JP2020515283A5 - - Google Patents

Info

Publication number

JP2020515283A5

JP2020515283A5 JP2019556553A JP2019556553A JP2020515283A5 JP 2020515283 A5 JP2020515283 A5 JP 2020515283A5 JP 2019556553 A JP2019556553 A JP 2019556553A JP 2019556553 A JP2019556553 A JP 2019556553A JP 2020515283 A5 JP2020515283 A5 JP 2020515283A5

Authority

JP

Japan

Prior art keywords

sequence

seq

sequence identity

amino acids

contiguous amino

Prior art date

2017-12-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001413 amino acids Chemical class 0.000 claims description 59
• 235000001014 amino acid Nutrition 0.000 claims description 55
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 43
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 39
• 229920001184 polypeptide Polymers 0.000 claims description 37
• 241000700605 Viruses Species 0.000 claims description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
• 102000040430 polynucleotide Human genes 0.000 claims description 10
• 108091033319 polynucleotide Proteins 0.000 claims description 10
• 239000002157 polynucleotide Substances 0.000 claims description 10
• 241001217856 Chimpanzee adenovirus Species 0.000 claims description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
• 241000701161 unidentified adenovirus Species 0.000 claims description 4
• 239000004475 Arginine Substances 0.000 claims description 2
• 239000004471 Glycine Substances 0.000 claims description 2
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
• 239000004472 Lysine Substances 0.000 claims description 2
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
• 235000004279 alanine Nutrition 0.000 claims description 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
• 239000004474 valine Substances 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims 1
• 238000000034 method Methods 0.000 description 13
• 230000028993 immune response Effects 0.000 description 3
• 241000712461 unidentified influenza virus Species 0.000 description 3
• 241000712431 Influenza A virus Species 0.000 description 2
• 208000037798 influenza B Diseases 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 235000018102 proteins Nutrition 0.000 description 2
• 102000004169 proteins and genes Human genes 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 2
• 238000007920 subcutaneous administration Methods 0.000 description 2
• 241000713196 Influenza B virus Species 0.000 description 1
• 241000713297 Influenza C virus Species 0.000 description 1
• 208000037797 influenza A Diseases 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1