocarcinoma Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 230000033607 mismatch repair Effects 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 4
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 230000033616 DNA repair Effects 0.000 claims 3
- 206010064571 Gene mutation Diseases 0.000 claims 3
- 206010023825 Laryngeal cancer Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 3
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 229940125644 antibody drug Drugs 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- PCHKPVIQAHNQLW-CQSZACIVSA-N niraparib Chemical compound N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCCNC1 PCHKPVIQAHNQLW-CQSZACIVSA-N 0.000 claims 3
- 229950011068 niraparib Drugs 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 3
- 201000002510 thyroid cancer Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- -1 JPI 289 Chemical compound 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 210000004392 genitalia Anatomy 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 2
- 210000003101 oviduct Anatomy 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- DENYZIUJOTUUNY-MRXNPFEDSA-N (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one Chemical compound FC=1C=C2C=3C=4C(CN5[C@@](C4NC3C1)(CCC5)C)=NNC2=O DENYZIUJOTUUNY-MRXNPFEDSA-N 0.000 claims 1
- NAORJNSNFJUGHU-UHFFFAOYSA-N 1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one Chemical compound C1CSCC2=C1NC=NC2=O NAORJNSNFJUGHU-UHFFFAOYSA-N 0.000 claims 1
- CTLOSZHDGZLOQE-UHFFFAOYSA-N 14-methoxy-9-[(4-methylpiperazin-1-yl)methyl]-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaene-8,10-dione Chemical compound O=C1C2=C3C=4C(OC)=CC=CC=4NC3=C3CCCC3=C2C(=O)N1CN1CCN(C)CC1 CTLOSZHDGZLOQE-UHFFFAOYSA-N 0.000 claims 1
- HRYKZAKEAVZGJD-UHFFFAOYSA-N 2-methyl-3,5,7,8-tetrahydro-4h-thiopyrano[4,3-d]pyrimidin-4-one Chemical compound C1CSCC2=C1N=C(C)NC2=O HRYKZAKEAVZGJD-UHFFFAOYSA-N 0.000 claims 1
- GSCPDZHWVNUUFI-UHFFFAOYSA-N 3-aminobenzamide Chemical compound NC(=O)C1=CC=CC(N)=C1 GSCPDZHWVNUUFI-UHFFFAOYSA-N 0.000 claims 1
- HYNBNUYQTQIHJK-UHFFFAOYSA-N 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2h-phthalazin-1-one Chemical compound C1CC(OC)CCN1C(=O)C1=CC(CC=2C3=CC=CC=C3C(=O)NN=2)=CC=C1F HYNBNUYQTQIHJK-UHFFFAOYSA-N 0.000 claims 1
- XJGXCBHXFWBOTN-UHFFFAOYSA-N 4-[[4-fluoro-3-[2-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl]phenyl]methyl]-2h-phthalazin-1-one Chemical compound C1CN2N=C(C(F)(F)F)N=C2CN1C(=O)C1=CC(CC=2C3=CC=CC=C3C(=O)NN=2)=CC=C1F XJGXCBHXFWBOTN-UHFFFAOYSA-N 0.000 claims 1
- QNQFPYADHVFRKQ-UHFFFAOYSA-N 4-[[4-fluoro-3-[5-methyl-3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]methyl]-2h-phthalazin-1-one Chemical compound C1=CC=C2C(CC=3C=C(C(=CC=3)F)C(=O)N3CC(N4C(=NN=C4C3)C(F)(F)F)C)=NNC(=O)C2=C1 QNQFPYADHVFRKQ-UHFFFAOYSA-N 0.000 claims 1
- GRPXLKXGJAGYSD-UHFFFAOYSA-N 6-[4-[(5-oxo-2,3,4,6-tetrahydro-1H-benzo[h][1,6]naphthyridin-8-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile Chemical compound O=C1C=2CCCNC=2C2=C(N1)C=C(C=C2)CN1CCN(CC1)C1=NC=C(C#N)C=C1 GRPXLKXGJAGYSD-UHFFFAOYSA-N 0.000 claims 1
- JLFSBHQQXIAQEC-UHFFFAOYSA-N 9x5a2qia7c Chemical compound C1=CC(C(=O)NN2)=C3C2=NC(CN2CC4=CC=CC=C4C2)=NC3=C1 JLFSBHQQXIAQEC-UHFFFAOYSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 108091092878 Microsatellite Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 201000004458 Myoma Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 229950002916 avelumab Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- BWVHYDYUKQEFHG-UHFFFAOYSA-N cep-8983 Chemical compound COC1=CC=CC2=C1C1=C3C(=O)NC(=O)C3=C3CCCC3=C1N2 BWVHYDYUKQEFHG-UHFFFAOYSA-N 0.000 claims 1
- HWGQMRYQVZSGDQ-HZPDHXFCSA-N chembl3137320 Chemical compound CN1N=CN=C1[C@H]([C@H](N1)C=2C=CC(F)=CC=2)C2=NNC(=O)C3=C2C1=CC(F)=C3 HWGQMRYQVZSGDQ-HZPDHXFCSA-N 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- HAVFFEMDLROBGI-UHFFFAOYSA-N m8926c7ilx Chemical compound C1CC(O)CCN1CC1=CC=C(OC=2C3=C(C(NN=C33)=O)C=CC=2)C3=C1 HAVFFEMDLROBGI-UHFFFAOYSA-N 0.000 claims 1
- ISGGVCWFTPTHIX-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)pyridine-3-carboximidamide;dihydrochloride Chemical compound Cl.Cl.C1CCCCN1CC(O)CONC(=N)C1=CC=CN=C1 ISGGVCWFTPTHIX-UHFFFAOYSA-N 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- FDLYAMZZIXQODN-UHFFFAOYSA-N olaparib Chemical compound FC1=CC=C(CC=2C3=CC=CC=C3C(=O)NN=2)C=C1C(=O)N(CC1)CCN1C(=O)C1CC1 FDLYAMZZIXQODN-UHFFFAOYSA-N 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 201000006037 primary mediastinal B-cell lymphoma Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- HMABYWSNWIZPAG-UHFFFAOYSA-N rucaparib Chemical compound C1=CC(CNC)=CC=C1C(N1)=C2CCNC(=O)C3=C2C1=CC(F)=C3 HMABYWSNWIZPAG-UHFFFAOYSA-N 0.000 claims 1
- 229950004707 rucaparib Drugs 0.000 claims 1
- INBJJAFXHQQSRW-STOWLHSFSA-N rucaparib camsylate Chemical compound CC1(C)[C@@H]2CC[C@@]1(CS(O)(=O)=O)C(=O)C2.CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23 INBJJAFXHQQSRW-STOWLHSFSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940121497 sintilimab Drugs 0.000 claims 1
- 229950007213 spartalizumab Drugs 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- JNAHVYVRKWKWKQ-CYBMUJFWSA-N veliparib Chemical compound N=1C2=CC=CC(C(N)=O)=C2NC=1[C@@]1(C)CCCN1 JNAHVYVRKWKWKQ-CYBMUJFWSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023067482A JP7717749B2 (ja) | 2017-05-09 | 2023-04-17 | 癌を治療するための併用療法 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762503879P | 2017-05-09 | 2017-05-09 | |
| US62/503,879 | 2017-05-09 | ||
| US201762508359P | 2017-05-18 | 2017-05-18 | |
| US62/508,359 | 2017-05-18 | ||
| US201762556255P | 2017-09-08 | 2017-09-08 | |
| US62/556,255 | 2017-09-08 | ||
| US201862634789P | 2018-02-23 | 2018-02-23 | |
| US62/634,789 | 2018-02-23 | ||
| US201862646332P | 2018-03-21 | 2018-03-21 | |
| US62/646,332 | 2018-03-21 | ||
| US201862648327P | 2018-03-26 | 2018-03-26 | |
| US62/648,327 | 2018-03-26 | ||
| PCT/US2018/031876 WO2018208968A1 (en) | 2017-05-09 | 2018-05-09 | Combination therapies for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023067482A Division JP7717749B2 (ja) | 2017-05-09 | 2023-04-17 | 癌を治療するための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020519621A JP2020519621A (ja) | 2020-07-02 |
| JP2020519621A5 true JP2020519621A5 (https=) | 2021-06-10 |
Family
ID=64105496
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561977A Pending JP2020519621A (ja) | 2017-05-09 | 2018-05-09 | 癌を治療するための併用療法 |
| JP2023067482A Active JP7717749B2 (ja) | 2017-05-09 | 2023-04-17 | 癌を治療するための併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023067482A Active JP7717749B2 (ja) | 2017-05-09 | 2023-04-17 | 癌を治療するための併用療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US12156872B2 (https=) |
| EP (1) | EP3621592A4 (https=) |
| JP (2) | JP2020519621A (https=) |
| KR (1) | KR20200018436A (https=) |
| CN (1) | CN110831580A (https=) |
| AU (3) | AU2018264992A1 (https=) |
| BR (1) | BR112019023591A2 (https=) |
| CA (1) | CA3063201A1 (https=) |
| IL (1) | IL270511B2 (https=) |
| MA (1) | MA48637A (https=) |
| MX (1) | MX2019013373A (https=) |
| TW (2) | TWI879716B (https=) |
| WO (1) | WO2018208968A1 (https=) |
| ZA (1) | ZA201907395B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| BR112019020211A2 (pt) | 2017-03-27 | 2020-04-22 | Tesaro, Inc. | composições de niraparib |
| KR102582624B1 (ko) | 2017-04-24 | 2023-09-22 | 테사로, 인코포레이티드 | 니라파립의 제조 방법 |
| TWI879716B (zh) | 2017-05-09 | 2025-04-11 | 美商提薩羅有限公司 | 治療癌症的組合療法 |
| AU2018270112A1 (en) | 2017-05-18 | 2019-12-12 | Tesaro, Inc. | Combination therapies for treating cancer |
| KR20250016494A (ko) | 2017-09-26 | 2025-02-03 | 테사로, 인코포레이티드 | 니라파립 제제 |
| EP3697442A4 (en) | 2017-09-30 | 2021-07-07 | Tesaro, Inc. | COMBINATION THERAPIES FOR TREATMENT OF CANCER |
| SG11202002499TA (en) | 2017-10-06 | 2020-04-29 | Tesaro Inc | Combination therapies and uses thereof |
| TW201938165A (zh) * | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | 治療癌症的方法及組合療法 |
| CN109053895B (zh) | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| US20230094843A1 (en) * | 2019-12-31 | 2023-03-30 | Fukang (Shanghai) Health Technology Co., Ltd | Pharmaceutical combination for treating tumors and application thereof |
| EP4190819A4 (en) * | 2021-03-12 | 2024-08-14 | Akeso Biopharma, Inc. | PHARMACEUTICAL COMBINATION CONTAINING BISPECIFIC ANTI-PD-1-ANTI-VEGFA ANTIBODY, AND USE THEREOF |
| US20240366584A1 (en) | 2021-06-21 | 2024-11-07 | Tesaro, Inc. | Combination treatment of cancer with a parp inhibitor and a lipophilic statin |
| WO2023159066A1 (en) | 2022-02-15 | 2023-08-24 | Tesaro, Inc. | Use of niraparib for the treatment of brain cancer |
| WO2025128263A1 (en) * | 2023-12-15 | 2025-06-19 | Pharmaessentia Corporation | Anti-pd-1 monoclonal antibody and methods of preparation thereof |
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| CA1333363C (en) | 1988-01-19 | 1994-12-06 | Judah Folkman | Angiogenesis inhibitor comprising fumagillin |
| ES2053890T3 (es) | 1988-09-01 | 1994-08-01 | Takeda Chemical Industries Ltd | Agente inhibidor de la angiogenesis. |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| US9707302B2 (en) * | 2013-07-23 | 2017-07-18 | Immunomedics, Inc. | Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| EP2007733B1 (en) | 2006-04-03 | 2016-05-25 | MSD Italia S.r.l. | Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors |
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| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| KR20100102607A (ko) | 2007-11-12 | 2010-09-24 | 바이파 사이언스 인코포레이티드 | Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 자궁암 및 난소암을 치료하는 방법 |
| CN103169973A (zh) | 2007-11-12 | 2013-06-26 | 彼帕科学公司 | 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌 |
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| JP5989965B2 (ja) | 2008-01-08 | 2016-09-07 | メルク シャープ エンド ドーム リミテッド | ２−｛４−［（３ｓ）−ピペリジン−３−イル］フェニル｝−２ｈ−インダゾール−７−カルボキサミドの薬学的に許容される塩 |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| US20120130144A1 (en) | 2009-02-04 | 2012-05-24 | Bipar Sciences, Inc. | Treatment of lung cancer with a nitrobenzamide compound in combination with a growth factor inhibitor |
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| DK3327148T3 (da) | 2010-06-18 | 2021-04-12 | Myriad Genetics Inc | Fremgangsmåder til forudsigelse af status for brca1- og brca2-gener i en cancercelle |
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2018
- 2018-05-09 TW TW107115829A patent/TWI879716B/zh active
- 2018-05-09 MA MA048637A patent/MA48637A/fr unknown
- 2018-05-09 EP EP18797986.9A patent/EP3621592A4/en not_active Withdrawn
- 2018-05-09 TW TW113103416A patent/TW202444417A/zh unknown
- 2018-05-09 US US16/612,363 patent/US12156872B2/en active Active
- 2018-05-09 JP JP2019561977A patent/JP2020519621A/ja active Pending
- 2018-05-09 BR BR112019023591-4A patent/BR112019023591A2/pt active Search and Examination
- 2018-05-09 CA CA3063201A patent/CA3063201A1/en active Pending
- 2018-05-09 WO PCT/US2018/031876 patent/WO2018208968A1/en not_active Ceased
- 2018-05-09 AU AU2018264992A patent/AU2018264992A1/en not_active Abandoned
- 2018-05-09 MX MX2019013373A patent/MX2019013373A/es unknown
- 2018-05-09 IL IL270511A patent/IL270511B2/en unknown
- 2018-05-09 CN CN201880044978.4A patent/CN110831580A/zh active Pending
- 2018-05-09 KR KR1020197036164A patent/KR20200018436A/ko active Pending
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2019
- 2019-11-07 ZA ZA2019/07395A patent/ZA201907395B/en unknown
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2021
- 2021-08-18 AU AU2021218080A patent/AU2021218080B2/en active Active
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2023
- 2023-04-17 JP JP2023067482A patent/JP7717749B2/ja active Active
- 2023-11-29 AU AU2023274126A patent/AU2023274126A1/en not_active Abandoned
- 2023-12-15 US US18/541,600 patent/US20240226082A1/en not_active Abandoned
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