JP2020519610A5 - - Google Patents
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- Publication number
- JP2020519610A5 JP2020519610A5 JP2019561911A JP2019561911A JP2020519610A5 JP 2020519610 A5 JP2020519610 A5 JP 2020519610A5 JP 2019561911 A JP2019561911 A JP 2019561911A JP 2019561911 A JP2019561911 A JP 2019561911A JP 2020519610 A5 JP2020519610 A5 JP 2020519610A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- formula
- och2ch2
- so3h
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*(C)C(N*(C)C)=O Chemical compound C*(C)C(N*(C)C)=O 0.000 description 9
- HKAKSVXTXXEOJF-UHFFFAOYSA-N CCS(C)N(C(C=C1)=O)C1=O Chemical compound CCS(C)N(C(C=C1)=O)C1=O HKAKSVXTXXEOJF-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023061810A JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305531.0 | 2017-05-10 | ||
| EP17305531 | 2017-05-10 | ||
| PCT/EP2018/061989 WO2018206635A1 (en) | 2017-05-10 | 2018-05-09 | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061810A Division JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020519610A JP2020519610A (ja) | 2020-07-02 |
| JP2020519610A5 true JP2020519610A5 (enExample) | 2022-08-12 |
Family
ID=58873750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561911A Pending JP2020519610A (ja) | 2017-05-10 | 2018-05-09 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
| JP2023061810A Abandoned JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061810A Abandoned JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20180369401A1 (enExample) |
| EP (1) | EP3621658A1 (enExample) |
| JP (2) | JP2020519610A (enExample) |
| KR (1) | KR102722886B1 (enExample) |
| CN (1) | CN110831633A (enExample) |
| AR (1) | AR111781A1 (enExample) |
| AU (2) | AU2018265333C1 (enExample) |
| BR (1) | BR112019023336A2 (enExample) |
| CA (1) | CA3062977A1 (enExample) |
| CO (1) | CO2019012108A2 (enExample) |
| EA (1) | EA201992667A1 (enExample) |
| EC (1) | ECSP19078277A (enExample) |
| IL (1) | IL270507B2 (enExample) |
| MA (1) | MA50764A (enExample) |
| MX (1) | MX2019013421A (enExample) |
| MY (1) | MY204075A (enExample) |
| PH (1) | PH12019550230A1 (enExample) |
| TN (1) | TN2019000303A1 (enExample) |
| TW (1) | TWI778059B (enExample) |
| UY (1) | UY37728A (enExample) |
| WO (1) | WO2018206635A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| IL267709B2 (en) | 2016-12-30 | 2025-04-01 | Vaxcyte Inc | Polypeptide-antigen conjugates with unnatural amino acids |
| WO2018206635A1 (en) | 2017-05-10 | 2018-11-15 | Sanofi | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
| CN111154133B (zh) * | 2020-01-03 | 2022-07-12 | 万华化学集团股份有限公司 | 一种环氧树脂发泡剂，环氧树脂组合物及环氧发泡材料的制备方法和用途 |
| CN114053426B (zh) * | 2020-07-30 | 2024-06-18 | 成都科岭源医药技术有限公司 | 一种双药链接组装单元及双药靶向接头-药物偶联物 |
| CN115105607B (zh) * | 2021-03-22 | 2024-12-20 | 成都科岭源医药技术有限公司 | 一种用于adc的双药-接头的制备方法及其用途 |
| KR20240016287A (ko) * | 2021-06-01 | 2024-02-06 | 아지노모토 가부시키가이샤 | 항체 및 기능성 물질의 콘쥬게이트 또는 이의 염, 및 이의 제조에 사용되는 화합물 또는 이의 염 |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| CN115212315A (zh) * | 2022-08-03 | 2022-10-21 | 联宁（苏州）生物制药有限公司 | 一种抗体偶联药物中间体及含有其的抗体偶联药物 |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4040907A (en) * | 1974-06-20 | 1977-08-09 | Syva Company | Iodothyronine enzyme conjugates |
| ATE203016T1 (de) | 1993-12-21 | 2001-07-15 | Univ Hawaii | Cryptophycine |
| WO1998008505A1 (en) * | 1996-08-30 | 1998-03-05 | Eli Lilly And Company | Pharmaceutical compounds |
| US20020128185A1 (en) | 1998-02-25 | 2002-09-12 | Chuan Shih | Pharmaceutical compounds |
| US7230101B1 (en) | 2002-08-28 | 2007-06-12 | Gpc Biotech, Inc. | Synthesis of methotrexate-containing heterodimeric molecules |
| US20050175619A1 (en) | 2004-02-05 | 2005-08-11 | Robert Duffy | Methods of producing antibody conjugates |
| US8212083B2 (en) | 2006-04-27 | 2012-07-03 | Intezyne Technologies, Inc. | Heterobifunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof |
| ZA200900545B (en) | 2006-07-18 | 2010-03-31 | Sanofi Aventis | Antagonist antibody against EPHA2 for the treatment of cancer |
| BRPI0812970A2 (pt) * | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
| FR2947269B1 (fr) | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
| US8953557B2 (en) | 2009-06-30 | 2015-02-10 | Alcatel Lucent | Roaming method for a mobile terminal in WLAN, related access controller and access point device |
| UY32914A (es) | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Anticuerpos que se usan específicamente al receptor epha2 |
| AU2014337317A1 (en) * | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| PT3057585T (pt) | 2013-10-15 | 2020-10-21 | Seagen Inc | Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando |
| US10758636B2 (en) * | 2013-11-12 | 2020-09-01 | Centre For Probe Development And Commercialization | Residualizing linkers and uses thereof |
| WO2016065142A2 (en) | 2014-10-22 | 2016-04-28 | The Johns Hopkins University | New scaffolds and multifunctional intermediates for imaging psma and cancer therapy |
| EP3229844B1 (en) * | 2014-12-09 | 2020-03-04 | AbbVie Inc. | Antibody drug conjugates with cell permeable bcl-xl inhibitors |
| CN107849146A (zh) * | 2015-04-21 | 2018-03-27 | 艾伯维施特姆森特克斯有限责任公司 | 卡奇霉素构建体和使用方法 |
| TWI714661B (zh) * | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
| CN108066772B (zh) * | 2016-11-14 | 2021-07-13 | 中国科学院上海药物研究所 | 靶向tacstd2的抗体与药物偶联体(adc)分子 |
| WO2018206635A1 (en) | 2017-05-10 | 2018-11-15 | Sanofi | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
-
2018
- 2018-05-09 WO PCT/EP2018/061989 patent/WO2018206635A1/en not_active Ceased
- 2018-05-09 JP JP2019561911A patent/JP2020519610A/ja active Pending
- 2018-05-09 EP EP18722557.8A patent/EP3621658A1/en active Pending
- 2018-05-09 CN CN201880044816.0A patent/CN110831633A/zh active Pending
- 2018-05-09 AR ARP180101213A patent/AR111781A1/es not_active Application Discontinuation
- 2018-05-09 MY MYPI2019006354A patent/MY204075A/en unknown
- 2018-05-09 BR BR112019023336-9A patent/BR112019023336A2/pt unknown
- 2018-05-09 MA MA050764A patent/MA50764A/fr unknown
- 2018-05-09 EA EA201992667A patent/EA201992667A1/ru unknown
- 2018-05-09 UY UY0001037728A patent/UY37728A/es not_active Application Discontinuation
- 2018-05-09 TN TNP/2019/000303A patent/TN2019000303A1/en unknown
- 2018-05-09 MX MX2019013421A patent/MX2019013421A/es unknown
- 2018-05-09 AU AU2018265333A patent/AU2018265333C1/en active Active
- 2018-05-09 KR KR1020197035740A patent/KR102722886B1/ko active Active
- 2018-05-09 CA CA3062977A patent/CA3062977A1/en active Pending
- 2018-05-09 US US15/975,423 patent/US20180369401A1/en not_active Abandoned
- 2018-05-09 TW TW107115718A patent/TWI778059B/zh active
- 2018-05-09 US US16/612,090 patent/US20200093934A1/en active Pending
-
2019
- 2019-10-29 CO CONC2019/0012108A patent/CO2019012108A2/es unknown
- 2019-10-31 EC ECSENADI201978277A patent/ECSP19078277A/es unknown
- 2019-11-04 US US16/673,367 patent/US11007275B2/en active Active
- 2019-11-05 PH PH12019550230A patent/PH12019550230A1/en unknown
- 2019-11-07 IL IL270507A patent/IL270507B2/en unknown
-
2021
- 2021-03-23 US US17/210,072 patent/US11998611B2/en active Active
-
2022
- 2022-06-30 AU AU2022204711A patent/AU2022204711C1/en active Active
-
2023
- 2023-04-06 JP JP2023061810A patent/JP2023085475A/ja not_active Abandoned
-
2024
- 2024-04-10 US US18/631,600 patent/US20250205348A1/en active Pending
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