JP2020515557A5 - - Google Patents
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- Publication number
- JP2020515557A5 JP2020515557A5 JP2019552891A JP2019552891A JP2020515557A5 JP 2020515557 A5 JP2020515557 A5 JP 2020515557A5 JP 2019552891 A JP2019552891 A JP 2019552891A JP 2019552891 A JP2019552891 A JP 2019552891A JP 2020515557 A5 JP2020515557 A5 JP 2020515557A5
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- JP
- Japan
- Prior art keywords
- salt
- compound selected
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479493P | 2017-03-31 | 2017-03-31 | |
| US62/479,493 | 2017-03-31 | ||
| PCT/EP2018/058056 WO2018178227A1 (en) | 2017-03-31 | 2018-03-29 | Synthesis of mcl-1 inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515557A JP2020515557A (ja) | 2020-05-28 |
| JP2020515557A5 true JP2020515557A5 (OSRAM) | 2021-03-11 |
| JP7032428B2 JP7032428B2 (ja) | 2022-03-08 |
Family
ID=61827753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019552891A Active JP7032428B2 (ja) | 2017-03-31 | 2018-03-29 | Ｍｃｌ－１阻害剤の合成 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11149024B2 (OSRAM) |
| EP (1) | EP3601230B1 (OSRAM) |
| JP (1) | JP7032428B2 (OSRAM) |
| KR (1) | KR102604876B1 (OSRAM) |
| CN (1) | CN110536884B (OSRAM) |
| AR (1) | AR111304A1 (OSRAM) |
| AU (1) | AU2018244180B2 (OSRAM) |
| CA (1) | CA3056712A1 (OSRAM) |
| CO (1) | CO2019010035A2 (OSRAM) |
| EA (1) | EA038226B1 (OSRAM) |
| ES (1) | ES2909751T3 (OSRAM) |
| IL (1) | IL269410B2 (OSRAM) |
| MX (1) | MX387814B (OSRAM) |
| TW (1) | TWI781996B (OSRAM) |
| WO (1) | WO2018178227A1 (OSRAM) |
| ZA (1) | ZA201905645B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110845520B (zh) | 2018-11-22 | 2021-04-13 | 苏州亚盛药业有限公司 | 作为mcl-1抑制剂的大环吲哚 |
| CN112204036B (zh) | 2019-01-23 | 2022-12-27 | 苏州亚盛药业有限公司 | 作为mcl-1抑制剂的大环稠合的吡唑 |
| BR112021025732A2 (pt) | 2019-06-21 | 2022-04-12 | Janssen Pharmaceutica Nv | Inibidores macrocíclicos de mcl-1 |
| ES2987630T3 (es) | 2019-07-09 | 2024-11-15 | Janssen Pharmaceutica Nv | Derivados de espirociclos macrocíclicos como inhibidores de MCL-1 |
| WO2021092053A1 (en) * | 2019-11-08 | 2021-05-14 | Unity Biotechnology, Inc. | Mcl-1 inhibitor macrocycle compounds for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| WO2021099580A1 (en) | 2019-11-21 | 2021-05-27 | Janssen Pharmaceutica Nv | Macrocyclic sulfonyl derivatives as mcl-1 inhibitors |
| EP4061819A1 (en) | 2019-11-21 | 2022-09-28 | Janssen Pharmaceutica NV | Macrocyclic indole derivatives as mcl-1 inhibitors |
| WO2021165370A1 (en) | 2020-02-21 | 2021-08-26 | Janssen Pharmaceutica Nv | Macrocyclic indole derivatives as inhibitors of mcl-1 |
| JP2023526985A (ja) | 2020-05-29 | 2023-06-26 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍｃｌ－１の阻害剤としての大環状７－ピラゾール－５－イル－インドール誘導体 |
| US20230234965A1 (en) | 2020-06-19 | 2023-07-27 | Janssen Pharmaceutica Nv | N-linked macrocyclic 4-(pyrazol-5-yl)-indole derivatives as inhibitors of mcl-1 |
| US20230234969A1 (en) | 2020-06-19 | 2023-07-27 | Janssen Pharmaceutica Nv | N-linked macrocyclic 7-(pyrazol-5-yl)-indole derivatives as inhibiors of mcl-1 |
| CN115776888A (zh) | 2020-07-08 | 2023-03-10 | 詹森药业有限公司 | 含大环醚的吲哚衍生物作为mcl-1抑制剂 |
| WO2022032284A1 (en) * | 2020-08-07 | 2022-02-10 | Zeno Management, Inc. | Macrocyclic compounds |
| CN116710458A (zh) | 2020-12-17 | 2023-09-05 | 詹森药业有限公司 | 作为mcl-1抑制剂的支链大环4-(吡唑-5-基)-吲哚衍生物 |
| CN116848126A (zh) | 2021-02-12 | 2023-10-03 | 詹森药业有限公司 | 大环1,3-桥联的6-氯-7-吡唑-4-基-1h-吲哚-2-羧酸酯和6-氯-7-嘧啶-5-基-1h-吲哚-2-羧酸酯衍生物作为mcl-1抑制剂用于治疗癌症 |
| WO2022261310A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
| EP4351564A1 (en) | 2021-06-11 | 2024-04-17 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2915811A1 (en) * | 2014-03-04 | 2015-09-09 | Centre Régional de Lutte contre le Cancer - Centre François Baclesse | MCL-1 modulating compounds for cancer treatment |
| US9949965B2 (en) * | 2014-10-17 | 2018-04-24 | Vanderbilt University | Tricyclic indole Mcl-1 inhibitors and uses thereof |
| CN105061315B (zh) * | 2015-08-06 | 2017-10-24 | 大连理工大学 | 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用 |
| ME03729B (me) * | 2016-04-22 | 2021-01-20 | Astrazeneca Ab | Makrociklički mcl1 inhibitor! za tretman raka |
| CN106478606B (zh) * | 2016-09-21 | 2019-05-10 | 沈阳药科大学 | N-取代吲哚类衍生物及其应用 |
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2018
- 2018-03-26 TW TW107110205A patent/TWI781996B/zh active
- 2018-03-28 AR ARP180100757A patent/AR111304A1/es unknown
- 2018-03-29 CA CA3056712A patent/CA3056712A1/en active Pending
- 2018-03-29 CN CN201880021146.0A patent/CN110536884B/zh active Active
- 2018-03-29 JP JP2019552891A patent/JP7032428B2/ja active Active
- 2018-03-29 ES ES18714249T patent/ES2909751T3/es active Active
- 2018-03-29 WO PCT/EP2018/058056 patent/WO2018178227A1/en not_active Ceased
- 2018-03-29 MX MX2019011468A patent/MX387814B/es unknown
- 2018-03-29 EA EA201992235A patent/EA038226B1/ru unknown
- 2018-03-29 AU AU2018244180A patent/AU2018244180B2/en active Active
- 2018-03-29 EP EP18714249.2A patent/EP3601230B1/en active Active
- 2018-03-29 US US16/497,919 patent/US11149024B2/en active Active
- 2018-03-29 KR KR1020197031979A patent/KR102604876B1/ko active Active
-
2019
- 2019-08-27 ZA ZA2019/05645A patent/ZA201905645B/en unknown
- 2019-09-16 CO CONC2019/0010035A patent/CO2019010035A2/es unknown
- 2019-09-17 IL IL269410A patent/IL269410B2/en unknown