AU2018258345A1 - Modified mri contrast agents and uses thereof - Google Patents

Modified mri contrast agents and uses thereof Download PDF

Info

Publication number
AU2018258345A1
AU2018258345A1 AU2018258345A AU2018258345A AU2018258345A1 AU 2018258345 A1 AU2018258345 A1 AU 2018258345A1 AU 2018258345 A AU2018258345 A AU 2018258345A AU 2018258345 A AU2018258345 A AU 2018258345A AU 2018258345 A1 AU2018258345 A1 AU 2018258345A1
Authority
AU
Australia
Prior art keywords
compound
composition
weight
protein
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2018258345A
Other languages
English (en)
Inventor
Paul A. Bertin
Cassandra E. CALLMANN
Treffly DITRI
Nathan C. Gianneschi
Clare L. M. LEGUYADER
Matthew P. THOMPSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vybyl Holdings Inc
University of California San Diego UCSD
Original Assignee
Vybyl Holdings Inc
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vybyl Holdings Inc, University of California Berkeley, University of California San Diego UCSD filed Critical Vybyl Holdings Inc
Publication of AU2018258345A1 publication Critical patent/AU2018258345A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AU2018258345A 2017-04-27 2018-04-25 Modified mri contrast agents and uses thereof Abandoned AU2018258345A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762491159P 2017-04-27 2017-04-27
US62/491,159 2017-04-27
PCT/US2018/029271 WO2018200615A2 (en) 2017-04-27 2018-04-25 Modified mri contrast agents and uses thereof

Publications (1)

Publication Number Publication Date
AU2018258345A1 true AU2018258345A1 (en) 2019-10-17

Family

ID=63920047

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018258345A Abandoned AU2018258345A1 (en) 2017-04-27 2018-04-25 Modified mri contrast agents and uses thereof

Country Status (9)

Country Link
US (1) US20200046859A1 (https=)
EP (1) EP3615088A4 (https=)
JP (1) JP2020517584A (https=)
KR (1) KR20190135500A (https=)
CN (1) CN110582306A (https=)
AU (1) AU2018258345A1 (https=)
CA (1) CA3057976A1 (https=)
SG (1) SG11201908911QA (https=)
WO (1) WO2018200615A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2998528A1 (en) * 2015-09-22 2017-03-30 The Regents Of The University Of California Modified cytotoxins and their therapeutic use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
JP3404787B2 (ja) * 1993-03-12 2003-05-12 三菱ウェルファーマ株式会社 新規ジエチレントリアミンペンタ酢酸誘導体、該誘導体と金属原子との錯化合物、及び該錯化合物を含む診断剤
AU726914B2 (en) * 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
US20030021750A1 (en) * 2001-04-04 2003-01-30 Bakan Douglas A. Novel functional agents for magnetic resonance imaging
JP5291930B2 (ja) * 2005-03-09 2013-09-18 独立行政法人科学技術振興機構 錯化合物及びそれから成るｍｒｉプローブ
WO2008144728A1 (en) * 2007-05-21 2008-11-27 Bracco Imaging S.P.A. Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications

Also Published As

Publication number Publication date
CN110582306A (zh) 2019-12-17
WO2018200615A3 (en) 2019-01-10
EP3615088A4 (en) 2021-01-27
CA3057976A1 (en) 2018-11-01
US20200046859A1 (en) 2020-02-13
KR20190135500A (ko) 2019-12-06
SG11201908911QA (en) 2019-11-28
EP3615088A2 (en) 2020-03-04
JP2020517584A (ja) 2020-06-18
WO2018200615A2 (en) 2018-11-01

Similar Documents

Publication Publication Date Title
US20230167154A1 (en) Melanocortin 1 receptor ligands and methods of use
US10654864B2 (en) Modified cytotoxins and their therapeutic use
CN102239138A (zh) 自磁性金属salen络合物
US20140065075A1 (en) Targeted contrast agents and uses thereof
US10898594B2 (en) PAMAM dendrimer based CEST imaging agents and uses thereof
US10286090B2 (en) Targeted contrast agents comprising a hydrazide functional group
US9539301B2 (en) Melanotropin ligands for skin care
AU2018258345A1 (en) Modified mri contrast agents and uses thereof
WO2018175622A1 (en) Modified anthracycline compounds and their therapeutic use
US20190381179A1 (en) Modified cytotoxins and their therapeutic use
WO2018175589A1 (en) Modified peptides and uses thereof for treating cancer
HK40019846A (en) Modified mri contrast agents and uses thereof
US20210137874A1 (en) Modified platinum compounds and therapeutic uses thereof
WO2013184678A1 (en) Molecular probes for multimodality imaging of anionic membrane surfaces
WO2018175595A1 (en) Modified histone deacetylase inhibitors and uses thereof
Vollett et al. Efficient one-step amide formation using amino porphyrins
Islam et al. Nanostructured gadolinium (III) micelles: Synthesis, characterization, cytotoxic activities, and MRI applications in vivo
WO2021007322A1 (en) Methods of using modified cytotoxins to treat cancer
You et al. A new magnetic resonance imaging probe specifically targeting vascular endothelial growth factor receptor 2: synthesis, characterization and biological evaluation
Sablan PRODRUG SYNTHESIS USING PACLITAXEL AND HYBRID PEPTIDES
JP2020094008A (ja) 金属アセン錯体を含む薬剤送達システム
CN1306863A (zh) 含磺胺基的顺磁性金属配合物磁共振成象造影剂

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period