JP2020518289A - ガンマデルタｔ細胞の増幅、組成物およびその使用 - Google Patents

ガンマデルタｔ細胞の増幅、組成物およびその使用 Download PDF

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Publication number
JP2020518289A
JP2020518289A JP2020512082A JP2020512082A JP2020518289A JP 2020518289 A JP2020518289 A JP 2020518289A JP 2020512082 A JP2020512082 A JP 2020512082A JP 2020512082 A JP2020512082 A JP 2020512082A JP 2020518289 A JP2020518289 A JP 2020518289A
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cells
population
isolated
expanded
cell
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Japanese (ja)
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JP2020518289A5 (OSRAM
Inventor
ビートソン，リチャード
ハイデイ，エイドリアン
ヌスバウマー，オリバー
ウルフ，リチャード
ルイサ イアンニット，マリア
ルイサ イアンニット，マリア
マウント，ナタリー
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GammaDelta Therapeutics Ltd
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GammaDelta Therapeutics Ltd
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Publication of JP2020518289A publication Critical patent/JP2020518289A/ja
Publication of JP2020518289A5 publication Critical patent/JP2020518289A5/ja
Priority to JP2023022974A priority Critical patent/JP7698672B2/ja
Priority to JP2025099083A priority patent/JP2025134795A/ja
Pending legal-status Critical Current

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JP2020512082A 2017-05-03 2018-05-03 ガンマデルタｔ細胞の増幅、組成物およびその使用 Pending JP2020518289A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023022974A JP7698672B2 (ja) 2017-05-03 2023-02-17 ガンマデルタｔ細胞の増幅、組成物およびその使用
JP2025099083A JP2025134795A (ja) 2017-05-03 2025-06-13 ガンマデルタｔ細胞の増幅、組成物およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1707048.3 2017-05-03
GBGB1707048.3A GB201707048D0 (en) 2017-05-03 2017-05-03 Expansion of gamma delta cells, compositions, and methods of use thereof
PCT/EP2018/061413 WO2018202808A2 (en) 2017-05-03 2018-05-03 Expansion of gamma delta t cells, compositions, and methods of use thereof

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JP2020518289A true JP2020518289A (ja) 2020-06-25
JP2020518289A5 JP2020518289A5 (OSRAM) 2021-06-17

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JP2020512082A Pending JP2020518289A (ja) 2017-05-03 2018-05-03 ガンマデルタｔ細胞の増幅、組成物およびその使用
JP2023022974A Active JP7698672B2 (ja) 2017-05-03 2023-02-17 ガンマデルタｔ細胞の増幅、組成物およびその使用
JP2025099083A Pending JP2025134795A (ja) 2017-05-03 2025-06-13 ガンマデルタｔ細胞の増幅、組成物およびその使用

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JP2023022974A Active JP7698672B2 (ja) 2017-05-03 2023-02-17 ガンマデルタｔ細胞の増幅、組成物およびその使用
JP2025099083A Pending JP2025134795A (ja) 2017-05-03 2025-06-13 ガンマデルタｔ細胞の増幅、組成物およびその使用

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US (2) US11655453B2 (OSRAM)
EP (1) EP3619298A2 (OSRAM)
JP (3) JP2020518289A (OSRAM)
KR (2) KR102812405B1 (OSRAM)
CN (1) CN110914410A (OSRAM)
AU (2) AU2018262698B2 (OSRAM)
BR (1) BR112019023076A2 (OSRAM)
CA (1) CA3062386A1 (OSRAM)
EA (1) EA201992610A1 (OSRAM)
GB (1) GB201707048D0 (OSRAM)
IL (3) IL270365B2 (OSRAM)
MX (2) MX2019013001A (OSRAM)
PH (1) PH12019502485A1 (OSRAM)
WO (1) WO2018202808A2 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023540551A (ja) * 2020-09-04 2023-09-25 ガンマデルタ セラピューティクス リミティッド 免疫療法組成物
JP2024513990A (ja) * 2021-04-16 2024-03-27 アセポディア バイオテクノロジーズ リミテッド ガンマ・デルタｔ細胞に富む新規組成物、その調製方法、およびその使用
JP2024515064A (ja) * 2021-04-09 2024-04-04 ガンマデルタ セラピューティクス リミティッド 新規方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2601896T3 (es) 2004-11-24 2017-02-16 Fred Hutchinson Cancer Research Center Procedimientos de uso de la IL-21 en la inmunoterapia adoptiva y la identificación de antígenos tumorales
GB201707048D0 (en) 2017-05-03 2017-06-14 King S College London Expansion of gamma delta cells, compositions, and methods of use thereof
GB201804701D0 (en) 2018-03-23 2018-05-09 Gammadelta Therapeutics Ltd Lymphocytes expressing heterologous targeting constructs
GB201818243D0 (en) * 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
CA3117895A1 (en) 2018-11-08 2020-05-14 GammaDelta Therapeutics Limited Methods for isolating and expanding cells
CN109517793B (zh) * 2018-11-30 2022-05-10 广州长峰生物技术有限公司 一种NK细胞和γδT细胞共培养的建立方法
GB201909144D0 (en) * 2019-06-25 2019-08-07 Autolus Ltd Culture medium
PH12022551009A1 (en) 2019-10-31 2023-03-20 Morphosys Ag Anti-tumor combination therapy comprising anti-cd19 antibody and gamma delta t-cells
KR20220123652A (ko) * 2019-12-03 2022-09-08 아디셋 바이오, 인크. 다가 제제를 이용하여 γδ T-세포 집단을 확장시키는 방법 및 이의 조성물
US20210290674A1 (en) * 2020-03-20 2021-09-23 GammaDelta Therapeutics Ltd. Methods for treating myeloid malignancies
AU2020436661A1 (en) 2020-03-20 2022-11-10 GammaDelta Therapeutics Limited V Delta1+ T cells for the treatment of myeloid malignancies
GB202006989D0 (en) 2020-05-12 2020-06-24 Gammadelta Therapeutics Ltd Methods for isolating gamma delta t cells
CN113234675A (zh) * 2021-03-31 2021-08-10 广西医科大学 一种γδT细胞以及采用体外制备γδT细胞的方法
WO2022221439A1 (en) * 2021-04-14 2022-10-20 The Trustees Of The University Of Pennsylvania Methods to determine treatment efficacy with gamma-delta t cells
CA3235971A1 (en) * 2021-10-20 2023-04-27 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for expanding tumor infiltrating gamma-delta t cells
US20250066477A1 (en) * 2022-01-05 2025-02-27 Inhibrx Biosciences, Inc. Gamma Delta T-Cell-Binding Polypeptides and Uses Thereof
EP4680729A1 (en) * 2023-03-17 2026-01-21 Legend Biotech Ireland Limited Methods of culturing v delta 1 t cells
CN120897748A (zh) 2023-04-07 2025-11-04 武田药品工业株式会社 用于治疗复发性或难治性急性骨髓性白血病的t细胞
WO2025017531A1 (en) 2023-07-20 2025-01-23 Takeda Pharmaceutical Company Limited Grid-free methods for making gamma delta t cells
CN121909213A (zh) * 2023-07-26 2026-04-21 詹森生物科技公司 用于细胞生长的材料和方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015189356A1 (en) * 2014-06-11 2015-12-17 Polybiocept Ab Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy
WO2016081518A2 (en) * 2014-11-17 2016-05-26 Adicet Bio, Inc. Engineered gamma delta t-cells
WO2016198480A1 (en) * 2015-06-09 2016-12-15 Lymphact - Lymphocyte Activation Technologies, S.A. Methods for the production of tcr gamma delta+ t cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028176A (en) 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
DE69940352D1 (de) * 1998-11-04 2009-03-12 Therapure Biopharma Inc Verfahren zur herstellung von gamma delta t zellen
EP1777294A1 (en) 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
EP2805971A1 (en) 2005-11-28 2014-11-26 ZymoGenetics, Inc. IL-21 antagonists
WO2012088446A1 (en) 2010-12-22 2012-06-28 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
PT2710123T (pt) 2011-05-19 2017-10-13 Inst De Medicina Molecular Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmos
ES2539845B1 (es) 2013-08-05 2016-04-13 Universidad De Alicante Procedimiento y síntesis de monolitos de carbón activo a partir de cascarilla de cacao
CN105848484A (zh) * 2013-10-25 2016-08-10 得克萨斯州大学系统董事会 用于免疫治疗的多克隆γδ T细胞
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
CN114099793A (zh) * 2015-04-10 2022-03-01 哈佛学院院长等 免疫细胞捕获装置及其制备和使用方法
WO2017015427A1 (en) 2015-07-21 2017-01-26 Novartis Ag Methods for improving the efficacy and expansion of immune cells
CA3003077A1 (en) * 2015-10-30 2017-05-04 King's College London Expansion of non-haematopoietic tissue-resident .gamma.delta. t cells and uses of these cells
GB201707048D0 (en) 2017-05-03 2017-06-14 King S College London Expansion of gamma delta cells, compositions, and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015189356A1 (en) * 2014-06-11 2015-12-17 Polybiocept Ab Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy
WO2016081518A2 (en) * 2014-11-17 2016-05-26 Adicet Bio, Inc. Engineered gamma delta t-cells
WO2016198480A1 (en) * 2015-06-09 2016-12-15 Lymphact - Lymphocyte Activation Technologies, S.A. Methods for the production of tcr gamma delta+ t cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J OF INVESTIGATIVE DERMATOLOGY, 2006, VOL.126, PP.1059-1070, JPN6021052535, ISSN: 0004898345 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023540551A (ja) * 2020-09-04 2023-09-25 ガンマデルタ セラピューティクス リミティッド 免疫療法組成物
JP2024515064A (ja) * 2021-04-09 2024-04-04 ガンマデルタ セラピューティクス リミティッド 新規方法
JP2024513990A (ja) * 2021-04-16 2024-03-27 アセポディア バイオテクノロジーズ リミテッド ガンマ・デルタｔ細胞に富む新規組成物、その調製方法、およびその使用

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