JP2020517584A - 修飾ｍｒｉ造影剤およびその使用 - Google Patents

修飾ｍｒｉ造影剤およびその使用 Download PDF

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Publication number
JP2020517584A
JP2020517584A JP2019553045A JP2019553045A JP2020517584A JP 2020517584 A JP2020517584 A JP 2020517584A JP 2019553045 A JP2019553045 A JP 2019553045A JP 2019553045 A JP2019553045 A JP 2019553045A JP 2020517584 A JP2020517584 A JP 2020517584A
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JP
Japan
Prior art keywords
compound
protein
weight
diagnostic composition
mri contrast
Prior art date
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Pending
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JP2019553045A
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English (en)
Japanese (ja)
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JP2020517584A5 (https=
Inventor
エル エム ルグヤデール クレア
エル エム ルグヤデール クレア
シー ギアネッシ ネイサン
シー ギアネッシ ネイサン
イー コールマン カッサンドラ
イー コールマン カッサンドラ
ピー トンプソン マシュー
ピー トンプソン マシュー
ディトリ トレフリー
ディトリ トレフリー
エイ バーティン ポール
エイ バーティン ポール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vybyl Holdings Inc
Original Assignee
Vybyl Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vybyl Holdings Inc filed Critical Vybyl Holdings Inc
Publication of JP2020517584A publication Critical patent/JP2020517584A/ja
Publication of JP2020517584A5 publication Critical patent/JP2020517584A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2019553045A 2017-04-27 2018-04-25 修飾ｍｒｉ造影剤およびその使用 Pending JP2020517584A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762491159P 2017-04-27 2017-04-27
US62/491,159 2017-04-27
PCT/US2018/029271 WO2018200615A2 (en) 2017-04-27 2018-04-25 Modified mri contrast agents and uses thereof

Publications (2)

Publication Number Publication Date
JP2020517584A true JP2020517584A (ja) 2020-06-18
JP2020517584A5 JP2020517584A5 (https=) 2021-06-10

Family

ID=63920047

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019553045A Pending JP2020517584A (ja) 2017-04-27 2018-04-25 修飾ｍｒｉ造影剤およびその使用

Country Status (9)

Country Link
US (1) US20200046859A1 (https=)
EP (1) EP3615088A4 (https=)
JP (1) JP2020517584A (https=)
KR (1) KR20190135500A (https=)
CN (1) CN110582306A (https=)
AU (1) AU2018258345A1 (https=)
CA (1) CA3057976A1 (https=)
SG (1) SG11201908911QA (https=)
WO (1) WO2018200615A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2998528A1 (en) * 2015-09-22 2017-03-30 The Regents Of The University Of California Modified cytotoxins and their therapeutic use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665174A (ja) * 1990-04-06 1994-03-08 Schering Ag ジエチレントリアミンペンタ酢酸−モノアミド及びその錯体及び錯塩、その製法、これを含有するｎｍｒ−、レントゲン−及び放射線−診断剤並びに放射線−又は射線療法剤及びその薬剤の製法
JPH06263705A (ja) * 1993-03-12 1994-09-20 Green Cross Corp:The 新規ジエチレントリアミンペンタ酢酸誘導体、該誘導体と金属原子との錯化合物、及び該錯化合物を含む診断剤
JP2000507577A (ja) * 1996-04-01 2000-06-20 エピックス メディカル，インコーポレイテッド 画像診断用の生物活性造影剤
JP2001504843A (ja) * 1996-12-04 2001-04-10 シエーリング アクチエンゲゼルシヤフト 大環状金属錯体カルボン酸、その使用並びにその製造法
WO2008144728A1 (en) * 2007-05-21 2008-11-27 Bracco Imaging S.P.A. Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030021750A1 (en) * 2001-04-04 2003-01-30 Bakan Douglas A. Novel functional agents for magnetic resonance imaging
JP5291930B2 (ja) * 2005-03-09 2013-09-18 独立行政法人科学技術振興機構 錯化合物及びそれから成るｍｒｉプローブ

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665174A (ja) * 1990-04-06 1994-03-08 Schering Ag ジエチレントリアミンペンタ酢酸−モノアミド及びその錯体及び錯塩、その製法、これを含有するｎｍｒ−、レントゲン−及び放射線−診断剤並びに放射線−又は射線療法剤及びその薬剤の製法
JPH06263705A (ja) * 1993-03-12 1994-09-20 Green Cross Corp:The 新規ジエチレントリアミンペンタ酢酸誘導体、該誘導体と金属原子との錯化合物、及び該錯化合物を含む診断剤
JP2000507577A (ja) * 1996-04-01 2000-06-20 エピックス メディカル，インコーポレイテッド 画像診断用の生物活性造影剤
JP2001504843A (ja) * 1996-12-04 2001-04-10 シエーリング アクチエンゲゼルシヤフト 大環状金属錯体カルボン酸、その使用並びにその製造法
WO2008144728A1 (en) * 2007-05-21 2008-11-27 Bracco Imaging S.P.A. Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BELYANIN, M. L. ET AL.: "Design, synthesis and evaluation of a new Mn - Contrast agent for MR imaging of myocardium based on", CHEMICAL PHYSICS LETTERS, vol. 665, JPN7022001154, 2016, pages 111 - 116, ISSN: 0004892852 *
CARAVAN, P. ET AL.: "7 Targeted MRI Contrast Agents", THE CHEMISTRY OF CONTRAST AGENTS IN MEDICAL MAGNETIC RESONANCE IMAGING, JPN7022001152, 25 March 2013 (2013-03-25), UK, pages 311 - 342, ISSN: 0004892851 *
CARNIATO, F. ET AL.: "A Chemical Strategy for the Relaxivity Enhancement of GdIII Chelates Anchored on Mesoporous Silica N", CHEMISTRY - A EUROPEAN JOURNAL, vol. 16, JPN7022001155, 2010, pages 10727 - 10734, ISSN: 0004892850 *
LAURENT, S. ET AL.: "Noncovalent Binding of Some New Lipophilic Gadolinium DTPA Complexes to Human Serum Albumin. A Struc", CHEMISTRY & BIODIVERSITY, vol. 7(12), JPN7022001156, 2010, pages 2846 - 2855, ISSN: 0004892849 *
OTHMAN, M. ET AL.: "Synthesis and physicochemical characterization of new squalenoyl amphiphilic gadolinium complexes as", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, JPN7022001153, 2011, pages 4367 - 4386, ISSN: 0004892853 *

Also Published As

Publication number Publication date
CN110582306A (zh) 2019-12-17
WO2018200615A3 (en) 2019-01-10
EP3615088A4 (en) 2021-01-27
CA3057976A1 (en) 2018-11-01
US20200046859A1 (en) 2020-02-13
KR20190135500A (ko) 2019-12-06
SG11201908911QA (en) 2019-11-28
EP3615088A2 (en) 2020-03-04
AU2018258345A1 (en) 2019-10-17
WO2018200615A2 (en) 2018-11-01

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