SG11201804412SA - Dimeric contrast agents - Google Patents
Dimeric contrast agentsInfo
- Publication number
- SG11201804412SA SG11201804412SA SG11201804412SA SG11201804412SA SG11201804412SA SG 11201804412S A SG11201804412S A SG 11201804412SA SG 11201804412S A SG11201804412S A SG 11201804412SA SG 11201804412S A SG11201804412S A SG 11201804412SA SG 11201804412S A SG11201804412S A SG 11201804412SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- colleretto
- giacosa
- ribes
- crb
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 3
- 238000003384 imaging method Methods 0.000 abstract 4
- 235000011483 Ribes Nutrition 0.000 abstract 3
- 241000220483 Ribes Species 0.000 abstract 3
- 210000000614 rib Anatomy 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 241001400064 Valeria Species 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
- A61K49/105—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA the metal complex being Gd-DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/122—Macromolecular compounds dimers of complexes or complex-forming compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 111111111M 11111111111111111111111111111111111111111111111111111111111111R111111111111111 (43) International Publication Date 15 June 2017 (15.06.2017) (10) International Publication Number WO 2017/098044 Al WIPO I PCT (51) International Patent Classification: C07D 257/02 (2006.01) A61K 49/10 (2006.01) (21) International Application Number: PCT/EP2016/080621 (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, Kfl, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.170) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art 21(3)) 12 December 2016 (12.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15199220.3 10 December 2015 (10.12.2015) EP (71) Applicant: BRACCO IMAGING SPA [IT/IT]; Via Egi- dio Folli, 50, 20134 Milano (IT). (72) Inventors: BOI, Valeria; Bracco Imaging S.p.A. - CRB, Via Ribes No. 5, 1-10010 Colleretto Giacosa (IT). NA- POLITANO, Roberta; Bracco Imaging S.p.A. - CRB, Via Ribes No. 5, 1-10010 Colleretto Giacosa (IT). LATTU- ADA, Luciano; Bracco Imaging S.p.A. - CRB, Via Ribes No. 5, 1-10010 Colleretto Giacosa (IT). (74) Agent: RAVIZZA, Claudio; Via Caduti di Marcinelle 13, 20134 Milan (IT). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, W O 20 17 /0980 44 Al (54) Title: DIMERIC CONTRAST AGENTS (57) : The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15199220 | 2015-12-10 | ||
| PCT/EP2016/080621 WO2017098044A1 (en) | 2015-12-10 | 2016-12-12 | Dimeric contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201804412SA true SG11201804412SA (en) | 2018-06-28 |
Family
ID=55027251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201804412SA SG11201804412SA (en) | 2015-12-10 | 2016-12-12 | Dimeric contrast agents |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10407412B2 (en) |
| EP (2) | EP3753929B1 (en) |
| JP (1) | JP6896733B2 (en) |
| KR (1) | KR102703336B1 (en) |
| CN (1) | CN108368067B (en) |
| AU (1) | AU2016368545C1 (en) |
| BR (1) | BR112018010815B1 (en) |
| CA (1) | CA3002897C (en) |
| DK (2) | DK3753929T3 (en) |
| ES (2) | ES2843998T3 (en) |
| FI (1) | FI3753929T3 (en) |
| HR (2) | HRP20221451T1 (en) |
| HU (2) | HUE060536T2 (en) |
| IL (1) | IL259836B (en) |
| LT (1) | LT3386954T (en) |
| MX (1) | MX2018007043A (en) |
| PL (2) | PL3753929T3 (en) |
| PT (1) | PT3386954T (en) |
| RU (1) | RU2739834C2 (en) |
| SG (1) | SG11201804412SA (en) |
| SI (2) | SI3753929T1 (en) |
| WO (1) | WO2017098044A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| SI3753929T1 (en) * | 2015-12-10 | 2023-01-31 | Bracco Imaging Spa | Dimeric contrast agents |
| CN110035996B (en) | 2016-11-28 | 2022-08-09 | 拜耳医药股份公司 | Novel highly relaxant gadolinium chelates for magnetic resonance imaging |
| WO2018108780A1 (en) * | 2016-12-12 | 2018-06-21 | Bracco Imaging Spa | Dimeric contrast agents |
| KR20210095168A (en) | 2018-11-23 | 2021-07-30 | 바이엘 악티엔게젤샤프트 | Formulation of Contrast Media and Method for Preparing Same |
| AU2020399182A1 (en) | 2019-12-13 | 2022-06-09 | Bracco Imaging Spa | Manufacturing of protected DO3A |
| US20230303592A1 (en) | 2020-07-27 | 2023-09-28 | Bracco Imaging S.P.A. | Manufacturing of dimeric contrast agents |
| KR20230116805A (en) * | 2020-12-04 | 2023-08-04 | 브라코 이미징 에스.피.에이. | Manufacturing method for preparing gadoteridol |
| AU2022317221A1 (en) * | 2021-07-27 | 2023-11-16 | Bracco Imaging Spa | Manufacturing of dimeric contrast agents |
| KR20240038926A (en) | 2021-07-27 | 2024-03-26 | 브라코 이미징 에스.피.에이. | Preparation process of gadolinium complex solution |
| WO2023110863A1 (en) | 2021-12-14 | 2023-06-22 | Bracco Imaging Spa | Process for manufacturing a mixture comprising a dimeric macrocycle intermediate of a gadolinium complex |
| EP4448499A1 (en) | 2021-12-14 | 2024-10-23 | Bracco Imaging SPA | Manufacturing of dimeric contrast agent |
| WO2024074648A1 (en) | 2022-10-07 | 2024-04-11 | Bracco Imaging Spa | Precipitation and isolation of gadolinium complex |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| IT1213029B (en) | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | PARAMAGNETIC METAL ION CHELATES. |
| DE3625417C2 (en) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecane derivatives |
| US5132409A (en) | 1987-01-12 | 1992-07-21 | Bracco Industria Chimica S.P.A. | Macrocyclic chelating agents and chelates thereof |
| GB9320277D0 (en) * | 1993-10-01 | 1993-11-17 | Nycomed Salutar Inc | Chelants |
| DE4009119A1 (en) | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-TETRAAZACYCLODODECANE-BUTYLTRIOLS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
| DE4035760A1 (en) | 1990-11-08 | 1992-05-14 | Schering Ag | MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
| DE4115789A1 (en) | 1991-05-10 | 1992-11-12 | Schering Ag | MACROCYCLIC POLYMER COMPLEX IMAGERS, THEIR COMPLEXES, METHOD FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AGENTS CONTAINING THEM |
| DE4318369C1 (en) * | 1993-05-28 | 1995-02-09 | Schering Ag | Use of macrocyclic metal complexes as temperature probes |
| GB9318550D0 (en) * | 1993-09-07 | 1993-10-20 | Nycomed Salutar Inc | Chelants |
| IT1291624B1 (en) | 1997-04-18 | 1999-01-11 | Bracco Spa | COMPLEX CHELATES OF PARAMAGNETIC METALS WITH LOW TOXICITY |
| DE19719033C1 (en) | 1997-04-29 | 1999-01-28 | Schering Ag | Ion pairs, processes for their preparation and their use as contrast agents |
| IT1292128B1 (en) | 1997-06-11 | 1999-01-25 | Bracco Spa | PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELANTS AND THEIR CHELATES WITH PARAMAGNETIC METALLIC IONS |
| AU752812B2 (en) * | 1997-11-17 | 2002-10-03 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| DE19849465A1 (en) * | 1998-10-21 | 2000-04-27 | Schering Ag | New dimeric ion pairs containing cationic and anionic metal complexes; useful as low viscosity contrast agents for X-ray, magnetic resonance and radiodiagnostic techniques, and as radiotherapy agents |
| DE10117242C1 (en) * | 2001-04-06 | 2002-05-16 | Schering Ag | New dimeric tetraazacyclododecane derivatives and their metal complexes useful as components of diagnostic agents, especially X-ray contrast agents, and radiotherapeutics |
| US6852854B1 (en) * | 2002-10-01 | 2005-02-08 | Psiloquest Inc. | Preformed carboxylated active ester for labeling biomolecules |
| US7208140B2 (en) | 2003-02-19 | 2007-04-24 | Schering Aktiengesellschaft | Trimeric macrocyclic substituted benzene derivatives |
| CN1993357B (en) * | 2004-07-02 | 2011-10-19 | 伯拉考成像股份公司 | High relaxation contrast agents containing chelating moieties with polyhydroxylated substituents for magnetic resonance imaging (MRI) |
| FR2891830B1 (en) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | SHORT AMINOALCOHOL COMPOUNDS AND METAL COMPLEXES FOR MEDICAL IMAGING |
| RU2425831C2 (en) * | 2005-12-02 | 2011-08-10 | Джи-И Хелткер АС | Multimeric magnetic resonance contrast agents |
| CL2008001002A1 (en) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
| EP2149567A1 (en) | 2008-07-18 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Cyclic polyamines for binding phosphatidylserine |
| EP2457594A1 (en) * | 2010-11-05 | 2012-05-30 | Bracco Imaging S.p.A | Cest systems exhibiting a concentration independent responsiveness |
| US9315524B2 (en) | 2012-05-07 | 2016-04-19 | Kumar Ranjan Bhushan | Magnetic resonance imaging agents for calcification |
| CN102727911B (en) | 2012-07-09 | 2013-07-24 | 中国科学院长春应用化学研究所 | Diamino polyethylene glycol modified paramagnetic metal complex magnetic resonance imaging contrast agent |
| US9155804B2 (en) | 2012-09-26 | 2015-10-13 | General Electric Company | Contrast enhancement agents and method of use thereof |
| US10786497B2 (en) | 2013-08-16 | 2020-09-29 | Equip, Llc | Discrete PEG constructs |
| SI3753929T1 (en) * | 2015-12-10 | 2023-01-31 | Bracco Imaging Spa | Dimeric contrast agents |
-
2016
- 2016-12-12 SI SI201631639T patent/SI3753929T1/en unknown
- 2016-12-12 AU AU2016368545A patent/AU2016368545C1/en active Active
- 2016-12-12 CN CN201680071558.6A patent/CN108368067B/en active Active
- 2016-12-12 MX MX2018007043A patent/MX2018007043A/en unknown
- 2016-12-12 CA CA3002897A patent/CA3002897C/en active Active
- 2016-12-12 DK DK20187182.9T patent/DK3753929T3/en active
- 2016-12-12 WO PCT/EP2016/080621 patent/WO2017098044A1/en active Application Filing
- 2016-12-12 RU RU2018123572A patent/RU2739834C2/en active
- 2016-12-12 ES ES16810346T patent/ES2843998T3/en active Active
- 2016-12-12 BR BR112018010815-4A patent/BR112018010815B1/en active IP Right Grant
- 2016-12-12 LT LTEP16810346.3T patent/LT3386954T/en unknown
- 2016-12-12 EP EP20187182.9A patent/EP3753929B1/en active Active
- 2016-12-12 PT PT168103463T patent/PT3386954T/en unknown
- 2016-12-12 ES ES20187182T patent/ES2932302T3/en active Active
- 2016-12-12 KR KR1020187016958A patent/KR102703336B1/en active IP Right Grant
- 2016-12-12 HR HRP20221451TT patent/HRP20221451T1/en unknown
- 2016-12-12 HU HUE20187182A patent/HUE060536T2/en unknown
- 2016-12-12 DK DK16810346.3T patent/DK3386954T3/en active
- 2016-12-12 SI SI201631038T patent/SI3386954T1/en unknown
- 2016-12-12 US US16/060,754 patent/US10407412B2/en active Active
- 2016-12-12 PL PL20187182.9T patent/PL3753929T3/en unknown
- 2016-12-12 FI FIEP20187182.9T patent/FI3753929T3/en not_active Application Discontinuation
- 2016-12-12 SG SG11201804412SA patent/SG11201804412SA/en unknown
- 2016-12-12 HU HUE16810346A patent/HUE052680T2/en unknown
- 2016-12-12 PL PL16810346T patent/PL3386954T3/en unknown
- 2016-12-12 JP JP2018530018A patent/JP6896733B2/en active Active
- 2016-12-12 EP EP16810346.3A patent/EP3386954B1/en active Active
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2018
- 2018-06-05 IL IL259836A patent/IL259836B/en unknown
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2019
- 2019-07-25 US US16/522,076 patent/US10882849B2/en active Active
-
2020
- 2020-10-01 US US17/060,396 patent/US11401262B2/en active Active
-
2021
- 2021-01-13 HR HRP20210061TT patent/HRP20210061T1/en unknown
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