JP2020536869A5 - - Google Patents
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- JP2020536869A5 JP2020536869A5 JP2020519286A JP2020519286A JP2020536869A5 JP 2020536869 A5 JP2020536869 A5 JP 2020536869A5 JP 2020519286 A JP2020519286 A JP 2020519286A JP 2020519286 A JP2020519286 A JP 2020519286A JP 2020536869 A5 JP2020536869 A5 JP 2020536869A5
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- cancer
- drug
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- agent
- inhibitor
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- 229940079593 drug Drugs 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 17
- 229940000425 combination drug Drugs 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 201000009030 Carcinoma Diseases 0.000 claims 3
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 3
- 230000000947 anti-immunosuppressive effect Effects 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 108091008605 VEGF receptors Proteins 0.000 claims 2
- 229940124674 VEGF-R inhibitor Drugs 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 229960000397 bevacizumab Drugs 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
- 150000004917 tyrosine kinase inhibitor derivatives Chemical group 0.000 claims 2
- 229940124676 vascular endothelial growth factor receptor Drugs 0.000 claims 2
- 239000002525 vasculotropin inhibitor Substances 0.000 claims 2
- PWJFNRJRHXWEPT-UHFFFAOYSA-N ADP ribose Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C1O PWJFNRJRHXWEPT-UHFFFAOYSA-N 0.000 claims 1
- SRNWOUGRCWSEMX-KEOHHSTQSA-N ADP-beta-D-ribose Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1C=2N=CN=C(C=2N=C1)N)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O SRNWOUGRCWSEMX-KEOHHSTQSA-N 0.000 claims 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims 1
- 239000002118 L01XE12 - Vandetanib Substances 0.000 claims 1
- 239000002138 L01XE21 - Regorafenib Substances 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000005890 Neuroma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- -1 Semakusanibu Chemical compound 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000003470 adrenal cortex hormone Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 229940124589 immunosuppressive drug Drugs 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 229960003784 lenvatinib Drugs 0.000 claims 1
- WOSKHXYHFSIKNG-UHFFFAOYSA-N lenvatinib Chemical compound C=12C=C(C(N)=O)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC1CC1 WOSKHXYHFSIKNG-UHFFFAOYSA-N 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- PCHKPVIQAHNQLW-CQSZACIVSA-N niraparib Chemical compound N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCCNC1 PCHKPVIQAHNQLW-CQSZACIVSA-N 0.000 claims 1
- 229950011068 niraparib Drugs 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 210000003101 oviduct Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims 1
- 229960000639 pazopanib Drugs 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000003439 radiotherapeutic effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 229960003876 ranibizumab Drugs 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 229960004836 regorafenib Drugs 0.000 claims 1
- ZOPOQLDXFHBOIH-UHFFFAOYSA-N regorafenib hydrate Chemical compound O.C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 ZOPOQLDXFHBOIH-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 229940121497 sintilimab Drugs 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 229950007213 spartalizumab Drugs 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 1
- 229960001796 sunitinib Drugs 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 229960000241 vandetanib Drugs 0.000 claims 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims 1
- 229950000578 vatalanib Drugs 0.000 claims 1
- YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762569239P | 2017-10-06 | 2017-10-06 | |
| US62/569,239 | 2017-10-06 | ||
| PCT/US2018/054606 WO2019071123A1 (en) | 2017-10-06 | 2018-10-05 | POLYRHEERAPIES AND USES THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020536869A JP2020536869A (ja) | 2020-12-17 |
| JP2020536869A5 true JP2020536869A5 (https=) | 2021-11-11 |
Family
ID=64051695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020519286A Pending JP2020536869A (ja) | 2017-10-06 | 2018-10-05 | 併用療法およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11801240B2 (https=) |
| EP (1) | EP3691685A1 (https=) |
| JP (1) | JP2020536869A (https=) |
| KR (1) | KR20200067164A (https=) |
| CN (1) | CN111182923A (https=) |
| AU (2) | AU2018346688A1 (https=) |
| BR (1) | BR112020006845A2 (https=) |
| CA (1) | CA3076859A1 (https=) |
| CL (2) | CL2020000907A1 (https=) |
| CO (1) | CO2020005223A2 (https=) |
| EA (1) | EA202090655A1 (https=) |
| IL (1) | IL273510A (https=) |
| MA (1) | MA50618A (https=) |
| MX (1) | MX2020003799A (https=) |
| PH (1) | PH12020550400A1 (https=) |
| SG (1) | SG11202002499TA (https=) |
| WO (1) | WO2019071123A1 (https=) |
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| BR112019020211A2 (pt) | 2017-03-27 | 2020-04-22 | Tesaro, Inc. | composições de niraparib |
| KR102582624B1 (ko) | 2017-04-24 | 2023-09-22 | 테사로, 인코포레이티드 | 니라파립의 제조 방법 |
| TWI879716B (zh) * | 2017-05-09 | 2025-04-11 | 美商提薩羅有限公司 | 治療癌症的組合療法 |
| AU2018270112A1 (en) | 2017-05-18 | 2019-12-12 | Tesaro, Inc. | Combination therapies for treating cancer |
| KR20250016494A (ko) | 2017-09-26 | 2025-02-03 | 테사로, 인코포레이티드 | 니라파립 제제 |
| EP3697442A4 (en) | 2017-09-30 | 2021-07-07 | Tesaro, Inc. | COMBINATION THERAPIES FOR TREATMENT OF CANCER |
| SG11202002499TA (en) | 2017-10-06 | 2020-04-29 | Tesaro Inc | Combination therapies and uses thereof |
| CA3080644A1 (en) * | 2017-12-06 | 2019-06-13 | Quanren WANG | Use of parp inhibitor in treating chemotherapy-resistant ovarian cancer or breast cancer |
| WO2020225753A2 (en) | 2019-05-06 | 2020-11-12 | Tesaro, Inc. | Methods for characterizing and treating a cancer type using cancer images |
| US20230123585A1 (en) * | 2020-03-03 | 2023-04-20 | The University Of Chicago | Compositions and methods for treating or preventing cancer using deubiquitinase inhibitors |
| CN112007042B (zh) * | 2020-09-10 | 2023-02-21 | 中国医学科学院医学生物学研究所 | 阿糖胞苷与原癌蛋白c-FOS抑制剂在制备治疗白血病的产品中的应用 |
| CN112316149A (zh) * | 2020-11-11 | 2021-02-05 | 王海涛 | 一种治疗tp53突变的晚期难治性实体瘤的药物及应用 |
| US20230414602A1 (en) * | 2020-11-27 | 2023-12-28 | SNBioScience Inc. | Pharmaceutical composition comprising insoluble camptothecin compound-containing nanoparticle for treatment of cancer and combination therapy thereof |
| US20240226059A1 (en) * | 2020-12-15 | 2024-07-11 | Kant Science Inc. | Composition for inhibiting angiogenesis and enhancing therapeutic effect of anticancer drugs in cancer patient |
| CN114748479B (zh) * | 2021-01-08 | 2023-10-20 | 轩竹生物科技股份有限公司 | 一种预防和/或治疗癌症的药物组合物 |
| KR20230133317A (ko) * | 2021-01-18 | 2023-09-19 | 액티브 바이오테크 에이비 | 골수이형성 증후군의 치료에 이용하기 위한 타스퀴니모드또는 이의 약제학적으로 허용가능한 염 |
| CN115177621B (zh) * | 2021-04-02 | 2023-09-01 | 上海市第一人民医院 | Av-951在制备用于抑制或治疗甲状腺相关眼病的药物中的应用 |
| CN113101288B (zh) * | 2021-05-08 | 2026-03-31 | 中国人民解放军空军军医大学 | 一种协同增效治疗脊索瘤的组合药物及其用途 |
| US20230201122A1 (en) * | 2021-12-23 | 2023-06-29 | Boston Scientific Medical Device Limited | Chemoembolic compositions and methods of treatment using them |
| CN116077643B (zh) * | 2021-12-31 | 2025-02-11 | 成都金瑞基业生物科技有限公司 | 治疗和/或预防肺癌的联合用药物及应用 |
| CN114712515A (zh) * | 2022-03-30 | 2022-07-08 | 上海交通大学医学院附属瑞金医院 | 一种dll4抑制剂联合parp抑制剂在制备治疗卵巢癌药物中的应用 |
| CN115177594B (zh) * | 2022-07-04 | 2023-08-15 | 武汉大学中南医院 | 一种阿昔替尼药物制剂及其制备方法 |
| CN115154589B (zh) * | 2022-08-26 | 2024-04-09 | 山东大学 | 白藜芦醇联合成纤维细胞生长因子1在缓解蒽环类药物诱导的心脏及肝脏毒性中的应用 |
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-
2018
- 2018-10-05 SG SG11202002499TA patent/SG11202002499TA/en unknown
- 2018-10-05 JP JP2020519286A patent/JP2020536869A/ja active Pending
- 2018-10-05 AU AU2018346688A patent/AU2018346688A1/en not_active Abandoned
- 2018-10-05 BR BR112020006845-4A patent/BR112020006845A2/pt not_active Application Discontinuation
- 2018-10-05 KR KR1020207012376A patent/KR20200067164A/ko not_active Ceased
- 2018-10-05 EP EP18796190.9A patent/EP3691685A1/en not_active Withdrawn
- 2018-10-05 MX MX2020003799A patent/MX2020003799A/es unknown
- 2018-10-05 CN CN201880065336.2A patent/CN111182923A/zh active Pending
- 2018-10-05 CA CA3076859A patent/CA3076859A1/en active Pending
- 2018-10-05 WO PCT/US2018/054606 patent/WO2019071123A1/en not_active Ceased
- 2018-10-05 MA MA050618A patent/MA50618A/fr unknown
- 2018-10-05 US US16/754,083 patent/US11801240B2/en active Active
- 2018-10-05 EA EA202090655A patent/EA202090655A1/ru unknown
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2020
- 2020-03-23 IL IL273510A patent/IL273510A/en unknown
- 2020-04-03 CL CL2020000907A patent/CL2020000907A1/es unknown
- 2020-04-03 PH PH12020550400A patent/PH12020550400A1/en unknown
- 2020-04-27 CO CONC2020/0005223A patent/CO2020005223A2/es unknown
- 2020-11-13 CL CL2020002958A patent/CL2020002958A1/es unknown
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2022
- 2022-03-21 AU AU2022201944A patent/AU2022201944A1/en not_active Abandoned
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