SG11201908911QA - Modified mri contrast agents and uses thereof - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT o n ono o onno (10) International Publication Number WO 2018/200615 A2 (51) International Patent Classification: A61K 49/10 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/029271 (22) International Filing Date: 25 April 2018 (25.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/491,159 27 April 2017 (27.04.2017) US (71) Applicants: THE REGENTS OF THE UNIVERSI- TY OF CALIFORNIA [US/US]; 1111 Franklin Street, 5th Floor, Oakland, California 94607 (US). VY- BYL HOLDINGS, INC. [US/US]; 2501 Davey Road, Woodridge, Illinois 60517 (US). (72) Inventors: LEGUYADER, Clare L. M.; 10300 N. Tor- rey Pines Rd., San Diego, California 92037 (US). GIAN- NESCHI, Nathan C.; 10300 N. Torrey Pines Rd., San Diego, California 92037 (US). CALLMANN, Cassandra E.; 10300 N. Torrey Pines Rd., San Diego, California 92037 (US). THOMPSON, Matthew P.; 10300 N. Torrey Pines Rd., San Diego, California 92037 (US). DITRI, Treffly; 10300 N. Torrey Pines Rd., San Diego, California 92037 (US). BERTIN, Paul A.; 2501 Davey Rd., Woodridge, Illi- nois 60517 (US). (74) Agent: DAILEY, Robert S.; Kilpatrick Townsend & Stockton LLP, 1001 W. 4th St., Winston Salem, North Car- olina 27101 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) = (54) Title: MODIFIED MRI CONTRAST AGENTS AND USES THEREOF N O O 00 O O FIG. 1 (57) : The present disclosure generally provides compounds useful as MRI contrast agents. In some aspects, the disclosure provides MRI contrast agents that are chemically modified to have one or more moieties that include hydrophobic portions. In some aspects, the disclosure provides compositions that include such modified MRI contrast agents and a protein, such as albumin or albumin mimetics. Further, the disclosure provides various uses of these compounds and compositions.