JP2020517584A5 - - Google Patents
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- JP2020517584A5 JP2020517584A5 JP2019553045A JP2019553045A JP2020517584A5 JP 2020517584 A5 JP2020517584 A5 JP 2020517584A5 JP 2019553045 A JP2019553045 A JP 2019553045A JP 2019553045 A JP2019553045 A JP 2019553045A JP 2020517584 A5 JP2020517584 A5 JP 2020517584A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- protein
- diagnostic composition
- less
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 239000002616 MRI contrast agent Substances 0.000 claims 7
- 102000008100 Human Serum Albumin Human genes 0.000 claims 6
- 108091006905 Human Serum Albumin Proteins 0.000 claims 6
- 125000000962 organic group Chemical group 0.000 claims 6
- 210000003722 extracellular fluid Anatomy 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000001165 hydrophobic group Chemical group 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 238000002296 dynamic light scattering Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- -1 carboxylic acid anion Chemical class 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- GFSTXYOTEVLASN-UHFFFAOYSA-K gadoteric acid Chemical group [Gd+3].OC(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 GFSTXYOTEVLASN-UHFFFAOYSA-K 0.000 claims 1
- 125000000743 hydrocarbylene group Chemical group 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 125000002524 organometallic group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000005166 vasculature Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491159P | 2017-04-27 | 2017-04-27 | |
| US62/491,159 | 2017-04-27 | ||
| PCT/US2018/029271 WO2018200615A2 (en) | 2017-04-27 | 2018-04-25 | Modified mri contrast agents and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020517584A JP2020517584A (ja) | 2020-06-18 |
| JP2020517584A5 true JP2020517584A5 (https=) | 2021-06-10 |
Family
ID=63920047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553045A Pending JP2020517584A (ja) | 2017-04-27 | 2018-04-25 | 修飾ｍｒｉ造影剤およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20200046859A1 (https=) |
| EP (1) | EP3615088A4 (https=) |
| JP (1) | JP2020517584A (https=) |
| KR (1) | KR20190135500A (https=) |
| CN (1) | CN110582306A (https=) |
| AU (1) | AU2018258345A1 (https=) |
| CA (1) | CA3057976A1 (https=) |
| SG (1) | SG11201908911QA (https=) |
| WO (1) | WO2018200615A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2998528A1 (en) * | 2015-09-22 | 2017-03-30 | The Regents Of The University Of California | Modified cytotoxins and their therapeutic use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| JP3404787B2 (ja) * | 1993-03-12 | 2003-05-12 | 三菱ウェルファーマ株式会社 | 新規ジエチレントリアミンペンタ酢酸誘導体、該誘導体と金属原子との錯化合物、及び該錯化合物を含む診断剤 |
| AU726914B2 (en) * | 1996-04-01 | 2000-11-23 | Epix Pharmaceuticals, Inc. | Bioactivated diagnostic imaging contrast agents |
| DE19652387A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung |
| US20030021750A1 (en) * | 2001-04-04 | 2003-01-30 | Bakan Douglas A. | Novel functional agents for magnetic resonance imaging |
| JP5291930B2 (ja) * | 2005-03-09 | 2013-09-18 | 独立行政法人科学技術振興機構 | 錯化合物及びそれから成るｍｒｉプローブ |
| WO2008144728A1 (en) * | 2007-05-21 | 2008-11-27 | Bracco Imaging S.P.A. | Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications |
-
2018
- 2018-04-25 US US16/492,660 patent/US20200046859A1/en not_active Abandoned
- 2018-04-25 KR KR1020197031523A patent/KR20190135500A/ko not_active Ceased
- 2018-04-25 EP EP18791343.9A patent/EP3615088A4/en not_active Withdrawn
- 2018-04-25 AU AU2018258345A patent/AU2018258345A1/en not_active Abandoned
- 2018-04-25 JP JP2019553045A patent/JP2020517584A/ja active Pending
- 2018-04-25 CN CN201880027317.0A patent/CN110582306A/zh active Pending
- 2018-04-25 WO PCT/US2018/029271 patent/WO2018200615A2/en not_active Ceased
- 2018-04-25 SG SG11201908911Q patent/SG11201908911QA/en unknown
- 2018-04-25 CA CA3057976A patent/CA3057976A1/en not_active Abandoned
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